EPS-DAR-00044
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-DAR-00044
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP40.07.0E-1010317371
StatusReviewed
Ensembl ProteinENSDARP00000040679
UniProt AccessionQ6NY98;
Protein NamemRNA guanylyltransferase
Protein Synonyms/Alias TPase; mRNA 5'-triphosphatase; GTP--RNA guanylyltransferase; GTase;
Gene Namerngtt
Gene Synonyms/Alias rngtt; si:ch211-241P10.5, zgc:76886;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000032261ENSDARP00000040679ENSDART00000040680
OrganismDanio rerio
Functional DescriptionBifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus (By similarity).
Protein Length598
Protein Sequence
(FASTA)
MSQTGAPPRW RNCPRRGQPV AGKFLPMKTM LGPRYDDKVP EENRFHPSML SNYLKSLKVK 60
MGLLVDLTNT TRFYDRADIE KEGIKYVKLS CKGHGECPTA ETTEMFIRLC EHFIEKTPTE 120
LIGVHCTHGF NRTGFLICAY LVEKMDWSIE AAVAAFAQAR PPGIYKGDYL KELFRRYGDV 180
EDAPAAPPLP EWCFDEDEEE DGEEDGSASA PASEPSSSHT GQSKKKKERL KLGAVFLEGV 240
SVKGVSQVTT QPKLGEIQRK CQQFSEWDRS GFPGAQPVSM DRKNIRMLEQ NGYKVSWKAD 300
GTRYMMLIDG RNEVYMIDRD NSVFHIENLE FPFRKDLRIH LSNTLLDGEM IIDKVNGQPV 360
PRYLIYDIIK FSGQPVGQCD FNRRLLCIEK EIISPRFEKM KLGQIDKAKE PFSVRNKPFF 420
DIHAARKLLE GSFTSQVSHE VDGLIFQPIG KYKPGRCDDI LKWKPPSHNS VDFRLKITKV 480
GGEGLIPQTV GLLYVGNYDM PFAQMKITKD LKQYDNKIIE CTFVNNTWVF MRQRVDKSFP 540
NAYDTAMAVC NSIQHPVTKE ILLEFLERCA QVQSRKNPAD SDLMPPPPPK RSANSIPQ 598
Nucleotide Sequence
(FASTA)
ATGTCGCAAA CCGGAGCGCC TCCCCGCTGG AGGAACTGTC CCAGGAGAGG ACAACCTGTG 60
GCCGGTAAAT TTCTACCCAT GAAAACCATG CTTGGGCCGC GCTATGATGA TAAAGTCCCT 120
GAGGAGAACC GGTTTCATCC CAGCATGCTG TCCAACTATC TGAAAAGCTT AAAGGTGAAG 180
ATGGGTTTAC TGGTGGACCT GACCAACACC ACCCGCTTCT ATGATCGAGC AGACATCGAA 240
AAAGAAGGAA TAAAATACGT GAAACTTTCC TGCAAAGGTC ATGGCGAATG CCCGACGGCA 300
GAGACCACAG AGATGTTCAT CAGGCTGTGT GAGCACTTCA TAGAGAAGAC GCCCACAGAG 360
CTCATCGGCG TTCACTGCAC GCACGGCTTC AACCGCACCG GCTTCTTAAT ATGTGCCTAC 420
CTGGTGGAGA AAATGGACTG GAGCATCGAG GCGGCTGTGG CAGCGTTCGC TCAGGCTCGT 480
CCGCCAGGCA TCTATAAAGG AGACTACCTG AAGGAGCTCT TCCGGCGGTA CGGGGATGTG 540
GAGGACGCTC CCGCCGCCCC GCCACTGCCC GAGTGGTGCT TCGATGAAGA CGAGGAGGAG 600
GATGGGGAGG AAGACGGCAG TGCCAGCGCT CCGGCCTCCG AGCCCAGCTC ATCTCACACC 660
GGGCAGAGCA AGAAGAAGAA GGAGAGACTC AAACTGGGCG CTGTGTTTCT GGAAGGCGTC 720
TCTGTCAAAG GAGTCTCTCA AGTCACAACA CAGCCCAAAC TCGGAGAAAT CCAGAGGAAG 780
TGCCAGCAGT TCTCAGAGTG GGACAGATCT GGCTTTCCTG GTGCTCAACC GGTATCGATG 840
GACCGCAAGA ACATTCGCAT GCTGGAGCAG AATGGGTATA AAGTCAGCTG GAAAGCAGAC 900
GGCACACGGT ACATGATGTT GATAGATGGG AGAAATGAAG TTTACATGAT CGACAGAGAC 960
AACTCTGTCT TCCACATAGA AAACCTGGAG TTTCCCTTCC GGAAGGATCT GCGCATCCAC 1020
CTTTCCAACA CACTTTTGGA TGGGGAGATG ATTATCGACA AGGTGAACGG CCAGCCTGTC 1080
