EKS-DAR-00450

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00450

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	478.8	8.2E-144	438	695	258

Status

Unreviewed

Ensembl Protein

ENSDARP00000104901

UniProt Accession

F1QYQ1;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

rps6ka1

Gene Synonyms/Alias

rps6ka1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000033437	ENSDARP00000104901	ENSDART00000129273
ENSDARG00000033437	ENSDARP00000126409	ENSDART00000151901
ENSDARG00000033437	ENSDARP00000044377	ENSDART00000044378
ENSDARG00000033437	ENSDARP00000126449	ENSDART00000151829

Organism

Danio rerio

Functional Description

Protein Length

755

Protein Sequence
(FASTA)

MPLAQLAEPW PKMELVQLET ENGQSTTEDG VSSSVKYKAQ HFYSLEKDIA AVSVKEDGEE 60

IKEINITHVV KEGSEKADAS QFELLKVLGQ GSFGKVFLVR KVTPPDNNQL YAMKVLRKAT 120

LKVRDRVRTK MERDILADVN HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT 180

EEDVKFYLAE LALGLDHLHG LGIIYRDLKP ENILLDEEGH IKLTDFGLCK EAIDHEKKAY 240

SFCGTVEYMA PEVVNRQGHT HSADWWSFGV LMFEMLTGSL PFQGKDRKET MNLILKARLG 300

MPQFLSSEAQ SLLRALFKRN PTNRLGSGSD GAEEIKRHSF FMTIDWNKLF RREIKPPFKP 360

AVARPDDTFY FDSEFTSRTP KDSPGVPPSA GAHQLFRGFS FVATAMLEEE GKEEPSKPPP 420

HPVVQQLHGK NILFSDGYVM KEDIGMGSFS VCKRCIHKVT NTEYAVKVID KTSTDPTEEI 480

EILLRYGQHP NIITLKDVYD NGKQVYLVTE LMRGGELLDR ILKQKFFSER EASAVLHTIT 540

KTVEYLHSQG VVHRDLKPSN ILYVDESGNP ESLRICDFGF AKQLRADNGL LMTPCYTANF 600

VAPEVLKRQG YDEGCDIWSL GVLLYTMIAG FTPFANGPED TPEEILSRIG SGRFTLTGGN 660

WDAVSDAAKD LVSKMLHVDP HQRLTARQVL KHPWIVQRDK LPNSQLQHQD AKLVKGAMAA 720

TYSALKSSQP PPELKPIESS FLAQRRVKKL PSTSL 755

Nucleotide Sequence
(FASTA)

