EPS-DAR-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	148.9	4.0E-43	405	562	158

Status

Unreviewed

Ensembl Protein

ENSDARP00000057558

UniProt Accession

E7FC31;

Protein Name

Protein Synonyms/Alias

Gene Name

gak

Gene Synonyms/Alias

gak;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000039384	ENSDARP00000057558	ENSDART00000057559

Organism

Danio rerio

Functional Description

Protein Length

1318

Protein Sequence
(FASTA)

MSLFQSALDF LAGPGGSGGA ASRDQNDFVG QVVELGELKL RIKRVIAEGG FAFVYEAQDL 60

GSSKDYALKR LLSNEEEKNK AIIQEVCFMK KLSGHPNVVQ FCSAASISKE ESDTGQAEFL 120

ILTELCRGQL VDFVKKVEQK GPMSCDTVLK IFYQSCRAVQ HMHKQSPAVI HRDLKIENLL 180

ISHQGTIKLC DFGSATTLAH YPDYSWSAHK RSMVEDEITR NTTPAYRTPE MIDLYSNYPI 240

NEKQDIWALG CILYLLCFKQ HPFEEGAKLQ IVNGKYSIPQ NDTKYTVFHQ LIRSMLKINP 300

EERLSINELV NQLQEIAAAR NVNPKSPITE LLEQNGGFGN NSAQLPSQIN NIHNSVIESP 360

GVYDTDPTMG GGFLDILKGG TERFLTNIKD TSSKVIQSVA SYAKGDLDLS YITSRLAVMS 420

FPAEGVESAI KNNIEDVRLF LDSRHAGHYA VYNLSKRSYR PARFHNRVSE CGWQPRRAPT 480

LKNLYSICKN MHQWLKQDQR NICIVHCLDG RAASAVVVCA FLCFCRLFST AEAAVYMFSM 540

KRCPPGISAS HKRYIEYMCD MMAEEPIIPH SKPITIRSVA MTPVPLFNKQ RNGCRPFCEV 600

YVGDERVATT SQEYDRMRDF KMEDGRAEIP LNITVQGDVL IVIYHARSTL GGRLQAKMAS 660

MKMFQIQFHT GFVPRNASTV KFAKYDLDAC DIQEKYPDLF QVHVNVEVEP QDRPSNKTPP 720

WENFATKGLN PKILFSSRDE QQEILTKFGK PELPRQPGST ACYASDPPQS ENSPDDPQTE 780

SDSPSPQSTD TNANNFFQTL DWEVDSGVWG KRNIYKQSYN TSRHFDHADG HLDDQEDLSG 840

GSEEESVSYS APIEGTLSRD TSEPLFEADF TNTPPEAQPD TEDLLGLNSE PGPAVPESGL 900

KSSASNSNLL NDLLFAPQTN TVPSASNEDL MGEDAGEDLF FSNSSSQPPP ATNKVDIKVQ 960

STDFFDPFGV GSASSGSDLF GDLLGSDAAN SGFKAPAPAS NSSLFNLNKL ASETPKMTSS 1020

ASQPDLLSGW DSWATSGTST TANLSTAANK PSLFVPFYAL NNLITASGVS SFSKAKSQSF 1080

DPFADLGNLG STLPGSSSAS FSGSGFKTAP SAGGPKNSGQ QWQQTPRPSS GPNKPWMPPN 1140

STARPQVVPQ AAKPNYNPSF SVIGGRQERG IRGPGFGPKP KVKEDDFEDL LCTQGFGSKP 1200

DRKMPRTIAE MRKQELSKDM DPLKLQILDW IEGKERNIRA LLSTLHTVLW EGETRWRPIN 1260

MADLVTPDQV KRVYRKAVLV VHPDKATGQP YEQYAKMIFM ELSDAWSEFE NQGSKALF 1318

Nucleotide Sequence
(FASTA)

