EKS-DAR-00653

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00653

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	499.8	3.5E-150	909	1178	270

Status

Unreviewed

Ensembl Protein

ENSDARP00000062906

UniProt Accession

F1QVU0;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ltk

Gene Synonyms/Alias

ltk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000042861	ENSDARP00000062906	ENSDART00000062907
ENSDARG00000042861	ENSDARP00000061546	ENSDART00000061547

Organism

Danio rerio

Functional Description

Protein Length

1504

Protein Sequence
(FASTA)

MDYITRQTFV KLALFIFTVL RSSCALLEKA AEDPVHPNPL QSSPAEDSDV SFCDFESPCS 60

WTLSSHSTGG DWFITSAQQH RSSRRDTQPI RDYSTGKSEG HFLLLKPSSS HLSAGRCSFH 120

MTSPVVLSSG PFCHLQLARF QPEPHAGNIS AFVKHTDSTD IKPIDLTIKE QESDSSQWEV 180

LEAVIGQLNE PFQVTVQYSA CSSHEVGFLA FDSLELKNCV MGDDYVDLGS DCEKYSSLQC 240

HSGGCIEKQR VCDFHTDCPE GEDEGLICST LPLGSYCSFE LGSCGWLAAD TQSSWRLVSG 300

QQLIEDTHLL GTTLKNTQGH FLFLKVRGHG DEREALVQSP ALPSTISNQD CQLQFSLYRY 360

GDFNGTVLLS VVESGASAPA LIWERSGHWK DAWQEITLPI TEILNGFHLK VQAFWTSGSK 420

ADIALDDISL SAACFDTELN ELLHEGLPHD LDFSPLPEPS ASEASPITWW FTSCGASGPF 480

GPTQAQCDSA YRNTNVSVVV GKEGPLRGVQ MWKVPATNTY KISAYGAAGG KGAKNHNKRS 540

HGVFISATFP LEKGDILYIL IGHQGEDACP GRNPQTHKIC LGESSVIEDG FDSDGSALKW 600

AGGGGGGGGA TYIYRMENGQ PLPLLIAAGG GGKAYLEDPE SSQDQSFREQ YENDTTVSGV 660

SGRSGAAGGG GGWSDVSSLS WAGKSLVEGG QGGSSCPEAL SVLGWATFGG FGGGGGACSA 720

GGGGGGYRGG DAPLLDDISA DGQDGLSFVH PMGKIFLQPL AAMESHGEAE IVVYLNCSHC 780

KTQSCKRDED TKLILCLCDS DEVLAPDNVT CAVVPMGSLA DGPPSLVFIM AVIVSTVVTG 840

VVLTCASLTL IYYRKKNHLH AVRIRLQSPE YKLSKIRSST IMTDYNPNYG YFGKAASLSE 900

LKEVPRKNIT LLRALGHGAF GEVYEGQVLG MNGENTAMQV AIKTLPEICS EQDEMDFLME 960

ALIMSKFSHQ NIVRCIGVSL QILPRFILLE LMTGGDMKSF LRLNRPRTNH SSSLSMLELL 1020

HMARDIALGC RYLEENHFIH RDIAARNCLL TCPGPDRVAK IGDFGMARDI YRASYYRKGG 1080

RAMLPVKWMP PEAFLEGIFT CKTDTWSFGV LLWEIFSLGY MPYPCKTNQE VLEFVTGGGR 1140

MDPPKSCPGP VYRIMTQCWQ HCPEHRPNFT TILERINYCT QDPDVINTPL PVECGPPVEE 1200

EGGTVIRPDG SGSMTPLLVA RSLSQDASPR ASITSVTPQA LKPRLQLQRP VHLTQEVGTY 1260

RETLEPCWAE PVPASGVCPG PWLQVPEHRP CSRSSSSSGS QKLKNKTKNL WNPTYGSWVL 1320

ESFGRGKSAL CHTQSMPLSC NPTSVSAPSS TSEHTDPVVE VNANVSASPP PSAAPSQTTL 1380

TPTAAPSRKS PTGAAGVSLA TVMDLAKLQS FPCGNVNYAY DEQSYETESL PVVVSKSLEP 1440

STSSAATSSL VALSQPGSFT HKPLVKRHAS YGHEDVRRYT QPEKPTRDRD SGFSLSEDLS 1500

VTPV 1504

Nucleotide Sequence
(FASTA)

