EKS-DAR-00020

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00020

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	523.5	1.9E-157	997	1264	268

Status

Unreviewed

Ensembl Protein

ENSDARP00000017066

UniProt Accession

Q1LWJ4;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

igf1ra

Gene Synonyms/Alias

igf1ra; DKEY-25F3.5-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000027423	ENSDARP00000017066	ENSDART00000010189

Organism

Danio rerio

Functional Description

Protein Length

1405

Protein Sequence
(FASTA)

MRSGTARDVW TLFWGPALFL STICLWCARG EVCGPHIDIR NDITEFKKLE NCTVVEGYLQ 60

ILLIGDKNNN LNQEHFRTLS FPKLTMVTDY ILLFRVSGLD SLSVLFPNLN VIRGRNLFYN 120

YALVIFEMTS LKDIGLYNLR NITRGAIRIE KNPELCYLDS VDWSLLMDAE FNNYIAGNKQ 180

SKECGDVCPG INEDRPHCIR TSFNDNYSYR CWTSNHCQKV CPKECEKRAC TDAGQCCHPQ 240

CLGSCTEADN DKACAACQHY FHEDRCVEAC PPDTYKFEGW RCITMEMCAR VHLPSEVDFV 300

IHNGECMPDC PPGFTRNETQ SMFCSACDGL CDKVCESKTI DSVDAAQSLQ GCTVIKGNLQ 360

INIRRGNNIA SELESFMGLI QTVTGYVRIK HTHTLGSLSF LKSLRYIVGE ELVDNTYAFH 420

AVDNHNLQYL WDWTQHNLTI KTGKLYFRFN PKLCMSEIRK MWEKTSVREK MAEDDVRSNG 480

ERASCESYIL KFRSNHTQST RIKLTWERYR PPDYRDLISF IVYYKEAPFQ NITEFDGQDG 540

CGSNSWNMVD VDLPQEKSID PGVLLSPLKP WTQYAIFVKA VTLVVEDKHV GGAKSEVVYI 600

RTNASAPSMP LDARAYANSS SSLMVKWSPP IAPNGNKTFY FLRWQQQAED GELYQHNYCS 660

KELKIPIRIS ATSLSDMEGE TKPTKSDVAG GEKGCCPCPK TKEDLKAEAE DRSYRKVFEN 720

FLHNSIFTPR PPDRKRRDLM GVANSTLVSG VSRNISVLES NITQPELPEK EYPFSEGKVH 780

TEFMEIHNLR PFTVYRIDIH ACNYEVHRCS AAAFVFSRTK PADKADDIPG SVTQERDEKG 840

EGIVLLRWPE PLHPNGLILM YEIKYRLGTE AEKHECVSRQ QYKVLRGAQL SNLASGNYSA 900

RVRATSLAGN GSWTEPVSFY VPPPKRNYDN AFYVAIIIPV IVLLLLLFVI VAVIIVTKKR 960

NSDRIGNGVL YASVNPEYFS PFEMYVPDEW EVAREKITMC RELGQGSFGM VYEGIAKGVV 1020

KDEPETRVAI KTVNESASVR ERIEFLNEAS VMKEFNCHHV VRLLGVVSQG QPTLVIMELM 1080

TRGDLKSHLR SLRSKEQGSS SQSLPPLKKM IQMAGEIADG MAYLNANKFV HRDLAARNCM 1140

VAEDFTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMSPE SLKDGVFTTN SDVWSFGVVL 1200

WEIATLAEQP YQGMSNEQVL RFVMEGGLLD KPDNCPDMLF ELMRMCWQYN PKMRPSFLEI 1260

INSIKEELEP PFREVSFFYS EENKPPDTEE LDMEVENMEN VPLDPASTLA PSSQGNTGIQ 1320

SQSPQPLSPA QGPGTPLGSA QTPSTSPPSS SASPGLALDK HSGQVAANGP VVLLGPAFDE 1380

TQPYAHMNGG RKNERALPLP QSSAC 1405

Nucleotide Sequence
(FASTA)

