EKS-DAR-00022
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00022
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR516.72.2E-1559871253267
StatusUnreviewed
Ensembl ProteinENSDARP00000046541
UniProt AccessionB0R0Q2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene Nameigf1rb
Gene Synonyms/Alias igf1rb; CH211-134B16.1-001;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000034434ENSDARP00000046541ENSDART00000046542
OrganismDanio rerio
Functional Description
Protein Length1380
Protein Sequence
(FASTA)
MRSSKQRRYW TLFSGLVLVL STLCHGEICG PGIDIGNDIG NFKRLENCTV IEGYLQILLI 60
GDKNSNNQEV FRTLSFPKLT MITDYLLLFR VSGLESLSTL FPNLAVIRGR NLFYNYALVI 120
FELTSLKDIG LYNLRNITRG AIRIEKNPEL CYLDSVDWSL ILDAELNNFI DGNKQSKECG 180
NVCPGIMEDN SQCTRCWTSN HCQKVCRCGQ RACTDSGQCC HPQCLGSCSV PDSDRACAAC 240
QNYNHEGRCV EDCPPGTYKF EGWRCITRDF CSKVHLPDYD RFVIHAGECM SDCPPGFTRD 300
ESHGVSVSML CTACDGPCDK ICDEKVIDSV DAAQSLKGCT VIKGNLHINI RRGTNIASEL 360
ENFLGLIKTV TGYIKIRSSH TLTSLSFLKS LRYIHGEELW DNTYAFAALD NQHLQLLWDW 420
SQHNLTISEG KLYFRLNPKL CMSEIRKMWA KTGIKDNFVE RDFRNNGDRA SCGTKILKFT 480
SNNTRSNQIK LMWESYRPSD SRDLVNFIVY YKEAPFQNIT EFDGQDSCGS DSWNMVDVDL 540
PDEKILNPGV VLSALKPWTQ YAIFVKAVTL IVEDRDRDKD RLHLGPQSEV VYIRTKPSAP 600
SMPVDIRAYS NSSSKLVVRW APPLAPNGNN TYYLLRWKQQ GEDRELYQHN YCSKELKIPV 660
RVSATGLTDT EDTKPTNHET GGRDKTPCCP CPKTEEDLKR IEDDIYYRKA FENFLHNAIF 720
TPRPPDRRRR DLFGVANVTS IHTLLAGHWN LTEGNFSDDE PPRREFSFLE RKVKERHIEI 780
TGLQPFTVYR IDLHACNEEV RHCSAAAFVF SRTKAAEKAD DIPGSVTWEG QEDSVFLKWP 840
EPDKPNGLIM LYEIQYRLGT EPEKHECVSR QHYRKHKGVK LSNLGPGNYS VRVRATSLAG 900
NGSWTEPIAF SVHQLEQSSY DPVMFIAILP ALLLIAGLVV FGYTWMNKNR NNDRLGNGVL 960
YASVNPEYFS AAEMYVPDEW EVEREKITMC RELGQGSFGM VYEGIAKGVV KDEPETRVAI 1020
KTVNESASLH ERIEFLNEAS VMKEFNCHHV VRLLGVVSQG QPTLVIMELM TRGDLKSYLR 1080
SLRSVENTSS LPLPPLKKMI QMAGEIADGM AYLNANKFVH RDLAARNCMV AEDFIVKIGD 1140
FGMTRDIYET DYYRKGGKGL LPVRWMSPES LKDGVFTTMS DVWSFGVVLW EIATLAEQPY 1200
QGMSNEQVLR FVMEGGLLDK PDNCPDMLFE LMRMCWQYNP KMRPSFLEII SSIKEDLEAG 1260
FKETSFFYSE ENKPPDTEEL DMENVGTMEN VPLEPSSSLQ PLAPSISPPQ QCTAAAQSCS 1320
SPSSPPSSPS STDKHPLPTS AANGPSMVLR GPFEEGQPYA HMNGGRKNER ALPLPQSSAC 1380
Nucleotide Sequence
(FASTA)
ATGAGGTCTA GCAAACAGAG GCGATATTGG ACCTTGTTTA GTGGTCTGGT GCTGGTCCTC 60
