EKS-DAR-00554

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00554

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.4	5.1E-116	49	300	252

Status

Unreviewed

Ensembl Protein

ENSDARP00000003234

UniProt Accession

E7F0G7;

Protein Name

Protein Synonyms/Alias

Gene Name

mark2b

Gene Synonyms/Alias

mark2b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000032458	ENSDARP00000003234	ENSDART00000005329

Organism

Danio rerio

Functional Description

Protein Length

788

Protein Sequence
(FASTA)

MSTRPQGVAV IENSSSQTHS DAKGGVRSSA PRCRNAVATA EEYPHIGNYR LLKTIGKGNF 60

AKVKLARHVL TSKEVAVKII DKTQLNSSSL QKVFREVRIM KLLNHPNIVK LFEVIETDKT 120

LYLVMEYASG GEVFDYLVAH GRMKEKEARA KFRQIVSAVQ YCHQKCIVHR DLKAENLLLD 180

ADMNIKIADF GFSNEFTVGN KLDTFCGSPP YAAPELFQGK KYDGPEVDVW SLGVILYTLV 240

SGSLPFDGQN LKELRERVLR GKYRIPFYMS TDCENLLKKF LILNPTKRGS LEQIMKDRWM 300

NVGYEDDDLK PYIEPQPDYK DPRRTDIMLQ MGFSQEEIED SLVKQKYNEV MATYLLLDYR 360

NSELDEGVNL SLKSRPGSDL TNSNAPSPPH KVQRSVSSTQ KPARRSTDQG SYSKRPQGEN 420

KHGVEDSGRK GSSSSTKVPP SPVISSERKK SSTPSTNSIL STGTSRSRNS PISERATLGV 480

QNGKDSLSTP GSRASTASAG PVLSSSSSSS RTRHHKSLST SAHPSPADLH SHRPSDPPQR 540

APGASPSAHN ISSAAGTDRT NFPRGVPTRN TFHLGQQRGA RDQQGSPYHG APASPSLSHG 600

NSQQRRPAAS GIFSKFTSKF VRRNLSFRFP RSPYEGEGQE EGSRSMLSSA EKSEKTSVGP 660

EDENKDPSSS PGGGTPPAAP VSSLKDQSKP RSLRFTWSMK TTSSMEPSEM MKEIRKVLDA 720

NSCEYELRER YMLLCMAGNP ARDDFVQWEM EVCKLPRLSL NGVRFKRISG TSIAFKNIAS 780

KIANELKL 788

Nucleotide Sequence
(FASTA)

