EKS-DAR-00013
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00013
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph492.05.6E-148621880260
StatusUnreviewed
Ensembl ProteinENSDARP00000059041
UniProt AccessionF1Q4V1;
Protein Name
Protein Synonyms/Alias
Gene Nameephb4a
Gene Synonyms/Alias ephb4a;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000040346ENSDARP00000111946ENSDART00000121947
ENSDARG00000040346ENSDARP00000059041ENSDART00000059042
ENSDARG00000040346ENSDARP00000113919ENSDART00000133074
ENSDARG00000040346ENSDARP00000124156ENSDART00000127561
OrganismDanio rerio
Functional Description
Protein Length989
Protein Sequence
(FASTA)
MELFSRNVAA FWIILLEFLL GSVAEEEVLM NTKTETSDLK WTTHSRSKPE WEEVSGLDEE 60
NNSVRTYQIC QADGSSSHWL RSKLIERRGA SQVYVELFFT MVECSSRNTH HRSCKETFNL 120
YYYQSDTDDA TATHPAWMEN PYTKVDTVAA DFLLRKGGEK KVNVKTLRLG PLSKRGFYLA 180
FQAQGACMAL LSVRVFFKKC PALTRSLSVF PETVPRSLVQ EAVGQCVANA AQPGPSPRPP 240
KMFCGEDGQW VDQPTTTCTC LPGFEASHGE LECRACPVGL FKMGSGTGPC SVCPENSQTG 300
ETGSAACVCR SGFYRALSDS ADTPCTRPPS SPRSPVPQVN DTSLTLEWSE PLDSGGRSDL 360
SYSVECRMCS TPGSPCTLCS DGVNYRPSQT GIQGRRVSIW GLRPHTTYSF TVMALNGVSA 420
QSQQGPAGET INITTSPNVP VLVSGLRKST ATESSLTLYW NTPTQSHYRI LQYQIRYCEK 480
ERGSEENSCH YMESNNNEVV LSDLRRATQY EVQVRARTFA GYGSFGKAIL FRTLPDEDDS 540
SSPLLVTGIL IAMGMLLLII VIGAAIYCIR KQNNYKDPEL SDKNGQYLMG QGVKVYIDPF 600
TYEDPNEAVR EFAKEIDVSC VKIEEVIGAG EFGEVCRGRL RIPGKKENYV AIKTLKGGYT 660
DKQRRDFLAE ASIMGQFQHP NIIHLEGIIT ASCPVMILTE FMENGALDSF LRLNDGQFTP 720
IQLVGMLRGI ASGMKYLSEM SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LQENSSDPTY 780
TSSLGGKIPI RWTAPEAIAF RKFTCASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE 840
QDYRLPPPPD CPTYLHQLML DCWQKERTAR PRFANIVSAL DKLIRNPASL KITAQEGAGP 900
SHPLLDQRSP LTPSSCGTVG DWLRAIKMER YEETFLQAGY TSMQLVTHIN TEDLLRLGIT 960
LAGHQKKILS SIEALGIQNK APPSPSVLF 989
Nucleotide Sequence
(FASTA)
ATGGAGCTCT TCTCCAGGAA TGTGGCCGCG TTTTGGATTA TCCTGCTGGA GTTCCTGCTC 60
GGATCAGTGG CGGAGGAAGA AGTCCTGATG AACACGAAAA CGGAGACATC AGATCTGAAG 120
TGGACGACAC ACTCTCGCTC TAAACCTGAG TGGGAGGAGG TCAGTGGTCT GGATGAGGAG 180
AACAACAGTG TGCGGACCTA TCAGATCTGC CAGGCGGACG GCTCCAGCAG TCATTGGCTG 240
CGTAGTAAGC TGATCGAGCG GCGGGGGGCG TCACAGGTGT ACGTGGAGCT GTTCTTCACT 300
ATGGTTGAGT GTTCATCTCG AAACACACAC CACCGCTCCT GCAAAGAGAC TTTCAACCTT 360
