EKS-DAR-00597

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00597

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	408.9	1.7E-122	43	295	253

Status

Unreviewed

Ensembl Protein

ENSDARP00000056597

UniProt Accession

B0S6K2;

Protein Name

Protein Synonyms/Alias

Polo-like kinase 3 (Drosophila);

Gene Name

plk3

Gene Synonyms/Alias

plk3; DKEY-4I23.3-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000038754	ENSDARP00000056597	ENSDART00000056598
ENSDARG00000038754	ENSDARP00000121537	ENSDART00000147278
ENSDARG00000038754	ENSDARP00000110122	ENSDART00000130919

Organism

Danio rerio

Functional Description

Protein Length

644

Protein Sequence
(FASTA)

MNPDMFKASP AAPPPAKPSR SKSEHVKPEL AQVVVDAKTG RSYCKGKLLG KGGFARCYEM 60

TDLANNKMYA VKVIPQSRVS KPHQREKIIN EIELHKSLQH KHVVKFSHHF EDQDNIYIFL 120

ELCSRKSLAH IWKARHTLTD PEVRYYLRQI ISSLKYLHNK GILHRDLKLG NFFVNENMEL 180

RLGDFGLAAK LETVEQRKKT ICGTPNYLAP EVLNRQGHGT ESDVWSLGCV MYTLLCGNPP 240

FETLDLKETY KCIKEVKYSL PSSLTPSAQK LISSILQKNP CDRLTLDQIL AHDYFTKGFT 300

PEKLPPSSCV MVPELNPPSP AKKFFTKMAK SLFGKKKSKT VEKTTSEEKD DISKLVSGMV 360

KHSIGRQMSY KTMGVNEATS PTVQLASSGP LDTPAEEESR KSASRSFKGT VASSTDGCDD 420

IPTPSAVAES AMKVLNSCLS SMPTASRNPP CLVKTKPFIW VTKWVDYSNK YGFGYQLSNQ 480

NVGVLFNEGT HLSLCDQRRT VHYCLTNNKH FSFPANALPE KLQSQKHIVD LMANYMEQNL 540

MEGGDINCED QSSSSSPLLL QWIKTDHALV MLFDNRTLQV NFYTDHTKII LCKPSDASYL 600

VTFISKERVS YSYPLNVLSE LGCSPELRQR LHYVVQLLQH YTNA 644

Nucleotide Sequence
(FASTA)

