EKS-DAR-00605

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00605

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	445.0	3.3E-133	150	470	321

Status

Unreviewed

Ensembl Protein

ENSDARP00000054415

UniProt Accession

F1Q693;

Protein Name

Protein Synonyms/Alias

Gene Name

dyrk1ab

Gene Synonyms/Alias

dyrk1ab;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000023814	ENSDARP00000007662	ENSDART00000010954
ENSDARG00000023814	ENSDARP00000054415	ENSDART00000054416

Organism

Danio rerio

Functional Description

Protein Length

734

Protein Sequence
(FASTA)

FPPGGETSAC KPSSVRLAPS LSFHAAGLQM AAPMPHSHQQ YSDCHQQSTD QSVTVLPYSD 60

QTQALTASQR HMPQCFRDPT LAPLRKLSID LIKTYKHINE VYYAKKKRRH QQGQGEDSSH 120

KKERKVFNDG YDDENYDYVV KNGEKWMDRY EIDSLIGKGS FGQVVKAYDR AEQEWVAIKI 180

IKNKKAFLNQ AQIEVRLLEL MNKHDTEMKY YIVHLKRHFM FRNHLCLVFE MLSYNLYDLL 240

RNTNFRGVSL NLTRKFAQQL CTALLFLATP ELSIIHCDLK PENILLCNPK RSAIKIVDFG 300

SSCQLGQRIY QYIQSRFYRS PEVLLGMPYD LAIDMWSLGC ILVEMHTGEP LFSGANEVDQ 360

MNKIVEVLGI PPNHIMDLAP KARKFFEKLS DGTWSIKKTK DGKRQYKPPA SRKLHAILGV 420

ECGGPGGRRA GESGHAVADY LKFKDLILRM LDYDPKTRIQ PYYALQHSFF KKTTDEGTNT 480

SSSVSTSPAL EQSQSSGTTS STSSSSGGSS GTSTSGRARS DPTHHHRHSS GHFGTAMPAI 540

DCDNLCPQAR QPYHPPVVWP GIVGPEPVTV ETHPVQETTF HVPPQHPKAG QVIATRPRPR 600

LYNSPTNSAS TQDSMEVVHG HLSMTSLSSS ASSSSTSSSS TGNHGNQAYQ LRHLPANTLD 660

FSQNGSLSMS MGLGAFSNPR QETGMAGNPT YPVATNTGTG HFIAEGHLGM RQGIDREDSP 720

MTGVCVQQSS MASS 734

Nucleotide Sequence
(FASTA)