ATGCCTCTTG CTCAACTGGC AGAGCCATGG CCCAAAATGG AGCTGGTGCA GTTGGAGACG 60

GAGAATGGGC AGAGCACCAC TGAGGATGGA GTTTCTTCAT CTGTAAAGTA CAAGGCACAG 120

CACTTCTACA GTCTAGAGAA AGACATTGCC GCTGTCAGTG TGAAGGAAGA TGGTGAGGAG 180

ATCAAGGAGA TCAACATCAC ACATGTGGTT AAGGAGGGAT CAGAGAAAGC AGATGCTTCG 240

CAGTTCGAGC TGCTCAAAGT GCTTGGACAG GGCTCCTTTG GAAAGGTGTT TTTGGTACGG 300

AAGGTAACCC CTCCTGACAA TAACCAGCTT TACGCCATGA AGGTCCTGAG GAAGGCCACA 360

CTCAAAGTGA GGGATCGAGT GAGGACCAAA ATGGAGAGAG ACATCCTAGC AGACGTCAAC 420

CATCCATTTG TGGTTAAACT CCATTATGCC TTTCAGACTG AGGGTAAACT CTATCTGATT 480

CTGGACTTCC TCAGAGGAGG GGATCTGTTC ACCAGGCTGT CAAAAGAGGT GATGTTCACA 540

GAGGAAGATG TCAAGTTTTA TCTGGCTGAG CTGGCATTGG GTCTAGATCA CCTGCACGGT 600

CTTGGCATCA TATACAGAGA TCTCAAACCT GAGAACATCC TCCTGGACGA AGAGGGTCAT 660

ATCAAACTCA CAGATTTTGG ATTGTGTAAG GAAGCTATCG ATCATGAGAA GAAGGCATAC 720

TCGTTCTGCG GGACGGTGGA GTACATGGCT CCAGAAGTGG TCAACCGGCA AGGACACACT 780

CACAGCGCTG ACTGGTGGTC ATTTGGGGTA CTGATGTTTG AGATGCTTAC GGGATCACTG 840

CCTTTCCAGG GAAAGGACAG AAAAGAAACA ATGAATCTCA TCTTGAAAGC GAGGTTGGGG 900

ATGCCTCAGT TCCTGAGCTC TGAAGCTCAA AGTTTATTGA GGGCTCTGTT CAAGAGGAAT 960

CCCACCAACA GACTGGGTTC TGGATCAGAC GGTGCTGAGG AAATCAAACG CCATTCATTC 1020

TTCATGACAA TTGACTGGAA TAAACTCTTC AGACGAGAGA TAAAACCCCC ATTTAAGCCA 1080

GCAGTGGCCA GACCAGACGA CACCTTTTAC TTTGACTCAG AGTTCACGTC TCGTACACCT 1140

AAAGATTCCC CTGGCGTTCC CCCCAGCGCT GGGGCCCATC AGCTTTTTAG GGGCTTCAGC 1200

TTTGTTGCCA CGGCGATGCT GGAGGAGGAG GGCAAAGAAG AGCCCTCAAA ACCCCCTCCA 1260

CACCCTGTGG TGCAGCAGCT TCACGGTAAG AACATTTTGT TCAGTGACGG ATATGTGATG 1320

AAGGAGGACA TCGGCATGGG CTCTTTCTCT GTCTGCAAAC GCTGCATACA CAAAGTAACC 1380

AACACAGAGT ACGCAGTGAA GGTAATTGAT AAAACAAGCA CGGATCCAAC TGAAGAGATT 1440

GAGATCCTGC TGAGATACGG CCAGCATCCC AACATCATCA CTCTCAAAGA TGTGTATGAT 1500

AATGGGAAGC AGGTCTATCT GGTCACTGAG TTGATGCGAG GAGGTGAGCT GCTGGACAGG 1560

ATCCTCAAGC AGAAGTTTTT CTCTGAGAGA GAGGCTAGTG CTGTGCTGCA CACTATCACA 1620

AAGACTGTGG AATACCTGCA CTCTCAAGGG GTTGTGCACA GGGACCTGAA GCCCAGTAAT 1680

ATTCTGTACG TTGATGAATC TGGAAATCCT GAATCTCTGC GCATTTGTGA TTTTGGCTTT 1740

GCCAAGCAGC TTCGTGCTGA TAATGGCCTC CTCATGACGC CTTGCTATAC CGCCAATTTC 1800

GTAGCACCTG AGGTACTGAA GAGACAGGGC TATGATGAAG GCTGTGACAT TTGGAGTCTC 1860

GGCGTATTAC TATACACTAT GATTGCTGGG TTTACGCCAT TTGCTAATGG ACCAGAAGAC 1920

ACTCCAGAAG AGATCCTGAG TCGGATAGGG AGTGGACGCT TTACTCTGAC GGGTGGCAAC 1980

TGGGACGCAG TGTCTGATGC TGCCAAAGAT TTGGTCTCAA AGATGCTCCA TGTGGACCCT 2040

CACCAGCGGC TCACAGCCAG GCAGGTGCTG AAACATCCAT GGATCGTTCA GAGAGACAAA 2100

CTTCCCAACA GCCAGCTACA ACATCAGGAT GCCAAGCTTG TCAAGGGTGC GATGGCCGCG 2160

ACATACTCGG CACTGAAGAG TTCCCAACCA CCTCCTGAGC TGAAGCCAAT CGAGTCCTCA 2220

TTCTTAGCTC AGAGACGGGT GAAAAAGCTC CCTTCCACCT CTCTGTAG 2268

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y++ked+G Gs+svckrc+hk tn+e+avk+idk+ +d++eeieillry+qhpni+tlkd

Q: 438   YVMKEDIGMGSFSVCKRCIHKVTNTEYAVKVIDKTSTDPTEEIEILLRYGQHPNIITLKD  497

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyd+gk vylv+el++GGelldri+k+kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 498   VYDNGKQVYLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLK  557

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+es++i+dfGfak++ra+ngll+tpcyt+nfvapevlkrqGyde+cd+

Q: 558   PSNILYVDESGNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDI  617

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytm+aG++pfangpedt+eeil +i++G+f+l G++wd+vs++akdlvsk+l+

Q: 618   WSLGVLLYTMIAGFTPFANGPEDTPEEILSRIGSGRFTLTGGNWDAVSDAAKDLVSKMLH  677

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+lkh+w+

Q: 678   VDPHQRLTARQVLKHPWI  695

         *****************8

Domain Sequence
(FASTA)

YVMKEDIGMG SFSVCKRCIH KVTNTEYAVK VIDKTSTDPT EEIEILLRYG QHPNIITLKD 60

VYDNGKQVYL VTELMRGGEL LDRILKQKFF SEREASAVLH TITKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPESLRICD FGFAKQLRAD NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGVLLYTM IAGFTPFANG PEDTPEEILS RIGSGRFTLT GGNWDAVSDA AKDLVSKMLH 240

VDPHQRLTAR QVLKHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013