EKS-DAR-00012
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00012
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph494.11.3E-148470729260
StatusUnreviewed
Ensembl ProteinENSDARP00000121122
UniProt AccessionF1QR66;
Protein Name
Protein Synonyms/Alias
Gene Nameephb4b
Gene Synonyms/Alias ephb4b;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000027112ENSDARP00000088414ENSDART00000097644
ENSDARG00000027112ENSDARP00000121122ENSDART00000136056
OrganismDanio rerio
Functional Description
Protein Length833
Protein Sequence
(FASTA)
VDTVAADFLL RRGGERKSNV KTVRVGPLSK KGFYLAFQTQ GACMALLSVR VFFKKCPAVS 60
RAFSSFPETL PHSLVQQAEG VCVDNSAPTG QSTAPPTMFC GEDGQWVGPP SSTCACKPGY 120
EPVDSDRCRA CGLGQYKASV GGSLCRVCPD NSNTHFAGSS LCVCRPGYHR ATSDLPDSAC 180
TKPPSAPRSI IYQINDTVVT LEWSEPLDRG GRSDLSYSVE CMHCRGSLCV QCADSITYRP 240
GQMGVPGRRV IIRGLLPHTT YTFTVLAQNG VSAVSHTSPA SSSVNITTSR DVAVPVSGIR 300
RIKASESSVS ISWTVPPQTQ HSIQDYQLRY SLKGQDDGWQ YVSSRSSSVV LNDLSRASQY 360
QVQVRARTAA GYGHFSSAVS ISTLPDDEES PSRLMLTGVL VAIGLLILIA VVIVAVFCFR 420
RSTRRRDPDP DKSGQFLMGQ GIKVYIDPFT YEDPNEAVRE FAKEIDVSFV KIEEVIGAGE 480
FGEVCRGRLK VPGKKENYVA IKTLKGGYTD KQRRDFLSEA SIMGQFQHPN IIHLEGVITA 540
SCPVMILTEY MENGALDSFL RLNDGQFTPI QLVGMLRGIA SGMKYLSEMS FVHRDLAARN 600
ILVNSNLVCK VSDFGLSRFL TENSSDPTYT SSLGGKIPIR WTAPEAIAFR KFTSASDVWS 660
YGIVMWEVMS FGERPYWDMS NQDVINAIEQ DYRLPPPPEC PASLHQLMLD CWQKERSSRP 720
RFCAIVSALD RLIRNPASLK ITGRIPDGPS HPLLDQRAPP PLSHCSSVAD WLRAIKMERY 780
EDAFMQAGFT AIQHITHIST EDLLRIGVTL AGHQKKILSS VQTLRIHGGS LRY 833
Nucleotide Sequence
(FASTA)
GTGGACACAG TTGCTGCTGA CTTCCTGTTG CGTCGCGGCG GAGAGAGGAA GTCCAATGTG 60
AAGACGGTGC GTGTGGGTCC GCTGTCGAAG AAAGGCTTCT ACCTGGCGTT TCAGACTCAG 120
GGCGCGTGCA TGGCTCTGCT GTCCGTCAGG GTTTTCTTCA AGAAGTGTCC TGCCGTCTCC 180
CGCGCCTTCT CCTCCTTCCC GGAGACGCTC CCTCACTCGC TGGTGCAGCA GGCGGAGGGT 240
GTGTGCGTGG ATAACTCCGC CCCCACTGGA CAGAGCACAG CTCCACCCAC TATGTTCTGC 300
GGGGAGGACG GTCAGTGGGT GGGGCCTCCG TCGTCTACAT GTGCTTGTAA ACCAGGATAC 360
GAACCTGTCG ACTCCGACCG CTGCAGGGCG TGTGGATTGG GCCAGTATAA AGCATCTGTC 420
GGAGGGAGCT TGTGTCGTGT GTGTCCAGAC AACAGTAACA CACACTTCGC TGGATCCAGT 480
CTGTGTGTGT GTCGTCCAGG ATACCACCGA GCCACCAGTG ACCTTCCGGA CTCAGCCTGC 540
ACCAAACCGC CATCGGCTCC GCGCAGCATC ATCTATCAGA TCAATGATAC GGTGGTCACC 600
CTGGAGTGGT CGGAGCCGCT AGATCGCGGT GGACGTTCTG ATCTCTCCTA CAGCGTGGAG 660
TGTATGCACT GCAGAGGCTC CCTATGCGTC CAGTGTGCAG ACAGCATCAC CTATAGGCCG 720
GGTCAGATGG GCGTGCCCGG GAGGCGTGTC ATCATCCGTG GACTCCTCCC ACACACCACC 780
TACACCTTCA CTGTGCTGGC CCAGAACGGC GTCAGCGCTG TCAGTCACAC AAGCCCCGCC 840
TCCAGCTCCG TCAACATCAC TACCAGCAGA GATGTGGCTG TCCCTGTGTC TGGTATCAGG 900
AGGATTAAAG CATCTGAGAG CAGCGTGTCC ATCAGCTGGA CGGTTCCTCC ACAAACGCAG 960
CACAGCATTC AGGATTATCA GCTGCGCTAC AGTCTGAAGG GTCAGGATGA TGGATGGCAG 1020
TACGTCAGCA GCAGGAGCAG CTCAGTGGTT CTGAATGATC TGAGTCGAGC GTCGCAGTAT 1080
CAGGTGCAGG TCAGAGCCAG AACCGCTGCG GGATACGGAC ACTTCAGCAG CGCCGTCAGC 1140
