EKS-DAR-00648

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00648

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	407.6	4.2E-122	711	967	257

Status

Unreviewed

Ensembl Protein

ENSDARP00000049892

UniProt Accession

F1Q4T5;

Protein Name

Protein Synonyms/Alias

Gene Name

erbb3b

Gene Synonyms/Alias

erbb3b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000036993	ENSDARP00000116216	ENSDART00000138974
ENSDARG00000036993	ENSDARP00000049892	ENSDART00000049893
ENSDARG00000036993	ENSDARP00000105384	ENSDART00000128510

Organism

Danio rerio

Functional Description

Protein Length

1430

Protein Sequence
(FASTA)

MGQQVLALCA LLFLCVPQPV TSQTQEVCTG TKNALSSTGT PEQHYNNLKE RYTGCEIVMG 60

NLEITQMEND LDFSFLGSIR EVTGYILIAM NQFRKLPLNQ LRVIRGSSLY DKEWALSVFH 120

NFDTHTGLED LGLTNLTEIL EGGVQIVHNR NLSYAPLINW QDIVRDGDAR IQIQDNGGRG 180

SCNPACGEFC WGPSNDQCQK LTKTVCALQC LGHCFGTNPN ECCHPECAGG CTGPRDTDCF 240

ACRHVNYSGS CVPHCPWPVV YNQQTFQVEP NADAMYQFGS ICVPKCPGHF VVDGSACVSS 300

CPPGKTEIEK NQIKQCETCI GLCPKVCEGT GANHRQTVDS SNIDSFINCT KIQGSLHFLI 360

LGIKGDVYNN IPPLEPEKLK VFNTVREITG ILNIQSWPDE LHDLSVFSSL TTIQGRSLYN 420

LHTRPFSLLV MKIPSLTSLG LRSLREISDG SVYITQNMNL CYHHTINWTQ IFPRNQLQRR 480

RNDIKENKQK IQCEEEGHVC DPLCSDAGCW GPGPEQCLSC RNYSRLGTCV SHCNLYSGEP 540

REFAASNKEC LACHSECLLQ NGKQTCLGKG ADQCVACSNL MDGPHCVSSC PNGVNGEKGQ 600

TIFKYSTAAG HCELCHFNCT RGCTGPALRD CVDPDRNVNS SQIAGIAVAV FAGITVLLAL 660

FVLGMLYHRG LAIRRKRALR RYLESGESME PLDPGEKGTK VHARILKPQE LRKGKLLGYG 720

VFGTVNKGFW IPEGDSLKIP VAIKTIQNRS SRQTFTEITD HMLSMGSLDH PYIVRLIGIC 780

PGASLQLITQ LSPHGSLLQH LRQHKDSLDP QRLLNWCVQI AKGMYYLEEH CMAHRNLAAR 840

NILLKSDYIV QISDFGVADL LYPDDKKYVY SEHKTPIKWM ALESILFGRY THQSDVWSYG 900

VTVWEMMSYG AEPYASMHPH DVPGLLEKGE RLAQPQICTI DVYMVMVKCW MIDENVRPTF 960

KELASEFTRM ARDPPRYLVV RPAQNGSGAE ESQRYVKSSH LEVGLEEEDD DEDEGLQVGF 1020

ATPPLQLSPT RSHSRVRIAS YKSTSEHTAP IGYLPMTPGP GDEPRQLRAQ RRKIGSVRTE 1080

SECSEGRGTI VDIEAIEITS QTGSLRRGRS RMDSAYISGG VSVASDPFSP GLEGVDEDHY 1140

GYVLPTERDF RSAVPHGRTS RNSKSTPKTD ATQEYELMNK QTNKLSSSPT DSTDHLKPAS 1200

LVSAHICSSL PQKKEMDSAQ TQDEILPQKR ETDSIQSQEN NLPQKSETDS TQTQESEKDA 1260

SFQPDNLESA ENCLIGSETL NDGGQSEDEE QLPRLAMVEY EYMDIRTDEH QQNVAGKRTT 1320

NGPNEVEREA IYQNISQPLR FHENPDSAGN TMQRRGEYVD MEASGRSGCE VGDYQNVPVK 1380

GRPVVGEESQ NTGLRSYIKV CAGVEPQNTS FDNPDYWHSR LFHKQDTVCT 1430

Nucleotide Sequence
(FASTA)