ATGTCAACCC GGCCTCAAGG AGTAGCTGTT ATAGAGAATT CATCCAGCCA GACTCACTCT 60

GATGCCAAAG GAGGAGTGCG TTCCAGCGCT CCACGCTGTC GAAATGCAGT GGCGACAGCG 120

GAAGAATACC CTCACATAGG AAATTACAGA CTGCTCAAGA CCATAGGCAA GGGCAACTTC 180

GCCAAGGTCA AACTGGCCCG ACATGTTCTC ACTTCTAAAG AGGTAGCGGT GAAAATCATA 240

GACAAGACAC AGCTCAACTC GTCTAGTCTT CAAAAAGTCT TCCGAGAAGT GAGAATCATG 300

AAGCTTCTGA ATCATCCAAA CATTGTGAAG TTATTTGAGG TGATCGAGAC AGACAAGACG 360

CTGTATTTAG TCATGGAGTA TGCCAGTGGA GGCGAGGTTT TTGATTACCT TGTTGCTCAC 420

GGGAGGATGA AAGAAAAGGA AGCGCGTGCC AAATTTAGAC AGATTGTCTC AGCTGTGCAG 480

TATTGCCATC AGAAGTGTAT TGTACACCGA GATCTCAAGG CTGAAAATCT TTTATTGGAT 540

GCTGACATGA ACATAAAGAT CGCTGACTTT GGCTTCAGTA ATGAGTTTAC GGTGGGCAAT 600

AAATTGGACA CGTTTTGCGG TAGCCCACCG TATGCAGCCC CTGAGCTCTT CCAGGGCAAG 660

AAGTATGACG GGCCAGAGGT GGATGTGTGG AGTCTGGGTG TCATTCTCTA CACACTGGTC 720

AGTGGCTCGC TGCCATTTGA CGGGCAGAAC CTGAAGGAGT TGCGAGAACG TGTGTTGAGA 780

GGGAAGTATC GGATTCCCTT CTATATGTCC ACAGACTGTG AGAACCTGCT GAAGAAGTTT 840

CTCATCCTCA ATCCAACCAA AAGGGGAAGT TTAGAGCAGA TCATGAAGGA TCGCTGGATG 900

AATGTAGGTT ATGAAGACGA TGACCTGAAA CCTTACATTG AGCCTCAACC AGACTACAAA 960

GACCCCAGGA GAACAGACAT AATGCTTCAG ATGGGCTTCT CTCAAGAAGA AATTGAGGAC 1020

TCTCTCGTCA AGCAAAAGTA CAATGAAGTC ATGGCCACAT ACCTGCTGCT CGACTATAGG 1080

AATTCAGAGC TTGACGAGGG GGTCAACCTG TCATTAAAGT CACGCCCAGG AAGTGACCTC 1140

ACTAACAGCA ACGCCCCTTC TCCACCTCAT AAGGTACAGC GCAGTGTGTC TTCGACTCAG 1200

AAACCTGCCA GAAGATCAAC AGATCAGGGC TCATACTCGA AAAGGCCTCA GGGAGAAAAC 1260

AAGCATGGAG TGGAGGATTC TGGGAGGAAA GGTTCAAGTA GCTCCACCAA AGTTCCACCC 1320

AGTCCGGTTA TCTCCAGTGA ACGTAAAAAG AGTTCGACAC CCTCTACTAA TAGTATCCTG 1380

TCTACAGGCA CAAGCCGCAG CAGAAACTCC CCTATTTCTG AGAGAGCCAC TCTAGGAGTG 1440

CAAAACGGCA AGGACAGCCT GAGCACCCCT GGGTCCCGCG CCTCCACGGC CTCAGCTGGC 1500

CCTGTGCTCT CTTCATCCTC CTCCTCCTCA CGCACCCGCC ATCACAAGTC CCTGTCCACC 1560

TCTGCCCATC CCAGTCCCGC AGACCTGCAC TCACATCGGC CCAGTGATCC CCCACAGAGA 1620

GCACCTGGTG CCTCCCCGTC AGCCCACAAT ATCAGCAGTG CAGCTGGGAC GGACCGTACC 1680

AATTTCCCCA GAGGGGTGCC CACCCGCAAC ACCTTCCACC TCGGCCAGCA GCGGGGAGCA 1740

CGAGACCAGC AGGGCTCTCC CTACCACGGA GCTCCCGCCT CCCCTTCCCT GTCACACGGG 1800

AACAGCCAAC AACGAAGACC CGCAGCTTCT GGCATCTTCA GCAAGTTCAC CTCCAAGTTT 1860

GTGCGCAGAA ATCTGTCATT CAGATTCCCC AGAAGCCCCT ATGAGGGAGA GGGTCAAGAG 1920

GAGGGGAGCA GATCTATGCT CAGCAGTGCA GAGAAGTCGG AGAAAACTAG CGTCGGGCCG 1980

GAAGATGAAA ACAAAGATCC CTCCTCGTCT CCGGGCGGCG GGACTCCTCC AGCCGCGCCA 2040

GTGTCCTCGC TTAAAGACCA GTCCAAACCT CGCTCTCTCC GCTTCACCTG GAGCATGAAG 2100

ACCACGTCTT CTATGGAGCC CAGCGAGATG ATGAAGGAGA TTCGGAAAGT TCTTGACGCC 2160

AACAGCTGCG AGTACGAGCT GCGCGAGCGT TACATGCTGC TTTGCATGGC TGGCAACCCT 2220

GCTCGTGACG ACTTTGTGCA GTGGGAGATG GAGGTGTGTA AGCTGCCCCG TCTCTCGCTC 2280

AATGGCGTAC GCTTTAAGAG GATATCCGGG ACGTCCATTG CCTTTAAAAA CATCGCCTCC 2340

AAAATCGCCA ATGAGCTCAA ACTGTGA 2367

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 49    YRLLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNI  108

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 109   VKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  168

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 169   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  228

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 229   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKR  288

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 289   GSLEQIMKDRWM  300

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTSKEVAVK IIDKTQLNSS SLQKVFREVR IMKLLNHPNI 60

VKLFEVIETD KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPTKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013