ATGGATTATA TTACTCGACA AACTTTTGTA AAACTTGCCC TTTTCATCTT CACAGTTTTG 60

AGGAGCAGTT GTGCTCTGTT GGAAAAAGCT GCAGAAGACC CAGTGCATCC AAATCCTCTT 120

CAATCCAGTC CAGCAGAAGA CAGCGATGTT TCGTTCTGTG ATTTCGAGTC TCCGTGTTCT 180

TGGACATTAT CCAGTCACAG CACTGGAGGA GACTGGTTTA TCACTTCAGC ACAGCAGCAC 240

AGATCTAGCA GACGCGACAC CCAGCCTATC AGAGATTACT CCACTGGAAA ATCTGAAGGA 300

CATTTTCTGC TGCTGAAGCC CAGCTCCAGT CATCTGTCTG CAGGCAGATG TAGTTTCCAC 360

ATGACCAGTC CTGTAGTTCT CAGCAGTGGG CCATTTTGTC ATCTCCAACT CGCTCGCTTT 420

CAACCAGAGC CACACGCTGG AAACATATCA GCCTTCGTGA AGCACACCGA CTCTACCGAC 480

ATCAAACCCA TTGACCTTAC AATCAAAGAA CAAGAAAGCG ACAGCTCGCA GTGGGAGGTC 540

TTGGAGGCTG TGATTGGTCA GTTGAATGAG CCCTTCCAGG TGACAGTGCA GTACTCTGCC 600

TGTAGCAGTC ATGAAGTTGG GTTTCTGGCA TTCGATTCAC TGGAGCTGAA GAACTGTGTC 660

ATGGGTGATG ATTATGTGGA TTTGGGTTCC GACTGTGAGA AATACTCATC TCTTCAATGT 720

CATTCTGGAG GCTGCATTGA GAAACAAAGA GTGTGTGATT TCCACACTGA CTGCCCAGAA 780

GGGGAGGACG AGGGCTTAAT ATGCAGCACT TTACCTTTGG GTTCATACTG TTCATTTGAG 840

TTGGGCTCCT GTGGTTGGTT AGCGGCTGAC ACACAGTCTT CTTGGAGACT AGTTAGTGGA 900

CAACAGCTGA TTGAAGACAC ACACCTGCTG GGCACAACTC TGAAGAACAC TCAAGGGCAT 960

TTCCTTTTCT TAAAGGTCAG AGGTCACGGT GATGAAAGAG AGGCGCTGGT TCAAAGCCCT 1020

GCATTGCCTT CAACTATATC CAATCAGGAC TGTCAGTTGC AGTTTTCTCT CTACCGGTAT 1080

GGGGATTTCA ATGGAACAGT GCTTTTGTCT GTGGTGGAGA GCGGAGCCTC AGCACCAGCA 1140

CTGATTTGGG AGAGATCCGG ACACTGGAAA GATGCCTGGC AAGAGATCAC TCTGCCGATC 1200

ACAGAGATTT TAAATGGCTT CCATCTTAAA GTGCAGGCTT TCTGGACTTC TGGCTCCAAG 1260

GCTGACATTG CACTGGATGA CATTTCATTA AGTGCAGCAT GTTTTGACAC AGAACTGAAT 1320

GAACTGCTTC ATGAAGGACT ACCGCATGAT TTAGACTTCA GTCCTCTTCC AGAACCATCA 1380

GCATCAGAGG CGTCTCCAAT TACATGGTGG TTTACATCCT GTGGAGCGAG TGGACCTTTC 1440

GGCCCGACTC AAGCCCAGTG TGACAGTGCC TACCGAAACA CCAATGTCAG CGTTGTGGTG 1500

GGGAAAGAGG GTCCTCTCAG GGGTGTACAG ATGTGGAAGG TCCCTGCTAC CAACACGTAC 1560

AAGATTTCAG CCTATGGAGC CGCAGGAGGC AAAGGAGCAA AGAACCATAA CAAGCGCTCA 1620

CACGGTGTGT TCATCTCAGC CACCTTCCCC CTGGAGAAAG GTGACATCCT CTACATCTTA 1680

ATTGGCCACC AAGGAGAAGA TGCCTGTCCA GGAAGGAACC CCCAAACCCA TAAAATCTGT 1740

CTGGGCGAGT CGTCTGTGAT TGAAGATGGT TTTGACAGCG ACGGTTCAGC CTTGAAGTGG 1800

GCAGGGGGTG GTGGCGGTGG AGGGGGAGCC ACATATATAT ATCGGATGGA GAACGGGCAA 1860

CCACTTCCTT TGCTGATTGC AGCTGGAGGG GGAGGAAAGG CCTACCTTGA GGATCCAGAA 1920

AGCAGCCAGG ACCAGAGTTT TCGGGAACAG TACGAGAATG ACACCACCGT TTCTGGTGTC 1980