ATGTCCCTGT TCCAGTCAGC GCTCGATTTC CTGGCCGGGC CCGGCGGATC CGGTGGCGCC 60

GCTAGCCGGG ATCAGAACGA TTTCGTCGGG CAGGTGGTGG AGCTCGGAGA GCTGAAGCTC 120

CGGATCAAAC GAGTCATCGC GGAAGGTGGA TTTGCATTCG TGTATGAAGC CCAGGATTTA 180

GGAAGCAGTA AGGACTATGC GCTCAAGAGG CTTCTGTCCA ACGAAGAGGA AAAGAACAAG 240

GCCATCATTC AGGAAGTCTG CTTCATGAAA AAGCTGTCTG GTCATCCTAA TGTTGTACAG 300

TTCTGCTCCG CTGCGTCCAT CAGTAAAGAA GAGTCTGACA CGGGCCAGGC CGAGTTCCTC 360

ATCCTAACGG AGCTCTGTAG AGGCCAGCTG GTGGATTTCG TCAAGAAGGT GGAGCAGAAA 420

GGACCGATGT CATGTGACAC AGTGCTGAAG ATCTTTTATC AGTCTTGTCG GGCCGTGCAG 480

CACATGCACA AACAGTCTCC AGCAGTCATA CACCGAGACC TGAAGATTGA GAATTTGTTG 540

ATCAGTCACC AGGGCACCAT AAAGCTTTGT GACTTTGGCA GCGCGACTAC ATTGGCACAT 600

TATCCAGACT ACAGCTGGTC TGCGCACAAG AGATCTATGG TGGAAGATGA GATAACAAGA 660

AACACAACTC CAGCGTACAG GACACCAGAG ATGATCGACC TGTATTCTAA CTACCCAATA 720

AATGAGAAGC AGGACATATG GGCTCTTGGT TGCATCCTAT ACCTGCTGTG CTTTAAGCAG 780

CACCCGTTTG AAGAGGGAGC CAAACTGCAG ATCGTAAACG GGAAATACAG CATTCCTCAA 840

AATGACACCA AGTACACAGT CTTTCACCAG CTTATACGAT CAATGTTGAA AATCAACCCT 900

GAAGAGCGGC TGTCTATCAA CGAGCTTGTT AACCAACTAC AGGAAATTGC TGCAGCGAGA 960

AATGTCAACC CCAAATCACC CATTACTGAG CTCCTGGAGC AGAACGGAGG ATTCGGGAAC 1020

AACAGCGCGC AGCTTCCCTC ACAGATCAAC AACATACACA ACTCTGTGAT TGAATCTCCA 1080

GGTGTGTATG ACACAGACCC GACCATGGGT GGAGGATTCC TGGATATCCT GAAAGGAGGA 1140

ACTGAACGAT TCCTTACCAA CATTAAAGAC ACTTCCTCTA AAGTCATCCA GTCGGTGGCC 1200

AGTTATGCTA AAGGAGACCT GGACCTGTCC TACATCACCT CCAGACTAGC AGTCATGTCT 1260

TTCCCAGCTG AAGGTGTTGA ATCTGCTATT AAGAATAACA TTGAGGATGT GCGTCTGTTC 1320

CTGGACTCTC GACACGCGGG TCATTACGCC GTTTATAACC TGTCCAAACG CTCCTACAGA 1380

CCAGCCAGGT TTCACAACAG GGTATCCGAG TGCGGTTGGC AGCCAAGGCG AGCTCCTACA 1440

CTGAAGAACT TGTACAGTAT ATGTAAAAAC ATGCATCAGT GGCTCAAACA GGACCAGAGG 1500

AACATCTGCA TCGTACACTG TCTGGACGGA CGGGCAGCGT CTGCTGTGGT GGTTTGTGCC 1560

TTCCTCTGTT TCTGTCGTCT CTTCTCCACC GCTGAGGCTG CAGTTTACAT GTTCAGCATG 1620

AAGCGATGTC CACCGGGCAT CTCAGCCTCA CACAAAAGGT ATATTGAATA CATGTGTGAT 1680

ATGATGGCAG AAGAGCCCAT AATCCCCCAC AGCAAGCCTA TAACCATTCG TTCAGTAGCC 1740

ATGACGCCCG TACCGCTCTT TAATAAGCAG AGGAATGGCT GTCGGCCGTT CTGTGAGGTC 1800

TATGTTGGAG ATGAGCGTGT CGCCACCACC TCACAGGAGT ACGACAGAAT GAGGGATTTT 1860

AAGATGGAGG ACGGGCGTGC GGAGATTCCT CTGAATATCA CCGTGCAGGG TGACGTTTTG 1920

ATTGTGATTT ATCATGCACG ATCCACGCTC GGCGGACGCC TGCAGGCCAA AATGGCATCC 1980

ATGAAAATGT TTCAGATTCA GTTTCATACA GGCTTTGTGC CCAGAAATGC CTCCACTGTC 2040

AAATTTGCAA AGTATGATCT GGACGCGTGT GACATCCAGG AGAAATATCC TGACCTCTTC 2100

CAGGTGCACG TCAATGTGGA GGTGGAGCCT CAGGATCGTC CCAGCAACAA GACTCCACCC 2160

TGGGAGAACT TCGCCACCAA AGGACTCAAT CCCAAGATCC TCTTCTCCAG CCGAGATGAA 2220

CAGCAGGAGA TTCTGACTAA ATTTGGTAAA CCAGAGCTTC CTCGTCAGCC TGGTTCGACA 2280

GCCTGTTATG CCTCTGACCC ACCGCAGTCG GAGAACTCTC CAGATGACCC GCAGACTGAG 2340

