EKS-DAR-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	359.6	2.0E-107	193	456	264

Status

Unreviewed

Ensembl Protein

ENSDARP00000036490

UniProt Accession

B0V1J5;

Protein Name

Protein Synonyms/Alias

Novel protein similar to vertebrate CHK2 checkpoint homolog (S. pombe) (CHEK2, zgc:55865);

Gene Name

chek2

Gene Synonyms/Alias

chek2; CH211-207K7.3; CH211-207K7.3-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000025820	ENSDARP00000036490	ENSDART00000036421

Organism

Danio rerio

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

MSEEAGPSGE SQSQTQSQTQ SQPASSSSSA PTSSSQGSSS GSGTLSSVDT VPVQELQSIP 60

EDEEEVQPQV WGRIIPLKQG FSVLNCTENQ YSFGRDKRCD YSFSNSILKK SPYFNTYSKK 120

HFRIFRDENL VYLEDLSGNG TWVDDEKLGN GKQSLLSNNS VIALAEQKHQ VFMFIDKMAD 180

DQANLPLEFS KKYHIARKIG TGVCGEVKLA IEKETFKKVA LKTINKHDFP SIGTATRNAE 240

REIEILKKID HPCLIKTEDF YQTEDSYYIV LEYIEGGELF GRIKAKKKLE EDIAKLYFYQ 300

MLKAVEYLHN NGIIHRDLKP ENVLLASHDD ICLIKITDFN QSKILEESSL MKTLCGTPTY 360

VAPEVFTHAS TVGYTKAVDY WSLGVLLFIC LGGYPPFNTE CTTMSVREQI INGEYRFIPS 420

QWKNVSNEAK DLVKKLLVVD PQKRLSVEEA LEHPWLKDDR MRQNANQLMN PGAANQPMRP 480

EATRKRKAQE GEGEPASKRK PGP 503

Nucleotide Sequence
(FASTA)