ATGGGACAGC AGGTGCTCGC GCTCTGCGCT CTCCTGTTCC TCTGTGTACC TCAGCCTGTC 60

ACTTCACAAA CACAAGAAGT TTGTACTGGC ACTAAAAATG CTCTGAGCTC CACGGGCACC 120

CCAGAACAGC ACTACAACAA CCTTAAAGAG CGCTACACCG GATGTGAGAT CGTCATGGGC 180

AATCTTGAGA TTACACAGAT GGAGAATGAC CTCGATTTCT CCTTTCTTGG AAGTATCCGA 240

GAGGTCACCG GCTACATCCT CATTGCGATG AACCAGTTTC GCAAGTTACC TTTGAATCAG 300

CTCAGAGTGA TTCGTGGCAG CAGCTTGTAT GACAAAGAAT GGGCTCTTTC TGTCTTTCAT 360

AACTTTGACA CTCACACTGG CCTGGAAGAT CTGGGCCTCA CCAACCTCAC AGAGATCTTG 420

GAAGGTGGAG TACAGATTGT CCACAACAGG AACCTCAGCT ATGCTCCATT GATCAACTGG 480

CAGGACATTG TCAGAGACGG TGACGCTCGC ATCCAGATCC AGGACAATGG AGGAAGAGGG 540

TCCTGCAATC CTGCATGTGG AGAGTTTTGC TGGGGTCCAA GTAATGATCA GTGTCAGAAA 600

TTGACTAAAA CAGTATGTGC ACTTCAGTGT CTGGGCCACT GTTTCGGCAC CAACCCTAAT 660

GAATGCTGCC ACCCCGAGTG TGCTGGAGGC TGCACTGGAC CCAGGGACAC AGACTGCTTT 720

GCCTGTCGAC ATGTCAATTA CTCTGGCTCC TGCGTCCCTC ACTGCCCTTG GCCTGTGGTC 780

TACAACCAAC AGACCTTTCA GGTGGAGCCC AATGCTGATG CCATGTATCA GTTCGGTTCC 840

ATCTGTGTTC CTAAATGTCC CGGGCACTTT GTTGTGGATG GCAGTGCATG CGTGAGCAGT 900

TGTCCTCCCG GTAAAACAGA AATAGAGAAG AATCAAATTA AACAGTGTGA GACCTGCATT 960

GGCCTGTGTC CTAAAGTATG TGAGGGAACT GGAGCCAATC ACAGACAGAC AGTGGACTCC 1020

AGTAACATTG ACAGCTTTAT CAATTGTACC AAGATCCAAG GAAGTCTACA TTTTCTGATC 1080

TTAGGTATCA AAGGAGACGT CTATAATAAC ATACCACCTC TGGAGCCTGA AAAACTCAAA 1140

GTGTTTAACA CAGTCAGAGA AATTACTGGT ATTTTGAACA TTCAGTCTTG GCCCGATGAA 1200

CTCCATGATC TATCTGTTTT CTCTAGTCTC ACTACCATTC AGGGAAGATC TCTGTACAAT 1260

CTTCACACCA GGCCATTCTC TTTGTTGGTG ATGAAGATTC CCTCCCTCAC ATCTCTAGGA 1320

CTGCGCTCCT TGCGGGAGAT CAGCGACGGC AGTGTATACA TCACTCAAAA TATGAACCTG 1380

TGTTATCACC ACACCATCAA CTGGACACAG ATCTTCCCAC GTAACCAATT GCAACGCAGA 1440

CGTAACGACA TCAAGGAAAA CAAACAAAAG ATCCAGTGTG AGGAAGAGGG CCATGTGTGC 1500

GACCCGTTGT GTTCAGACGC AGGATGTTGG GGCCCGGGGC CTGAGCAGTG TTTGTCATGC 1560

AGGAACTACA GTCGGCTCGG CACCTGTGTG TCTCACTGTA ACCTCTACTC CGGAGAGCCA 1620

CGGGAGTTTG CAGCATCTAA TAAGGAGTGT CTTGCTTGTC ACTCAGAGTG TCTGTTGCAG 1680

AATGGGAAAC AAACATGCCT AGGAAAAGGT GCAGATCAGT GTGTAGCGTG TTCAAACCTG 1740

ATGGACGGCC CTCACTGTGT TTCTTCTTGT CCTAATGGAG TGAATGGAGA AAAGGGGCAG 1800

ACCATATTTA AATACTCCAC TGCAGCGGGT CATTGTGAGC TCTGTCACTT CAACTGCACA 1860

CGAGGATGTA CAGGCCCTGC GTTGAGAGAC TGTGTTGATC CTGACAGAAA TGTGAACAGC 1920

TCTCAGATTG CAGGTATAGC AGTTGCCGTG TTTGCTGGTA TTACTGTGCT TCTGGCGCTG 1980