ATGAGATCTG GAACAGCGAG GGATGTTTGG ACCTTATTTT GGGGTCCTGC GCTGTTTCTC 60

TCCACCATCT GCCTGTGGTG TGCCCGTGGA GAAGTCTGTG GTCCTCATAT TGATATCCGC 120

AATGACATCA CTGAGTTCAA GAAGCTGGAA AACTGCACGG TGGTGGAAGG CTACCTGCAG 180

ATTCTCCTTA TTGGAGACAA GAACAACAAC CTCAACCAGG AACACTTTCG CACACTGTCC 240

TTCCCCAAGT TGACCATGGT AACGGACTAC ATTCTCCTGT TCCGTGTCTC CGGTCTGGAC 300

AGCCTGAGTG TGCTCTTCCC TAACCTCAAC GTCATCCGAG GACGCAATCT ATTCTACAAC 360

TACGCCCTGG TCATCTTCGA AATGACCAGC CTGAAAGATA TCGGTCTGTA TAACCTGAGG 420

AACATCACCA GAGGGGCCAT CCGAATCGAA AAGAACCCAG AGCTGTGCTA CTTGGATTCG 480

GTTGACTGGT CACTCCTTAT GGATGCAGAG TTTAACAACT ACATCGCTGG AAACAAGCAG 540

TCCAAAGAAT GCGGAGATGT TTGTCCAGGC ATCAATGAGG ATAGACCGCA TTGCATAAGG 600

ACCAGTTTCA ATGACAACTA CAGTTATCGC TGCTGGACCT CTAACCACTG CCAGAAAGTG 660

TGTCCTAAGG AGTGTGAGAA GAGAGCGTGC ACGGATGCGG GCCAGTGTTG TCACCCCCAG 720

TGCCTGGGCA GCTGTACGGA AGCAGACAAT GATAAAGCAT GCGCCGCCTG CCAGCATTAC 780

TTTCACGAGG ACCGATGTGT CGAGGCCTGC CCGCCAGATA CCTACAAGTT TGAAGGATGG 840

CGCTGCATCA CTATGGAGAT GTGTGCCCGT GTTCACCTAC CCAGCGAGGT GGACTTCGTC 900

ATTCACAATG GAGAGTGTAT GCCGGACTGT CCACCCGGAT TCACCCGAAA TGAGACTCAG 960

AGTATGTTTT GCAGCGCGTG TGACGGCCTG TGCGATAAAG TCTGCGAATC TAAAACAATC 1020

GACTCTGTGG ACGCGGCTCA ATCACTGCAG GGCTGCACAG TCATCAAAGG CAACCTGCAA 1080

ATCAACATCC GCCGGGGCAA TAACATTGCA TCAGAGCTGG AGAGTTTCAT GGGGCTGATC 1140

CAGACAGTGA CTGGATATGT AAGGATCAAG CACACTCATA CTCTGGGCTC TCTGTCCTTC 1200

CTCAAGAGCC TGCGATACAT TGTTGGAGAA GAGCTTGTGG ATAATACATA CGCATTCCAT 1260

GCAGTGGACA ATCACAACTT GCAGTATCTC TGGGACTGGA CTCAGCACAA TCTGACCATT 1320

AAAACGGGGA AACTATACTT TCGCTTCAAT CCCAAGCTTT GCATGTCTGA GATCCGAAAA 1380

ATGTGGGAGA AAACCAGCGT CAGGGAAAAG ATGGCAGAGG ACGATGTTCG TAGCAATGGA 1440

GAGCGAGCAA GTTGTGAGAG TTATATTCTT AAGTTCAGAT CCAACCACAC TCAGAGTACT 1500

CGGATAAAGC TCACTTGGGA GCGATATCGA CCGCCAGACT ACAGAGACCT CATCAGCTTC 1560

ATTGTGTATT ACAAGGAGGC ACCATTCCAG AACATCACTG AATTCGATGG ACAGGATGGG 1620

TGTGGCTCTA ATAGCTGGAA CATGGTGGAT GTGGACCTTC CTCAGGAAAA ATCGATAGAT 1680

CCTGGAGTAC TGCTGTCCCC CCTTAAACCC TGGACTCAGT ATGCCATCTT TGTGAAGGCC 1740

GTCACTCTGG TTGTAGAGGA CAAGCATGTT GGGGGAGCTA AGAGTGAGGT GGTCTACATC 1800

CGCACCAATG CATCAGCGCC GTCAATGCCC CTTGATGCCC GTGCATATGC CAACTCCTCT 1860

