EKS-DAR-00646

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00646

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	466.5	4.5E-140	713	969	257

Status

Unreviewed

Ensembl Protein

ENSDARP00000010252

UniProt Accession

F1R5S1;

Protein Name

Protein Synonyms/Alias

Gene Name

erbb2

Gene Synonyms/Alias

erbb2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000026294	ENSDARP00000010252	ENSDART00000003932
ENSDARG00000026294	ENSDARP00000099586	ENSDART00000114258

Organism

Danio rerio

Functional Description

Protein Length

1275

Protein Sequence
(FASTA)

MEADRSFGLA WVLLLLLGIT AATGREVCLG TDMKLALPSS LENHYEMLRL LYTGCQVVHG 60

NLEITHLQGN PDLSFLQEIV EVQGYVLIAH VSVRSLPLDN LRIIRGSQLY KSNYALAVHN 120

NSNSSQAGLG LRELRLRSLT EILLGGVYIW GNPQLCFPRN INWEDTVSKV QNKPLHLQDI 180

PKNCPRCSSA CKSGGCWGEK DQDCQTLTSV NCSSGCSRCK GPKPSDCCHV QCAAGCTGPK 240

DSDCLACRHF NDSGTCKDSC PPPTIYDPIT FQSKPNKDKK FSFGATCVKQ CPHNYLAMEV 300

ACTMVCPKAN KEVISVEPDG QETQKCEKCE GECPKVCYGL GMGNLQGVSV VNSTNIGMFT 360

GCEKIYGSLA FLSDSFKGNA DTNSSGLQPS DLEKLKTIEE ITGYLYIDAW SENLLDLSVF 420

ENLKVIRGRM LYKGVFSLGV QSLQIESLGL RSLRSVSGGL VLIHNNSRLC YTSSLPWTSL 480

LHPTQGPNLI SNNNKDQQTC VSEGKICDPL CGDSGCWGPG PSQCVSCLNY KRGTECVELC 540

NVLHGSVREF EDGFNCVPCH PECRPINGTA SCTGPGPDQC TDCTHFQDGD VCVERCPSGV 600

KEEQHTVWKY SNATGHCLPC ETNCTVSCPL DDRGCPIQQK TGPGTTVAIT VGGVLLFIIL 660

LALLVFYLRR QKHQKKKETI RRRLQEHELV EPLTPSGAMP NQAQMRILKE TELKKLRVLG 720

SGAFGTVFKG IWAPDGENVR IPVAIKVLRE NTSPKANKEI LDEAYVMAGV ASPYVCRLLG 780

ICLTSTVQLV TQLMPYGCLL DYVRENKDRI GSQYLLSWCV QIAKGMSYLE EVRLVHRDLA 840

ARNVLVKNPN HVKITDFGLA RLLDIDEKEY HADGGKVPIK WMALESILHR KFTHQSDVWS 900

YGVTVWELMT FGMKPYESFQ ARDIPELLEA GERLSQPCNC TKEVYMIMVK CWQIDPDNRP 960

RFKDLVEEFT TMARDPSRYV VIQNEDQMSL SSPVDSEFFR ILMAEEGGNV KEFLDAEEYL 1020

VPQPGSIFNT HGEMRANGPS RHHSHRSTDQ MVEVDGLPNG RELYSSVSMI EQSQYPTLPV 1080

GATANGMWPG TQYPPLARSI SHRSAGGQSD SVFLDGYVED SCPPSSPCRY SKDPTMPNGI 1140

DGDLETDGNM VFLSHTLPRG THTQPEYVNQ DIASERPSTL PRKASERRFI LNGLSTGNSV 1200

ENPEYLVPIG SITPTSPAFD NPYYHDIAAK AQVVARVAIN GGTNHRQPNG FMTPTAENPE 1260

YLGLADTWSG HKEYT 1275

Nucleotide Sequence
(FASTA)