TTTGTGCTTG GTATGCTGTA TCACAGAGGC TTGGCCATTC GCCGCAAAAG AGCACTGAGA 2040

AGATATCTAG AGAGTGGTGA GAGCATGGAG CCGCTGGATC CAGGAGAGAA GGGGACAAAA 2100

GTGCATGCCC GCATCCTAAA ACCACAGGAG CTGCGAAAGG GCAAACTTCT GGGCTACGGA 2160

GTCTTTGGCA CCGTCAATAA GGGTTTTTGG ATTCCTGAAG GTGACTCCCT AAAAATCCCT 2220

GTGGCCATAA AGACCATCCA GAACCGCAGC AGTCGGCAGA CCTTCACAGA GATCACTGAT 2280

CATATGCTTT CAATGGGAAG CCTGGATCAC CCGTATATAG TGCGTCTCAT TGGGATCTGC 2340

CCTGGGGCCA GTTTGCAGTT GATCACGCAG CTCAGTCCTC ATGGATCATT ACTTCAACAC 2400

CTTCGCCAGC ACAAAGACAG CCTGGACCCT CAGCGGCTGC TCAACTGGTG TGTGCAGATC 2460

GCTAAGGGCA TGTATTATCT GGAGGAGCAC TGCATGGCCC ATAGGAACCT GGCTGCACGA 2520

AACATACTGC TCAAGAGTGA CTACATAGTA CAGATCTCGG ACTTTGGGGT TGCAGATCTG 2580

CTCTATCCAG ATGATAAGAA ATATGTGTAC AGTGAACACA AGACACCAAT AAAATGGATG 2640

GCATTAGAGA GCATCCTCTT CGGCAGATAC ACTCATCAGA GTGACGTGTG GAGCTACGGT 2700

GTGACGGTAT GGGAGATGAT GTCATACGGA GCGGAGCCAT ACGCTTCTAT GCATCCTCAT 2760

GATGTGCCGG GTCTGCTGGA GAAAGGAGAG CGTCTGGCTC AACCTCAGAT CTGCACCATA 2820

GACGTCTACA TGGTCATGGT CAAGTGCTGG ATGATTGATG AAAATGTGAG ACCCACATTT 2880

AAAGAACTGG CCAGTGAATT TACAAGAATG GCAAGGGACC CGCCACGCTA CCTTGTGGTG 2940

AGGCCTGCTC AGAATGGCAG CGGTGCAGAG GAAAGCCAGC GGTATGTTAA AAGCTCTCAT 3000

CTAGAGGTAG GATTGGAAGA GGAGGACGAT GATGAAGATG AAGGGTTGCA GGTTGGGTTT 3060

GCGACTCCTC CTCTCCAGCT CTCACCTACT AGAAGTCATT CCCGTGTCCG GATTGCCTCC 3120

TACAAGAGCA CCTCAGAACA CACAGCACCG ATAGGTTATC TCCCCATGAC CCCAGGCCCA 3180

GGAGATGAGC CTAGACAGTT GCGAGCCCAG AGGAGGAAGA TTGGCTCAGT GAGGACAGAG 3240

TCTGAGTGTT CAGAGGGACG GGGGACCATC GTGGACATTG AAGCCATTGA AATCACTTCT 3300

CAAACAGGCA GTCTTCGCAG AGGACGTAGT CGAATGGACA GTGCCTACAT ATCTGGCGGA 3360

GTGTCTGTCG CATCAGATCC ATTCTCTCCT GGTCTGGAGG GAGTAGATGA AGACCATTAT 3420

GGATACGTGC TGCCTACCGA AAGAGATTTC AGAAGTGCTG TTCCTCATGG TAGGACATCC 3480

AGAAACTCCA AAAGCACTCC AAAAACAGAT GCCACGCAAG AGTACGAGCT AATGAACAAA 3540

CAGACAAACA AACTTTCCTC CTCGCCCACA GACAGCACTG ACCATTTAAA ACCAGCATCC 3600

CTTGTTTCTG CACACATATG TAGCAGTTTA CCTCAGAAAA AAGAAATGGA CTCAGCACAA 3660

ACCCAAGATG AAATTTTACC ACAGAAAAGA GAAACAGACT CAATACAAAG CCAAGAGAAC 3720

AATTTACCAC AGAAAAGTGA AACGGACTCA ACTCAAACCC AAGAGTCAGA GAAGGATGCT 3780

AGTTTTCAAC CTGACAACTT GGAGTCTGCT GAAAACTGTC TGATTGGATC GGAAACATTA 3840

AACGATGGTG GTCAATCTGA AGATGAAGAA CAGCTGCCAC GATTGGCGAT GGTCGAATAT 3900