TCCACACTCT GCCATGGAGA AATCTGTGGT CCAGGCATTG ATATTGGCAA CGACATCGGT 120
AATTTCAAGC GGCTGGAAAA CTGTACTGTG ATTGAGGGAT ACCTGCAGAT CCTCCTCATC 180
GGCGATAAAA ACAGTAACAA TCAGGAGGTC TTCCGCACCC TCAGCTTCCC CAAACTGACC 240
ATGATTACGG ATTACCTTCT CCTCTTCCGT GTCTCAGGAC TGGAAAGCCT CAGCACCCTC 300
TTTCCGAACT TGGCTGTGAT CCGTGGCCGC AACTTGTTCT ACAACTACGC CCTGGTCATA 360
TTTGAGTTGA CCAGCCTGAA GGACATCGGC CTCTACAATC TGCGGAATAT CACACGGGGT 420
GCAATACGGA TCGAGAAGAA TCCCGAGCTC TGCTACTTGG ATTCAGTGGA CTGGTCTCTC 480
ATTTTGGATG CTGAGTTGAA CAACTTTATT GATGGAAATA AGCAGTCCAA GGAGTGCGGA 540
AATGTTTGTC CGGGAATCAT GGAGGACAAC TCTCAGTGCA CGAGATGCTG GACCTCAAAC 600
CATTGCCAAA AAGTGTGTCG GTGTGGTCAG CGAGCGTGCA CAGACTCTGG TCAGTGTTGT 660
CATCCTCAGT GTTTGGGCAG CTGCAGTGTT CCCGACAGTG ACCGGGCCTG CGCCGCCTGC 720
CAGAACTACA ATCACGAGGG CCGCTGTGTG GAGGACTGTC CACCGGGGAC GTATAAGTTT 780
GAGGGCTGGC GCTGCATCAC CAGAGATTTC TGCTCTAAAG TGCATCTGCC AGACTACGAC 840
CGATTCGTCA TCCACGCTGG AGAGTGTATG TCTGACTGCC CACCCGGATT CACACGCGAC 900
GAGAGCCATG GTGTGTCTGT CAGCATGTTG TGCACTGCCT GTGACGGCCC GTGTGACAAG 960
ATCTGTGATG AAAAGGTCAT CGACTCGGTG GATGCAGCGC AGTCGCTTAA GGGCTGCACC 1020
GTTATCAAAG GCAACCTGCA TATCAACATC CGCCGAGGCA CTAACATCGC CTCAGAGCTG 1080
GAGAACTTCC TGGGACTCAT CAAGACTGTG ACGGGATACA TTAAAATACG GTCATCGCAC 1140
ACCCTGACCT CGCTCTCCTT CCTCAAGAGC CTGAGATACA TCCATGGAGA GGAACTCTGG 1200
GACAACACGT ATGCCTTCGC TGCTTTGGAT AACCAGCATC TGCAGCTTCT GTGGGACTGG 1260
TCACAGCACA ACCTGACCAT AAGTGAAGGA AAACTGTACT TCCGGTTGAA CCCCAAACTC 1320
TGCATGTCCG AGATCCGCAA AATGTGGGCC AAGACAGGAA TTAAGGACAA CTTTGTGGAA 1380
AGAGATTTCC GCAACAACGG GGACCGTGCA AGCTGTGGGA CTAAAATCTT AAAGTTTACT 1440
TCGAATAACA CGAGGAGTAA TCAAATCAAG CTGATGTGGG AAAGTTATCG ACCGTCTGAT 1500
TCCAGAGATC TTGTCAATTT TATTGTGTAC TACAAAGAAG CGCCTTTCCA GAACATTACA 1560
GAGTTTGATG GTCAGGACAG TTGCGGATCG GACAGCTGGA ACATGGTTGA CGTGGACTTA 1620
CCGGATGAGA AAATCCTGAA CCCAGGAGTT GTGCTGTCCG CGCTGAAGCC CTGGACTCAG 1680
TATGCCATCT TTGTTAAAGC TGTAACGTTA ATTGTGGAGG ACAGGGACAG AGACAAGGAC 1740
AGACTGCATC TTGGGCCACA GAGTGAAGTG GTGTACATTC GCACTAAACC ATCAGCGCCC 1800
TCAATGCCTG TAGACATCCG TGCATACTCT AATTCTTCAT CAAAGCTGGT GGTGCGCTGG 1860
GCTCCACCTC TGGCCCCCAA TGGAAACAAC ACCTACTACT TGCTCCGCTG GAAGCAGCAG 1920
GGCGAGGACC GTGAACTCTA CCAGCACAAC TACTGCTCCA AAGAACTGAA GATCCCTGTA 1980
