EKS-DAR-00674

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00674

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	343.1	2.1E-102	15	272	258

Status

Unreviewed

Ensembl Protein

ENSDARP00000091124

UniProt Accession

Q1JQ22;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

zgc:136354;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000033444	ENSDARP00000091124	ENSDART00000100351

Organism

Danio rerio

Functional Description

Protein Length

889

Protein Sequence
(FASTA)

MDTAGVSHTD PLDDYELIHR IGSGTYGDVF KARSIKTSVI AAIKVVKLDP GDDISSIQNE 60

ITMMKDCTHK NIVAYFGSYL RNNKLWICME FCGGGSLQDI YHVTGPLKER QIAYVSRETL 120

QGLHHLHQTG KMHRDIKGAN ILLTERGDVK LADFGVAAEI NASVAKRKSF IGTPYWMAPE 180

VAAVEKKGGY NQLCDIWAVG ITAIELAELQ PPMFDLHPMR ALMLMSKSSF QPPKLKEKNK 240

WSTEFHSFIK MALTKNPRKR PTAEKILQHA FVMQLLTRNL VIELLDTVNN PDLQQTQTMD 300

ESDLETCSVL PDKIHSLAKL PVQRTLSEQQ FDHVKFGLPM RKETDPCPVL EAYDDWSSIS 360

ADKDSPSLLE CVEEALMERS LTIKRVSSVE HSPNEEDKYG TVKRMASSPQ STALCHQEKK 420

APTPSSIPSP IIGSSSLKNP SPNTNPSLLS ESALLIGSTL SHMSLITNSC LFTDSSFLSH 480

STSLGSLCLT PTEDPGGTRT YSTPPDSPVS PEWSTLRRKQ DDSKAVVNGL PPTPQVHMGA 540

CFSKVFNGCP LKTHCAVTWV LPKTRDQYLM LGAEEGVYTL NLNELHEDTM EKLLPQRCIW 600

LYVMNNVLMS ISGKSSQLTS HSLPALFEYR RNMQRRQGHL AINAHRLSTK INARKYAMSV 660

KIPDTKGCRR CSVVRNPYND SVFLCAAVPT GLVLLMWYEP LQKFMQLKHI ALSLPEFLPI 720

FELLVQETKE LPQVCVGVRS YPNQKDTSGE MHFDIIHLDD TPQGLPDGET LEVKQVIQLD 780

RDTILVALEN IVKVVNLQAC MSQQKTPELD FEFSIHTLVC LQDSVLVFWK HGLKGKSLQT 840

NEVTQEITDR SRVFQVLGTS RDIILQSTPT DDPSAMSNLY ILTGHESSY 889

Nucleotide Sequence
(FASTA)

