EKS-DAR-00752

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00752

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	406.1	1.1E-121	547	801	255

Status

Unreviewed

Ensembl Protein

ENSDARP00000034214

UniProt Accession

E7F1M5;

Protein Name

Protein Synonyms/Alias

Gene Name

fynrk

Gene Synonyms/Alias

fynrk; CU928042.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000027807	ENSDARP00000124324	ENSDART00000149973
ENSDARG00000027807	ENSDARP00000034214	ENSDART00000032212

Organism

Danio rerio

Functional Description

Protein Length

820

Protein Sequence
(FASTA)

MDLRVTSILL LVVVLAEATP DRYYHVKKQP YPTKSHTVAG EPGIPGSPGS PGPPGPPGMP 60

GSPGKNGVGH MGPAGPPGPP GPAGYSSPGK PGTPGAPGKS GAPGYPGEKG QPGPAGPQGA 120

RGAPGSPGSP GPAGLSSPGK PGPHGMPGAM GPRGEPGLKG HPGIPGLPGQ KGEPGHGYAG 180

KPGGPGPMGP QGPSGQPGQP GVGKPGPSGF PGEPGKSGMP GRDGSPGPMG MPGPKGHTGA 240

PGIGAPGKPG QNGAPGMPGQ IGQKGPQGPS GQPGAPGLPG VGKPGSPGMP GDRGVPGTSG 300

TTGQKGEPGP TGHTGMPGAI GPIGPPGPQG ARGFQGEAGP QGLKGDVGMV GAPGARGAKG 360

EQGAQGFSGK PGIPGPIGPP GPQGHMGHTG AKGEDWWFSK AITGISANKK GYIPANYVAP 420

VESLDAEPWY FPETKRSDAE KMLISQENKK GAFLIRNCES QPGELSLSVR DDVKVKHYKI 480

RKLDNGGYYL STARNFPTLR ELVEHYSKHE DGLCVRLAEP CKKSVAPETH GLSYNTVDQW 540

EIERSSVKLL KQLGAGQFGE VFEGLWNDTT PVAVKTLKPG NMDPKDFLRE AQIMKKLRHS 600

KLIQLYAVCT LEEPIYIITE LMSNGSLLEY LQNDRGATLR MSDQIDMGAQ VASGMAYLEL 660

QNYIHRDLAA RNVLVGDNNV CKVADFGLAR VFQMDNEDNV YEAKEGTKFP VKWTAPEAIN 720

ENKFTIKSDV WSFGILLYEI VTFGQTPYPT MTNFQVVQQL PKGYRMSSPP NCHKCLYDIM 780

LDCWKDVPAD RPTFETLQWK LEDFFDMDIT SYDDANRFAK 820

Nucleotide Sequence
(FASTA)

