EKS-DAR-00787
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00787
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR538.71.4E-161583910328
StatusUnreviewed
Ensembl ProteinENSDARP00000099069
UniProt AccessionE7FFW1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene Namekita
Gene Synonyms/Alias kita;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000043317ENSDARP00000024170ENSDART00000011135
ENSDARG00000043317ENSDARP00000099069ENSDART00000110967
ENSDARG00000043317ENSDARP00000098291ENSDART00000108974
OrganismDanio rerio
Functional Description
Protein Length979
Protein Sequence
(FASTA)
MYVLVYPLVC SSNVKHSRFL SGRSRPTITP EGPRLTVPLY SNFSLHCQSN STVRWQHENR 60
PMRTLKEEQR QGQQTILKVN RAGPQHLGKY SCREEKTGEK SSIYVYVKDP ENPFRRTIVF 120
DIVAAEGDTT VIPCLATDPD MKNLNLQKCD GQPLPNSLRY SASLETGVSV EKVRKEFEGC 180
YVCVGTLDAA TVKSGRYQLT VRLVPDAPPP ITLGQPQRVL LTQGEKLSLS CSTSNVNSDI 240
AVKWKAPNGV NPSVHQNSHL LTEPITHVRT AILSLSSVTM QDAGNYSCEA INEKGTTAKP 300
VWVNIYEKGF INITSVDNST RRVRAGESLS LRVVMNAYPK PHTFSWSYSG VKLTNTTDHV 360
ITSRTHGNSY TSELKLVRLK VSESGIYTFS CLNRDATIRQ TFEVHVISKP QIVSYEGPID 420
GQVRCVAEGY PTPQIKWYYC DLPHSRCSNL LNATQEEEDV VTVTMTNPPF GKGAVESRLN 480
ITKNNYATLE CVASANGEIV YTLFSISENT VPHELFTPLL IGFVAAAVIL VLILIVLTYK 540
YMQKPKYQIQ WKVIEGIHGN NYVYIDPTQL PYDHQWEFPR DKLRFGKTLG SGAFGKVVEA 600
TAYGMSKADT VMTVAVKMLK PSAHATEKEA LMSELKVLSY LGNHINIVNL LGACTVGGPT 660
LVITEYCCFG DLLNFLRRRR VYFYYTTLGE DAYYRNVMMQ SEPNDSRNGY MTMKPSVLGI 720
LSSENRRSLN KGDSYSDSDA VSEILQEDGL TLDTEDLLSF SYQVAKGMDF LASKNCIHRD 780
LAARNILLTQ GRVAKICDFG LARDITTDSN YVVKGNARLP VKWMSPESIF ECVYTFESDV 840
WSYGILLWEI FSLGSSPYPG MPVDSKFYKM IKEGYRMESP EFSPSEMYDI MHSCWDADPV 900
KRPSFSKIVE KIEQQISDST KHIYLNFSSR LPAAPGPREE SSSHVHRLNS VGSHSTATQP 960
LLSSNDVFLD RSSPSHPVV 979
Nucleotide Sequence
(FASTA)
ATGTACGTAC TTGTCTATCC TCTTGTATGT TCATCAAATG TTAAACATTC TCGTTTCCTC 60
TCAGGCAGGT CGAGGCCTAC CATTACCCCA GAAGGTCCCC GGCTAACAGT ACCACTGTAC 120
AGCAACTTCA GTTTGCATTG CCAGAGTAAC AGTACAGTGC GCTGGCAGCA TGAAAACCGT 180
CCCATGCGTA CCCTGAAGGA GGAACAAAGA CAGGGTCAAC AGACAATTCT TAAAGTAAAC 240
AGAGCCGGCC CTCAACACTT GGGCAAATAT TCGTGTAGAG AGGAGAAGAC TGGTGAAAAG 300
AGCTCAATCT ATGTGTATGT GAAAGATCCT GAAAATCCCT TCAGGAGGAC CATCGTGTTC 360
GACATTGTTG CGGCAGAAGG AGATACGACG GTGATCCCAT GCTTGGCAAC AGACCCAGAT 420
ATGAAAAACT TGAACCTGCA GAAATGTGAC GGACAGCCCC TTCCCAACAG TCTGCGATAT 480
