EKS-DAR-00626

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00626

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	377.3	1.0E-112	233	523	291

Status

Unreviewed

Ensembl Protein

ENSDARP00000039831

UniProt Accession

F1QKF4;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr2

Gene Synonyms/Alias

tgfbr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000034541	ENSDARP00000039831	ENSDART00000039832

Organism

Danio rerio

Functional Description

Protein Length

556

Protein Sequence
(FASTA)

MERYQLSVLC WWTFLISTVV DWRGVDGNNP FYRPYRIPQL CKFCDVLESN CNGKDTCESN 60

CSITSICESP DEICVAIWRQ SDDNNTIETL CHNPTVPLYG IMVENNNNTK CEMKKRISNS 120

GPFHICSCNE VECNDMLLFK LPTNNQVVLV ILVSLLPLLV LAVLVIASFY WYRMYRRRKL 180

DEWETKKPSK HKGPKGPLDC SDACAIMMDD DRSDSSSTHA NNINHNMDPL PIELDLQVGK 240

GRFAEVYKAK LRQSPSEQFE TVAVKIFPYE EYASWKNEKD IFQDIDLKHE NILHFLTAEE 300

RKVEKQYWLI TAFHPRGNLQ EYLMRHLLSW EDLRLLGSSL ASGVAHLHSD HTPCGRPKVP 360

IVHRDLKSSN ILVKNDLTCC LCDFGLGLRL DNSLSVDELA NSGQVGTARY MAPEVLESRI 420

NLENIESFKQ TDVYSMALVL WEITSRCNAI GEVKDYEPPF GSKVREHPCV ESMKDNVLRD 480

RGRPEIPSSW MKHQGVAAVC ATINECWDHD PEARLTAQCV AERFNEMDDD LDKLSTCSSS 540

EEKIPEDCAV SVSDDK 556

Nucleotide Sequence
(FASTA)

