EPS-DAR-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PSP-Other/RPAP2	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSDARP00000056033

UniProt Accession

B0UYH6;

Protein Name

Putative RNA polymerase II subunit B1 CTD phosphatase rpap2

Protein Synonyms/Alias

RNA polymerase II-associated protein 2;

Gene Name

rpap2

Gene Synonyms/Alias

rpap2; si:dkey-63k7.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000038397	ENSDARP00000056033	ENSDART00000056034

Organism

Danio rerio

Functional Description

Protein phosphatase that displays CTD phosphataseactivity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).

Protein Length

601

Protein Sequence
(FASTA)

MDAGEVTRKS RPSKSKKKGG KGTQAISAED EAKRREAVKE QLRQKLELER KARQVVERLL 60

EDSVTEEFLM DCAWHITPAN YKDTVEERSI AKLCGYPMCP NKLTNVPTQQ YKISTKTNKV 120

YDITERKCFC SNFCYKASKS FELQISKIPL WLRKEESPPE IKLMKQGDGG SSGQEIKLID 180

KPITEADIDN PIEDIPESNK DLIQGENGDI EQDFVSSVVS NQHKQVHWGK LPKRDEVSED 240

AAEYSHSEHE QRINGENKDE SESSQTPQPQ KDTTDHPALE KNASEIEGTL ELLNQDKSTQ 300

QEGENTSSSQ PESDISVPVA GDLNITQVGM SKRSAAGLKG LLKDHHKAKT ASTAISQCLL 360

ERLRQAFIEW RTKETMIFLY GPDYASGMQL STAGAWEEEQ LDEDDLDEAE VGVRSAEGGP 420

SRTSAPVPDV ETLRKETEML ELRVREFYKG VCVLPEEVET AAVKETEHTQ DSGKDPPLPL 480

VDSHAQHQIQ KRIVVEKLSH SLRDIVGPLR LTMSDVINDV NNLVRTFRFT NTNIIHKSPE 540

WTLIAVVLLS VLTEVSPLLR ESLASVSSLE YISCFMKELK LEDKDLHNLV LLFKPCVPIQ 600

T 601

Nucleotide Sequence
(FASTA)

ATGGATGCCG GTGAAGTGAC AAGAAAGAGT CGGCCCTCAA AGTCCAAGAA GAAAGGTGGA 60

AAGGGAACCC AAGCTATTTC AGCAGAGGAT GAAGCGAAAA GGAGGGAAGC TGTTAAAGAA 120

CAACTCCGAC AGAAGCTTGA GTTGGAGCGT AAAGCCCGGC AGGTGGTTGA GCGGCTGTTG 180

GAGGACAGCG TGACAGAAGA GTTCCTCATG GACTGTGCCT GGCACATCAC TCCTGCCAAC 240

TACAAAGACA CTGTGGAAGA ACGATCCATT GCTAAACTGT GTGGATATCC CATGTGCCCA 300

AATAAATTAA CTAATGTGCC CACTCAACAA TATAAAATAT CCACCAAGAC AAATAAAGTC 360

TATGATATTA CAGAGCGTAA GTGCTTTTGC AGTAATTTCT GCTACAAAGC CTCCAAAAGT 420

TTTGAGCTCC AGATATCAAA GATTCCACTT TGGCTTCGAA AGGAGGAGAG TCCACCTGAG 480

ATTAAGCTGA TGAAACAAGG AGATGGAGGC AGCTCAGGAC AGGAGATAAA GCTGATTGAC 540

AAGCCTATAA CAGAAGCAGA CATCGACAAT CCCATCGAGG ACATTCCCGA GTCTAACAAG 600

GACTTGATCC AGGGTGAAAA CGGTGACATC GAACAAGACT TTGTCTCCAG TGTGGTGTCC 660

AATCAGCACA AACAAGTTCA CTGGGGAAAA CTGCCAAAGA GAGATGAAGT GAGTGAAGAT 720

GCTGCTGAAT ATTCACATTC AGAACATGAA CAAAGAATCA ATGGAGAAAA TAAAGATGAA 780

AGCGAATCTT CACAAACTCC TCAACCACAA AAAGACACAA CCGATCATCC TGCACTGGAA 840

AAAAACGCCT CTGAAATTGA AGGGACTTTG GAGCTTTTGA ATCAGGATAA ATCAACCCAA 900

CAGGAAGGTG AAAACACAAG CTCTTCACAG CCTGAATCTG ACATCTCTGT TCCTGTGGCT 960

GGCGACCTGA ACATTACTCA GGTGGGAATG AGTAAAAGAT CAGCTGCGGG CCTCAAAGGC 1020

CTGTTGAAGG ATCATCATAA AGCTAAAACG GCTTCTACAG CCATCAGTCA GTGTCTTCTG 1080

GAGCGTCTAC GGCAAGCCTT TATAGAGTGG AGAACTAAGG AAACCATGAT ATTTCTTTAT 1140

GGTCCGGATT ACGCCTCAGG GATGCAACTG TCTACAGCAG GAGCATGGGA AGAGGAGCAG 1200

TTGGATGAAG ATGACCTGGA TGAGGCTGAG GTGGGCGTGA GATCAGCTGA AGGAGGACCT 1260

TCCAGAACCA GCGCTCCAGT TCCTGATGTG GAGACTCTGA GAAAAGAGAC AGAAATGTTG 1320

GAGCTGAGAG TGAGGGAGTT TTACAAAGGA GTGTGTGTTC TGCCGGAAGA GGTCGAGACG 1380

GCCGCTGTTA AAGAGACTGA ACACACACAG GACAGTGGGA AAGATCCCCC TCTGCCTTTG 1440

GTTGATTCTC ACGCGCAGCA CCAGATTCAG AAACGCATTG TTGTGGAGAA GCTCAGCCAC 1500

AGCTTGAGAG ATATTGTTGG ACCCCTTCGT CTAACAATGA GTGATGTCAT CAATGATGTA 1560

AATAATTTGG TCCGGACATT CAGATTTACG AACACAAACA TTATTCACAA AAGCCCAGAG 1620

TGGACTTTAA TTGCTGTGGT TCTTCTGTCA GTGTTAACAG AAGTGTCACC ATTGTTGCGA 1680

GAGTCGTTGG CGAGCGTGTC TTCGTTAGAA TACATCTCCT GTTTCATGAA AGAGCTGAAA 1740

CTGGAGGACA AAGATCTTCA CAACCTCGTG CTGCTCTTCA AACCGTGCGT CCCTATACAA 1800

ACGTGA 1806

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016591	; C:DNA-directed RNA polymerase II, holoenzyme
GO:0008420	; F:CTD phosphatase activity
GO:0046872	; F:metal ion binding
GO:0070940	; P:dephosphorylation of RNA polymerase II C-terminal domain
GO:0009301	; P:snRNA transcription

KEGG

InterPros

IPR007308

; DUF408.

Pfam

PF04181

; RPAP2_Rtr1; 1.

SMARTs

Prosites

PS51479

; ZF_RTR1; 1.

Prints

Created Date

20-Feb-2013