TCGGACTCAC CGTCACCCCA GAGCACAGAC ACCAACGCCA ACAACTTCTT TCAGACGCTG 2400

GACTGGGAAG TTGATTCAGG AGTCTGGGGA AAACGCAACA TTTATAAACA ATCATATAAC 2460

ACAAGTCGAC ACTTTGACCA CGCTGACGGC CACTTGGATG ACCAGGAAGA TTTGAGCGGC 2520

GGCTCGGAGG AGGAGTCAGT GTCGTACTCT GCCCCTATTG AAGGGACTCT GTCACGGGAC 2580

ACCAGTGAGC CGCTGTTTGA AGCAGACTTT ACAAACACTC CGCCTGAAGC TCAACCCGAC 2640

ACTGAGGACC TGCTGGGTCT GAACTCTGAG CCCGGTCCTG CTGTTCCAGA GAGCGGTTTG 2700

AAGAGCTCCG CCAGTAACAG TAATTTACTG AACGATCTAC TGTTCGCCCC TCAGACCAAC 2760

ACTGTGCCTT CAGCGAGCAA TGAAGACCTG ATGGGGGAAG ATGCGGGAGA AGATCTCTTC 2820

TTTTCCAACT CGTCCAGCCA GCCGCCACCA GCCACTAATA AAGTTGATAT AAAAGTTCAG 2880

AGTACAGATT TCTTCGACCC ATTCGGCGTG GGTTCGGCCT CCTCAGGGTC TGATTTGTTT 2940

GGTGATCTGC TGGGTTCAGA TGCTGCTAAC AGTGGCTTCA AAGCTCCAGC TCCTGCATCA 3000

AACTCCAGCC TCTTCAACCT CAACAAGTTA GCAAGTGAAA CCCCGAAGAT GACCTCATCA 3060

GCGAGTCAGC CTGATCTGTT GAGTGGGTGG GACAGCTGGG CCACCAGCGG AACCAGTACG 3120

ACTGCTAACT TGAGCACTGC TGCCAACAAA CCTTCTTTAT TTGTGCCTTT TTATGCTTTA 3180

AATAATCTTA TTACAGCCTC AGGAGTCTCG TCTTTCTCCA AGGCCAAATC CCAGAGTTTT 3240

GACCCTTTCG CAGACCTGGG AAATCTCGGC TCAACACTAC CTGGCTCCTC CAGTGCTAGC 3300

TTTTCTGGCT CAGGGTTTAA AACGGCGCCC TCTGCAGGCG GCCCTAAAAA CTCAGGTCAG 3360

CAGTGGCAGC AAACACCTCG ACCCTCTTCA GGCCCAAACA AACCCTGGAT GCCTCCGAAC 3420

TCCACGGCAC GGCCACAAGT TGTTCCTCAA GCAGCCAAAC CAAACTACAA CCCCAGCTTT 3480

AGTGTGATCG GCGGACGGCA GGAGAGGGGC ATCAGGGGCC CCGGATTTGG TCCAAAGCCT 3540

AAAGTGAAAG AAGACGACTT TGAGGATCTT CTGTGCACAC AAGGTTTTGG CTCCAAACCT 3600

GACAGGAAGA TGCCCAGAAC AATCGCTGAG ATGAGGAAGC AGGAGCTGTC CAAAGACATG 3660

GACCCTCTCA AACTACAGAT CTTGGACTGG ATCGAGGGGA AGGAGAGGAA CATCCGCGCT 3720

CTTCTGTCCA CGCTTCACAC AGTCCTGTGG GAGGGCGAGA CCCGCTGGAG ACCCATCAAC 3780

ATGGCAGATC TGGTCACTCC AGACCAGGTC AAAAGGGTCT ATAGGAAGGC TGTGCTCGTC 3840

GTGCATCCAG ACAAGGCCAC GGGTCAGCCG TACGAGCAGT ACGCTAAGAT GATCTTCATG 3900

GAGCTCAGCG ACGCCTGGTC CGAGTTCGAG AACCAAGGAT CCAAAGCCCT GTTCTGA 3957

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dldl y+t r+  +sfPae+ e+  +nn+++v  +lds+h ++y +ynl s r y +++

Q: 405   GDLDLSYITSRLAVMSFPAEGVESAIKNNIEDVRLFLDSRHAGHYAVYNL-SKRSYRPAR  463

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g++  +aP+l++l sick++++Wl +d++n+ ++hc  g+    v+vca+l

Q: 464   FHNRVSECGWQPRRAPTLKNLYSICKNMHQWLKQDQRNICIVHCLDGRAASAVVVCAFLC  523

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqll  171

         + + +++a+ a+++f+++r            s +ry++y + ++

Q: 524   FCRLFSTAEAAVYMFSMKRCPPG-----ISASHKRYIEYMCDMM  562

         ******************97654.....47899******98765

Domain Sequence
(FASTA)

GDLDLSYITS RLAVMSFPAE GVESAIKNNI EDVRLFLDSR HAGHYAVYNL SKRSYRPARF 60

HNRVSECGWQ PRRAPTLKNL YSICKNMHQW LKQDQRNICI VHCLDGRAAS AVVVCAFLCF 120

CRLFSTAEAA VYMFSMKRCP PGISASHKRY IEYMCDMM 158

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013