ATGAATCCGG ATATGTTCAA AGCGTCTCCA GCGGCTCCAC CGCCCGCCAA GCCGAGCCGG 60

AGTAAATCGG AGCACGTTAA GCCGGAGCTC GCGCAGGTGG TGGTGGACGC GAAGACCGGG 120

AGGTCGTACT GTAAAGGAAA GCTCTTGGGA AAGGGTGGTT TTGCACGGTG CTATGAGATG 180

ACTGATCTTG CAAACAACAA GATGTATGCG GTGAAGGTTA TTCCTCAAAG CAGAGTCTCA 240

AAGCCACACC AGAGGGAGAA GATCATTAAT GAAATCGAGC TCCACAAAAG CCTCCAACAC 300

AAGCATGTAG TGAAGTTCTC TCATCATTTT GAGGACCAAG ACAATATTTA CATCTTCCTT 360

GAGCTCTGCA GCAGAAAGTC TCTGGCACAC ATTTGGAAAG CAAGACACAC GTTGACCGAT 420

CCAGAAGTAC GTTACTACCT CAGACAGATC ATTTCTTCAC TCAAATACCT CCACAACAAA 480

GGCATCCTCC ACAGAGACCT CAAACTAGGA AATTTTTTTG TGAATGAAAA CATGGAGTTG 540

AGATTGGGTG ATTTTGGCCT GGCAGCAAAG CTGGAGACAG TCGAGCAGAG GAAGAAGACC 600

ATCTGTGGGA CGCCAAACTA CCTTGCGCCA GAGGTCTTAA ACAGACAAGG CCATGGGACA 660

GAGTCAGATG TTTGGTCGCT GGGTTGTGTA ATGTACACTC TACTGTGTGG GAATCCACCT 720

TTTGAAACCT TAGACTTGAA AGAGACCTAC AAGTGTATTA AGGAAGTGAA ATACAGCCTT 780

CCTTCATCCC TCACTCCATC GGCACAGAAG CTGATCTCCT CTATCCTTCA GAAAAACCCC 840

TGCGACCGCC TTACGCTGGA TCAGATACTG GCCCACGACT ACTTCACAAA GGGTTTCACC 900

CCAGAAAAAC TCCCTCCCAG CAGCTGTGTG ATGGTGCCTG AGCTTAATCC ACCCAGTCCT 960

GCTAAGAAGT TCTTCACCAA GATGGCTAAA AGTCTATTTG GCAAGAAGAA ATCGAAAACT 1020

GTTGAGAAGA CCACTTCTGA GGAGAAAGAT GACATTTCTA AACTGGTGTC AGGCATGGTG 1080

AAACACTCCA TCGGTCGGCA AATGAGCTAC AAGACAATGG GAGTGAATGA GGCCACTTCT 1140

CCAACGGTTC AGCTGGCGAG CTCTGGGCCT CTGGACACTC CAGCTGAGGA GGAGTCGAGA 1200

AAGTCTGCGT CTCGATCTTT CAAAGGCACC GTGGCCAGCA GCACTGATGG TTGTGACGAC 1260

ATCCCTACCC CTTCTGCTGT AGCCGAATCT GCCATGAAGG TTCTTAACAG CTGCTTGTCT 1320

TCCATGCCAA CAGCTTCAAG AAACCCTCCC TGCCTTGTTA AAACCAAGCC TTTCATCTGG 1380

GTAACCAAGT GGGTCGACTA CTCCAACAAA TACGGCTTCG GTTACCAGCT TTCCAATCAA 1440

AACGTCGGCG TACTTTTCAA CGAAGGCACT CATCTGAGCC TCTGTGACCA GCGGAGGACT 1500

GTACATTACT GTCTGACAAA CAACAAACAC TTTAGCTTTC CTGCTAATGC GCTACCAGAG 1560

AAGCTCCAGA GTCAGAAACA CATCGTTGAT TTGATGGCTA ACTACATGGA GCAGAACCTA 1620

ATGGAGGGTG GAGATATCAA CTGTGAGGAC CAATCTTCAA GCTCTTCTCC GCTGCTTCTG 1680

CAGTGGATCA AGACTGATCA TGCCTTAGTC ATGCTCTTTG ACAACCGAAC CCTACAGGTC 1740

AACTTTTACA CAGACCACAC AAAAATCATC CTGTGCAAGC CCTCGGACGC CTCATACCTG 1800

GTGACGTTCA TCAGCAAGGA GCGAGTCTCT TATTCCTACC CTCTGAACGT GCTTTCTGAA 1860

CTGGGCTGCT CTCCAGAGCT CCGGCAGCGG CTTCATTATG TGGTTCAGCT TCTTCAGCAC 1920

TACACCAACG CATAA 1935

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y++gkllGkGgfa+cye++dl +++++avkv+p+s++ k++qrek+ +eie+h+sl+hk+

Q: 43    YCKGKLLGKGGFARCYEMTDLANNKMYAVKVIPQSRVSKPHQREKIINEIELHKSLQHKH  102

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +vk++++fed++n+y++lelcsr+sla+++k+r++lt+pevryylrqi+s+lkylh+k i

Q: 103   VVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARHTLTDPEVRYYLRQIISSLKYLHNKGI  162

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+++gdfGla++le+ e+rkkt+cGtPny+aPevl+++gh++e+

Q: 163   LHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTES  222

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet +lkety++ik+ +yslPssl+++a++li+++l+k+P +

Q: 223   DVWSLGCVMYTLLCGNPPFETLDLKETYKCIKEVKYSLPSSLTPSAQKLISSILQKNPCD  282

         ************************************************************

S: 241   rpsleevlkdefl  253

         r++l+++l ++++

Q: 283   RLTLDQILAHDYF  295

         ***********98

Domain Sequence
(FASTA)

YCKGKLLGKG GFARCYEMTD LANNKMYAVK VIPQSRVSKP HQREKIINEI ELHKSLQHKH 60

VVKFSHHFED QDNIYIFLEL CSRKSLAHIW KARHTLTDPE VRYYLRQIIS SLKYLHNKGI 120

LHRDLKLGNF FVNENMELRL GDFGLAAKLE TVEQRKKTIC GTPNYLAPEV LNRQGHGTES 180

DVWSLGCVMY TLLCGNPPFE TLDLKETYKC IKEVKYSLPS SLTPSAQKLI SSILQKNPCD 240

RLTLDQILAH DYF 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013