TCAGCCAGTC TTGAGACAGG AGTGTCCGTG GAAAAAGTCA GGAAGGAATT TGAGGGATGT 540
TACGTCTGCG TCGGAACTTT GGATGCCGCT ACGGTTAAAT CAGGAAGATA TCAACTTACT 600
GTTCGGCTTG TTCCAGACGC ACCTCCTCCG ATCACACTGG GTCAGCCTCA AAGAGTGTTG 660
CTCACCCAGG GGGAAAAACT CTCCCTATCC TGCTCCACCT CAAATGTCAA CAGCGACATC 720
GCAGTCAAGT GGAAGGCTCC AAACGGAGTG AACCCGTCAG TACACCAGAA CTCACATCTT 780
CTGACGGAGC CCATTACTCA CGTGAGGACG GCCATCCTCA GCCTGAGCTC TGTGACCATG 840
CAGGACGCCG GCAATTACAG CTGTGAGGCC ATAAATGAGA AAGGGACCAC TGCAAAGCCA 900
GTCTGGGTCA ACATCTATGA AAAAGGATTC ATTAATATAA CAAGTGTGGA TAACAGTACT 960
AGGAGAGTGC GGGCTGGTGA AAGTCTGTCT CTGCGAGTGG TAATGAACGC TTACCCAAAG 1020
CCGCATACTT TTTCCTGGAG CTACAGTGGT GTAAAACTTA CCAATACTAC TGATCATGTG 1080
ATCACCAGCC GGACACATGG AAATAGTTAC ACCAGCGAGC TGAAGCTAGT GCGTCTCAAG 1140
GTGTCAGAAA GTGGCATTTA CACCTTTTCA TGCTTAAACC GAGACGCAAC TATCCGTCAA 1200
ACGTTCGAAG TCCATGTCAT CAGCAAACCG CAGATTGTGT CCTATGAAGG GCCGATTGAT 1260
GGACAGGTGC GCTGTGTGGC CGAAGGTTAT CCCACTCCTC AGATCAAGTG GTATTACTGT 1320
GACCTGCCTC ATTCAAGGTG CTCTAATCTA CTGAATGCCA CTCAGGAGGA GGAGGATGTT 1380
GTCACCGTGA CCATGACAAA TCCTCCCTTT GGGAAAGGCG CAGTGGAGAG CCGTCTAAAC 1440
ATCACCAAGA ACAATTACGC CACTCTTGAA TGCGTGGCAT CTGCCAATGG GGAAATCGTG 1500
TACACACTCT TCTCTATCAG CGAGAACACT GTTCCTCATG AACTCTTTAC ACCGCTGCTC 1560
ATCGGTTTTG TAGCCGCAGC TGTTATCCTT GTTCTCATCC TGATCGTGCT GACCTACAAG 1620
TACATGCAGA AACCCAAATA CCAAATCCAA TGGAAAGTCA TAGAGGGTAT TCATGGAAAC 1680
AACTATGTGT ACATTGACCC CACTCAGCTT CCATACGACC ACCAGTGGGA GTTTCCCAGA 1740
GATAAGCTGC GATTTGGAAA AACTCTTGGA TCTGGAGCAT TTGGAAAGGT GGTGGAGGCA 1800
ACGGCTTATG GGATGTCCAA AGCAGACACT GTGATGACGG TAGCTGTGAA GATGCTGAAA 1860
CCGAGTGCCC ATGCAACAGA GAAAGAGGCT CTGATGTCAG AGCTGAAGGT GCTTAGTTAT 1920
CTTGGCAACC ACATTAACAT TGTCAACCTG CTTGGGGCAT GCACTGTTGG AGGTCCAACT 1980
CTAGTTATAA CAGAGTACTG CTGTTTCGGC GACCTGTTGA ACTTCCTGCG CAGAAGGAGA 2040
GTATATTTCT ACTACACAAC ACTAGGCGAA GATGCTTACT ATAGAAATGT CATGATGCAG 2100
TCAGAACCAA ATGACAGCAG AAATGGATAC ATGACCATGA AGCCCTCTGT ACTGGGAATC 2160
CTGTCCTCCG AAAACAGACG ATCACTTAAT AAAGGGGATT CGTACAGTGA TTCTGATGCC 2220
GTCAGTGAGA TTCTGCAGGA AGACGGCTTG ACTCTGGACA CTGAGGATCT TCTCAGCTTC 2280
TCCTACCAAG TAGCCAAAGG GATGGATTTT CTAGCATCAA AAAACTGTAT TCACAGAGAC 2340
CTGGCTGCCA GAAACATTCT CCTCACCCAA GGCAGAGTGG CCAAGATCTG TGACTTTGGA 2400
CTAGCACGAG ACATCACAAC TGACTCAAAC TATGTTGTCA AAGGCAATGC TCGTCTCCCA 2460
