EKS-DAR-00793
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00793
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK336.23.3E-100194496303
StatusUnreviewed
Ensembl ProteinENSDARP00000092301
UniProt AccessionF6NJE2;
Protein Name
Protein Synonyms/Alias
Gene Nameirak1
Gene Synonyms/Alias irak1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000025949ENSDARP00000122405ENSDART00000138859
ENSDARG00000025949ENSDARP00000092301ENSDART00000101527
ENSDARG00000025949ENSDARP00000118154ENSDART00000137975
OrganismDanio rerio
Functional Description
Protein Length685
Protein Sequence
(FASTA)
LLYNLSASVM NDFTRVMDSL SNSDWISFAS QIISDQTELR LLEQSPRRTS NLMHNWGCRN 60
GTVGALLKIL EGLQWFRARD IILKAQLCNH IYVPSRLSEN KSCIIINPSI ACAQNHKEQQ 120
PSTVTFIKEH LPVPGNMFPE IRPLPRPSPP PPDSVSSTIS KTTEEVFCLN PPPLSSSAMS 180
WPFEEIQRGT CNFSPCKQIG EGGFGHVYKA VMRNTEFAVK KLKEDSHLDW NVVKESFRTE 240
VDKLSQYRHP NIMDFVGYCI SGQTYCVIYV YMPNGSLDDR LRNEFQDSNA LSWSQRVNVL 300
LGTAKAIQYL HSCSPALIHG DIKSSNILLG DHLEPKLGDF GLARLCRNPN KTPGKTSTVA 360
QTATVRGTLA YLPEEYLKDG QLGVEIDAYS FGVVMLEVLT GRQALEVDSQ SKTVFLKDLV 420
TEEEDDGRSF SKAKHSRDLS YGQTAEHICK KHLDRRLTAK DAPATHGSAD IARLACQCLE 480
RRRKKRPRMT DVFKALQDVH SGLKISDRST TINKSPVATP EPLRSDSSSI DSLSHHFSKL 540
RPQEDTYPCV HKPVFHTLTT TVTTESGCSV SQLNEESWAS QSSGVPCESD ESQGFSQYLT 600
SHCSRSKSVS CGAQGIESTK TDISSVEKQP QNVIINPARQ RLVQKMELYE EGRILTSDLL 660
SSGASLYRGM SAQTREPEES DEFAS 685
Nucleotide Sequence
(FASTA)
TTACTGTACA ATTTATCCGC GTCTGTTATG AATGACTTCA CTCGGGTTAT GGACTCGCTT 60
TCAAACTCAG ACTGGATATC TTTCGCTTCA CAAATCATAT CAGATCAGAC TGAACTACGC 120
CTTTTGGAGC AAAGCCCTCG ACGGACGAGT AACCTCATGC ACAATTGGGG TTGTCGCAAT 180
GGGACAGTTG GAGCACTGCT GAAGATTCTT GAGGGACTCC AGTGGTTCAG AGCTCGTGAT 240
ATCATTCTCA AAGCACAACT ATGTAACCAC ATCTATGTGC CAAGCAGGTT ATCAGAAAAC 300
AAATCTTGTA TTATAATAAA TCCATCAATT GCATGTGCAC AGAATCATAA AGAGCAACAA 360
CCCAGTACAG TCACATTTAT CAAAGAGCAT CTCCCTGTCC CCGGTAACAT GTTTCCAGAG 420
ATCAGGCCTT TACCCAGGCC TAGCCCTCCA CCACCTGACT CCGTGAGCTC AACAATCTCA 480
AAAACAACTG AAGAGGTATT TTGTTTGAAT CCCCCGCCTC TCTCCTCCTC TGCAATGAGC 540
TGGCCGTTTG AGGAAATACA GAGAGGCACC TGCAACTTTT CCCCATGCAA GCAGATTGGG 600
GAAGGAGGTT TTGGACACGT GTATAAAGCT GTGATGAGAA ACACTGAGTT TGCGGTGAAG 660
AAGCTGAAAG AGGATTCTCA CTTGGACTGG AATGTCGTGA AGGAAAGTTT CAGGACGGAA 720
GTGGACAAAC TCTCTCAGTA CAGACATCCC AACATTATGG ACTTTGTTGG CTACTGTATT 780
TCAGGACAAA CTTACTGTGT CATATATGTT TATATGCCCA ACGGCTCTTT AGATGACCGG 840
CTGCGCAATG AGTTTCAGGA CAGCAATGCC CTCTCTTGGT CGCAGCGTGT AAATGTGTTG 900
CTGGGAACTG CAAAAGCTAT TCAGTACCTG CATTCATGCT CACCTGCTCT TATTCATGGA 960
GACATCAAAA GCTCTAACAT CCTTTTAGGG GATCATCTTG AGCCCAAGCT CGGGGATTTT 1020
GGATTGGCGC GTTTATGCCG AAATCCTAAT AAAACCCCAG GCAAGACATC CACTGTGGCT 1080
CAGACTGCAA CGGTACGAGG AACTCTCGCA TACCTCCCGG AAGAATACCT CAAGGATGGC 1140
CAGCTTGGAG TGGAGATTGA TGCCTACAGT TTTGGAGTGG TCATGCTAGA GGTACTCACT 1200
GGACGACAAG CTCTTGAGGT TGATTCCCAA TCCAAAACAG TTTTCTTGAA AGACCTGGTA 1260
ACAGAGGAGG AAGATGATGG GAGAAGCTTC AGCAAAGCGA AGCACTCTCG AGATTTGTCC 1320
TACGGTCAAA CAGCAGAGCA CATCTGCAAA AAACATCTGG ATCGTCGACT GACCGCTAAA 1380
GATGCACCTG CAACTCATGG GTCAGCGGAC ATCGCTCGGC TGGCATGTCA GTGTTTAGAG 1440
CGGAGGAGGA AGAAGAGACC TCGCATGACA GATGTGTTCA AAGCGCTTCA GGATGTGCAT 1500
