EKS-DAR-00449

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00449

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	480.5	2.3E-144	417	674	258

Status

Unreviewed

Ensembl Protein

ENSDARP00000044704

UniProt Accession

E7F164;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

rps6ka2

Gene Synonyms/Alias

rps6ka2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000028469	ENSDARP00000044704	ENSDART00000044705

Organism

Danio rerio

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MDTNMRKFTV RRWFSVYLRR KSRSKSSSLC KLEDDSILKE FDISHHVKEG FEKADPSQFE 60

LLKVLGQGSY GKVFLVRKIK GSDTGQLYAM KVLKKATLKG VRDRVRSKME RDILAEVNHP 120

FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVVMFTE EDVKFYLAEL ALALDHLHSL 180

GIIYRDLKPE NILLDEEGHI KITDFGLSKE AIDHDKRAYS FCGTIEYMAP EVVNRRGHTQ 240

SADWWSFGVL MFEMLTGSLP FQGKDRKETM ALILKAKLGM PQFLSPEVQS LLRALFKRNP 300

SNRLGAGPDG VEEIKRHIFF ATIDWNKLYR REIKPPFKPA VGRPEDTFHF DPEFTSRTPT 360

DSPGVPASAN AHQLFRGFSF VATNLGQEQP LTEIKQNSVN PIVQQLHGNN IHFTDGYELK 420

EDIGIGAYSV CKRCVHRITS VEYAVKIIDR SKKDPSEEIE ILLRYGQHPN IITLKDVYDD 480

GKFVYLVMEL MRGGELLDRI LRQKCFSERE ASAVLCTITK TVEYLHSQGV VHRDLKPSNI 540

LYVDETGDPE SIRICDFGFA KQLRAENGLL MTPCYTANFV APEVLKKQGY DAACDIWSLG 600

ILLYTMLAGF TPFANGPDDT PEEILARIGS GKFALSGGNW DTVSDAAKDI VTKMLHVDPH 660

QRLTAPLVLR HAWIVNRDQL SQSQLIRQDV TLVKGAMAAT YSALNRSPQA PKLEPVLSSC 720

LAQRRGMKRL TSTRL 735

Nucleotide Sequence
(FASTA)