GTAAAATGGA TGTCCCCGGA GAGCATCTTT GAGTGTGTTT ACACCTTTGA GAGTGACGTC 2520
TGGTCTTATG GCATCCTGCT GTGGGAGATC TTCTCTCTTG GGAGTAGTCC ATATCCAGGG 2580
ATGCCTGTGG ACTCTAAATT CTATAAGATG ATCAAGGAAG GATATCGAAT GGAGTCTCCG 2640
GAGTTTTCCC CAAGTGAAAT GTACGATATC ATGCACTCGT GCTGGGATGC CGACCCTGTC 2700
AAGAGACCCT CATTTAGCAA GATAGTGGAG AAGATCGAAC AACAGATTTC AGACAGCACT 2760
AAACACATTT ACTTAAACTT CAGCTCCAGG TTGCCAGCAG CACCAGGCCC CCGTGAGGAA 2820
TCCAGTTCTC ATGTCCATCG GCTAAACTCA GTGGGCAGTC ACAGCACAGC CACTCAACCT 2880
CTGCTCTCCA GCAACGACGT CTTTTTGGAT AGATCGAGTC CAAGTCACCC TGTAGTCTGA 2940
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lGsGafGkvveatayG+sk+d+v++vavkmlk++a+++ekealmselk+ls+lG
Q: 583   LRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHATEKEALMSELKVLSYLG  642
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact+gGp++viteycc+Gdlln+lrr+r  f  + l       e++++++
Q: 643   NHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTL------GEDAYYRN  696
         ***************************************9995544......45788887
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         +    +++s+ +   +s + y+ +k++v  + ss++ +  + k +s+ ++++ +++ +ed
Q: 697   V----MMQSEPN---DSRNGYMTMKPSVLGILSSENRRSLN-KGDSYSDSDAVSEILQED  748
         7....5666655...66899*******99999887766555.559***************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
           +l+ edllsfsyqvakGm+flasknc+hrdlaarn+llt+G+v+kicdfGlardi++d
Q: 749   GLTLDTEDLLSFSYQVAKGMDFLASKNCIHRDLAARNILLTQGRVAKICDFGLARDITTD  808
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwm+pesif+++yt++sdvwsyGillweifslGs+pypg++vdskfy
Q: 809   SNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFY  868
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         k+ikeGyrm++p+++++e+y+im++cw+a+p krpsf+++ve
Q: 869   KMIKEGYRMESPEFSPSEMYDIMHSCWDADPVKRPSFSKIVE  910
         ***************************************986
Domain Sequence
(FASTA)
LRFGKTLGSG AFGKVVEATA YGMSKADTVM TVAVKMLKPS AHATEKEALM SELKVLSYLG 60
NHINIVNLLG ACTVGGPTLV ITEYCCFGDL LNFLRRRRVY FYYTTLGEDA YYRNVMMQSE 120
PNDSRNGYMT MKPSVLGILS SENRRSLNKG DSYSDSDAVS EILQEDGLTL DTEDLLSFSY 180
QVAKGMDFLA SKNCIHRDLA ARNILLTQGR VAKICDFGLA RDITTDSNYV VKGNARLPVK 240
WMSPESIFEC VYTFESDVWS YGILLWEIFS LGSSPYPGMP VDSKFYKMIK EGYRMESPEF 300
SPSEMYDIMH SCWDADPVKR PSFSKIVE 328
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013