EKS-DAR-00453
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00453
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb398.23.1E-119384643260
StatusUnreviewed
Ensembl ProteinENSDARP00000065261
UniProt AccessionA2BIB3;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene Namerps6ka4
Gene Synonyms/Alias rps6ka4; si:dkey-273o13.5; DKEY-273O13.5-001;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000044436ENSDARP00000065261ENSDART00000065262
OrganismDanio rerio
Functional Description
Protein Length745
Protein Sequence
(FASTA)
MENFELLKVL GTGAYGKVFL VRKISGHDKG KLYAMKVLKK AAIVQKAKTA EHTRTERQVL 60
EHIRQSPFLV TLHYAFQTQT KLHLILDYVS GGEMFTHLYQ RDHFSEDEVR IYVGEIILAL 120
EHLHKLGIVY RDIKLENILL DSDGHVVLTD FGLSKEFLEE EKERTYSFCG TIEYMAPEII 180
RGKSGHGKAV DWWSLGILMF ELLTGASPFT LEGERNSQSE VSKRILRCEP PFPSIIGPLA 240
QDLLRKLIVK DPHKRLGSGP RGAEEIKGHP FFKGLNWSDL AEKKVQSPFR PELRDELDVG 300
NFAEEFTGME PVYSPASTPP STDRLFQGYS FVAPSILFNK NVVMADVLDA HVNVDRPGSA 360
TVQRSAMLKE SQFFQHYELC LQGSPLGEGS FSVCRKCRHK QSGQEYAVKI VSRRMEAMTQ 420
REIAALRQCE SHPNIVTLHE VYTDQYHTYL VMEMLRGGEL LERIRKRKMF AEWEASQLMK 480
SLVSAVSYMH EAGVVHRDLK PENVLFADES DESVLKVIDF GFARLFPAGS GSAPLQTPCF 540
TLQYAAPELF HSSGYDQACD LWSLGVILYT MLSGQVPFQS EKKVMTSSHA ADIMHKIKEG 600
DFSLDGEAWK GVSEEAKDLV RGLLTVDPER RLKLSALKEN AWLQGGGVMS STPLCTPDVL 660
ESTGPTVRTY VNATYKAFNR GKREGFFLKS VDNAPLAKRR KMKMTSTGVE TRRSSSSSSS 720
SSSSSASHSK TQNCQSLNPH EDPKL 745
Nucleotide Sequence
(FASTA)
ATGGAGAACT TTGAACTTCT CAAAGTGCTT GGCACAGGAG CTTACGGGAA AGTGTTTTTG 60
GTCCGAAAAA TCAGCGGCCA TGATAAAGGC AAACTGTACG CCATGAAGGT GCTAAAGAAA 120
GCAGCCATCG TTCAGAAGGC AAAGACTGCG GAGCACACTA GAACCGAGCG ACAGGTATTG 180
GAGCACATCC GCCAGTCCCC CTTCCTGGTC ACCCTCCATT ATGCCTTTCA GACGCAAACC 240
AAACTGCATC TCATACTAGA CTATGTGAGC GGAGGAGAGA TGTTCACACA CCTCTATCAG 300
AGAGATCATT TCTCAGAGGA TGAGGTGAGG ATCTATGTGG GGGAGATTAT TCTGGCTCTG 360
GAGCATCTGC ATAAGCTTGG CATTGTGTAC CGAGACATTA AGCTGGAGAA CATTTTATTG 420
GACAGTGATG GTCATGTGGT TTTGACAGAC TTTGGGCTGA GTAAGGAGTT TCTGGAGGAG 480
GAGAAAGAGA GGACTTATTC ATTCTGTGGC ACTATAGAAT ACATGGCACC TGAGATTATC 540
AGAGGGAAGT CTGGCCATGG CAAGGCAGTG GACTGGTGGA GTCTGGGCAT CCTGATGTTC 600
GAGCTGTTGA CAGGAGCATC TCCGTTCACT CTGGAGGGAG AGAGAAATTC CCAGAGCGAG 660
GTGTCCAAAC GCATCCTTCG TTGTGAGCCT CCATTTCCTT CCATCATCGG ACCCTTGGCT 720
CAAGATCTCC TGCGGAAGTT GATAGTGAAA GACCCTCATA AGAGGCTGGG CTCTGGGCCT 780
CGAGGAGCTG AGGAGATCAA GGGTCATCCT TTCTTTAAGG GTTTAAACTG GTCAGACTTG 840
GCAGAGAAAA AAGTCCAGAG TCCCTTCCGC CCTGAACTGC GGGATGAGCT GGATGTGGGA 900
AACTTTGCAG AGGAGTTTAC AGGAATGGAG CCGGTTTATT CCCCTGCCAG CACACCGCCT 960
AGTACAGACC GTCTGTTTCA GGGCTACTCT TTCGTGGCTC CTTCGATCTT ATTCAATAAG 1020
AATGTGGTGA TGGCGGATGT TTTGGATGCT CATGTTAACG TTGACCGGCC TGGTTCTGCT 1080
ACAGTCCAGC GTAGTGCAAT GCTGAAGGAG TCTCAGTTTT TCCAGCACTA TGAGCTGTGT 1140
CTGCAGGGGT CTCCACTGGG TGAGGGCAGT TTCTCAGTCT GCAGGAAGTG CAGACACAAG 1200
CAGAGCGGTC AGGAATACGC TGTGAAAATC GTTAGTCGAA GGATGGAGGC CATGACTCAG 1260
AGAGAGATCG CAGCTCTACG CCAGTGTGAA TCTCACCCAA ACATTGTCAC GCTCCATGAG 1320