ATGGAGCGAT ATCAGCTTTC TGTGCTCTGC TGGTGGACTT TTTTGATTTC TACAGTTGTG 60

GATTGGCGCG GAGTCGATGG AAATAATCCT TTTTACCGTC CCTATCGGAT TCCTCAACTA 120

TGTAAATTCT GTGATGTGTT GGAAAGCAAC TGCAATGGCA AAGACACCTG TGAAAGCAAC 180

TGCTCCATCA CGTCCATCTG TGAGAGTCCA GATGAGATCT GTGTGGCTAT CTGGAGGCAG 240

AGTGATGACA ACAACACAAT CGAGACGTTG TGCCACAACC CCACCGTGCC CCTCTACGGC 300

ATCATGGTGG AGAACAACAA CAACACCAAG TGCGAAATGA AAAAGAGGAT TTCAAACAGC 360

GGCCCTTTCC ACATCTGCTC CTGCAACGAG GTAGAGTGCA ACGACATGCT GCTGTTCAAA 420

CTTCCCACCA ATAACCAGGT GGTGTTGGTG ATCCTGGTCA GTCTTCTGCC TCTGCTGGTT 480

CTGGCTGTGC TGGTCATCGC CTCCTTCTAC TGGTATCGCA TGTACCGCCG CAGAAAACTC 540

GACGAGTGGG AGACCAAGAA GCCTTCTAAA CACAAGGGTC CCAAAGGCCC TCTGGACTGC 600

AGTGACGCCT GCGCCATCAT GATGGATGAC GACCGCTCAG ACAGCAGCTC CACACATGCC 660

AACAACATCA ATCACAACAT GGATCCGCTG CCCATCGAGC TCGACCTGCA GGTGGGCAAG 720

GGCCGCTTCG CTGAGGTGTA CAAAGCCAAG CTGAGACAAA GCCCTTCAGA GCAGTTCGAG 780

ACAGTAGCAG TAAAGATCTT CCCCTATGAA GAGTACGCGT CCTGGAAGAA CGAGAAGGAC 840

ATCTTTCAGG ACATCGACCT GAAGCACGAG AACATCCTGC ACTTCCTAAC AGCAGAGGAG 900

CGCAAGGTGG AGAAACAGTA CTGGCTGATC ACAGCGTTTC ACCCACGGGG GAACCTGCAG 960

GAGTACTTGA TGCGCCACTT GCTCAGCTGG GAAGACCTGC GGCTGCTTGG CAGTTCCCTG 1020

GCAAGTGGCG TGGCTCATTT GCATAGTGAC CACACACCCT GTGGGAGACC CAAAGTGCCC 1080

ATCGTCCATC GGGACCTCAA GAGTTCCAAC ATCCTGGTGA AGAACGACCT GACATGTTGT 1140

CTCTGTGACT TCGGGCTCGG GCTTCGTTTG GACAACTCGC TGTCGGTGGA TGAACTGGCT 1200

AACAGTGGAC AGGTGGGTAC AGCCCGGTAC ATGGCTCCAG AGGTGCTGGA ATCGAGGATC 1260

AACCTTGAAA ACATTGAGTC CTTCAAGCAA ACCGATGTCT ACTCTATGGC TCTAGTGCTG 1320

TGGGAAATCA CGTCCAGATG TAACGCCATC GGAGAGGTTA AAGACTATGA ACCTCCATTT 1380

GGCTCTAAAG TCCGAGAGCA CCCCTGTGTG GAGAGCATGA AAGACAATGT GCTGCGAGAC 1440

CGAGGCAGGC CAGAGATCCC CAGCAGCTGG ATGAAACACC AGGGAGTGGC AGCAGTTTGT 1500

GCAACCATCA ATGAATGCTG GGATCACGAC CCTGAAGCCC GGCTGACTGC ACAGTGTGTG 1560

GCTGAACGCT TCAACGAGAT GGACGACGAC CTGGACAAAC TGTCCACCTG CAGCAGCTCT 1620

GAGGAAAAGA TTCCCGAAGA CTGTGCCGTG AGCGTGAGCG ACGACAAATG A 1671

Domain Profile

S: 2     klleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrheni  55

         +l  ++gkGr++eV+kaklr+      e+vAvKif++e+ aswk+Ek+i+q + l+heni

Q: 233   ELDLQVGKGRFAEVYKAKLRQspseqfETVAVKIFPYEEYASWKNEKDIFQDIDLKHENI  292

         566789***************9999999********************************

S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115

         l+f++a++++  ++++++l+t++h++g+L++yL r+ l++e+l  l +slasG+ahLH++

Q: 293   LHFLTAEERK--VEKQYWLITAFHPRGNLQEYLMRHLLSWEDLRLLGSSLASGVAHLHSD  350

         *******977..779*********************************************

S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175

          ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL l+l+++ ++ +la++ qvGt R

Q: 351   -HTPCGRPKVPIVHRDLKSSNILVKNDLTCCLCDFGLGLRLDNSLSVDELANSGQVGTAR  409

         .8999*******************************************************

S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235

         YmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++P

Q: 410   YMAPEVLESRINLENIESFKQTDVYSMALVLWEITSRCNA-IGEVKDYEPPFGSKVREHP  468

         ****************************************.999****************

S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++e+mk+ v++++ rP+ip++w k++ +++++ +++ecWd+dpeaRlta++v++r

Q: 469   CVESMKDNVLRDRGRPEIPSSWMKHQGVAAVCATINECWDHDPEARLTAQCVAER  523

         ****************************************************987

Domain Sequence
(FASTA)

ELDLQVGKGR FAEVYKAKLR QSPSEQFETV AVKIFPYEEY ASWKNEKDIF QDIDLKHENI 60

LHFLTAEERK VEKQYWLITA FHPRGNLQEY LMRHLLSWED LRLLGSSLAS GVAHLHSDHT 120

PCGRPKVPIV HRDLKSSNIL VKNDLTCCLC DFGLGLRLDN SLSVDELANS GQVGTARYMA 180

PEVLESRINL ENIESFKQTD VYSMALVLWE ITSRCNAIGE VKDYEPPFGS KVREHPCVES 240

MKDNVLRDRG RPEIPSSWMK HQGVAAVCAT INECWDHDPE ARLTAQCVAE R 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013