TATTACTACC AAAGCGACAC GGATGACGCC ACAGCCACCC ACCCGGCGTG GATGGAGAAC 420
CCCTACACCA AGGTGGACAC AGTGGCCGCA GACTTCCTAC TGCGCAAAGG CGGAGAGAAG 480
AAAGTCAACG TGAAGACGCT GCGTTTGGGC CCGTTGAGCA AGCGTGGATT CTACCTGGCG 540
TTTCAGGCTC AGGGCGCGTG CATGGCTCTG CTCTCCGTGC GTGTTTTCTT CAAGAAGTGT 600
CCGGCGCTCA CGCGCTCACT ATCCGTCTTC CCGGAGACCG TTCCCCGCTC GCTGGTCCAG 660
GAGGCAGTGG GCCAGTGTGT GGCCAACGCA GCACAGCCTG GCCCCAGTCC CAGACCGCCC 720
AAGATGTTCT GCGGAGAAGA TGGACAGTGG GTGGACCAGC CCACCACCAC CTGCACTTGC 780
CTGCCGGGCT TCGAGGCCAG CCATGGAGAG CTGGAGTGTA GAGCGTGTCC TGTGGGTCTG 840
TTCAAGATGG GTTCTGGTAC CGGTCCGTGT TCTGTGTGTC CTGAGAACAG TCAGACGGGA 900
GAGACGGGTT CTGCTGCATG TGTGTGCCGC TCTGGGTTTT ATCGCGCTCT GAGTGACAGT 960
GCAGATACAC CCTGCACACG TCCTCCGTCG TCTCCGCGCA GCCCCGTCCC GCAAGTAAAC 1020
GACACATCTC TGACTCTGGA GTGGAGCGAG CCGTTGGACA GCGGCGGCCG CTCGGATCTC 1080
AGCTACAGCG TGGAGTGTAG GATGTGCTCC ACCCCTGGAA GTCCCTGCAC ACTATGCAGT 1140
GACGGTGTGA ATTATCGGCC GTCCCAAACA GGGATCCAAG GCCGGCGCGT GAGCATTTGG 1200
GGTCTGAGAC CTCACACCAC CTACAGCTTC ACTGTCATGG CCCTCAACGG GGTCTCCGCT 1260
CAGAGTCAGC AGGGGCCTGC AGGAGAGACC ATCAACATCA CCACCAGTCC CAATGTTCCT 1320
GTGTTGGTTT CGGGCTTGAG GAAGAGCACA GCCACTGAAT CCAGCCTGAC GCTGTACTGG 1380
AACACACCCA CCCAGTCACA CTACAGGATC CTGCAGTACC AGATACGCTA CTGCGAGAAG 1440
GAGCGCGGAT CTGAAGAAAA CTCCTGTCAT TATATGGAGA GCAATAACAA CGAGGTGGTT 1500
TTGAGCGACT TGCGAAGGGC CACGCAGTAT GAGGTTCAAG TCCGAGCTCG GACATTCGCC 1560
GGATATGGAA GCTTTGGTAA AGCCATCCTC TTTCGAACTC TACCTGACGA AGATGATTCC 1620
TCGTCTCCCC TGCTTGTTAC TGGGATCCTG ATAGCCATGG GGATGCTGCT CCTCATCATC 1680
GTCATTGGGG CGGCCATTTA TTGCATAAGG AAGCAAAATA ACTACAAAGA TCCAGAGCTG 1740
AGCGACAAAA ACGGACAATA TCTCATGGGT CAAGGAGTGA AGGTCTACAT CGATCCCTTC 1800
ACTTATGAAG ACCCTAATGA GGCCGTGAGA GAGTTTGCTA AAGAGATCGA TGTCTCGTGT 1860
GTCAAAATCG AGGAGGTTAT TGGGGCAGGT GAGTTTGGGG AAGTGTGTCG GGGACGACTG 1920
AGGATTCCGG GTAAGAAGGA GAACTATGTG GCCATCAAGA CCCTGAAGGG TGGATATACA 1980
GACAAGCAAA GGAGGGACTT CCTGGCTGAG GCCTCCATCA TGGGCCAGTT CCAGCACCCC 2040
AACATTATTC ACCTGGAGGG CATAATAACA GCAAGCTGCC CCGTCATGAT CCTCACCGAA 2100
TTCATGGAGA ACGGAGCTCT GGACTCTTTC CTCAGACTCA ACGATGGACA GTTTACACCG 2160
ATACAGTTAG TCGGGATGCT GCGGGGCATT GCATCAGGAA TGAAATATCT CTCAGAAATG 2220
AGTTACGTAC ACCGAGATCT TGCAGCGCGC AACATTCTTG TGAACAGTAA CCTGGTCTGC 2280