AGTGGCAGAT CTGGAGCAGC AGGTGGAGGA GGTGGATGGA GCGACGTGTC CTCTCTCTCA 2040

TGGGCAGGGA AATCTCTTGT TGAAGGGGGT CAAGGAGGCT CATCCTGTCC TGAGGCTCTG 2100

TCAGTGCTGG GATGGGCTAC ATTTGGAGGA TTCGGAGGAG GAGGAGGCGC GTGCTCCGCT 2160

GGAGGGGGCG GTGGAGGATA CAGAGGTGGT GATGCACCTC TTCTTGACGA CATCTCAGCA 2220

GATGGACAAG ATGGCCTCTC TTTTGTTCAC CCCATGGGAA AGATATTTCT GCAACCTCTG 2280

GCAGCCATGG AGAGTCACGG CGAAGCTGAA ATCGTGGTCT ATCTGAACTG CAGCCACTGT 2340

AAAACCCAGA GCTGCAAACG CGATGAAGAC ACCAAGCTCA TCCTGTGCCT CTGCGACAGC 2400

GACGAGGTTC TGGCACCAGA CAACGTCACC TGCGCAGTGG TTCCAATGGG CTCTCTGGCA 2460

GACGGGCCTC CATCCCTGGT CTTCATCATG GCAGTGATCG TGTCCACAGT GGTGACCGGT 2520

GTCGTTCTGA CCTGTGCCAG CCTGACTCTC ATATATTATC GTAAGAAGAA CCACCTGCAT 2580

GCGGTCAGGA TTCGACTGCA GAGTCCAGAG TACAAGCTTA GCAAAATTCG CTCGTCCACC 2640

ATCATGACCG ACTACAACCC CAACTATGGT TATTTTGGAA AGGCAGCCTC TCTGAGTGAA 2700

CTGAAGGAAG TGCCGCGTAA AAACATCACC CTCCTCAGGG CGTTGGGACA CGGTGCCTTT 2760

GGGGAAGTGT ATGAAGGACA GGTTTTGGGT ATGAATGGAG AAAACACAGC CATGCAAGTC 2820

GCTATAAAGA CTCTTCCAGA AATCTGCTCT GAGCAGGACG AGATGGATTT CCTAATGGAG 2880

GCTCTGATCA TGAGTAAGTT CAGCCATCAG AACATTGTCC GCTGCATTGG CGTCAGTCTG 2940

CAGATCCTGC CACGCTTCAT CCTGCTGGAG CTCATGACAG GAGGAGACAT GAAGAGCTTC 3000

TTGAGACTCA ATCGACCCAG AACTAACCAT TCGTCTTCTC TAAGCATGCT GGAGCTTCTT 3060

CATATGGCCA GAGACATCGC TCTTGGCTGT CGCTACCTTG AAGAAAACCA CTTCATCCAC 3120

AGGGACATCG CCGCTCGCAA CTGCCTTTTG ACTTGTCCTG GTCCAGACAG AGTGGCTAAA 3180

ATTGGAGATT TCGGGATGGC CCGAGATATT TACAGGGCCA GTTACTATAG GAAGGGTGGC 3240

CGTGCCATGC TGCCAGTCAA ATGGATGCCA CCTGAAGCTT TCCTAGAGGG CATTTTTACA 3300

TGCAAGACTG ACACCTGGTC ATTCGGGGTA CTGCTGTGGG AGATTTTCTC TCTTGGGTAC 3360

ATGCCTTATC CCTGCAAAAC TAACCAGGAA GTGCTGGAGT TTGTAACTGG TGGAGGTCGC 3420

ATGGATCCAC CTAAGAGCTG CCCTGGGCCT GTTTATCGGA TCATGACACA GTGTTGGCAA 3480

CACTGTCCAG AACACAGACC AAACTTCACT ACTATTTTAG AGAGGATCAA CTACTGTACA 3540

CAGGATCCTG ATGTCATCAA CACCCCTCTT CCAGTGGAGT GTGGTCCTCC TGTTGAAGAA 3600

GAAGGGGGCA CTGTGATCCG CCCTGACGGA TCAGGCAGCA TGACCCCTCT TCTAGTTGCC 3660

CGCTCTTTGT CCCAGGATGC TTCCCCTCGA GCAAGCATCA CCAGTGTCAC TCCACAGGCC 3720

CTCAAACCCC GTTTGCAGCT ACAAAGACCA GTCCACCTCA CACAAGAAGT GGGCACATAC 3780

CGAGAGACAC TGGAGCCCTG TTGGGCAGAG CCTGTTCCTG CTTCAGGAGT CTGTCCAGGA 3840

CCATGGCTTC AAGTCCCAGA GCATCGGCCA TGCTCCAGAA GTAGTTCATC ATCGGGCAGC 3900