ATGGACCTCA GAGTAACAAG CATTCTTCTT CTGGTTGTGG TGCTGGCCGA GGCGACCCCT 60

GACAGATACT ATCATGTGAA GAAACAGCCG TATCCTACTA AATCCCACAC TGTTGCTGGT 120

GAACCTGGTA TTCCGGGTTC TCCAGGCTCA CCTGGACCCC CTGGCCCACC AGGCATGCCT 180

GGAAGTCCTG GAAAGAACGG TGTTGGACAT ATGGGCCCAG CGGGTCCACC TGGACCACCA 240

GGTCCAGCAG GCTACTCCTC ACCTGGTAAA CCTGGAACCC CAGGCGCACC TGGAAAATCA 300

GGCGCACCTG GATATCCAGG TGAAAAGGGA CAACCAGGCC CAGCTGGACC TCAAGGTGCG 360

AGAGGAGCAC CAGGATCACC TGGAAGCCCT GGACCTGCTG GCCTTTCATC TCCTGGGAAG 420

CCTGGACCAC ATGGGATGCC TGGAGCAATG GGCCCACGTG GAGAACCTGG CCTAAAGGGT 480

CATCCTGGAA TTCCTGGATT GCCAGGCCAG AAGGGAGAAC CTGGGCATGG TTATGCAGGA 540

AAACCTGGCG GTCCTGGCCC AATGGGCCCT CAAGGTCCTT CAGGTCAGCC TGGCCAGCCT 600

GGAGTTGGAA AACCTGGACC ATCTGGATTT CCTGGAGAGC CTGGAAAGTC TGGAATGCCA 660

GGTAGAGATG GATCACCAGG TCCAATGGGT ATGCCAGGCC CAAAAGGTCA CACAGGGGCA 720

CCTGGAATAG GAGCACCAGG AAAACCCGGC CAGAATGGAG CTCCAGGTAT GCCTGGCCAA 780

ATCGGACAAA AAGGACCTCA AGGACCCTCA GGACAGCCAG GTGCTCCAGG TCTGCCTGGT 840

GTTGGCAAAC CAGGATCACC TGGAATGCCA GGAGACCGGG GAGTGCCAGG AACCTCAGGT 900

ACAACAGGTC AAAAAGGAGA ACCAGGGCCA ACAGGCCACA CAGGTATGCC AGGTGCTATT 960

GGCCCAATAG GTCCACCTGG TCCTCAGGGT GCTAGAGGAT TCCAGGGAGA AGCAGGTCCA 1020

CAGGGACTTA AAGGTGATGT TGGTATGGTT GGGGCTCCCG GAGCAAGAGG TGCAAAGGGT 1080

GAGCAAGGAG CACAAGGCTT CTCAGGAAAA CCTGGTATTC CTGGTCCAAT AGGTCCCCCA 1140

GGTCCACAGG GTCATATGGG GCACACAGGT GCCAAAGGAG AGGACTGGTG GTTCTCCAAG 1200

GCAATAACCG GCATCTCCGC CAACAAAAAG GGCTACATTC CGGCGAACTA TGTGGCGCCC 1260

GTGGAGAGCC TGGATGCTGA ACCATGGTAT TTTCCAGAAA CAAAGCGCTC GGATGCCGAG 1320

AAGATGTTGA TTTCTCAAGA GAACAAGAAG GGAGCTTTTC TAATCAGGAA CTGTGAAAGT 1380

CAGCCCGGGG AGCTGTCACT CTCAGTGCGG GACGATGTAA AAGTCAAGCA TTACAAGATC 1440

AGAAAGCTGG ATAATGGCGG ATACTACTTG TCAACGGCAC GTAATTTTCC CACGCTGAGG 1500

GAACTGGTGG AGCACTACTC CAAACACGAA GATGGCCTCT GCGTCCGTCT GGCAGAACCC 1560

TGTAAAAAAT CAGTGGCTCC AGAGACGCAT GGTCTATCCT ATAACACTGT GGATCAATGG 1620

GAGATCGAGC GTTCCTCTGT GAAGCTCCTG AAGCAGCTGG GAGCAGGGCA GTTTGGCGAG 1680

GTGTTTGAAG GCTTATGGAA TGACACCACA CCGGTCGCTG TCAAAACACT CAAACCAGGA 1740

AATATGGACC CCAAAGACTT CCTACGGGAA GCTCAGATCA TGAAGAAGCT CCGTCACTCC 1800

AAACTCATCC AGTTGTATGC GGTCTGCACT CTGGAGGAGC CCATATACAT CATCACAGAG 1860

CTCATGAGCA ACGGAAGTCT ACTGGAGTAT CTGCAGAATG ACCGAGGTGC AACCCTCCGC 1920

ATGTCTGATC AGATTGACAT GGGAGCCCAG GTGGCCTCAG GCATGGCTTA CCTGGAACTG 1980

CAGAACTACA TCCACAGGGA TCTCGCGGCT CGCAATGTTC TAGTGGGGGA TAACAATGTG 2040

TGTAAGGTGG CGGACTTCGG CCTGGCACGA GTATTTCAGA TGGACAATGA GGATAATGTT 2100

TACGAGGCCA AAGAAGGAAC CAAGTTTCCG GTGAAATGGA CTGCTCCCGA GGCCATCAAC 2160

GAGAACAAGT TCACCATCAA ATCTGACGTC TGGTCTTTTG GAATCCTACT GTATGAAATT 2220

GTGACGTTTG GACAGACGCC TTACCCAACC ATGACCAACT TTCAGGTGGT GCAGCAGCTG 2280

CCCAAAGGCT ACCGGATGTC CTCTCCTCCA AACTGCCACA AATGTTTGTA TGACATCATG 2340

CTGGATTGCT GGAAGGACGT CCCCGCGGAC AGACCCACCT TCGAAACGCT GCAGTGGAAA 2400

CTGGAGGACT TCTTCGATAT GGACATCACC TCTTACGATG ACGCAAACCG CTTCGCCAAA 2460

TAA 2463

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +kl+k+lG+GqfGev++g+w+++++vavktlk+g+++p++fl+eaqi+kklrh+kl++ly

Q: 547   VKLLKQLGAGQFGEVFEGLWNDTTPVAVKTLKPGNMDPKDFLREAQIMKKLRHSKLIQLY  606

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ eePiyi+telm++Gsll++l++++g +l++++++d+ aqva+Gmayle +n+ihr

Q: 607   AVCTLEEPIYIITELMSNGSLLEYLQNDRGATLRMSDQIDMGAQVASGMAYLELQNYIHR  666

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie....ddeytakegaklPikWtaPeaiklgkfti  176

         dlaarnvlvg+++v+kvadfGlar+++    d+ y+akeg+k+P+kWtaPeai+++kfti

Q: 667   DLAARNVLVGDNNVCKVADFGLARVFQmdneDNVYEAKEGTKFPVKWTAPEAINENKFTI  726

         ************************9877777999**************************

S: 177   ksdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkk  236

         ksdvWsfGill+eivt G++Pyp mtn +v++q+ +gyr++ p +c + ly+++l cwk

Q: 727   KSDVWSFGILLYEIVTFGQTPYPTMTNFQVVQQLPKGYRMSSPPNCHKCLYDIMLDCWKD  786

         ************************************************************

S: 237   dpeerPtfetlqevl  251

          p +rPtfetlq++l

Q: 787   VPADRPTFETLQWKL  801

         ************986

Domain Sequence
(FASTA)

VKLLKQLGAG QFGEVFEGLW NDTTPVAVKT LKPGNMDPKD FLREAQIMKK LRHSKLIQLY 60

AVCTLEEPIY IITELMSNGS LLEYLQNDRG ATLRMSDQID MGAQVASGMA YLELQNYIHR 120

DLAARNVLVG DNNVCKVADF GLARVFQMDN EDNVYEAKEG TKFPVKWTAP EAINENKFTI 180

KSDVWSFGIL LYEIVTFGQT PYPTMTNFQV VQQLPKGYRM SSPPNCHKCL YDIMLDCWKD 240

VPADRPTFET LQWKL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR008160	; Collagen.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01391	; Collagen; 3.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013