CCACGCTATC TCATCTATGA CATCATCAAG TTTAGCGGTC AACCGGTGGG TCAGTGTGAC 1140
TTCAACAGAC GTCTGCTGTG TATCGAGAAG GAGATCATCT CCCCACGCTT TGAGAAAATG 1200
AAGCTGGGCC AGATCGACAA AGCCAAGGAG CCCTTCAGTG TCAGGAATAA GCCTTTCTTC 1260
GACATCCACG CTGCGCGCAA GCTCCTGGAG GGCAGTTTCA CCTCGCAGGT CAGCCATGAA 1320
GTGGATGGTC TCATCTTCCA GCCTATAGGG AAATATAAGC CAGGCCGATG TGATGACATC 1380
CTGAAGTGGA AGCCGCCGAG TCACAACTCT GTGGATTTCA GACTCAAGAT CACCAAAGTC 1440
GGCGGCGAGG GGCTGATCCC GCAGACGGTT GGTCTCCTGT ACGTGGGGAA CTATGACATG 1500
CCCTTTGCGC AAATGAAGAT AACAAAGGAC CTGAAGCAGT ACGATAATAA AATAATCGAG 1560
TGCACGTTCG TCAACAACAC CTGGGTGTTC ATGCGGCAGA GAGTTGACAA GAGCTTCCCC 1620
AACGCATACG ACACGGCCAT GGCCGTGTGT AACAGTATCC AGCATCCCGT CACCAAGGAG 1680
ATCCTGCTGG AGTTTCTGGA GCGCTGCGCT CAGGTTCAGT CCCGCAAAAA CCCAGCCGAC 1740
TCGGACCTCA TGCCCCCACC GCCACCCAAG AGGAGCGCCA ACAGCATCCC GCAGTAG 1797
Domain Profile
S: 75    aaefidea.....kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieavkrkrps  129
         +  fi  +     k++ + + vHC++G++R++ l++aYL++ +++s++ A+ a+ + rp 
Q: 103   TEMFIRLCehfieKTPTELIGVHCTHGFNRTGFLICAYLVEKMDWSIEAAVAAFAQARPP  162
         334555555556688999****************************************98
S: 130   iepnegfleQL  140
          + + ++l+ L
Q: 163   GIYKGDYLKEL  173
         77777777666
Domain Sequence
(FASTA)
TEMFIRLCEH FIEKTPTELI GVHCTHGFNR TGFLICAYLV EKMDWSIEAA VAAFAQARPP 60
GIYKGDYLKE L 71
KeywordComplete proteome; GTP-binding; Hydrolase; mRNA capping; mRNA processing; Multifunctional enzyme; Nucleotide-binding; Nucleotidyltransferase; Nucleus; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00022
EPS-BOT-00017
EPS-CAJ-00018
EPS-CAF-00025
EPS-CAP-00017
EPS-CII-00008
EPS-ECT-00014
EPS-FEC-00023
EPS-GAA-00032
EPS-HOS-00017
EPS-ICT-00019
EPS-MAM-00017
EPS-MOD-00018
EPS-MYL-00021
EPS-ORN-00025
EPS-ORA-00018
EPS-ORC-00019
EPS-OTG-00019
EPS-PES-00025
EPS-PEM-00015
EPS-POA-00025
EPS-SAH-00019
EPS-TAG-00021
EPS-TAR-00033
EPS-TEN-00025
EPS-XET-00022
EPS-XIM-00040
Gene Ontology
GO:0005634; C:nucleus
GO:0005525; F:GTP binding
GO:0004484; F:mRNA guanylyltransferase activity
GO:0004651; F:polynucleotide 5'-phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006370; P:7-methylguanosine mRNA capping
GO:0035335; P:peptidyl-tyrosine dephosphorylation
KEGG
dre:405803;
InterPros
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR017074; mRNA_cap_enz_bifunc.
IPR001339; mRNA_cap_enzyme.
IPR013846; mRNA_cap_enzyme_C.
IPR012340; NA-bd_OB-fold.
IPR016027; NA-bd_OB-fold-like.
IPR000387; Tyr/Dual-specificity_Pase.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF03919; mRNA_cap_C; 1.
PF01331; mRNA_cap_enzyme; 1.
SMARTs
Prosites
PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
Prints
Created Date20-Feb-2013