EKS-DAR-00628

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00628

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	365.1	4.9E-109	172	460	289

Status

Unreviewed

Ensembl Protein

ENSDARP00000106562

UniProt Accession

F1Q6M3;

Protein Name

Protein Synonyms/Alias

Gene Name

acvr2b

Gene Synonyms/Alias

acvr2b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000044422	ENSDARP00000106562	ENSDART00000121592
ENSDARG00000044422	ENSDARP00000124769	ENSDART00000150207
ENSDARG00000044422	ENSDARP00000028046	ENSDART00000019975

Organism

Danio rerio

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

DPSHGEVETR ECLYYNVNWE VEKTNRSGVE RCEGEKDKRS HCYASWRNNS GSIQLVKKGC 60

WLDDFNCYDR QECVATEENP QVFFCCCEGN FCNERFTHLP DISGTSMISP PPVSPSLLNV 120

LVYSLLPLSM LSMAVLLAFW MYRHRKPPYG HVDVNEDPGP SPPSPLVGLK PLQLLEVKAR 180

GRFGCVWKAQ MINEYVAVKI FPIQDKLSWQ NEREMFSTPG MKHDNLLRFI AAEKRGSNLE 240

MEFWLITEFH ERGSLTDYLK GNAVSWADLC VIAESMACGL AYLHEDVPRS KGEGPKPAIA 300

HRQTNTHTQM IQISNKSSIQ KFGLETRFEP GKPPGDTHGQ VGTRRYMAPE VLEGAINFQR 360

DSFLRIDMYA MGLVLWELVS RCKAADGPVD EYMLPFEEEI GQHPSLEDLQ DAVVHKKLRP 420

AFKDCWLKHS GLCQMCETME ECWDHDAEAR LSAGCVQERI SQIRRVSSST SDCLFSMVTS 480

LTNVDLPPKE SSI 493

Nucleotide Sequence
(FASTA)

GACCCCAGTC ATGGCGAGGT GGAGACGCGG GAGTGTTTGT ACTATAACGT TAACTGGGAG 60

GTGGAGAAGA CGAACCGTAG CGGTGTGGAG CGATGTGAAG GAGAGAAAGA CAAACGCTCG 120

CACTGCTACG CCTCCTGGAG GAACAACTCC GGCTCCATCC AGCTCGTCAA GAAGGGCTGC 180

TGGCTCGACG ACTTCAACTG CTACGACAGA CAGGAGTGTG TGGCCACAGA GGAGAATCCT 240

CAGGTGTTTT TCTGCTGCTG TGAAGGAAAC TTCTGCAATG AGAGATTCAC ACACCTGCCG 300

GACATCAGTG GAACCAGTAT GATCTCTCCT CCTCCAGTGT CTCCATCTCT GCTGAATGTG 360

TTGGTTTACT CTCTGCTGCC GCTCTCCATG CTCTCCATGG CTGTGCTGTT GGCATTCTGG 420

ATGTACCGAC ACAGAAAACC TCCGTACGGA CATGTGGACG TCAATGAGGA TCCAGGCCCA 480

TCTCCTCCAT CTCCTCTGGT GGGTCTGAAG CCTCTGCAGC TGCTGGAGGT TAAAGCTCGC 540

GGACGCTTCG GCTGCGTCTG GAAGGCTCAG ATGATCAATG AATATGTAGC TGTCAAGATT 600

TTCCCCATTC AGGATAAGCT GTCATGGCAG AACGAGCGGG AGATGTTTTC CACTCCGGGA 660

ATGAAACATG ATAACCTGCT GCGCTTCATC GCTGCTGAGA AACGCGGATC TAACCTGGAG 720

ATGGAGTTCT GGCTCATCAC TGAGTTTCAT GAGCGGGGCT CTCTGACGGA CTATCTGAAG 780

GGGAACGCAG TGAGCTGGGC CGATCTGTGT GTGATAGCGG AGAGCATGGC CTGTGGTCTG 840

GCGTATCTGC ATGAAGACGT GCCGCGCTCC AAAGGAGAAG GCCCCAAACC AGCCATCGCA 900

CACAGACAGA CAAACACACA CACACAGATG ATCCAAATAT CTAACAAATC TTCAATCCAG 960

AAATTTGGAC TAGAAACGAG ATTTGAGCCG GGGAAACCGC CGGGAGACAC ACATGGCCAG 1020

GTGGGCACGA GGAGGTACAT GGCCCCGGAG GTGCTGGAAG GAGCCATAAA CTTCCAGCGG 1080

GACTCCTTTC TGCGGATAGA CATGTACGCC ATGGGCCTGG TGCTGTGGGA GCTGGTGTCA 1140

CGCTGCAAAG CTGCTGATGG TCCTGTGGAC GAGTACATGC TGCCGTTTGA GGAGGAGATC 1200

GGTCAGCACC CGTCGCTGGA GGATCTGCAG GATGCTGTGG TCCATAAGAA GCTGCGGCCG 1260

GCGTTTAAGG ACTGCTGGCT CAAGCATTCA GGTCTGTGTC AGATGTGCGA GACCATGGAG 1320

GAGTGCTGGG ATCATGACGC AGAGGCTCGT CTGTCGGCCG GCTGTGTGCA GGAGCGCATC 1380

TCTCAGATCC GCCGCGTCAG CAGCTCCACC TCAGACTGCC TGTTCTCCAT GGTGACCTCG 1440

CTCACCAACG TGGACCTGCC GCCCAAAGAG TCCAGCATCT GA 1482

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka++ +e+vAvKif+ +d+ sw++E+e+++t+ ++h+n+l+fia

Q: 172   LQLLEVKARGRFGCVWKAQMINEYVAVKIFPIQDKLSWQNEREMFSTPGMKHDNLLRFIA  231

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++e++l+te+he+gsL+dyLk + +++ +l+ +a+s+a+Gla+LHe+++ +k

Q: 232   AEKRGSNLEMEFWLITEFHERGSLTDYLKGNAVSWADLCVIAESMACGLAYLHEDVPRSK  291

         **********************************************************99

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g   KpaiaHR  +++  +++ ++++ i  +GL  ++e  k   d  ++ qvGt+RYmaP

Q: 292   GeGPKPAIAHRQTNTHTQMIQISNKSSIQKFGLETRFEPGKPPGD--THGQVGTRRYMAP  349

         989***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ ++f r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Psle+

Q: 350   EVLEGAINFQR-DSFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLED  408

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++ vv+kklrP +++ w k++ l ++++++eecWd+d+eaRl+a +v++r+

Q: 409   LQDAVVHKKLRPAFKDCWLKHSGLCQMCETMEECWDHDAEARLSAGCVQERI  460

         *************************************************985

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQM INEYVAVKIF PIQDKLSWQN EREMFSTPGM KHDNLLRFIA 60

AEKRGSNLEM EFWLITEFHE RGSLTDYLKG NAVSWADLCV IAESMACGLA YLHEDVPRSK 120

GEGPKPAIAH RQTNTHTQMI QISNKSSIQK FGLETRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD SFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEDLQD 240

AVVHKKLRPA FKDCWLKHSG LCQMCETMEE CWDHDAEARL SAGCVQERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013