GTCTATACTG ATCAGTACCA TACGTATCTG GTAATGGAGA TGTTGCGTGG TGGAGAGCTG 1380
TTAGAGCGAA TCAGGAAAAG GAAGATGTTT GCAGAATGGG AGGCCAGTCA GCTGATGAAG 1440
AGCCTGGTGT CTGCGGTCAG CTACATGCAT GAGGCTGGAG TTGTGCACCG AGACCTCAAA 1500
CCGGAGAACG TGCTGTTCGC TGATGAGTCG GATGAGTCTG TGTTGAAGGT TATTGACTTT 1560
GGCTTTGCAC GGTTGTTTCC GGCGGGGAGC GGGAGTGCCC CTCTGCAGAC CCCCTGCTTT 1620
ACATTGCAGT ACGCAGCGCC TGAGCTCTTC CACAGCTCGG GATATGACCA GGCGTGTGAC 1680
CTCTGGAGCC TTGGGGTCAT ATTGTACACC ATGCTCTCTG GCCAAGTTCC ATTCCAGAGT 1740
GAGAAAAAAG TTATGACATC ATCGCACGCT GCCGACATCA TGCACAAGAT CAAAGAGGGC 1800
GATTTCTCAT TGGATGGAGA AGCCTGGAAG GGCGTGTCCG AGGAGGCCAA AGATCTAGTG 1860
AGAGGTTTGC TAACCGTGGA TCCTGAGCGG CGGCTGAAGC TCTCGGCTCT GAAGGAGAAC 1920
GCCTGGCTTC AGGGAGGCGG CGTCATGTCC TCGACCCCGC TCTGCACCCC TGATGTTCTG 1980
GAGTCCACCG GTCCCACCGT CCGCACTTAT GTTAATGCCA CCTACAAGGC GTTCAACCGG 2040
GGGAAGCGTG AGGGTTTTTT CCTTAAAAGT GTCGACAACG CGCCGCTAGC AAAACGGCGC 2100
AAGATGAAAA TGACCAGTAC TGGCGTGGAG ACCAGACGCA GCTCGTCTTC CTCCTCTTCC 2160
TCCTCGTCCT CATCCGCTTC CCATTCCAAG ACGCAGAATT GCCAATCTCT GAATCCACAC 2220
GAGGACCCCA AACTGTGA 2238
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
          +lG+Gs+svc++c+hk+++qe+avki++++ ++ t++ei++l+++e+hpnivtl++vy 
Q: 384   SPLGEGSFSVCRKCRHKQSGQEYAVKIVSRRmEAMTQREIAALRQCESHPNIVTLHEVYT  443
         579****************************9****************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpen  123
         d+ ++ylv+e+l+GGell+ri+k+k+f+e eas+++++lv+av+y+he Gvvhrdlkpen
Q: 444   DQYHTYLVMEMLRGGELLERIRKRKMFAEWEASQLMKSLVSAVSYMHEAGVVHRDLKPEN  503
         ************************************************************
S: 124   ilyvdesdnaesikiidfGfaklkraeng..llktpcytlnfvapevlkrqGydeacdlw  181
         +l++desd++  +k+idfGfa+l +a +g  +l+tpc+tl+++ape+++  Gyd+acdlw
Q: 504   VLFADESDESV-LKVIDFGFARLFPAGSGsaPLQTPCFTLQYAAPELFHSSGYDQACDLW  562
         *******9987.*************9988779****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+lytml+G+vpf    +  ++++a++i+ kikeG+fsl+Geaw++vseeakdlv++
Q: 563   SLGVILYTMLSGQVPFqsekKVMTSSHAADIMHKIKEGDFSLDGEAWKGVSEEAKDLVRG  622
         ****************77655578899*********************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp++rlkl+ l+++ wl
Q: 623   LLTVDPERRLKLSALKENAWL  643
         ********************7
Domain Sequence
(FASTA)
SPLGEGSFSV CRKCRHKQSG QEYAVKIVSR RMEAMTQREI AALRQCESHP NIVTLHEVYT 60
DQYHTYLVME MLRGGELLER IRKRKMFAEW EASQLMKSLV SAVSYMHEAG VVHRDLKPEN 120
VLFADESDES VLKVIDFGFA RLFPAGSGSA PLQTPCFTLQ YAAPELFHSS GYDQACDLWS 180
LGVILYTMLS GQVPFQSEKK VMTSSHAADI MHKIKEGDFS LDGEAWKGVS EEAKDLVRGL 240
LTVDPERRLK LSALKENAWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-CAE-00125
EKS-CII-00093
EKS-CIS-00194
EKS-DRM-00077
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAE-00060
EKS-MUM-00169
EKS-ORN-00204
EKS-OTG-00168
EKS-PES-00145
EKS-RAN-00161
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
EKS-XIM-00199
Gene Ontology
GO:0005840; C:ribosome
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
dre:561959;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013