EKS-DAR-00744
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00744
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src447.13.3E-134278527250
StatusReviewed
Ensembl ProteinENSDARP00000037198
UniProt AccessionF1RDG9; Q4KMJ8;
Protein NameTyrosine-protein kinase fynb
Protein Synonyms/Alias Proto-oncogene c-Fynb;
Gene Namefynb
Gene Synonyms/Alias fynb;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000025319ENSDARP00000037198ENSDART00000036635
OrganismDanio rerio
Functional DescriptionTyrosine-protein kinase implicated in the control ofcell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity).
Protein Length544
Protein Sequence
(FASTA)
MGCVQCKDKE AAKLTDDRDT SLSQSGVGYR YGVDPTPQHY PAFSGTGTAV AAIPNYNNFH 60
GAAVSQGMTV FGGISTSTHQ GTLRTRGGTG VTLFVALYDY EARTEDDLSF RKGEKFQIIN 120
STEGDWWDAR SLTTGGTGYI PSNYVAPVDS IQAEDWYFGK LGRKDAERQL LSTGNPRGTF 180
LIRESETTKG AFSLSIRDWD DVKGDHVKHY KIRKLDSGGY YITTRAQFET LQQLVQHYTE 240
RAAGLCCRLV VPCHKGMPRL TDLSVKTKDV WEIPRESLQL IKRLGNGQFG EVWMGTWNGN 300
TKVAIKTLKP GTMSPESFLE EAQIMKKLRH DKLVQLYAVV SEEPIYIVTE YMGKGSLLDF 360
LKDGEGRALK LPNLVDMAAQ VAGGMAYIER MNYIHRDLRS ANILVGDSLV CKIADFGLAR 420
LIEDNEYTAR QGAKFPIKWT APEAALYGKF TIKSDVWSFG ILLTELVTKG RVPYPGMNNR 480
EVLEQVERGY RMQCPQDCPS SLHELMVQCW KKDAEERPTF EYLQAFLEDY FTATEPQYQP 540
GDNL 544
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGCAATGTAA GGACAAAGAG GCTGCTAAGT TAACAGACGA CCGGGACACC 60
AGCTTGTCTC AGAGCGGAGT GGGTTACCGA TATGGCGTCG ACCCAACACC GCAGCACTAC 120
CCAGCCTTCA GCGGGACCGG AACTGCTGTC GCAGCCATTC CCAATTACAA CAACTTCCAC 180
GGAGCCGCTG TCTCGCAGGG CATGACAGTC TTCGGAGGGA TCAGCACATC CACACACCAA 240
GGAACACTCC GCACACGAGG GGGCACAGGT GTGACTCTGT TTGTAGCTCT CTATGATTAT 300
GAGGCCAGGA CTGAAGATGA TCTCAGTTTC AGGAAAGGAG AGAAGTTTCA AATCATCAAC 360
AGCACTGAGG GTGACTGGTG GGACGCCCGA TCTCTAACCA CCGGAGGAAC CGGCTACATT 420
CCCAGCAACT ATGTCGCCCC AGTGGACTCA ATCCAGGCTG AAGACTGGTA TTTTGGAAAG 480
TTGGGTCGTA AGGATGCAGA GAGGCAGCTT CTTTCTACAG GGAACCCCCG TGGCACATTC 540
CTAATCCGCG AGAGTGAAAC CACTAAAGGC GCCTTCTCAT TGTCTATCCG GGACTGGGAC 600
GATGTAAAGG GCGACCATGT AAAACATTAT AAAATCCGCA AACTGGACAG TGGAGGCTAC 660
TACATAACCA CTAGAGCTCA GTTCGAGACC CTTCAGCAGC TGGTCCAGCA TTACACCGAG 720
CGGGCAGCGG GGCTTTGCTG CCGCTTGGTC GTACCCTGCC ACAAAGGGAT GCCAAGGCTC 780
ACCGACCTGT CTGTCAAAAC CAAAGACGTG TGGGAGATCC CGCGGGAGTC CCTGCAGCTC 840
ATAAAGCGCT TGGGCAACGG CCAGTTTGGG GAGGTTTGGA TGGGCACGTG GAACGGCAAC 900
ACTAAAGTTG CCATAAAGAC CCTGAAGCCG GGAACCATGT CTCCTGAGTC TTTCCTGGAG 960
GAAGCGCAGA TCATGAAGAA ACTGCGGCAT GATAAACTCG TGCAGCTGTA CGCCGTGGTG 1020
TCTGAAGAGC CCATCTACAT CGTCACTGAG TACATGGGCA AAGGCAGTCT CCTAGATTTC 1080
TTGAAGGACG GAGAGGGACG AGCGCTGAAA CTGCCCAACC TGGTGGACAT GGCGGCCCAG 1140