TTTCCTCCAG GGGGAGAGAC CTCAGCATGC AAACCCTCGT CTGTCCGGCT TGCACCCTCT 60

CTTTCTTTCC ATGCTGCTGG TCTTCAGATG GCTGCTCCCA TGCCTCATTC GCACCAGCAG 120

TACAGTGACT GTCACCAGCA GAGTACAGAC CAGTCTGTCA CTGTACTGCC GTACAGTGAT 180

CAGACACAAG CACTCACTGC CAGCCAGAGG CACATGCCCC AGTGCTTTCG TGACCCCACT 240

TTAGCTCCTC TGAGGAAGCT GTCCATAGAC CTGATCAAAA CCTACAAACA CATCAATGAG 300

GTGTATTATG CAAAAAAGAA ACGACGGCAT CAACAGGGTC AAGGTGAGGA CTCCAGCCAC 360

AAGAAAGAAA GGAAAGTCTT TAATGATGGC TATGATGACG AGAACTACGA TTACGTTGTC 420

AAGAATGGGG AAAAATGGAT GGACCGCTAT GAAATCGACT CTTTGATTGG AAAAGGGTCA 480

TTTGGACAGG TTGTAAAAGC CTACGACCGA GCTGAGCAAG AGTGGGTAGC TATTAAGATC 540

ATCAAGAACA AGAAGGCCTT TCTGAATCAA GCTCAAATTG AAGTACGACT TCTCGAGCTC 600

ATGAACAAAC ATGACACAGA GATGAAATAC TATATTGTGC ACTTGAAACG GCACTTCATG 660

TTCCGGAATC ATCTTTGCTT AGTATTTGAA ATGCTGTCCT ACAATTTGTA TGACTTGTTA 720

CGAAATACGA ACTTCAGAGG TGTTTCTTTG AATCTGACAC GGAAGTTTGC CCAGCAGTTG 780

TGTACAGCAC TACTGTTTCT CGCTACACCT GAGCTCAGCA TCATCCACTG TGACTTAAAG 840

CCAGAGAACA TCCTGCTATG TAACCCCAAG AGAAGTGCCA TCAAAATAGT GGATTTTGGG 900

AGCTCCTGCC AACTGGGACA AAGGATATAT CAGTACATCC AGAGTCGATT CTACCGCTCC 960

CCTGAAGTGT TATTGGGAAT GCCATATGAC CTGGCCATAG ATATGTGGTC TCTGGGCTGT 1020

ATTCTGGTGG AAATGCACAC AGGAGAACCT TTATTTAGTG GAGCCAATGA GGTGGACCAA 1080

ATGAACAAAA TTGTTGAAGT ACTTGGGATC CCACCCAATC ACATTATGGA CCTAGCACCA 1140

AAAGCCAGGA AGTTTTTTGA AAAGCTGTCA GATGGAACAT GGAGTATTAA GAAGACCAAA 1200

GATGGAAAAA GGCAGTACAA ACCTCCGGCA TCTCGAAAGC TCCATGCCAT CTTGGGAGTG 1260

GAATGCGGTG GACCAGGTGG TCGTCGGGCG GGAGAATCTG GCCACGCAGT AGCTGACTAC 1320

TTGAAGTTCA AGGACCTCAT TCTCAGAATG CTGGACTATG ACCCCAAGAC GCGGATTCAG 1380

CCCTACTATG CCCTCCAGCA CAGTTTCTTC AAGAAAACGA CGGATGAAGG AACCAATACA 1440

AGCAGTAGTG TGTCAACAAG TCCTGCACTT GAGCAGTCGC AGTCATCAGG GACCACTTCT 1500

AGTACATCCT CAAGCTCAGG AGGATCATCT GGAACAAGCA CCAGTGGCAG AGCAAGATCC 1560

GATCCAACTC ACCACCATCG GCACAGCAGC GGGCATTTCG GCACAGCTAT GCCAGCCATA 1620

GACTGTGACA ACCTGTGCCC TCAGGCGAGA CAGCCTTATC ATCCACCAGT TGTATGGCCT 1680

GGAATCGTAG GACCAGAACC TGTCACTGTA GAGACTCATC CAGTCCAGGA AACCACTTTT 1740

CATGTGCCTC CCCAGCATCC CAAGGCAGGA CAGGTCATTG CAACGCGACC ACGGCCACGA 1800

CTCTACAACT CGCCCACCAA CAGCGCCTCC ACCCAGGATT CCATGGAGGT GGTGCACGGT 1860

CATCTGTCCA TGACATCTCT GTCTTCCTCA GCATCCTCTT CCTCCACATC TTCCTCTTCC 1920

ACAGGAAACC ACGGCAACCA GGCTTACCAG CTCCGCCATC TTCCTGCCAA CACCCTGGAC 1980

TTTAGCCAAA ACGGAAGTTT AAGTATGAGT ATGGGTTTGG GTGCCTTCTC AAATCCCCGC 2040

CAAGAGACTG GTATGGCTGG AAATCCCACG TACCCCGTTG CCACAAACAC AGGAACTGGT 2100

CACTTTATAG CAGAGGGACA CCTGGGCATG AGACAAGGCA TTGATAGGGA AGATTCTCCA 2160

ATGACTGGAG TCTGTGTTCA GCAGAGCTCG ATGGCCAGCT CGTGA 2205

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 150   YEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  209

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 210   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLAt  269

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 270   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  328

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++++ a ka+kff+k

Q: 329   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPNHIMDLAPKARKFFEK  388

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

          ++ ++ +k++          ++rk + +l+v+        p+ +++ge+ + ++d+l f

Q: 389   LSDGTWSIKKTkdgkrqykpPASRKLHAILGVE-----CGGPGGRRAGESGHAVADYLkF  443

         ********9985444444333333444444433.....445999****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 444   KDLILRMLDYDPKTRIQPYYALQHSFF  470

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPNHIMDLA PKARKFFEKL 240

SDGTWSIKKT KDGKRQYKPP ASRKLHAILG VECGGPGGRR AGESGHAVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013