CAGAAGCTAA AGAACAAGAC TAAAAACCTC TGGAACCCCA CCTACGGTTC CTGGGTCCTA 3960

GAGAGCTTTG GACGTGGAAA GTCAGCTCTG TGCCACACTC AGTCTATGCC TCTATCCTGC 4020

AACCCCACGT CTGTTTCTGC CCCGTCCTCT ACCTCGGAGC ACACAGACCC TGTAGTAGAA 4080

GTTAATGCAA ATGTTTCAGC TTCCCCACCT CCATCTGCTG CACCGTCACA AACTACGTTG 4140

ACTCCCACAG CGGCTCCCTC TAGGAAGAGT CCCACAGGGG CTGCTGGTGT CTCGCTGGCC 4200

ACTGTTATGG ACTTAGCAAA GCTTCAGAGC TTTCCATGTG GCAACGTAAA CTATGCGTAT 4260

GATGAACAGA GCTACGAGAC TGAGAGTTTG CCTGTGGTTG TGTCCAAATC TCTGGAGCCC 4320

AGCACCAGCT CTGCAGCTAC ATCTTCACTG GTTGCCCTCA GCCAACCCGG CAGCTTTACC 4380

CACAAACCAT TGGTGAAGCG TCATGCCAGT TACGGACATG AGGATGTAAG GAGGTACACC 4440

CAGCCTGAGA AGCCCACCAG GGACAGGGAT TCTGGCTTTT CCTTGTCTGA AGACCTGAGT 4500

GTCACCCCTG TGTAG 4515

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+ralG+GafGevyeg+v g++g+++ ++va+ktlpe +seqde+dfl+eali+skf+

Q: 909   ITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDEMDFLMEALIMSKFS  968

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl+ lpr+illel++GGd+ksflr +rp++++ ssl+m +ll++a+d+a

Q: 969   HQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNRPRTNHSSSLSMLELLHMARDIAL  1028

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkggra+lpvkw

Q: 1029  GCRYLEENHFIHRDIAARNCLLTCPGPDRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  1088

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeafleGift+ktd+wsfGvllwe+fslG++pyp k+nqevle+v+ Ggr+d+pk +p

Q: 1089  MPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTGGGRMDPPKSCP  1148

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h pe+rp+f++iler+++

Q: 1149  GPVYRIMTQCWQHCPEHRPNFTTILERINY  1178

         ***************************986

Domain Sequence
(FASTA)

ITLLRALGHG AFGEVYEGQV LGMNGENTAM QVAIKTLPEI CSEQDEMDFL MEALIMSKFS 60

HQNIVRCIGV SLQILPRFIL LELMTGGDMK SFLRLNRPRT NHSSSLSMLE LLHMARDIAL 120

GCRYLEENHF IHRDIAARNC LLTCPGPDRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180

MPPEAFLEGI FTCKTDTWSF GVLLWEIFSL GYMPYPCKTN QEVLEFVTGG GRMDPPKSCP 240

GPVYRIMTQC WQHCPEHRPN FTTILERINY 270

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048066	; P:developmental pigmentation
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR023415	; LDLR_class-A_CS.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS01209	; LDLRA_1; 1.
PS50068	; LDLRA_2; 1.
PS50060	; MAM_2; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013