TCGGGGTTGA AGATCTCCGA CAGATCAACC ACGATCAATA AGTCTCCTGT AGCCACACCT 1560
GAGCCTCTGC GCTCCGACAG CAGCTCCATA GACTCTCTCT CCCATCACTT CTCCAAACTC 1620
CGGCCTCAGG AGGACACGTA CCCCTGCGTT CACAAGCCTG TCTTTCACAC GTTGACTACT 1680
ACAGTGACTA CAGAGTCCGG CTGCTCGGTC TCGCAGCTGA ATGAGGAGTC GTGGGCTTCA 1740
CAGTCATCTG GTGTGCCTTG CGAATCGGAT GAGAGTCAAG GCTTTTCTCA GTACTTGACG 1800
AGCCATTGTA GCAGATCTAA GTCAGTGTCG TGTGGAGCCC AAGGCATTGA GAGCACTAAA 1860
ACAGACATTT CTTCAGTGGA AAAGCAACCA CAGAATGTTA TCATCAACCC CGCTAGGCAG 1920
CGATTGGTAC AGAAAATGGA GCTTTATGAA GAAGGGAGGA TTTTAACTTC TGATTTGTTG 1980
TCGTCAGGCG CCTCACTATA CCGAGGGATG AGCGCTCAAA CCAGAGAGCC AGAAGAGAGT 2040
GATGAGTTTG CAAGT 2055
Domain Profile
S: 2     sednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnil  61
         s  ++igeGgfg+vy++ ++nt +avkklke  +l+++ +k+sf tE+  l+++rH+ni+
Q: 194   SPCKQIGEGGFGHVYKAVMRNTEFAVKKLKEDSHLDWNVVKESFRTEVDKLSQYRHPNIM  253
         56689*******************************************************
S: 62    ellgysaeseklcLvYqymknGsLedrLqcq.kgsepLsWpqRlsillGtaraiefLHea  120
         +++gy++ ++++c++Y ym+nGsL drL+ + ++s+ LsW qR+++llGta+ai++LH+ 
Q: 254   DFVGYCISGQTYCVIYVYMPNGSLDDRLRNEfQDSNALSWSQRVNVLLGTAKAIQYLHSC  313
         ******************************99****************************
S: 121   spslihgdiksaNiLLDekltpKlgDfglar...fapesekqsstvlrtskvrgtlaYlp  177
         sp+lihgdiks+NiLL ++l+pKlgDfglar      +++ ++stv++t +vrgtlaYlp
Q: 314   SPALIHGDIKSSNILLGDHLEPKLGDFGLARlcrNPNKTPGKTSTVAQTATVRGTLAYLP  373
         *******************************4322234456789****************
S: 178   eefirvgqltvkvDvySfGiVllEvltGlra..vdedrktkyLkdllkeeieeekv....  231
         ee+++ gql v++D ySfG+V+lEvltG++a  vd + kt+ Lkdl+ ee ++ +     
Q: 374   EEYLKDGQLGVEIDAYSFGVVMLEVLTGRQAleVDSQSKTVFLKDLVTEEEDDGRSfska  433
         *******************************9999999*********99999988899**
S: 232   .............eilekfldkkagkl..eeel.lealielalaclaekakkrPtmsqvl  275
                      +i++k+ld++      + +  ++ +++la++cl++++kkrP m++v 
Q: 434   khsrdlsygqtaeHICKKHLDRRLTAKdaPATHgSADIARLACQCLERRRKKRPRMTDVF  493
         **********************987652244441456889*******************9
S: 276   ell  278
         + l
Q: 494   KAL  496
         876
Domain Sequence
(FASTA)
SPCKQIGEGG FGHVYKAVMR NTEFAVKKLK EDSHLDWNVV KESFRTEVDK LSQYRHPNIM 60
DFVGYCISGQ TYCVIYVYMP NGSLDDRLRN EFQDSNALSW SQRVNVLLGT AKAIQYLHSC 120
SPALIHGDIK SSNILLGDHL EPKLGDFGLA RLCRNPNKTP GKTSTVAQTA TVRGTLAYLP 180
EEYLKDGQLG VEIDAYSFGV VMLEVLTGRQ ALEVDSQSKT VFLKDLVTEE EDDGRSFSKA 240
KHSRDLSYGQ TAEHICKKHL DRRLTAKDAP ATHGSADIAR LACQCLERRR KKRPRMTDVF 300
KAL 303
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00380
EKS-ANC-00394
EKS-BOT-00406
EKS-CAE-00355
EKS-CAJ-00411
EKS-CAF-00406
EKS-DRM-00191
EKS-EQC-00398
EKS-ERE-00006
EKS-FEC-00392
EKS-GAG-00345
EKS-GAA-00495
EKS-GOG-00398
EKS-HOS-00412
EKS-ICT-00385
EKS-LAC-00421
EKS-LOA-00415
EKS-MAM-00407
EKS-MEG-00339
EKS-MIM-00062
EKS-MOD-00395
EKS-MUM-00438
EKS-MUP-00400
EKS-MYL-00401
EKS-ORN-00520
EKS-ORA-00354
EKS-ORC-00381
EKS-OTG-00408
EKS-PAT-00384
EKS-PES-00362
EKS-PEM-00221
EKS-POA-00398
EKS-PRC-00006
EKS-PTV-00116
EKS-RAN-00420
EKS-SAH-00376
EKS-SUS-00360
EKS-TAG-00479
EKS-TAR-00515
EKS-TEN-00517
EKS-TUT-00120
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013