ATGGATACGA ACATGCGCAA ATTTACCGTC AGAAGATGGT TTTCCGTCTA CCTTCGGAGA 60

AAGTCGCGGT CCAAAAGCTC GAGTCTATGC AAACTGGAGG ATGACAGCAT CTTAAAGGAG 120

TTCGATATCA GCCATCATGT GAAAGAGGGC TTTGAGAAGG CAGATCCGTC ACAGTTCGAG 180

CTGCTTAAAG TGCTTGGTCA GGGCTCCTAT GGAAAGGTTT TCTTAGTGAG AAAAATCAAA 240

GGCTCAGATA CAGGACAACT CTATGCCATG AAGGTCTTAA AAAAGGCAAC ACTTAAAGGA 300

GTGCGGGACA GAGTAAGATC CAAAATGGAG CGAGATATTC TAGCAGAAGT GAATCATCCC 360

TTCATTGTCA AACTTCATTA TGCCTTTCAG ACAGAAGGAA AGCTGTACCT TATATTGGAC 420

TTTCTCAGAG GGGGAGATCT TTTCACACGT CTCTCCAAAG AGGTTGTAAT GTTTACGGAG 480

GAAGATGTGA AGTTCTATCT GGCTGAGCTA GCATTGGCTT TGGATCATCT TCATAGTCTG 540

GGCATCATCT ATCGGGATCT AAAACCAGAG AACATTCTCC TTGATGAGGA AGGCCACATA 600

AAGATCACAG ATTTCGGCCT GAGCAAAGAG GCAATCGACC ATGACAAACG AGCGTACTCG 660

TTCTGTGGGA CCATTGAGTA CATGGCCCCA GAGGTGGTCA ATAGACGAGG TCACACTCAA 720

AGCGCTGACT GGTGGTCCTT TGGAGTCTTA ATGTTTGAAA TGCTGACTGG ATCCCTGCCA 780

TTTCAAGGCA AAGACCGCAA AGAGACCATG GCACTTATTC TCAAGGCAAA ACTGGGCATG 840

CCGCAATTCC TTAGCCCAGA AGTCCAGAGT TTATTGAGGG CCCTCTTCAA AAGAAACCCA 900

TCTAATAGAT TAGGCGCAGG ACCTGATGGA GTTGAAGAAA TCAAACGGCA TATATTTTTC 960

GCAACCATAG ACTGGAATAA GTTGTATAGA CGAGAAATCA AGCCTCCATT CAAACCCGCA 1020

GTCGGCCGAC CAGAGGACAC CTTCCATTTT GACCCTGAGT TTACATCTCG CACACCGACG 1080

GACTCACCCG GTGTTCCAGC CAGCGCTAAC GCTCACCAGC TCTTCCGTGG CTTCAGCTTT 1140

GTTGCCACTA ACCTGGGTCA AGAGCAACCT TTGACTGAGA TCAAGCAAAA CTCAGTAAAC 1200

CCCATTGTAC AGCAACTTCA TGGTAACAAC ATTCATTTCA CTGACGGCTA TGAACTCAAG 1260

GAGGACATCG GCATTGGAGC GTATTCGGTC TGCAAACGTT GTGTCCACAG AATCACCAGT 1320

GTGGAGTATG CTGTTAAAAT TATTGACAGA TCCAAGAAGG ACCCCTCTGA AGAGATCGAG 1380

ATTCTTCTGC GATACGGCCA GCATCCAAAC ATCATTACTC TGAAAGATGT CTATGATGAT 1440

GGCAAGTTTG TGTATCTGGT GATGGAGCTG ATGAGAGGAG GAGAGCTGCT GGACCGGATC 1500

CTGCGTCAGA AGTGCTTTTC AGAGCGGGAG GCCTCAGCTG TGCTCTGTAC TATTACCAAG 1560

ACTGTGGAAT ATTTGCATTC ACAAGGGGTT GTGCATCGAG ATTTGAAGCC TAGTAACATC 1620

CTGTATGTGG ATGAAACAGG CGATCCAGAG TCCATCAGAA TCTGTGATTT TGGGTTTGCC 1680

AAACAGTTAA GGGCTGAAAA TGGTCTGCTC ATGACACCTT GCTATACTGC GAACTTTGTG 1740

GCACCAGAGG TCCTTAAGAA ACAGGGTTAT GATGCAGCCT GTGATATCTG GAGTCTGGGC 1800

ATCTTACTCT ACACAATGCT GGCAGGTTTC ACGCCCTTTG CTAACGGCCC TGACGACACA 1860

CCAGAGGAGA TCTTGGCTCG CATTGGCAGT GGGAAATTTG CCTTGTCAGG AGGCAACTGG 1920

GACACGGTGT CTGACGCAGC TAAGGACATT GTGACTAAAA TGCTACACGT GGACCCTCAT 1980

CAGCGGCTAA CAGCACCACT TGTTCTCAGA CATGCGTGGA TCGTGAACCG GGATCAGTTA 2040

TCTCAGAGTC AGCTGATCAG ACAGGATGTG ACTCTGGTGA AGGGTGCGAT GGCTGCCACA 2100

TACTCTGCTT TAAATCGATC ACCTCAGGCA CCAAAACTAG AACCAGTGCT GTCGTCCTGT 2160

CTGGCTCAAA GAAGAGGCAT GAAAAGACTC ACATCCACTC GTCTATAG 2208

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+G G+ysvckrcvh+ t  e+avkiid+sk+d+seeieillry+qhpni+tlkd

Q: 417   YELKEDIGIGAYSVCKRCVHRITSVEYAVKIIDRSKKDPSEEIEILLRYGQHPNIITLKD  476

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgk+vylv+el++GGelldri+++k+fsereasa+l+t++k+veylh+qGvvhrdlk

Q: 477   VYDDGKFVYLVMELMRGGELLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLK  536

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvde++++esi+i+dfGfak++raengll+tpcyt+nfvapevlk+qGyd+acd+

Q: 537   PSNILYVDETGDPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDI  596

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaG++pfangp+dt+eeila+i++Gkf+lsG++wd+vs++akd+v+k+l+

Q: 597   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKFALSGGNWDTVSDAAKDIVTKMLH  656

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl++  +l+h w+

Q: 657   VDPHQRLTAPLVLRHAWI  674

         *****************8

Domain Sequence
(FASTA)

YELKEDIGIG AYSVCKRCVH RITSVEYAVK IIDRSKKDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKFVYL VMELMRGGEL LDRILRQKCF SEREASAVLC TITKTVEYLH SQGVVHRDLK 120

PSNILYVDET GDPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK KQGYDAACDI 180

WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKFALS GGNWDTVSDA AKDIVTKMLH 240

VDPHQRLTAP LVLRHAWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013