ATCAGCACGC TACCTGATGA TGAAGAGTCT CCGTCGCGGC TGATGCTCAC TGGTGTCCTG 1200
GTTGCTATAG GACTGCTCAT CCTCATCGCC GTGGTGATTG TTGCCGTGTT CTGCTTCAGA 1260
CGCTCGACTC GGAGGAGGGA TCCAGACCCG GATAAGAGCG GCCAGTTCCT GATGGGTCAG 1320
GGGATTAAAG TGTACATTGA TCCGTTCACG TACGAGGATC CGAATGAGGC TGTGCGGGAA 1380
TTCGCTAAAG AGATCGACGT GTCGTTTGTG AAGATCGAGG AGGTCATCGG TGCTGGTGAG 1440
TTTGGTGAGG TGTGTCGCGG CCGGCTCAAG GTTCCCGGGA AGAAAGAGAA CTACGTGGCC 1500
ATCAAGACGC TGAAGGGCGG ATACACGGAC AAGCAGAGGC GTGACTTCCT GTCTGAGGCG 1560
TCAATCATGG GTCAGTTCCA GCACCCCAAC ATCATTCATC TGGAGGGAGT GATCACAGCT 1620
TCCTGTCCCG TCATGATTCT GACCGAGTAC ATGGAGAACG GAGCACTCGA CTCCTTCCTG 1680
CGGCTGAATG ATGGTCAGTT CACTCCTATC CAGCTGGTGG GGATGCTGCG TGGAATCGCG 1740
TCTGGAATGA AGTATCTGTC TGAGATGAGC TTCGTTCATC GTGATCTGGC GGCGAGGAAC 1800
ATCCTGGTCA ACAGTAACCT GGTGTGCAAA GTGTCCGACT TCGGCCTGTC CCGATTCCTG 1860
ACGGAGAACT CGTCTGATCC CACCTACACC AGCTCACTGG GCGGGAAGAT CCCGATCCGC 1920
TGGACGGCTC CTGAAGCCAT CGCCTTCCGC AAGTTCACCT CAGCGTCAGA CGTCTGGAGC 1980
TACGGCATCG TCATGTGGGA GGTGATGTCA TTCGGAGAGA GGCCGTACTG GGACATGAGC 2040
AACCAGGACG TGATAAACGC CATCGAGCAG GACTACCGCC TGCCGCCTCC CCCAGAATGC 2100
CCTGCGTCTC TCCATCAGCT GATGCTGGAC TGCTGGCAGA AGGAGAGATC GTCCCGGCCG 2160
CGCTTCTGCG CCATCGTCTC TGCCCTCGAC AGACTGATCC GCAACCCTGC CTCACTCAAG 2220
ATCACCGGAC GCATCCCTGA TGGGCCGTCT CACCCTCTCC TGGACCAGCG TGCTCCTCCT 2280
CCGCTCTCTC ACTGCAGCTC AGTTGCTGAT TGGCTGAGAG CCATAAAGAT GGAGCGATAC 2340
GAGGACGCGT TCATGCAGGC CGGATTCACA GCCATCCAAC ACATCACACA CATCTCCACT 2400
GAGGATCTTC TGCGGATCGG CGTGACTTTA GCGGGACACC AGAAGAAGAT TCTGTCCAGC 2460
GTCCAAACAC TGCGCATCCA CGGCGGATCC CTGCGATACT GA 2502
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e +vaiktlk+g+t+kqrrdflseasi+Gqf+hp
Q: 470   VKIEEVIGAGEFGEVCRGRLKVPGKKENYVAIKTLKGGYTDKQRRDFLSEASIMGQFQHP  529
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGv+t s pvmi+teymengaldsflr +dgqft iqlvgmlrGiasgmkyls+m
Q: 530   NIIHLEGVITASCPVMILTEYMENGALDSFLRLNDGQFTPIQLVGMLRGIASGMKYLSEM  589
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         ++vhrdlaarnilvnsnlvckvsdfGlsr+l ++s +++yt+s ggkipirwtapeaia+
Q: 590   SFVHRDLAARNILVNSNLVCKVSDFGLSRFLTENSsDPTYTSSlGGKIPIRWTAPEAIAF  649
         *******************************76666*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp +cpa+l+qlml
Q: 650   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPECPASLHQLML  709
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqk+r++rp+f  ivs+l
Q: 710   DCWQKERSSRPRFCAIVSAL  729
         ****************9975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KVPGKKENYV AIKTLKGGYT DKQRRDFLSE ASIMGQFQHP 60
NIIHLEGVIT ASCPVMILTE YMENGALDSF LRLNDGQFTP IQLVGMLRGI ASGMKYLSEM 120
SFVHRDLAAR NILVNSNLVC KVSDFGLSRF LTENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPE CPASLHQLML 240
DCWQKERSSR PRFCAIVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013