AGGGTTTCAG CCACGGGTTT GACAGACACT GAAGACACGA AGCCGACCAA TCATGAAACA 2040
GGAGGACGAG ACAAAACCCC CTGCTGTCCC TGCCCTAAAA CAGAGGAGGA TCTGAAGCGA 2100
ATCGAGGATG ACATCTACTA CCGCAAAGCC TTCGAGAACT TCCTCCACAA TGCCATTTTC 2160
ACTCCCAGAC CTCCAGACAG GCGACGGAGG GATTTGTTTG GTGTGGCCAA CGTAACCTCT 2220
ATTCACACTC TGCTAGCGGG ACACTGGAAC CTGACCGAGG GAAACTTCTC AGATGACGAG 2280
CCGCCTAGAC GAGAATTTTC CTTTCTGGAG AGGAAGGTGA AAGAGCGACA CATTGAAATC 2340
ACTGGCCTGC AGCCTTTTAC CGTTTACCGC ATTGACCTAC ACGCGTGCAA TGAAGAGGTT 2400
CGACACTGCA GTGCCGCTGC ATTCGTCTTC TCTCGCACCA AAGCAGCAGA AAAAGCTGAT 2460
GACATCCCCG GCTCTGTGAC CTGGGAGGGT CAGGAGGATT CAGTGTTCCT GAAGTGGCCT 2520
GAACCAGATA AACCCAACGG CCTAATCATG CTCTATGAGA TCCAGTATCG ACTTGGAACA 2580
GAGCCTGAGA AGCACGAGTG TGTTTCCCGT CAACATTACA GGAAGCACAA AGGAGTGAAA 2640
CTCTCAAACT TGGGACCAGG GAACTATTCT GTCCGTGTTC GGGCCACGTC TCTCGCTGGA 2700
AACGGATCCT GGACAGAGCC CATAGCTTTC TCCGTGCATC AGCTGGAACA ATCCAGTTAT 2760
GATCCTGTAA TGTTTATCGC CATCCTCCCG GCCTTACTGT TAATCGCTGG TCTGGTAGTA 2820
TTTGGGTACA CCTGGATGAA CAAGAACCGA AACAATGACA GGCTTGGAAA TGGAGTACTT 2880
TACGCCTCCG TTAACCCAGA GTACTTCAGT GCAGCAGAGA TGTATGTGCC GGATGAATGG 2940
GAAGTGGAGC GGGAGAAGAT CACGATGTGC CGAGAGCTTG GACAGGGGTC GTTTGGTATG 3000
GTGTATGAGG GCATCGCCAA AGGTGTCGTT AAAGATGAGC CGGAAACCAG GGTGGCCATT 3060
AAAACGGTCA ACGAATCGGC CAGTTTACAT GAGCGCATTG AGTTCCTTAA TGAAGCCTCC 3120
GTGATGAAAG AGTTCAACTG TCACCATGTG GTGCGTCTGC TGGGCGTGGT CTCGCAGGGT 3180
CAGCCCACTC TGGTTATCAT GGAGCTGATG ACGAGAGGAG ATCTGAAGAG TTACTTACGC 3240
TCACTTCGAT CCGTTGAGAA CACCTCCAGC TTGCCTTTGC CGCCATTAAA GAAGATGATT 3300
CAGATGGCTG GAGAGATCGC GGATGGCATG GCATACCTCA ACGCCAATAA GTTTGTTCAC 3360
AGAGACTTAG CAGCAAGGAA CTGCATGGTG GCTGAAGATT TTATTGTCAA AATCGGTGAT 3420
TTTGGCATGA CGAGAGACAT TTATGAGACG GATTACTACA GAAAAGGAGG TAAAGGCCTG 3480
CTGCCTGTGC GCTGGATGTC CCCAGAGTCC CTCAAAGATG GAGTGTTCAC CACCATGTCT 3540
GATGTCTGGT CTTTCGGGGT GGTTTTGTGG GAAATAGCCA CCCTGGCGGA GCAGCCGTAT 3600
CAGGGGATGT CCAATGAGCA GGTCCTGCGG TTCGTGATGG AGGGAGGCCT GCTGGACAAA 3660
CCAGACAACT GCCCTGACAT GCTGTTCGAG CTGATGCGCA TGTGCTGGCA GTATAACCCC 3720
AAAATGCGGC CGTCCTTCCT GGAGATCATC AGCAGCATCA AGGAGGACCT GGAGGCAGGC 3780
TTCAAGGAGA CCAGCTTTTT CTACAGCGAG GAGAACAAGC CCCCAGACAC GGAGGAGCTG 3840