TCATCCCTGA TGGTGAAGTG GTCTCCTCCT ATCGCTCCCA ACGGAAACAA AACATTCTAC 1920

TTTCTCCGTT GGCAGCAGCA GGCAGAAGAT GGTGAACTCT ACCAGCATAA CTACTGCTCT 1980

AAAGAGCTTA AGATCCCAAT CCGGATCTCG GCCACATCTT TGTCAGACAT GGAGGGCGAG 2040

ACAAAGCCCA CAAAATCAGA TGTTGCCGGG GGTGAGAAGG GTTGCTGCCC CTGCCCAAAA 2100

ACCAAGGAGG ACCTGAAGGC AGAAGCTGAA GACCGATCCT ACCGCAAAGT CTTTGAGAAC 2160

TTCCTGCACA ACTCTATTTT CACACCCAGA CCTCCAGACA GGAAGCGTCG AGACTTGATG 2220

GGAGTGGCCA ACAGCACACT AGTGTCGGGT GTGAGCAGGA ACATCTCAGT TCTGGAGAGT 2280

AACATCACTC AGCCAGAGCT GCCAGAAAAA GAGTACCCGT TCTCTGAAGG CAAAGTCCAC 2340

ACAGAGTTCA TGGAGATACA CAACCTTCGG CCCTTCACCG TCTACCGCAT TGACATCCAC 2400

GCCTGCAACT ATGAAGTCCA CCGGTGCAGT GCTGCGGCCT TTGTGTTCTC CAGAACCAAA 2460

CCGGCAGATA AAGCGGATGA TATTCCCGGC TCTGTGACTC AGGAGAGGGA TGAGAAGGGA 2520

GAAGGAATAG TGCTTCTGCG GTGGCCTGAA CCTCTTCACC CCAACGGACT GATCCTCATG 2580

TATGAGATCA AATATCGTCT GGGAACTGAG GCTGAGAAGC ATGAATGTGT ATCACGACAG 2640

CAGTACAAAG TTCTGCGAGG AGCTCAGCTT AGCAATTTGG CCTCTGGAAA TTATTCAGCT 2700

CGAGTCAGAG CCACTTCTCT GGCTGGAAAC GGGTCTTGGA CTGAACCAGT GTCCTTCTAC 2760

GTGCCACCCC CTAAACGGAA TTATGATAAT GCCTTCTACG TGGCCATCAT TATCCCTGTT 2820

ATAGTACTAC TTTTGCTACT CTTCGTGATC GTAGCTGTCA TCATTGTGAC CAAAAAGAGG 2880

AATAGTGACA GGATAGGAAA TGGTGTGCTG TATGCTTCTG TGAACCCCGA GTACTTCAGT 2940

CCATTTGAAA TGTATGTGCC AGATGAATGG GAAGTGGCTC GAGAGAAGAT CACCATGTGC 3000

CGTGAGCTGG GCCAGGGCTC TTTTGGTATG GTGTATGAGG GCATTGCAAA GGGTGTCGTT 3060

AAAGATGAAC CTGAGACCAG AGTGGCTATC AAGACTGTAA ACGAATCCGC CAGCGTACGT 3120

GAACGCATCG AGTTCCTGAA CGAAGCTTCA GTTATGAAGG AGTTCAACTG TCACCATGTG 3180

GTCCGTCTTC TGGGTGTGGT TTCACAAGGA CAGCCTACTC TAGTTATAAT GGAGCTGATG 3240

ACGCGGGGTG ATCTGAAAAG CCACTTGCGC TCGCTCCGAT CCAAAGAGCA GGGCTCCAGC 3300

AGCCAGTCTT TGCCTCCGCT GAAGAAGATG ATTCAGATGG CGGGTGAGAT AGCGGATGGG 3360

ATGGCGTACC TCAATGCCAA CAAGTTCGTC CATCGAGATC TGGCTGCCAG AAACTGCATG 3420

GTTGCTGAAG ACTTTACAGT TAAAATCGGA GACTTTGGCA TGACGAGGGA CATCTATGAG 3480

ACTGACTACT ATCGCAAAGG AGGCAAAGGG CTGCTGCCGG TCCGCTGGAT GTCTCCAGAG 3540

TCTTTGAAAG ATGGCGTCTT CACAACTAAT TCTGATGTCT GGTCGTTTGG TGTGGTTTTA 3600

TGGGAGATCG CCACATTAGC CGAACAGCCC TACCAGGGCA TGTCCAACGA GCAGGTACTG 3660

CGCTTCGTCA TGGAGGGAGG ACTTCTGGAT AAACCGGACA ACTGCCCCGA CATGCTGTTT 3720

