EKS-DAR-00760
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00760
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK317.21.7E-94151387237
StatusUnreviewed
Ensembl ProteinENSDARP00000062431
UniProt AccessionQ6NYW1;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase kinase kinase 12;
Gene Namemap3k12
Gene Synonyms/Alias map3k12; zgc:77370;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000042565ENSDARP00000062431ENSDART00000062432
OrganismDanio rerio
Functional Description
Protein Length856
Protein Sequence
(FASTA)
MACVHEQHAP SPSLSGFTTP LSDPPFCRPD PEVPASTPDT ELTPTQCVLR NVLSIDPVGG 60
GSGTHSNSPT LSDEPTNFSN SVLKLQEGGA EGGAVRSQAD SFRLQPGGGG FLEGLFGCLK 120
PVWTMIGKAY STEHKQSQEE CWEVPFEEIS ELQWVGSGAQ GAVFLGKFHG EEVAVKKVRD 180
IKETEIKHLR KLKHPNIITF KGVCTQAPCY CILMEYCAQG QLYEVLRAGR KITPCLLVDW 240
AMGIAGGMNY LHLHKIIHRD LKSPNMLITH DDLVKISDFG TSKELRDKST KMSFAGTVAW 300
MAPEVIRNEP VSEKVDIWSF GVVLWEMLTG EIPYKDVDSS AIIWGVGNNS LQLPLPDSCP 360
DGFKILLRQC WNCKPRNRPS FRQILLHLDI ASADVLSTPQ ETYFKSQAEW REEVKQHFEK 420
IKSEGTCLHR LDEELINRRR EELRHALDIR EHYERKLERA NNLYMELNAV MLQLELKEKE 480
LLRREQCLDK KYPGLFKHHT SNTVDKLIKK RSAPQKLPPH GKRPDLLRSE IILPKMDAGV 540
LQVTVPPCSN RGSTSPSRAR RVKTRHRRGG RGSSGDLSGP KHPSAPASRE REPVANTPPP 600
AAPIAESVSG STMREGQLEP PPLKLDETPP RSDTASEDAA SLPFSSSPDS PCCGRSGAVG 660
RPQAEEREEG PGAVRLPRGS SGSHLTPSAI LYRAAITRKQ RRGVSSEEEE GEVDSEVELP 720
RRRRPTSITK CQSVSTFSSE NLSVSEGEEG HTTDHSHSGT PDVVSTNTDE RLDDRSDDLI 780
SQGSEIPVDI TDPTLSEREA AALEQERANF DLEQNILETR ALCEDSDCDS AELDQSGSGE 840
PSRPPSAGGW GQGPQN 856
Nucleotide Sequence
(FASTA)
ATGGCTTGTG TCCATGAGCA GCATGCCCCA TCCCCGTCCC TCTCCGGCTT CACCACGCCG 60
CTCTCCGACC CGCCCTTCTG CCGTCCTGAC CCTGAGGTTC CGGCCAGCAC CCCGGACACT 120
GAGCTTACCC CGACCCAGTG CGTGCTGCGT AACGTGCTGT CCATCGACCC CGTGGGCGGC 180
GGCAGTGGCA CCCACAGCAA CAGCCCCACC CTGAGTGATG AGCCCACCAA CTTCTCCAAC 240
AGCGTGCTGA AGCTGCAGGA GGGTGGAGCG GAGGGCGGAG CGGTGCGCAG CCAGGCCGAC 300
AGCTTCAGAC TGCAGCCCGG CGGAGGAGGC TTCCTGGAAG GCCTGTTCGG CTGCCTGAAG 360
CCCGTGTGGA CCATGATCGG AAAAGCCTAC TCTACTGAAC ACAAGCAAAG CCAGGAGGAG 420
TGCTGGGAGG TGCCGTTCGA GGAGATCTCG GAGCTGCAGT GGGTGGGCAG CGGCGCTCAG 480
GGCGCAGTCT TCCTGGGCAA GTTTCATGGA GAGGAAGTGG CAGTGAAGAA AGTCAGAGAC 540
ATCAAGGAGA CGGAGATCAA ACACCTGCGC AAACTCAAAC ATCCCAACAT CATCACCTTC 600
AAGGGTGTGT GTACACAGGC TCCGTGTTAC TGCATCCTCA TGGAGTACTG TGCGCAGGGT 660
CAGCTGTATG AGGTGCTGCG TGCGGGCCGG AAGATCACGC CGTGCCTGCT GGTGGACTGG 720
GCCATGGGCA TCGCCGGCGG CATGAACTAC CTGCACCTGC ACAAGATCAT CCACAGAGAC 780
CTCAAGTCTC CAAATATGCT GATCACACAC GATGACCTGG TGAAGATCTC CGACTTCGGC 840
ACGTCTAAAG AGCTCAGGGA TAAAAGCACC AAGATGTCGT TCGCTGGCAC CGTGGCCTGG 900
ATGGCACCGG AGGTGATACG GAACGAACCT GTGTCTGAGA AAGTGGACAT CTGGTCATTC 960
GGTGTGGTGC TGTGGGAGAT GCTGACCGGG GAGATCCCCT ATAAAGATGT GGACTCGTCT 1020
GCTATCATTT GGGGTGTCGG AAACAACAGC TTGCAGCTCC CTCTTCCAGA CAGCTGCCCT 1080
GATGGGTTCA AGATCCTGCT CAGACAGTGC TGGAACTGTA AGCCCAGGAA CAGGCCATCG 1140
TTCCGGCAGA TTCTGCTTCA TCTGGACATC GCCTCCGCAG ACGTGCTGTC CACCCCACAG 1200
GAGACGTACT TTAAGTCTCA GGCGGAGTGG CGAGAGGAGG TGAAGCAACA CTTTGAGAAG 1260
ATTAAATCTG AGGGCACGTG TCTGCACCGT CTGGATGAAG AGCTGATCAA CCGGCGCCGA 1320
GAAGAACTCA GGCATGCGCT GGACATCAGA GAGCACTACG AGAGGAAGCT GGAGAGGGCC 1380
AATAACCTCT ACATGGAGCT CAATGCAGTA ATGCTTCAGC TGGAGCTCAA GGAGAAGGAG 1440
CTGCTCAGGA GGGAACAGTG TCTGGATAAG AAGTACCCTG GTCTGTTCAA GCATCACACC 1500
TCAAACACAG TGGACAAACT CATCAAGAAG AGAAGCGCCC CGCAGAAACT GCCGCCTCAC 1560