GAATACATGG ACATACGTAC AGATGAACAC CAACAAAATG TAGCTGGCAA ACGTACAACA 3960

AACGGTCCAA ATGAGGTGGA GAGGGAAGCG ATTTATCAAA ATATAAGTCA GCCTCTAAGA 4020

TTTCATGAAA ATCCAGATTC TGCTGGCAAT ACGATGCAGA GGCGCGGTGA ATATGTGGAC 4080

ATGGAGGCAT CTGGGAGAAG TGGCTGTGAG GTTGGAGATT ATCAGAATGT CCCGGTAAAG 4140

GGAAGGCCTG TTGTGGGAGA GGAGTCGCAA AATACTGGCC TCAGATCTTA CATAAAAGTG 4200

TGTGCTGGAG TGGAGCCGCA AAACACTTCT TTTGACAACC CAGATTACTG GCACAGCAGA 4260

CTTTTCCACA AGCAGGACAC CGTGTGCACA TGA 4293

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k k lG G+fGtv kG wipeg+++kipvaik +++++++++++e++d++l ++sldh

Q: 711   LRKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTIQNRSSRQTFTEITDHMLSMGSLDH  770

         6999********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         +++vrl+g+c   +lql+tql p+G+ll+++r+hkd+l +q llnwcvqiakGm+ylee+

Q: 771   PYIVRLIGICPGASLQLITQLSPHGSLLQHLRQHKDSLDPQRLLNWCVQIAKGMYYLEEH  830

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

          + hr+laarn+l+ks   v+i+dfG+a+ll  d+k++ +++ k+pikw+alesil+ +y

Q: 831   CMAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVYSEHKTPIKWMALESILFGRY  890

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwe++++Ga+py++++ +++p llekGerlaqp+ictidvymv+vkcw

Q: 891   THQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVKCW  950

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 951   MIDENVRPTFKELASEF  967

         ***************99

Domain Sequence
(FASTA)

LRKGKLLGYG VFGTVNKGFW IPEGDSLKIP VAIKTIQNRS SRQTFTEITD HMLSMGSLDH 60

PYIVRLIGIC PGASLQLITQ LSPHGSLLQH LRQHKDSLDP QRLLNWCVQI AKGMYYLEEH 120

CMAHRNLAAR NILLKSDYIV QISDFGVADL LYPDDKKYVY SEHKTPIKWM ALESILFGRY 180

THQSDVWSYG VTVWEMMSYG AEPYASMHPH DVPGLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENVRPTF KELASEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007413	; P:axonal fasciculation
GO:0048066	; P:developmental pigmentation
GO:0031101	; P:fin regeneration
GO:0008347	; P:glial cell migration
GO:0048882	; P:lateral line development
GO:0048914	; P:myelination of anterior lateral line nerve axons
GO:0048932	; P:myelination of posterior lateral line nerve axons
GO:0001755	; P:neural crest cell migration
GO:0014044	; P:Schwann cell development
GO:0023014	; P:signal transduction by phosphorylation
GO:0001964	; P:startle response
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013