GAGCTAATGC GTATGTGCTG GCAGTATAAC CCTAAGATGC GGCCATCTTT CCTGGAGATC 3780

ATCAACAGCA TAAAAGAGGA ACTGGAGCCT CCTTTCCGGG AGGTTAGCTT TTTCTACAGT 3840

GAGGAGAACA AGCCACCCGA TACTGAGGAA CTGGACATGG AGGTGGAGAA CATGGAGAAC 3900

GTCCCGCTGG ATCCTGCATC CACATTGGCC CCCTCTTCTC AGGGGAACAC AGGAATTCAA 3960

TCCCAGAGCC CGCAGCCGCT CTCCCCAGCG CAGGGGCCTG GGACGCCGCT TGGGTCTGCA 4020

CAGACCCCCT CCACCTCTCC GCCCTCATCC TCAGCCTCTC CAGGCCTGGC TCTGGATAAG 4080

CACTCAGGAC AGGTAGCGGC AAATGGACCG GTGGTGCTGC TGGGGCCGGC GTTTGACGAG 4140

ACGCAGCCTT ACGCACACAT GAACGGCGGG AGGAAGAACG AGCGAGCGCT GCCACTGCCT 4200

CAGTCCTCGG CCTGCTGA 4218

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i++ relGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as reriefl+easvmkef+

Q: 997   ITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFN  1056

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslr +e+  ++ + p l+k+iqma+e

Q: 1057  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRSKEQGSSSQSLPPLKKMIQMAGE  1116

         *****************************************888888888**********

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1117  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1176

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+l+kp+ncp

Q: 1177  MSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCP  1236

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei++++

Q: 1237  DMLFELMRMCWQYNPKMRPSFLEIINSI  1264

         *************************986

Domain Sequence
(FASTA)

ITMCRELGQG SFGMVYEGIA KGVVKDEPET RVAIKTVNES ASVRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRSKE QGSSSQSLPP LKKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTNSDVWSF GVVLWEIATL AEQPYQGMSN EQVLRFVMEG GLLDKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIINSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0031076	; P:embryonic camera-type eye development
GO:0031101	; P:fin regeneration
GO:0003007	; P:heart morphogenesis
GO:0048009	; P:insulin-like growth factor receptor signaling pathway
GO:0046777	; P:protein autophosphorylation
GO:0048752	; P:semicircular canal morphogenesis
GO:0021522	; P:spinal cord motor neuron differentiation

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013