GGCAAGAGAC CGGACCTCCT GCGCTCAGAG ATCATCCTCC CCAAGATGGA TGCCGGAGTG 1620
CTGCAAGTGA CTGTCCCGCC ATGCTCAAAC CGAGGATCTA CCTCACCCAG TCGGGCACGC 1680
AGGGTCAAAA CCCGTCACCG GCGGGGCGGC AGGGGGAGCA GCGGGGATCT GTCGGGACCC 1740
AAGCACCCTT CTGCCCCTGC CAGCCGAGAG CGCGAGCCTG TGGCCAACAC TCCTCCGCCT 1800
GCTGCGCCTA TCGCCGAGAG CGTTTCCGGA TCCACCATGA GGGAGGGTCA GCTGGAGCCG 1860
CCGCCACTGA AGCTGGACGA GACTCCGCCC AGAAGTGACA CGGCCAGTGA GGACGCGGCA 1920
TCATTGCCCT TCTCCAGCAG CCCGGACTCC CCCTGTTGCG GGCGGAGCGG TGCCGTGGGC 1980
AGACCACAGG CGGAGGAGCG GGAGGAGGGC CCCGGGGCTG TGCGGCTGCC CAGAGGATCC 2040
AGCGGGAGCC ACCTGACGCC CTCCGCCATA CTCTACCGCG CTGCTATCAC ACGCAAACAG 2100
CGCCGTGGTG TTTCCTCAGA AGAGGAAGAG GGCGAGGTGG ACAGTGAGGT GGAATTACCA 2160
AGAAGACGAC GGCCAACCAG TATAACCAAG TGCCAATCAG TGTCCACGTT CAGCTCAGAG 2220
AACCTGTCGG TTTCAGAAGG CGAGGAGGGC CACACCACCG ACCATTCCCA CAGCGGGACT 2280
CCAGACGTGG TCAGCACCAA CACTGACGAG CGGCTGGACG ACCGCAGCGA TGACCTGATC 2340
TCGCAGGGCT CCGAGATCCC TGTGGACATC ACAGACCCAA CCCTGTCTGA ACGAGAGGCC 2400
GCTGCCCTCG AACAGGAAAG GGCCAACTTT GACCTGGAAC AAAACATCCT GGAGACGCGT 2460
GCGCTCTGTG AGGACTCGGA CTGTGACAGT GCTGAACTGG ACCAGTCTGG CAGCGGAGAG 2520
CCGAGCCGTC CCCCGAGTGC TGGAGGATGG GGCCAGGGTC CACAAAACTG A 2571
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62
         + +++gsga+g+v+ +k++++evavKk+r+ +e+         e+k+l+kl+hpnii+++
Q: 151   ELQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKET---------EIKHLRKLKHPNIITFK  201
         6799**************************9999.........*****************
S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122
         Gvc++ p+++++mey+++g+L++vl++   r+i++  lv+wa+ iA Gm+YLh +   ki
Q: 202   GVCTQAPCYCILMEYCAQGQLYEVLRA--GRKITPCLLVDWAMGIAGGMNYLHLH---KI  256
         ***************************..99************************...9*
S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181
         ihrdLks+n+L+ ++++ +ki+dFGt++el + stkms+agt+awmaPEv+++e+vsek+
Q: 257   IHRDLKSPNMLI-THDDLVKISDFGTSKELRDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  315
         ************.99999*************99***************************
S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241
         D+wS+gvvLWe+lt+e+Pykd+++ ai+++v++++l+lp+p+scp+ +k L+++cwn +p
Q: 316   DIWSFGVVLWEMLTGEIPYKDVDSSAIIWGVGNNSLQLPLPDSCPDGFKILLRQCWNCKP  375
         ************************************************************
S: 242   ekRpsfseivks  253
         ++Rpsf++i+ +
Q: 376   RNRPSFRQILLH  387
         *********876
Domain Sequence
(FASTA)
ELQWVGSGAQ GAVFLGKFHG EEVAVKKVRD IKETEIKHLR KLKHPNIITF KGVCTQAPCY 60
CILMEYCAQG QLYEVLRAGR KITPCLLVDW AMGIAGGMNY LHLHKIIHRD LKSPNMLITH 120
DDLVKISDFG TSKELRDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWEMLTG 180
EIPYKDVDSS AIIWGVGNNS LQLPLPDSCP DGFKILLRQC WNCKPRNRPS FRQILLH 237
KeywordComplete proteome; Kinase; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-ANC-00369
EKS-BOT-00381
EKS-CAP-00413
EKS-DIO-00060
EKS-EQC-00370
EKS-FEC-00368
EKS-GAA-00465
EKS-GOG-00371
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MYL-00378
EKS-OCP-00078
EKS-ORN-00489
EKS-ORC-00358
EKS-ORL-00450
EKS-OTG-00383
EKS-PEM-00201
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00481
EKS-XET-00494
EKS-XIM-00479
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
GO:0046777; P:protein autophosphorylation
KEGG
dre:404626;
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013