EKS-DAR-00748

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00748

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	441.1	2.2E-132	245	495	251

Status

Unreviewed

Ensembl Protein

ENSDARP00000040554

UniProt Accession

Q66I04;

Protein Name

Protein Synonyms/Alias

Novel protein (Zgc:92124); Zgc:92124;

Gene Name

lyn

Gene Synonyms/Alias

lyn; CH73-38P6.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000031715	ENSDARP00000040554	ENSDART00000040555

Organism

Danio rerio

Functional Description

Protein Length

510

Protein Sequence
(FASTA)

MGCKKSKLDG DQNGCVLEPV NKEHPVRTDQ TYVRDPTSYK PPITSQNAGL LPGQVFQKME 60

EKEKIVVALY PYEAIHADDL GFKKGEKLKI IEEHGEWWKA RSLTTRKEGF IPSNYVAEAD 120

TMETEEWFYK DITRKDAERQ LLAPANKPGS YLIRESETSK GSYSLSIRDV DAQGQDVVKH 180

YKIRSLDNGG YYISPKITFS DISSMIKHYH KQSDGLCRKL DKACEKPKAQ KPWDKDAWEI 240

SKDSIKMVKK LGAGQFGEVW MAFYNNSTKV AVKTLKPGTM SVEAFLEEAN LMKTLQHDRL 300

VRLYAVVTKT EPIYIITEYM ANGSLLDFLK SQAGSKIQLP KLIDFSAQIA EGMAYIEKKN 360

YIHRDLRAAN VLVSEMLLCK IADFGLARVI EDDQYTAREG AKFPIKWTAP EAINYGSFTI 420

KSDMWSFGVL LYEIITYGKI PYPGMSNSEV MSSVQRGYRM PRPENCPVEL YEIMTTCWKN 480

KPEDRPTFDY IQSVLDDFYT ATEGQYQQQP 510

Nucleotide Sequence
(FASTA)

ATGGGTTGTA AAAAATCCAA GTTGGATGGT GACCAAAATG GATGTGTGCT TGAACCAGTG 60

AACAAAGAGC ATCCAGTACG TACTGACCAA ACATATGTGA GAGATCCAAC CTCCTATAAG 120

CCTCCTATAA CTTCCCAAAA TGCCGGTCTC CTGCCTGGTC AGGTTTTCCA AAAAATGGAA 180

GAGAAGGAAA AAATCGTTGT CGCTTTATAT CCATATGAAG CCATTCACGC TGATGATCTG 240

GGCTTTAAAA AAGGAGAGAA GTTAAAAATT ATTGAGGAGC ATGGCGAGTG GTGGAAAGCG 300

AGGTCTTTGA CCACACGAAA AGAAGGTTTC ATTCCCTCAA ACTATGTTGC AGAAGCAGAC 360

ACTATGGAGA CAGAAGAATG GTTCTATAAA GACATCACGA GAAAGGATGC AGAGAGACAG 420

CTGTTGGCAC CGGCTAATAA ACCTGGATCT TACCTCATAC GGGAGAGCGA AACCTCAAAA 480

GGAAGTTATT CACTATCGAT CAGAGACGTA GACGCTCAGG GCCAGGATGT TGTTAAACAT 540

TATAAGATCA GATCTCTGGA TAATGGCGGT TACTACATCT CCCCAAAGAT CACGTTCAGT 600

GACATCAGCA GCATGATAAA ACATTACCAC AAACAGTCAG ATGGATTATG TCGAAAGCTG 660

GATAAAGCAT GCGAGAAACC TAAAGCGCAA AAACCTTGGG ACAAAGATGC CTGGGAAATC 720

TCTAAAGACT CCATAAAGAT GGTGAAGAAA CTCGGAGCTG GACAGTTTGG AGAAGTATGG 780

ATGGCCTTCT ACAATAACAG CACCAAAGTG GCAGTGAAAA CTCTGAAGCC AGGCACAATG 840

TCAGTGGAGG CGTTTCTAGA GGAGGCCAAC CTGATGAAGA CCTTACAGCA CGACAGACTT 900

GTGCGTCTCT ATGCTGTCGT CACCAAAACT GAGCCCATCT ACATCATCAC TGAGTACATG 960

GCTAATGGAA GCTTATTGGA TTTCTTGAAA AGTCAAGCTG GCTCCAAAAT ACAGTTACCA 1020

AAGTTGATAG ATTTTTCTGC ACAGATAGCC GAAGGAATGG CCTACATTGA GAAGAAAAAC 1080

TACATCCACC GAGACCTGAG AGCAGCTAAT GTGCTGGTTT CAGAGATGCT GCTGTGCAAA 1140

ATAGCTGATT TTGGCCTGGC CCGAGTAATT GAGGATGACC AATACACGGC CAGAGAAGGG 1200

GCAAAATTTC CTATCAAATG GACGGCACCA GAAGCCATCA ACTATGGCTC TTTCACCATC 1260

AAATCAGATA TGTGGTCCTT CGGGGTTCTC CTGTATGAGA TTATAACATA CGGGAAAATT 1320

CCTTATCCAG GCATGAGCAA CAGCGAAGTC ATGAGCAGTG TCCAGAGAGG TTACCGGATG 1380

CCCCGTCCCG AAAACTGTCC GGTTGAACTT TACGAGATCA TGACCACATG CTGGAAGAAT 1440

AAACCAGAAG ACCGGCCCAC GTTTGACTAT ATTCAGAGTG TACTGGACGA CTTCTACACG 1500

GCCACTGAAG GCCAGTACCA GCAGCAGCCA TGA 1533

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +k+vkklG+GqfGevw++ +++s+kvavktlk+gt+s eafleea+++k+l+h++lv+ly

Q: 245   IKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSVEAFLEEANLMKTLQHDRLVRLY  304

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+ma+Gslldflk++ g+k++lpkl+d++aq+aeGmay+e+kn+ihr

Q: 305   AVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEGMAYIEKKNYIHR  364

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+e l++k+adfGlar+iedd+yta+egak+PikWtaPeai++g+ftiksd+

Q: 365   DLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAPEAINYGSFTIKSDM  424

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+t+Gk+PypGm+n+ev+++v+rgyr+prpe+cp elye++++cwk++pe+

Q: 425   WSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVELYEIMTTCWKNKPED  484

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf+++q+vl

Q: 485   RPTFDYIQSVL  495

         *******9976

Domain Sequence
(FASTA)

IKMVKKLGAG QFGEVWMAFY NNSTKVAVKT LKPGTMSVEA FLEEANLMKT LQHDRLVRLY 60

AVVTKTEPIY IITEYMANGS LLDFLKSQAG SKIQLPKLID FSAQIAEGMA YIEKKNYIHR 120

DLRAANVLVS EMLLCKIADF GLARVIEDDQ YTAREGAKFP IKWTAPEAIN YGSFTIKSDM 180

WSFGVLLYEI ITYGKIPYPG MSNSEVMSSV QRGYRMPRPE NCPVELYEIM TTCWKNKPED 240

RPTFDYIQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

dre:447804

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013