ATGGAGGCGG ACAGAAGTTT TGGGCTCGCC TGGGTCCTCC TGCTGCTGTT GGGCATTACA 60

GCCGCCACAG GGAGAGAAGT ATGTCTCGGG ACCGATATGA AACTGGCTTT ACCCTCCAGT 120

CTGGAAAATC ATTATGAAAT GCTCAGGCTG CTCTACACAG GCTGTCAGGT GGTTCATGGT 180

AACCTGGAGA TCACACACCT GCAGGGCAAT CCAGACCTCT CTTTCCTGCA GGAGATAGTG 240

GAGGTTCAGG GGTATGTGCT GATAGCTCAC GTCTCCGTGC GCTCTCTTCC ACTGGACAAT 300

CTGCGGATTA TACGAGGCAG TCAGCTTTAT AAATCCAACT ATGCTCTCGC TGTACACAAC 360

AACAGCAACA GCAGTCAGGC TGGACTCGGC CTGAGAGAAC TTCGCCTCAG GAGTCTAACA 420

GAAATCCTGC TTGGTGGGGT TTATATTTGG GGAAATCCCC AGCTTTGCTT TCCTCGGAAC 480

ATTAACTGGG AAGACACAGT TAGTAAAGTT CAAAACAAAC CACTGCACCT GCAAGACATT 540

CCAAAAAACT GTCCTCGTTG CTCTTCAGCT TGTAAATCTG GTGGATGTTG GGGAGAAAAA 600

GATCAGGACT GCCAAACATT GACGTCTGTG AACTGCTCAT CTGGCTGTTC GCGCTGTAAG 660

GGCCCGAAAC CCAGTGACTG CTGCCATGTC CAGTGTGCTG CTGGTTGTAC TGGGCCCAAA 720

GACTCGGATT GTCTGGCCTG TCGACACTTC AATGACAGCG GGACATGTAA AGACAGCTGT 780

CCACCGCCCA CTATCTACGA CCCAATCACC TTCCAGTCCA AACCCAACAA AGACAAAAAG 840

TTCAGCTTCG GAGCCACCTG TGTTAAACAG TGTCCCCATA ACTACCTGGC AATGGAAGTG 900

GCATGCACAA TGGTCTGTCC CAAAGCCAAC AAGGAAGTCA TATCTGTGGA GCCAGACGGC 960

CAAGAAACAC AGAAATGTGA AAAGTGTGAA GGAGAGTGTC CAAAAGTGTG TTATGGTCTG 1020

GGAATGGGAA ACCTGCAGGG AGTTTCAGTG GTGAATTCAA CCAACATCGG CATGTTCACC 1080

GGCTGCGAGA AGATCTACGG CAGTTTGGCT TTTCTTTCAG ACTCCTTCAA AGGAAATGCA 1140

GACACCAATT CATCCGGCCT GCAACCCAGC GATCTGGAGA AGTTGAAGAC GATAGAAGAA 1200

ATCACAGGAT ATCTGTACAT AGATGCATGG TCAGAAAACT TGCTTGATCT GAGTGTTTTT 1260

GAAAACCTGA AGGTGATCAG AGGACGAATG CTTTACAAGG GTGTTTTCTC TTTGGGAGTT 1320

CAGTCTCTGC AGATCGAGTC GCTGGGATTG CGTTCTTTAC GCAGTGTCAG TGGAGGTTTA 1380

GTGCTGATTC ATAATAACTC CAGACTGTGT TACACCTCCT CTCTGCCCTG GACCTCACTG 1440

CTCCACCCAA CACAAGGACC AAACCTCATC AGCAACAACA ACAAAGACCA GCAAACATGT 1500

GTTTCAGAGG GGAAAATATG TGACCCCTTG TGTGGGGATT CAGGTTGTTG GGGTCCAGGA 1560

CCCAGTCAAT GTGTGTCTTG TCTGAATTAC AAACGAGGAA CTGAGTGTGT GGAGCTGTGT 1620

AATGTCCTAC ACGGGTCAGT GCGGGAGTTT GAGGATGGAT TTAACTGTGT TCCTTGTCAT 1680

CCCGAGTGTC GACCAATCAA TGGCACTGCC TCCTGTACAG GCCCAGGTCC AGATCAGTGT 1740

ACAGACTGTA CGCACTTTCA AGATGGAGAC GTGTGTGTCG AGCGCTGTCC CAGTGGAGTC 1800

AAAGAGGAAC AACACACTGT GTGGAAATAC TCCAATGCTA CGGGACACTG TCTGCCCTGT 1860

GAGACCAACT GTACTGTCTC GTGTCCACTG GATGATAGAG GGTGTCCCAT TCAACAGAAA 1920

ACTGGGCCCG GCACAACAGT TGCAATCACG GTCGGTGGAG TGCTTCTCTT CATCATTTTG 1980

CTGGCTCTGC TGGTGTTTTA CCTACGGCGA CAGAAACATC AGAAAAAGAA AGAAACCATA 2040

AGGAGACGCC TACAGGAGCA TGAGCTGGTG GAGCCGCTGA CCCCGAGTGG AGCAATGCCA 2100

AACCAGGCTC AGATGCGGAT CCTTAAGGAG ACAGAGCTGA AGAAGCTCAG AGTGCTCGGC 2160

TCCGGAGCCT TCGGCACCGT CTTCAAGGGT ATCTGGGCTC CTGATGGGGA GAACGTGAGG 2220

ATCCCTGTGG CCATCAAAGT TTTACGTGAG AACACCTCAC CCAAAGCCAA CAAAGAAATC 2280

CTGGATGAGG CTTATGTGAT GGCGGGTGTA GCGAGCCCAT ATGTGTGCCG TTTGCTGGGA 2340

ATCTGTCTGA CATCAACGGT TCAGCTGGTT ACTCAGCTCA TGCCATACGG ATGCTTGTTG 2400

GACTACGTCA GAGAGAACAA GGACCGAATT GGCTCTCAGT ATCTCCTCAG CTGGTGTGTT 2460