GACATGGAGA ACGTGGGAAC CATGGAGAAC GTCCCTCTAG AACCGTCTTC CAGCCTGCAG 3900
CCCCTTGCGC CCTCAATATC CCCCCCTCAG CAGTGCACAG CTGCGGCCCA GAGCTGCTCG 3960
TCCCCGTCCT CGCCTCCTTC ATCACCCAGC TCCACGGACA AACACCCGCT TCCGACATCA 4020
GCGGCCAACG GGCCCTCCAT GGTCCTGAGG GGGCCTTTTG AGGAGGGTCA GCCTTACGCT 4080
CATATGAACG GGGGCCGGAA GAACGAGCGT GCCTTGCCTC TGCCCCAGTC TTCGGCTTGC 4140
TGA 4143
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i++ relGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as +eriefl+easvmkef+
Q: 987   ITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASLHERIEFLNEASVMKEFN  1046
         799*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslr  +en ++l+ p l+k+iqma+e
Q: 1047  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRS-VENTSSLPLPPLKKMIQMAGE  1105
         *************************************7.67888888888**********
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+a+kfvhrdlaarncmvaed+ vkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 1106  IADGMAYLNANKFVHRDLAARNCMVAEDFIVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1165
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         mspeslkdGvft+ sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+l+kp+ncp
Q: 1166  MSPESLKDGVFTTMSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCP  1225
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         ++l+elmr+cwqynpk+rpsflei++++
Q: 1226  DMLFELMRMCWQYNPKMRPSFLEIISSI  1253
         *************************976
Domain Sequence
(FASTA)
ITMCRELGQG SFGMVYEGIA KGVVKDEPET RVAIKTVNES ASLHERIEFL NEASVMKEFN 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRSVE NTSSLPLPPL KKMIQMAGEI 120
ADGMAYLNAN KFVHRDLAAR NCMVAEDFIV KIGDFGMTRD IYETDYYRKG GKGLLPVRWM 180
SPESLKDGVF TTMSDVWSFG VVLWEIATLA EQPYQGMSNE QVLRFVMEGG LLDKPDNCPD 240
MLFELMRMCW QYNPKMRPSF LEIISSI 267
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031076; P:embryonic camera-type eye development
GO:0031101; P:fin regeneration
GO:0008354; P:germ cell migration
GO:0003007; P:heart morphogenesis
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0048752; P:semicircular canal morphogenesis
GO:0021522; P:spinal cord motor neuron differentiation
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013