EKS-DAR-00552

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00552

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.9	3.6E-116	56	307	252

Status

Unreviewed

Ensembl Protein

ENSDARP00000008926

UniProt Accession

A2CEF7;

Protein Name

Protein Synonyms/Alias

Novel protein similar to vertebrate MAP/microtubule affinity-regulating kinase 3 (MARK3);

Gene Name

MARK3 (2 of 3)

Gene Synonyms/Alias

DKEY-23G12.2-001, zgc:153725;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000026630	ENSDARP00000081648	ENSDART00000087214
ENSDARG00000026630	ENSDARP00000008926	ENSDART00000026213

Organism

Danio rerio

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHTS HTDGRNEVAS RPGRSGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETDKTLYL VMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKHIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTIGNKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPVKRGTLEQ 300

IMKDRWINAG CEEEELKPFV EPELDISDQK RIDIMVGMGY SREEIHESLT RMKYDEITAT 360

YLLLGRKSTE LEVSDSSSSS NLSLAKARPN SEHNNGQSPS HLKVQKNAST NQKQRRYSDQ 420

AGPTIPSVGY PKRSQTTSAE SEHKEEGSAQ ARKSSSSGSR GMAPASPMLG NANNPNKADI 480

PDRKKSAGAP GNNSVSSGMT RRNTYVCSER NATDRHSVIQ NGKENSTSTA QTSQRNPGSS 540

THSISSATPP DRLRFPRGTL SRSTFHGGQL RERRTATYNG PPASPTLSHD ATPLSQSRSR 600

GSTNLFTKLT SKLTRRVPAE CDRNGRYDDS SRNVSGDQKE EHKDAKPRSL RFTWSMKTTS 660

SMEPTEMMRE IRKVLDANNC DYEQRERFLL LCVHGDGHAE SLVQWEMEVC KLPRLSLNGV 720

RFKRISGTSI AFKNIASKIA NELKL 745

Nucleotide Sequence
(FASTA)

ATGTCAACTA GAACACCACT ACCTACTGTC AATGAGAGAG ATACAGAAAA CCACACATCA 60

CACACAGATG GGCGTAATGA AGTGGCATCT CGTCCTGGGC GGTCGGGCGC TCGCTGTCGA 120

AACTCCATTG CCTCTTGTGC CGATGAGCAG CCACATATCG GCAACTACCG GCTCCTCAAA 180

ACCATCGGCA AGGGCAACTT TGCCAAGGTC AAATTGGCAC GGCACATTCT CACAGGACGA 240

GAGGTGGCCA TAAAAATTAT TGACAAGACA CAACTTAATC CTACCAGCCT TCAAAAGCTC 300

TTCAGGGAAG TAAGAATAAT GAAGATTCTC AATCATCCAA ATATTGTAAA GCTGTTTGAG 360

GTCATAGAAA CAGACAAGAC CCTTTACCTG GTGATGGAGT ACGCCAGCGG AGGGGAGGTG 420

TTTGACTACC TCGTAGCGCA CGGACGCATG AAGGAGAAGG AGGCCAGAGC TAAATTTAGA 480

CAGATTGTAT CAGCAGTTCA GTACTGCCAT CAAAAACACA TTGTCCACAG AGATCTCAAG 540

GCAGAAAATC TACTTCTGGA TGCGGACATG AACATTAAAA TTGCAGACTT CGGTTTCAGT 600

AATGAATTCA CCATCGGGAA CAAACTAGAC ACGTTTTGCG GCAGCCCGCC GTACGCAGCG 660

CCAGAGCTTT TCCAGGGCAA GAAGTACGAC GGGCCGGAGG TGGACGTGTG GAGTTTGGGG 720

GTTATTCTGT ACACGCTGGT CAGCGGATCG TTGCCCTTTG ATGGACAGAA TCTAAAGGAG 780

CTTCGTGAGC GAGTGTTGAG AGGCAAATAT CGGATTCCCT TCTACATGTC TACTGACTGT 840

GAAAACCTCC TAAAACGCTT CCTGGTGCTG AACCCAGTCA AACGGGGCAC GCTCGAGCAA 900

ATCATGAAGG ATCGATGGAT CAATGCGGGC TGTGAGGAGG AAGAGCTCAA ACCCTTTGTT 960

GAGCCCGAGC TCGACATCTC TGATCAGAAG AGAATCGATA TCATGGTGGG AATGGGTTAC 1020

TCACGGGAGG AGATCCATGA ATCTCTAACC AGGATGAAGT ACGATGAAAT CACAGCGACG 1080

TACCTGCTGT TAGGCAGAAA GTCTACTGAG TTGGAGGTGA GTGATTCGAG CTCCAGCAGT 1140

AACCTCTCTT TGGCGAAGGC CAGACCCAAC AGTGAACACA ACAACGGCCA GTCACCGTCT 1200

CACCTCAAAG TCCAGAAGAA CGCCTCAACC AACCAGAAAC AGCGGCGCTA CAGTGACCAA 1260

GCTGGTCCCA CCATTCCCTC GGTGGGTTAC CCTAAGAGAA GTCAGACCAC TTCAGCAGAA 1320

AGTGAGCATA AAGAGGAGGG CAGTGCTCAG GCACGCAAGT CCAGCTCATC TGGCAGCCGT 1380

GGGATGGCTC CAGCGAGCCC CATGCTGGGC AACGCCAACA ACCCCAACAA GGCCGACATT 1440

CCTGACCGCA AAAAGAGCGC CGGTGCCCCT GGGAACAATT CAGTGTCCAG CGGCATGACC 1500

AGGAGAAACA CGTATGTGTG TAGTGAGAGA AACGCAACCG ACCGGCACTC CGTCATCCAG 1560

AACGGCAAAG AGAACAGTAC GAGCACGGCT CAGACGAGTC AGCGAAACCC TGGTTCCTCC 1620

ACCCACAGCA TTAGCAGTGC GACTCCACCA GACCGCCTGC GTTTCCCTAG AGGAACTCTG 1680

AGCCGCAGCA CATTCCATGG AGGACAACTG AGAGAGAGAC GCACCGCCAC ATACAATGGA 1740

CCTCCAGCTT CTCCAACATT ATCACACGAC GCCACGCCAC TGTCACAGTC CCGGAGCCGT 1800

GGATCAACAA ACCTTTTCAC CAAGCTCACA TCCAAACTCA CACGCAGAGT GCCGGCAGAA 1860

TGCGATAGAA ATGGGAGATA TGACGACTCA AGTCGTAATG TGTCAGGGGA TCAGAAAGAG 1920

GAACATAAAG ACGCCAAACC CCGCTCGCTC CGATTCACCT GGAGCATGAA GACCACCTCG 1980

TCCATGGAGC CCACAGAAAT GATGCGCGAG ATCCGCAAAG TCCTGGACGC CAACAACTGC 2040

GACTACGAGC AGCGCGAGCG ATTCCTGCTG CTCTGCGTCC ACGGCGACGG CCACGCCGAG 2100

AGTTTGGTCC AATGGGAGAT GGAGGTGTGC AAACTGCCCC GCCTCTCGCT AAACGGCGTG 2160

CGCTTCAAGC GGATATCAGG AACATCCATC GCTTTCAAAA ACATCGCATC CAAAATTGCC 2220

AACGAACTGA AGCTGTAA 2238

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETD KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKHIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTI GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPVKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:767634

;

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013