CAGATTGCAA AGGGAATGAG TTACCTTGAA GAAGTGAGGC TGGTTCACAG AGATCTTGCG 2520

GCTAGAAATG TTCTGGTGAA AAACCCAAAC CACGTGAAGA TTACAGACTT TGGGCTTGCC 2580

AGATTGCTGG ACATCGATGA GAAGGAGTAC CACGCTGATG GAGGAAAGGT GCCGATCAAA 2640

TGGATGGCGC TGGAGTCTAT ATTACACCGG AAGTTTACTC ACCAAAGTGA CGTGTGGAGC 2700

TACGGGGTGA CCGTGTGGGA GCTGATGACC TTTGGCATGA AGCCGTATGA GAGTTTTCAA 2760

GCGCGGGACA TTCCAGAGCT GCTGGAGGCC GGGGAGCGAC TCTCACAGCC GTGCAACTGC 2820

ACCAAAGAAG TCTACATGAT CATGGTCAAA TGTTGGCAGA TCGATCCTGA CAATCGACCG 2880

AGATTTAAGG ACCTGGTGGA GGAATTCACC ACCATGGCAC GGGATCCCTC ACGTTATGTT 2940

GTCATCCAGA ACGAAGATCA GATGAGTCTT TCGAGTCCTG TTGATAGCGA GTTCTTCCGC 3000

ATCTTGATGG CAGAGGAGGG CGGGAATGTG AAGGAGTTTC TGGATGCAGA GGAATACCTG 3060

GTACCACAAC CTGGCAGCAT CTTCAACACA CATGGAGAAA TGAGAGCCAA CGGGCCGAGC 3120

AGACACCACT CACACCGGAG TACAGATCAA ATGGTAGAGG TGGATGGTTT GCCCAATGGG 3180

AGAGAGTTGT ATTCTTCTGT CAGCATGATA GAACAGAGTC AATACCCAAC TCTTCCTGTG 3240

GGCGCAACAG CCAATGGCAT GTGGCCTGGG ACACAGTACC CGCCTCTAGC CCGGAGCATA 3300

TCACACCGCT CAGCTGGAGG CCAATCAGAC TCTGTGTTTC TGGACGGTTA CGTGGAGGAC 3360

AGCTGCCCCC CATCCAGCCC TTGTCGCTAT TCTAAAGACC CCACCATGCC CAACGGCATT 3420

GATGGAGATC TGGAGACTGA TGGCAACATG GTTTTCCTGT CTCACACACT GCCACGAGGA 3480

ACACACACGC AACCTGAGTA TGTGAACCAG GACATAGCAT CAGAGCGGCC CAGCACACTT 3540

CCACGCAAGG CCAGCGAGAG GAGATTCATC CTCAATGGCC TCAGCACAGG GAACAGTGTG 3600

GAGAACCCAG AATATCTGGT GCCAATAGGC AGCATCACAC CCACCTCGCC AGCATTCGAC 3660

AACCCCTACT ACCACGATAT TGCAGCAAAA GCTCAGGTAG TGGCCAGAGT GGCCATAAAT 3720

GGAGGAACAA ATCACAGGCA GCCCAACGGA TTCATGACGC CCACCGCAGA AAACCCAGAG 3780

TACCTGGGCC TGGCAGACAC ATGGAGCGGC CACAAGGAGT ACACCTAA 3828

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lkkl+vlGsGafGtv+kGiw p+genv+ipvaikvl+e+t++kanke+ldea+v+a + +

Q: 713   LKKLRVLGSGAFGTVFKGIWAPDGENVRIPVAIKVLRENTSPKANKEILDEAYVMAGVAS  772

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++Gsq+ll wcvqiakGmsylee

Q: 773   PYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQYLLSWCVQIAKGMSYLEEV  832

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ deke++a+ggkvpikw+alesil+rk+

Q: 833   RLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDEKEYHADGGKVPIKWMALESILHRKF  892

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG kpy++++a++ip+lle Gerl+qp +ct +vym++vkcw

Q: 893   THQSDVWSYGVTVWELMTFGMKPYESFQARDIPELLEAGERLSQPCNCTKEVYMIMVKCW  952

         ************************************************************

S: 241   midaesrpkfkelaeef  257

          id++ rp+fk+l+eef

Q: 953   QIDPDNRPRFKDLVEEF  969

         ****************9

Domain Sequence
(FASTA)

LKKLRVLGSG AFGTVFKGIW APDGENVRIP VAIKVLRENT SPKANKEILD EAYVMAGVAS 60

PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDRIGS QYLLSWCVQI AKGMSYLEEV 120

RLVHRDLAAR NVLVKNPNHV KITDFGLARL LDIDEKEYHA DGGKVPIKWM ALESILHRKF 180

THQSDVWSYG VTVWELMTFG MKPYESFQAR DIPELLEAGE RLSQPCNCTK EVYMIMVKCW 240

QIDPDNRPRF KDLVEEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013