ATGTCTGAGG AAGCTGGACC CAGCGGTGAA TCTCAGTCCC AAACTCAGTC CCAAACTCAA 60

TCCCAGCCTG CGTCTAGCTC CTCATCCGCC CCAACATCGT CAAGCCAGGG CTCGTCCTCG 120

GGCTCCGGGA CTCTGAGTTC GGTGGACACA GTACCTGTCC AGGAGCTCCA GTCCATCCCG 180

GAAGATGAGG AGGAGGTCCA GCCGCAGGTG TGGGGCCGCA TCATTCCTCT GAAGCAGGGG 240

TTCAGCGTGC TCAATTGCAC AGAAAACCAG TACAGCTTTG GGCGGGATAA AAGATGCGAT 300

TATAGTTTCA GCAACTCCAT TCTGAAAAAA TCACCGTATT TCAACACATA CAGCAAGAAA 360

CATTTTAGGA TTTTTAGGGA TGAGAATCTG GTTTATCTCG AGGACCTGAG TGGAAACGGC 420

ACATGGGTGG ACGACGAGAA ACTGGGAAAC GGGAAGCAAA GTCTACTTAG CAATAACTCC 480

GTTATCGCTC TCGCAGAACA AAAACATCAA GTTTTTATGT TCATAGATAA GATGGCGGAC 540

GATCAAGCAA ACCTTCCTTT GGAGTTCAGT AAGAAATATC ATATAGCACG AAAGATTGGG 600

ACAGGCGTCT GTGGTGAAGT GAAGCTTGCC ATTGAGAAGG AAACCTTTAA AAAGGTTGCT 660

CTGAAAACTA TAAACAAACA CGACTTTCCA TCAATAGGGA CAGCCACACG AAATGCTGAG 720

CGGGAAATCG AAATTTTAAA GAAAATTGAT CATCCGTGCC TGATCAAAAC TGAAGATTTC 780

TACCAGACTG AAGACTCCTA CTACATTGTT TTGGAGTATA TTGAAGGTGG CGAGCTGTTT 840

GGCAGGATCA AGGCCAAAAA AAAACTGGAG GAAGATATCG CCAAACTCTA CTTTTATCAG 900

ATGCTCAAGG CTGTGGAGTA TCTCCACAAT AACGGGATCA TCCATCGAGA TCTCAAACCT 960

GAGAACGTGC TGCTGGCTTC ACATGACGAC ATCTGTTTGA TTAAGATTAC GGATTTTAAT 1020

CAGTCCAAGA TTTTGGAGGA ATCCTCCCTG ATGAAGACGC TCTGTGGGAC GCCCACATAT 1080

GTGGCCCCAG AGGTGTTCAC GCACGCCTCG ACTGTGGGAT ACACAAAAGC TGTGGATTAT 1140

TGGAGTCTGG GAGTCCTACT GTTCATCTGT TTGGGTGGAT ATCCTCCATT TAACACTGAG 1200

TGCACCACCA TGTCTGTCCG TGAGCAGATC ATTAATGGCG AGTACCGCTT CATCCCCTCT 1260

CAGTGGAAGA ACGTTTCAAA TGAAGCCAAA GATTTGGTCA AGAAGCTCCT GGTTGTGGAT 1320

CCACAGAAGC GTCTGAGTGT TGAAGAGGCA CTAGAGCATC CCTGGTTAAA AGATGACAGG 1380

ATGAGACAAA ATGCAAACCA GCTGATGAAT CCTGGAGCTG CAAATCAACC AATGCGTCCA 1440

GAAGCAACAA GGAAACGCAA GGCACAAGAG GGAGAAGGTG AACCAGCATC CAAGAGGAAA 1500

CCCGGGCCTT GA 1512

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrksirssreikkakeveeeveilkkl  60

         y + +++G+G +g+vkla+ek+t kkva+k ++k+      +  + +++ e+e+eilkk+

Q: 193   YHIARKIGTGVCGEVKLAIEKETFKKVALKTINKHD---FPSIGTATRNAEREIEILKKI  249

         56889*****************************99...333345578899*********

S: 61    shPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkylh  120

         +hP+++k +d++++e+s+y+vle++egGel+ ++ akk l+ed++kl+f+q+l+av+ylh

Q: 250   DHPCLIKTEDFYQTEDSYYIVLEYIEGGELFGRIKAKKKLEEDIAKLYFYQMLKAVEYLH  309

         ************************************************************

S: 121   ekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvkk  180

         ++giihrDlkPen+Ll ++++ +l+kitDf ++k+l+e slmktlCGtp+yvaPev ++

Q: 310   NNGIIHRDLKPENVLLASHDDICLIKITDFNQSKILEESSLMKTLCGTPTYVAPEVFTHA  369

         ************************************************************

S: 181   graeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkiseea  240

          +++yt++vD WslGv+lf++l GypPf  e t++s++eqi +g+y fi+++wk++s+ea

Q: 370   STVGYTKAVDYWSLGVLLFICLGGYPPFNTECTTMSVREQIINGEYRFIPSQWKNVSNEA  429

         ************************************************************

S: 241   kdlikklLvvdPeerlsieealnhpWl  267

         kdl+kklLvvdP++rls+eeal+hpWl

Q: 430   KDLVKKLLVVDPQKRLSVEEALEHPWL  456

         **************************8

Domain Sequence
(FASTA)

YHIARKIGTG VCGEVKLAIE KETFKKVALK TINKHDFPSI GTATRNAERE IEILKKIDHP 60

CLIKTEDFYQ TEDSYYIVLE YIEGGELFGR IKAKKKLEED IAKLYFYQML KAVEYLHNNG 120

IIHRDLKPEN VLLASHDDIC LIKITDFNQS KILEESSLMK TLCGTPTYVA PEVFTHASTV 180

GYTKAVDYWS LGVLLFICLG GYPPFNTECT TMSVREQIIN GEYRFIPSQW KNVSNEAKDL 240

VKKLLVVDPQ KRLSVEEALE HPWL 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013