ATGGACACAG CAGGCGTATC GCACACGGAT CCGCTCGATG ACTATGAGCT AATACATCGC 60

ATAGGCAGCG GGACATACGG AGATGTTTTT AAGGCCCGTA GCATCAAGAC TTCAGTCATT 120

GCAGCCATTA AAGTGGTCAA ACTGGACCCT GGTGATGATA TTTCAAGCAT TCAAAATGAG 180

ATAACCATGA TGAAAGACTG CACTCACAAA AACATTGTTG CCTATTTTGG CAGCTACCTA 240

AGAAATAACA AGTTATGGAT CTGCATGGAA TTCTGTGGAG GAGGGTCATT GCAAGATATT 300

TACCATGTCA CTGGTCCTCT GAAAGAGAGA CAGATAGCTT ATGTTAGCAG AGAGACACTT 360

CAGGGGCTAC ACCACCTCCA TCAGACTGGA AAAATGCATA GAGACATAAA AGGTGCCAAC 420

ATTCTTTTGA CAGAGCGAGG AGATGTCAAA CTAGCGGATT TTGGAGTGGC AGCTGAGATC 480

AACGCATCTG TTGCTAAAAG AAAATCCTTT ATCGGGACAC CATACTGGAT GGCTCCAGAA 540

GTTGCAGCCG TGGAAAAGAA AGGTGGTTAC AACCAGTTGT GTGATATCTG GGCAGTGGGC 600

ATCACAGCTA TTGAGCTAGC AGAGCTACAG CCACCTATGT TTGACCTACA CCCTATGAGA 660

GCTTTAATGC TGATGTCCAA GAGCAGTTTT CAGCCTCCGA AACTGAAGGA AAAGAACAAA 720

TGGTCCACAG AATTTCACAG TTTCATCAAA ATGGCTCTCA CCAAGAACCC TCGGAAAAGG 780

CCAACAGCAG AAAAGATCCT ACAACATGCT TTTGTCATGC AGCTCCTCAC ACGCAACCTT 840

GTTATAGAGC TGCTGGACAC AGTCAATAAC CCTGATCTGC AACAGACACA GACTATGGAT 900

GAAAGCGATC TAGAGACTTG CAGCGTCCTA CCAGATAAGA TTCATTCTTT AGCAAAACTT 960

CCTGTTCAGA GGACTCTGTC AGAACAGCAG TTTGACCATG TGAAGTTTGG ACTACCTATG 1020

AGAAAGGAGA CAGATCCCTG TCCAGTTCTG GAGGCATATG ATGACTGGAG CTCTATCAGC 1080

GCAGACAAGG ACTCACCGAG TTTGTTAGAA TGTGTGGAAG AGGCCTTGAT GGAAAGGAGT 1140

TTAACTATAA AGAGGGTCTC TTCAGTTGAG CACTCACCAA ATGAAGAGGA TAAATATGGG 1200

ACTGTGAAGA GGATGGCCTC TTCTCCCCAA TCAACAGCCC TCTGCCATCA AGAAAAAAAA 1260

GCTCCCACTC CCTCTTCTAT CCCCTCGCCT ATTATTGGCT CTAGCTCTCT GAAGAACCCT 1320

TCCCCCAACA CTAACCCTAG CCTACTCAGT GAATCGGCTT TGCTTATTGG TTCAACATTG 1380

TCCCACATGT CGCTCATCAC AAACTCCTGC CTATTCACAG ACTCCTCCTT CCTCAGTCAT 1440

TCCACCAGTC TAGGTTCCCT CTGTTTAACT CCAACTGAAG ACCCAGGAGG AACAAGGACT 1500

TATTCCACCC CGCCGGACTC TCCTGTCTCT CCAGAATGGA GCACTCTCAG AAGGAAACAG 1560

GATGACTCTA AAGCTGTTGT CAATGGACTG CCACCTACAC CACAAGTACA TATGGGGGCC 1620

TGCTTCTCCA AAGTATTCAA CGGCTGTCCA TTAAAGACTC ACTGTGCTGT TACATGGGTT 1680

CTACCTAAAA CCAGAGATCA ATATCTTATG CTGGGTGCTG AGGAAGGGGT CTACACCCTC 1740

AACCTCAATG AATTACATGA GGACACTATG GAAAAGTTGC TTCCACAGAG ATGCATTTGG 1800

TTATATGTGA TGAACAATGT CCTTATGTCC ATCTCAGGAA AGTCATCACA GTTGACTTCT 1860

CATAGCCTGC CAGCACTGTT TGAGTATCGC AGAAATATGC AACGTAGACA GGGACATCTC 1920

GCAATTAATG CACACCGCCT GAGCACAAAG ATAAATGCAA GGAAGTATGC CATGTCAGTA 1980

AAAATCCCAG ACACCAAGGG CTGTAGAAGA TGCAGTGTGG TACGAAACCC CTACAATGAC 2040

AGTGTTTTCT TGTGTGCCGC TGTGCCCACT GGATTGGTTC TTCTCATGTG GTATGAACCT 2100

TTGCAGAAGT TCATGCAGCT TAAGCACATT GCTTTGAGTC TGCCAGAGTT CCTGCCTATC 2160

TTTGAACTAC TTGTACAGGA AACTAAGGAG CTGCCACAGG TCTGTGTCGG GGTGAGAAGT 2220

TATCCCAACC AAAAAGACAC CTCTGGAGAG ATGCACTTTG ACATCATCCA CCTGGATGAC 2280

ACACCACAGG GCCTGCCAGA TGGTGAGACT CTGGAGGTCA AGCAAGTGAT TCAGCTTGAC 2340

AGGGACACGA TTCTTGTCGC ACTGGAAAAC ATCGTGAAGG TTGTTAATTT GCAGGCATGC 2400

ATGAGCCAAC AGAAGACCCC TGAACTAGAT TTTGAGTTTT CCATTCACAC GCTGGTGTGC 2460

CTGCAGGACA GTGTTCTTGT CTTCTGGAAG CATGGCCTAA AAGGAAAGAG TTTACAAACT 2520

AATGAGGTTA CCCAGGAGAT CACAGATAGA AGTCGAGTTT TTCAAGTTTT GGGAACATCT 2580

AGGGATATTA TTTTGCAAAG TACTCCTACA GATGATCCGT CGGCCATGAG CAACCTATAC 2640

ATACTCACAG GGCACGAAAG CAGCTACTGA 2670

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel+++ig+G++g+v++ar++kt+ ++aik+++l+  ++++++q+ei+++k+++h+niv+

Q: 15    YELIHRIGSGTYGDVFKARSIKTSVIAAIKVVKLDPGDDISSIQNEITMMKDCTHKNIVA  74

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+d+++  ++ +lkE+qiay+ re+l++L++lH+ +++

Q: 75    YFGSYLRNNKLWICMEFCGGGSLQDIYH--VTGPLKERQIAYVSRETLQGLHHLHQTGKM  132

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlte+g+VkL+dfgvaa+++++++krk+++gtpywmAPEv a+e + gY++

Q: 133   HRDIKGANILLTERGDVKLADFGVAAEINASVAKRKSFIGTPYWMAPEVAAVEkKGGYNQ  192

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaielae +pP++dl+p++al++++k++  ppklk+k+k+s+ef++f++ +

Q: 193   LCDIWAVGITAIELAELQPPMFDLHPMRALMLMSKSSfqPPKLKEKNKWSTEFHSFIKMA  252

         **********************************99988*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a+++l+h+F+

Q: 253   LTKNPRKRPTAEKILQHAFV  272

         *******************7

Domain Sequence
(FASTA)

YELIHRIGSG TYGDVFKARS IKTSVIAAIK VVKLDPGDDI SSIQNEITMM KDCTHKNIVA 60

YFGSYLRNNK LWICMEFCGG GSLQDIYHVT GPLKERQIAY VSRETLQGLH HLHQTGKMHR 120

DIKGANILLT ERGDVKLADF GVAAEINASV AKRKSFIGTP YWMAPEVAAV EKKGGYNQLC 180

DIWAVGITAI ELAELQPPMF DLHPMRALML MSKSSFQPPK LKEKNKWSTE FHSFIKMALT 240

KNPRKRPTAE KILQHAFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

dre:692287

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013