GTGGCTGGAG GCATGGCCTA CATCGAGCGG ATGAACTACA TCCACAGAGA CCTGCGCTCC 1200
GCTAACATCC TGGTTGGTGA CAGCCTGGTG TGTAAGATTG CTGACTTCGG CCTGGCCAGA 1260
CTCATTGAAG ACAATGAATA CACCGCCCGA CAGGGGGCTA AATTCCCTAT TAAGTGGACG 1320
GCTCCAGAGG CGGCGCTGTA CGGGAAGTTC ACCATTAAAT CTGATGTCTG GTCTTTTGGA 1380
ATTCTGCTAA CAGAGCTGGT CACGAAGGGC AGAGTTCCCT ATCCAGGCAT GAATAACAGA 1440
GAGGTGCTGG AGCAGGTGGA GCGCGGCTAC CGCATGCAGT GTCCTCAGGA CTGCCCCAGC 1500
TCTCTGCATG AGCTGATGGT GCAGTGCTGG AAGAAGGACG CAGAGGAGCG GCCCACCTTC 1560
GAGTACCTGC AGGCCTTCCT GGAGGATTAC TTCACCGCCA CCGAACCTCA GTATCAGCCC 1620
GGAGACAACC TCTAG 1635
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kklrh+klv+ly
Q: 278   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLY  337
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m kGslldflk+ eg++lklp+lvd+aaqva Gmay+e++n+ihr
Q: 338   AVVSE-EPIYIVTEYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHR  396
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+++n+lvg+slv+k+adfGlarlied+eyta++gak+PikWtaPea+ +gkftiksdv
Q: 397   DLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDV  456
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte+vtkG+vPypGm+n+evleqvergyr+ +p++cp++l+el+++cwkkd+ee
Q: 457   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQDCPSSLHELMVQCWKKDAEE  516
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 517   RPTFEYLQAFL  527
         *******9876
Domain Sequence
(FASTA)
LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LRHDKLVQLY 60
AVVSEEPIYI VTEYMGKGSL LDFLKDGEGR ALKLPNLVDM AAQVAGGMAY IERMNYIHRD 120
LRSANILVGD SLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GKFTIKSDVW 180
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMQCPQD CPSSLHELMV QCWKKDAEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Cytoplasm; Developmental protein; Kinase; Lipoprotein; Manganese; Metal-binding; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00339
EKS-ANC-00354
EKS-BOT-00365
EKS-CAE-00300
EKS-CAJ-00369
EKS-CAF-00366
EKS-CAP-00398
EKS-CHH-00039
EKS-DAN-00035
EKS-FEC-00353
EKS-GAM-00219
EKS-GAA-00446
EKS-GOG-00358
EKS-HOS-00371
EKS-ICT-00346
EKS-LAC-00380
EKS-MAM-00365
EKS-MOD-00354
EKS-MUM-00397
EKS-MUP-00359
EKS-MYL-00364
EKS-ORN-00471
EKS-ORA-00320
EKS-ORC-00343
EKS-PAT-00345
EKS-PES-00325
EKS-POA-00355
EKS-PRC-00071
EKS-PTV-00093
EKS-RAN-00379
EKS-SAH-00336
EKS-SUS-00322
EKS-TUB-00053
EKS-TUT-00097
EKS-VIP-00051
EKS-XET-00483
EKS-XIM-00459
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0060027; P:convergent extension involved in gastrulation
GO:0045859; P:regulation of protein kinase activity
KEGG
dre:574422;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013