EKS-DAR-00613

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00613

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	464.0	3.8E-139	208	494	287

Status

Unreviewed

Ensembl Protein

ENSDARP00000061972

UniProt Accession

F1QQ20;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr1b

Gene Synonyms/Alias

tgfbr1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000042259	ENSDARP00000061972	ENSDART00000061973

Organism

Danio rerio

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MKMMMKMMMM EAVPCRLVFL AVFFGSRVQQ TEGLQCYCHR CPNHTCTTDG LCYVSITRAG 60

SLTTQQSWCI GKGELVPPDR PFVCAPSTKD NSGIYPLCCD TDWCNKDPDI KAFPVPTQKP 120

PALGPVAFAA LIAGPVCVLC FLMVTVFYIC HSRSVIHHRV PSEEDPSLDH PFITVGTTLK 180

DLIYDMTTSG SGSGLPLLVQ RTIARTIILQ ESIGKGRFGE VWRGRWRGEE VAVKIFSSRE 240

ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 300

VEGMIKLSLS TASGLAHLHM EIVGTQGKPA IAHRDLKSKN ILVKKNGTCC IADLGLAVRH 360

DSATDTIDIA PNHRVGTKRY MAPEVLDDSI NMKHFESFKR ADIYAMGLVF WEIASRCSIG 420

GIHEDYQLPY HDLVQSDPSV EEMRRVVCEQ KLRPNIPNRW QSCEALRVMA KIMRECWYAN 480

GAARLTALRI KKTLSQLSQQ EGIKM 505

Nucleotide Sequence
(FASTA)

ATGAAGATGA TGATGAAGAT GATGATGATG GAGGCAGTGC CGTGTCGACT GGTGTTTCTC 60

GCCGTGTTCT TCGGATCCCG GGTCCAGCAG ACTGAAGGTC TACAGTGCTA CTGCCACCGC 120

TGCCCGAACC ACACGTGTAC GACGGACGGG CTGTGTTACG TGTCCATCAC CCGCGCGGGC 180

AGCTTGACCA CACAGCAGAG CTGGTGCATC GGTAAGGGGG AGCTGGTCCC GCCCGACCGC 240

CCCTTCGTCT GCGCACCGTC CACTAAAGAC AACAGCGGCA TCTATCCGCT CTGCTGCGAC 300

ACCGACTGGT GCAACAAGGA CCCCGACATC AAAGCATTCC CAGTGCCGAC GCAGAAGCCT 360

CCCGCTCTGG GGCCCGTGGC GTTCGCAGCG CTGATCGCGG GGCCGGTGTG TGTGCTGTGT 420

TTCCTGATGG TCACCGTCTT CTACATCTGC CACAGCCGCT CCGTCATTCA CCACCGCGTG 480

CCCAGCGAGG AGGACCCGTC CCTGGACCAC CCCTTCATCA CTGTGGGCAC CACACTCAAA 540

GACCTGATCT ATGACATGAC CACATCTGGA TCTGGCTCCG GTCTGCCTCT GCTGGTGCAG 600

CGTACGATCG CTCGCACCAT CATCCTGCAG GAGAGCATCG GTAAGGGCCG GTTCGGGGAG 660

GTGTGGCGCG GCCGCTGGAG AGGAGAGGAG GTGGCGGTGA AGATCTTCTC CTCCAGAGAG 720

GAGCGCTCCT GGTTCCGGGA GGCCGAGATC TACCAGACCG TCATGCTGAG ACACGAGAAC 780

ATCCTGGGCT TCATCGCCGC AGACAACAAA GATAACGGCA CGTGGACTCA GCTGTGGCTG 840

GTGTCGGATT ATCATGAGCA CGGTTCTCTG TTCGATTACC TGAACCGCTA CACAGTGACT 900

GTAGAGGGGA TGATCAAACT CTCCCTGTCC ACCGCCAGCG GCCTCGCTCA CCTGCACATG 960

GAGATCGTCG GCACACAGGG GAAGCCTGCG ATCGCCCACC GGGATCTGAA GTCTAAGAAT 1020

ATCCTGGTGA AGAAGAACGG CACATGCTGT ATTGCAGACC TGGGGTTGGC CGTCCGGCAC 1080

GACTCCGCCA CCGACACCAT CGACATCGCT CCCAATCACA GAGTCGGCAC CAAACGGTAT 1140

ATGGCTCCAG AAGTGCTGGA TGATTCCATA AACATGAAGC ATTTCGAGTC CTTCAAGAGG 1200

GCTGATATCT ACGCCATGGG CCTGGTGTTC TGGGAGATCG CCAGCCGCTG CTCTATCGGA 1260

GGTATTCATG AAGATTATCA GCTGCCGTAT CATGATCTGG TCCAGTCAGA CCCGTCAGTG 1320

GAGGAGATGC GGAGGGTGGT GTGTGAACAG AAACTGAGGC CAAACATCCC CAACAGATGG 1380

CAGAGCTGCG AGGCTCTGCG TGTGATGGCT AAGATCATGC GGGAGTGCTG GTACGCTAAC 1440

GGAGCGGCTC GACTGACGGC GCTGCGCATC AAGAAGACTC TTTCCCAGCT CAGCCAGCAG 1500

GAGGGAATCA AGATGTAG 1518

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e igkGr+geVw++++rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fiaa

Q: 208   ILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA  267

         58899*******************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++l ls+asGlahLH+eivgt+g

Q: 268   DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQG  327

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPEv

Q: 328   --KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV  385

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++++n+k+fe+fkraD+Y++gLv+WE+asRc+  ++++e+y+lp+++ v+sdPs+eem+

Q: 386   LDDSINMKHFESFKRADIYAMGLVFWEIASRCSI-GGIHEDYQLPYHDLVQSDPSVEEMR  444

         **********************************.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 445   RVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  494

         ************************************************97

Domain Sequence
(FASTA)

ILQESIGKGR FGEVWRGRWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 60

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL SLSTASGLAH LHMEIVGTQG 120

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 180

DSINMKHFES FKRADIYAMG LVFWEIASRC SIGGIHEDYQ LPYHDLVQSD PSVEEMRRVV 240

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013