EKS-DAR-00454

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00454

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	509.0	4.3E-153	374	632	259

Status

Unreviewed

Ensembl Protein

ENSDARP00000043235

UniProt Accession

F1R125;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

LOC566430

Gene Synonyms/Alias

LOC566430;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000031702	ENSDARP00000043235	ENSDART00000043236

Organism

Danio rerio

Functional Description

Protein Length

684

Protein Sequence
(FASTA)

MGTLRDLQYA LQEKIEELRQ RDALIDELEL ELDQKDELIQ KLQNELDKYR SVIRPATQQV 60

HKQSALQEHQ RTKRQAISAE PTAFDIQDLS HVTLPFYPKS PQSKELIKEA ILDNDFMKNL 120

ELSQIQEIVD CMYPVEYDKE SCIIKEGDVG SLVYVMEDGK VEVTKEGMKL CTMGPGKVFG 180

ELAILYNCTR TATVQTLTNV KLWAIDRQCF QTIMMRTGLI KHAEYMEFLK SVPTFQGLQE 240

EILSKLADVL EETHYSDGEY IIRQGARGDT FFIISKGKVN VTREDAPNGT PVYLRALGKG 300

DWFGEKALQG EDIRTANVIA AEAVTCLVID RESFKHLIGG LDDVSNKGYD DAGAKAKYEA 360

ENAFFSNLKL VDFNIIDTLG VGGFGRVELV QLKSEETKTF AMKILKKRHI VDTRQQEHIR 420

SEKQIMQEAH SDFIVRLYRT FKDSKYLYML MEACLGGELW TILRDRGSFE DSTTRFYTAC 480

VVEAFAYLHS KGIIYRDLKP ENLILDHRGY AKLVDFGFAK KIGFGKKTWT FCGTPEYVAP 540

EIILNKGHDI SADYWSLGIL MYELLTGSPP FSGPDPMKTY NIILRGIDMI EFPKKITKNA 600

GNLIKKLCRD NPSERLGNLK NGVKDIQKHK WFEGFNWEGL RKGTLIPPII PDVASPTDTS 660

NFDSFPEDNE DPPPDDNSGW DTDF 684

Nucleotide Sequence
(FASTA)

ATGGGCACTT TACGCGATCT CCAGTACGCG TTACAGGAGA AGATTGAAGA ATTGAGACAG 60

AGAGACGCGC TTATCGACGA GCTGGAGTTG GAGCTCGACC AGAAAGACGA ACTCATACAG 120

AAGCTACAGA ATGAGTTAGA CAAGTACCGA TCCGTGATAA GACCCGCAAC TCAACAAGTC 180

CACAAGCAGA GTGCCCTTCA GGAGCACCAG AGGACCAAGA GACAGGCGAT CTCAGCCGAA 240

CCCACAGCCT TTGATATCCA AGACCTCAGT CACGTCACTC TGCCTTTCTA CCCAAAGAGT 300

CCACAGTCTA AAGAACTAAT CAAAGAGGCC ATTCTTGACA ACGACTTTAT GAAGAACCTG 360

GAGCTGTCTC AGATCCAGGA GATTGTAGAC TGCATGTACC CTGTGGAGTA TGATAAAGAG 420

AGCTGTATCA TCAAAGAAGG TGACGTGGGC TCCCTGGTCT ATGTCATGGA AGACGGCAAG 480

GTGGAGGTGA CCAAGGAGGG CATGAAACTG TGTACCATGG GACCTGGGAA AGTTTTCGGA 540

GAGCTCGCCA TTCTATACAA CTGCACCAGG ACCGCTACGG TACAGACCCT CACAAATGTG 600

AAGTTATGGG CCATTGACCG GCAGTGTTTC CAGACCATCA TGATGAGGAC AGGACTCATC 660

AAACATGCAG AGTACATGGA GTTCCTGAAG AGCGTTCCCA CATTCCAGGG CCTCCAAGAA 720

GAAATCCTCA GCAAGCTGGC TGATGTGCTG GAGGAGACTC ACTACAGTGA TGGAGAGTAC 780

ATTATTAGAC AAGGTGCCAG AGGGGACACG TTCTTTATCA TTAGCAAAGG AAAGGTGAAT 840

GTGACTCGAG AAGATGCACC CAATGGGACT CCTGTCTATC TGCGTGCATT AGGAAAAGGA 900

GACTGGTTTG GAGAAAAAGC TCTTCAAGGA GAAGACATCA GGACGGCTAA TGTCATCGCT 960

GCTGAAGCAG TTACCTGCCT CGTCATCGAC AGAGAATCCT TCAAACACTT GATTGGAGGT 1020

CTTGACGACG TCTCAAACAA AGGCTATGAT GATGCTGGCG CCAAAGCAAA ATACGAGGCG 1080

GAGAATGCCT TCTTCTCCAA CCTGAAGCTG GTGGACTTTA ACATCATCGA CACCTTGGGA 1140

GTTGGAGGAT TTGGGAGAGT TGAGCTGGTG CAGCTCAAGA GTGAAGAGAC CAAAACATTT 1200

GCAATGAAGA TTCTGAAGAA GCGTCACATT GTGGACACGC GACAACAGGA GCACATCCGC 1260

TCTGAGAAGC AAATCATGCA GGAGGCACAT TCAGACTTCA TTGTAAGGTT GTACAGGACT 1320

TTCAAAGACA GCAAATACCT GTATATGTTA ATGGAGGCCT GTTTAGGAGG AGAGCTTTGG 1380

ACCATTCTTA GAGACAGAGG ATCATTTGAA GACTCCACTA CAAGGTTTTA CACAGCCTGT 1440

GTGGTTGAAG CCTTCGCTTA CCTGCATTCC AAAGGAATAA TCTACCGGGA TTTAAAGCCA 1500

GAAAATCTCA TTCTGGATCA CAGAGGATAT GCCAAGCTTG TGGACTTTGG CTTTGCTAAA 1560

AAGATTGGAT TTGGGAAGAA AACGTGGACT TTCTGTGGAA CGCCGGAGTA TGTAGCCCCA 1620

GAGATCATAC TTAATAAAGG CCACGACATC TCTGCAGATT ACTGGTCATT GGGAATTCTT 1680

ATGTATGAAC TCTTGACCGG AAGCCCACCG TTTTCAGGAC CAGATCCAAT GAAGACTTAT 1740

AATATCATTT TAAGAGGAAT CGACATGATA GAATTTCCAA AGAAGATCAC CAAAAATGCT 1800

GGAAATCTCA TTAAAAAACT ATGCAGGGAC AACCCGTCTG AGCGGTTAGG AAACTTGAAA 1860

AATGGAGTGA AAGACATCCA AAAGCACAAA TGGTTTGAAG GCTTTAACTG GGAAGGACTG 1920

CGGAAAGGAA CTCTCATTCC TCCTATTATT CCTGATGTTG CAAGCCCGAC TGACACCAGT 1980

AACTTTGATA GCTTTCCTGA GGACAACGAG GACCCTCCTC CTGATGACAA CTCTGGCTGG 2040

GACACTGATT TCTAA 2055

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+e+k+fa+kilkk+hivdt+qqeh++sek+i++ea+sdf

Q: 374   NIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDF  433

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 434   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  493

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 494   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  553

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+kitk+a +likklcrdnp+

Q: 554   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPS  613

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 614   ERLGNLKNGVKDIQKHKWF  632

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEETKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQEAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKITKNAGNL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013