AAGGTGTCCG ACTTTGGTCT GTCGAGATTC CTGCAGGAGA ATTCATCGGA TCCCACGTAC 2340
ACCAGCTCAC TGGGTGGTAA AATTCCCATC CGCTGGACGG CACCCGAAGC TATCGCCTTC 2400
CGTAAATTCA CCTGCGCGTC CGATGTGTGG AGTTACGGGA TTGTCATGTG GGAAGTGATG 2460
TCGTTTGGAG AACGACCGTA CTGGGACATG AGCAACCAGG ATGTGATTAA TGCCATTGAG 2520
CAGGATTACC GTCTGCCACC GCCGCCGGAC TGTCCCACAT ACTTGCACCA GCTGATGCTG 2580
GACTGCTGGC AGAAGGAGAG GACGGCCCGG CCACGCTTCG CCAACATCGT CTCAGCTCTG 2640
GACAAGCTGA TCCGCAACCC GGCCTCACTC AAAATCACAG CGCAGGAGGG GGCGGGCCCC 2700
TCTCACCCTC TGCTGGACCA GCGGTCTCCA CTCACGCCCT CATCCTGCGG GACAGTGGGT 2760
GACTGGCTGC GGGCCATCAA GATGGAGCGC TACGAGGAGA CATTTCTGCA GGCGGGATAC 2820
ACGTCCATGC AGCTCGTCAC CCACATCAAC ACGGAGGATC TGCTGCGTTT GGGAATAACT 2880
TTAGCAGGTC ACCAGAAGAA GATTCTCTCC AGCATTGAGG CTCTCGGGAT TCAAAACAAA 2940
GCACCACCTT CTCCGTCGGT TTTGTTT 2967
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grl++pgk+e +vaiktlk+g+t+kqrrdfl+easi+Gqf+hp
Q: 621   VKIEEVIGAGEFGEVCRGRLRIPGKKENYVAIKTLKGGYTDKQRRDFLAEASIMGQFQHP  680
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leG++t s pvmi+te+mengaldsflr +dgqft iqlvgmlrGiasgmkyls+m
Q: 681   NIIHLEGIITASCPVMILTEFMENGALDSFLRLNDGQFTPIQLVGMLRGIASGMKYLSEM  740
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+l+++s +++yt+s ggkipirwtapeaia+
Q: 741   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLQENSsDPTYTSSlGGKIPIRWTAPEAIAF  800
         *******************************88877*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkft asdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp+ l+qlml
Q: 801   RKFTCASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTYLHQLML  860
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqk+r++rp+f++ivs+l
Q: 861   DCWQKERTARPRFANIVSAL  880
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL RIPGKKENYV AIKTLKGGYT DKQRRDFLAE ASIMGQFQHP 60
NIIHLEGIIT ASCPVMILTE FMENGALDSF LRLNDGQFTP IQLVGMLRGI ASGMKYLSEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LQENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTCASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTYLHQLML 240
DCWQKERTAR PRFANIVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0035475; P:angioblast cell migration involved in selective angioblast sprouting
GO:0060026; P:convergent extension
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013