EKS-DAR-00078

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00078

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	370.2	1.3E-110	40	324	285

Status

Unreviewed

Ensembl Protein

ENSDARP00000045176

UniProt Accession

F1QKU6;

Protein Name

Protein Synonyms/Alias

Gene Name

cdk10

Gene Synonyms/Alias

cdk10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000034256	ENSDARP00000045176	ENSDART00000045177

Organism

Danio rerio

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MESTADTDLE PLKLKSLKTD RTFVIPHSER LGKCRSVKEF EKINRIGEGT YGIVYRARDT 60

RTNEIVALKK VRMDKEKDGI PISSLREINL LIRLRHPNIV ELKEVVVGSH LESLFLVMSY 120

CEQDLASLLE NMQSPFSEAQ VKCIVLQLLK GLAYLHHNFI LHRDLKVSNL LMTDKGCVKI 180

ADFGLARVYG IPLQPMTPRV VTLWYRAPEL LLGTKTQTTA LDMWAVGCIF AELLAHKPLL 240

PGASEIQQLD LIVQLLGTPN ESIWPGFSRL PLVGQYSLRK QPYNNLKNKF TWLSEAGLRL 300

LNLLFMYNPQ RRATAIDCLE SSYFKEKPLP CEPELMPTFP HHRNKRSASE TEHQTKRSKV 360

Nucleotide Sequence
(FASTA)

ATGGAGAGCA CAGCAGACAC AGACCTGGAG CCCCTAAAGC TGAAGTCTTT AAAAACCGAC 60

AGGACGTTTG TGATACCGCA CAGCGAACGG CTGGGGAAGT GCAGGAGTGT GAAGGAGTTT 120

GAGAAGATAA ATCGGATTGG AGAGGGAACA TACGGAATCG TGTACCGAGC ACGCGATACA 180

CGGACGAATG AGATTGTTGC CCTGAAGAAA GTGCGAATGG ATAAAGAGAA AGATGGGATT 240

CCCATCAGCA GTTTGAGGGA AATTAACTTA TTAATCAGAC TGAGACACCC AAATATCGTG 300

GAGCTGAAGG AAGTGGTGGT GGGAAGCCAT TTGGAGAGCC TGTTTTTAGT GATGAGCTAC 360

TGCGAGCAGG ATCTTGCCAG TCTGCTGGAG AACATGCAGT CGCCGTTCTC TGAAGCTCAG 420

GTGAAGTGTA TTGTCCTACA GCTGCTGAAA GGACTGGCCT ATTTACATCA CAACTTCATT 480

CTTCACCGGG ATCTGAAGGT TTCAAATCTA CTGATGACTG ACAAGGGCTG TGTTAAAATA 540

GCCGACTTTG GCCTGGCGCG TGTTTACGGT ATCCCTTTAC AGCCCATGAC TCCTCGAGTG 600

GTCACGCTGT GGTACCGGGC TCCAGAGCTC CTCCTGGGGA CAAAGACGCA GACCACGGCT 660

CTGGATATGT GGGCTGTGGG CTGCATCTTC GCCGAGCTTC TGGCTCATAA ACCCCTGCTG 720

CCGGGAGCCT CAGAGATCCA GCAGCTGGAT CTGATCGTGC AGCTGTTGGG AACGCCGAAT 780

GAGAGCATCT GGCCGGGTTT CTCGCGTCTG CCGCTGGTGG GTCAGTACAG TCTGAGGAAA 840

CAGCCCTACA ACAACCTGAA GAACAAGTTC ACCTGGTTAT CAGAGGCTGG TCTGAGACTC 900

CTCAACCTGC TGTTCATGTA CAACCCGCAG CGCAGAGCCA CGGCCATCGA CTGTCTAGAA 960

AGTTCCTACT TCAAGGAGAA GCCGCTGCCT TGTGAACCGG AGCTGATGCC CACATTTCCA 1020

CATCACAGGA ACAAACGCAG CGCATCTGAG ACTGAACACC AGACCAAGAG GAGCAAAGTA 1080

TGA 1083

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ek+++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 40    FEKINRIGEGTYGIVYRARDTRTNEIVALKKVRMDKEKDGIPISSLREINLLIRLRHPNI  99

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++l+Lv+ ++eqdL++ll+++++  +s+++vk ++lqll+glaylH+n

Q: 100   VELKEVVVGSHlESLFLVMSYCEQDLASLLENMQS-PFSEAQVKCIVLQLLKGLAYLHHN  158

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          ilHRDlK +NlL++++g++k+aDfGlar ++ pl+ +t++vvTlwYraPelLlg+k+ +

Q: 159   FILHRDLKVSNLLMTDKGCVKIADFGLARVYGIPLQPMTPRVVTLWYRAPELLLGTKTQT  218

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         ta+D+W+vgci+aell++kpl++g sei+ql+ i++llgtp+e++wp++s+lp +  +s+

Q: 219   TALDMWAVGCIFAELLAHKPLLPGASEIQQLDLIVQLLGTPNESIWPGFSRLPLVGqYSL  278

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l++++p++R +a ++l+++yf

Q: 279   RKQPYNNLKNKFTWLSEAGLRLLNLLFMYNPQRRATAIDCLESSYF  324

         ********************************************98

Domain Sequence
(FASTA)

FEKINRIGEG TYGIVYRARD TRTNEIVALK KVRMDKEKDG IPISSLREIN LLIRLRHPNI 60

VELKEVVVGS HLESLFLVMS YCEQDLASLL ENMQSPFSEA QVKCIVLQLL KGLAYLHHNF 120

ILHRDLKVSN LLMTDKGCVK IADFGLARVY GIPLQPMTPR VVTLWYRAPE LLLGTKTQTT 180

ALDMWAVGCI FAELLAHKPL LPGASEIQQL DLIVQLLGTP NESIWPGFSR LPLVGQYSLR 240

KQPYNNLKNK FTWLSEAGLR LLNLLFMYNP QRRATAIDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013