EPS-DAR-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	587.1	1.3E-176	167	477	311

Status

Unreviewed

Ensembl Protein

ENSDARP00000092872

UniProt Accession

F1Q4M0;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

zgc:110801;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000034313	ENSDARP00000106662	ENSDART00000129380
ENSDARG00000034313	ENSDARP00000092879	ENSDART00000102103
ENSDARG00000034313	ENSDARP00000092872	ENSDART00000102096

Organism

Danio rerio

Functional Description

Protein Length

481

Protein Sequence
(FASTA)

MAEEERNASA EKLKEKANDY FKDKDYENAI KYYTEALDLN PTNPIYYSNR SLSYLRTECY 60

GYALADATRA LELDKNYLKG YYRRATSNMA LGKFKAALKD YETVVRVRPN DKDAKMKYQE 120

CNKIVKQKAF ERAIASDELK RSVVDSLDIE NMTIEDDYAG PKLEDGKVTL KFMEDLMDWF 180

KDQKKLHRKC AYQILVQVKE VLTKLPSLVE ITLKESEKIT ICGDTHGQYY DLLNIFELNS 240

LPSPTNPYLF NGDFVDRGSF SVEVILTLFG FKLLYPEHFH LLRGNHETDN MNQMYGFEGE 300

VKAKYSSQMF KLFSEVFQWL PLAQCINDKV LVMHGGLFSE DGVTLDDIRK IDRNRQPPDS 360

GPMCDLLWSD PQLQNGRSIS KRGVSCQFGP DVTERFLEQN KLEYIVRSHE VKAEGYEVTH 420

SGKCITVFSA PNYCDQMGNK GAYIHLRGSD LKPEFHQFTA VPHPNVKPMA YANSLMQMGM 480

M 481

Nucleotide Sequence
(FASTA)

ATGGCGGAAG AAGAGCGGAA TGCCAGTGCA GAGAAACTCA AGGAGAAGGC TAATGACTAC 60

TTTAAAGATA AAGACTATGA GAACGCCATC AAGTATTACA CAGAAGCACT GGATCTCAAC 120

CCAACCAATC CCATATACTA CAGTAACCGG AGTCTGTCGT ATCTGCGCAC CGAGTGCTAT 180

GGCTATGCGC TGGCCGATGC CACCCGAGCC CTGGAGCTGG ACAAGAACTA CCTTAAGGGC 240

TACTATCGGC GAGCCACCTC CAACATGGCC CTGGGGAAGT TTAAAGCAGC ACTCAAAGAT 300

TATGAAACGG TGGTTAGAGT TCGGCCCAAT GACAAAGATG CCAAGATGAA GTACCAGGAA 360

TGTAATAAGA TTGTCAAGCA GAAGGCCTTT GAACGGGCCA TCGCCAGCGA CGAGCTCAAA 420

CGATCAGTAG TCGACTCCTT AGACATCGAG AACATGACAA TTGAGGACGA CTATGCGGGA 480

CCTAAACTTG AAGATGGGAA GGTTACGCTG AAGTTCATGG AAGACTTGAT GGATTGGTTC 540

AAAGACCAAA AGAAACTGCA CAGAAAGTGT GCTTACCAGA TACTGGTTCA AGTTAAAGAA 600

GTTTTAACCA AACTTCCTAG TCTTGTTGAG ATTACATTAA AAGAGTCAGA GAAAATCACT 660

ATTTGTGGCG ATACACATGG CCAGTACTAT GATCTTCTAA ATATTTTTGA GCTGAACAGC 720

TTACCATCTC CAACTAATCC CTATCTGTTC AACGGAGACT TTGTGGACCG CGGATCTTTT 780

TCTGTCGAGG TCATTCTTAC GCTTTTTGGC TTCAAGCTGC TCTATCCAGA ACACTTCCAC 840

CTGCTAAGAG GTAACCATGA AACTGATAAC ATGAACCAGA TGTATGGCTT CGAGGGTGAG 900

GTAAAAGCGA AGTACTCCTC CCAGATGTTC AAGCTGTTCA GTGAAGTCTT CCAGTGGCTT 960

CCTCTTGCGC AGTGCATCAA TGACAAAGTA CTGGTGATGC ACGGTGGACT GTTTAGTGAG 1020

GACGGTGTGA CCTTAGATGA CATTAGAAAG ATAGACAGGA ACAGGCAGCC GCCAGATTCT 1080

GGTCCGATGT GTGATCTCCT GTGGTCAGAT CCTCAGCTGC AGAACGGACG CTCCATCAGT 1140

AAGCGCGGCG TGAGCTGTCA GTTCGGGCCC GACGTTACAG AGCGATTCTT GGAGCAGAAC 1200

AAACTGGAGT ACATCGTGCG CAGCCATGAG GTCAAAGCCG AAGGCTACGA GGTCACTCAC 1260

TCAGGGAAGT GCATAACCGT GTTTTCAGCG CCAAATTACT GTGACCAGAT GGGGAATAAA 1320

GGAGCGTACA TTCATCTCAG GGGATCAGAC CTCAAGCCAG AGTTTCACCA GTTTACTGCT 1380

GTGCCTCATC CAAATGTCAA ACCGATGGCA TACGCCAACT CCCTGATGCA GATGGGTATG 1440

ATGTAG 1446

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+ +f+++l++++k++kkl+rk+a++ilv+v++vl+kl  ++e ++ke++kit+cGdth

Q: 167   KVTLKFMEDLMDWFKDQKKLHRKCAYQILVQVKEVLTKLPSLVEITLKESEKITICGDTH  226

         7999********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gq+ydllnifeln lps++npylfnGdfvdrGsfsveviltlfg+kllyP+hf+llrGnh

Q: 227   GQYYDLLNIFELNSLPSPTNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPEHFHLLRGNH  286

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn++yGfegevkaky++++++lf+evf+wlPlaq+in+kvlvmhGGlfsedgvtld

Q: 287   ETDNMNQMYGFEGEVKAKYSSQMFKLFSEVFQWLPLAQCINDKVLVMHGGLFSEDGVTLD  346

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirki+rn+qPP++G++c+llWsdPq +nGr++skrGv++qfGpdvt+rfle+nkl+yi+

Q: 347   DIRKIDRNRQPPDSGPMCDLLWSDPQLQNGRSISKRGVSCQFGPDVTERFLEQNKLEYIV  406

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++gk++tvfsapnycd++gn++++ih+r++dl++ +++f+av+hp+v

Q: 407   RSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTAVPHPNV  466

         ************************************************************

S: 302   kpmaysngllg  312

         kpmay+n+l++

Q: 467   KPMAYANSLMQ  477

         ********998

Domain Sequence
(FASTA)

KVTLKFMEDL MDWFKDQKKL HRKCAYQILV QVKEVLTKLP SLVEITLKES EKITICGDTH 60

GQYYDLLNIF ELNSLPSPTN PYLFNGDFVD RGSFSVEVIL TLFGFKLLYP EHFHLLRGNH 120

ETDNMNQMYG FEGEVKAKYS SQMFKLFSEV FQWLPLAQCI NDKVLVMHGG LFSEDGVTLD 180

DIRKIDRNRQ PPDSGPMCDL LWSDPQLQNG RSISKRGVSC QFGPDVTERF LEQNKLEYIV 240

RSHEVKAEGY EVTHSGKCIT VFSAPNYCDQ MGNKGAYIHL RGSDLKPEFH QFTAVPHPNV 300

KPMAYANSLM Q 311

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013