EKS-DAR-00636
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00636
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/DDR486.36.1E-146575863289
StatusUnreviewed
Ensembl ProteinENSDARP00000068113
UniProt AccessionE7FFT8;
Protein Name
Protein Synonyms/Alias
Gene Nameddr2a
Gene Synonyms/Alias ddr2a;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000051913ENSDARP00000068113ENSDART00000073623
ENSDARG00000051913ENSDARP00000124159ENSDART00000149902
OrganismDanio rerio
Functional Description
Protein Length868
Protein Sequence
(FASTA)
MNVPSPTEMK QLWKMHFPLL ILLYLSGAVQ SQVNPGVCRS PLGMSRGQIL DEDISASSQW 60
SESTAAKYGR LDCEEGDGAW CPEIPAEPEN MKEFLQIDLR SLHFITLVGT QGRHAGGIGN 120
EFAQTYKIKY SRDGSRWISW RNRQGKEVIE GNRNAYDIVL KDLEPPIIAR FVRFMPVIDH 180
SMNVCMRVEL YGCEWLDGLV SYNSPLGQQM SLNGQHIYLN DSVYDGAMSY SMTEGLGQLT 240
DGMCGLDDFT LSHVYNVWPG YDYVGWTNES FPNGYVEIMF EFDRTRNFTT MKVHCNNMFS 300
RRVKTFQKVV CYFRSELDWE ATPVSFSPVM DDVNPSARFV TVSLYNHMAS AIKCQYYFSD 360
IWMMFSEITF QSDTAMYNTT LTPPRTDPPL TNQPGDDPTH KVDDSNTRIL IGCLVAIIFI 420
LVAIIVIILW RQVWQKMLEK VSRRMLDDEL TASLSIQSET FTYNNNNSPS SVPSEQESSS 480
TYERIFPLGP DYQEPSRLVR KLPEFSQTSE DTASTITASK TPSVNVQEGV PHYAEADIVN 540
LQGVTGGNTY AVPALTMDLL SGKDVAVEEF SRKLLTFKEK LGEGQFGEVH LCEAEGMQDF 600
MDKDFSFDVT ENQTVLVAVK MLRADANKNA RNDFLKEIKI MSRLKDPNII RLLAVCMSSD 660
PLCMITEYME NGDLNQFLSR HEPEGMIALL SNAPTVSYSN LHHMASQIAS GMKYLSSLNF 720
VHRDLATRNC LVGKNFTIKI ADFGMSRNLY SGDYYRIQGR AVLPIRWMSW ESILLGKFTT 780
SSDVWAFGVT LWEMLTFCKE QPYSQLSDEQ VIENTGEFFR DQRRQIYLPQ PPMCPDPVYK 840
LMLSCWHRNT KERPSFQEIH HTLLECKP 868
Nucleotide Sequence
(FASTA)
ATGAACGTCC CGTCTCCGAC TGAGATGAAG CAGCTTTGGA AGATGCACTT TCCACTGCTG 60
ATCCTCCTTT ACCTATCAGG AGCTGTCCAG TCTCAAGTAA ACCCAGGTGT GTGTCGGTCC 120
CCATTAGGCA TGTCCAGGGG GCAGATTTTA GATGAAGATA TATCAGCTTC AAGTCAGTGG 180
TCAGAATCCA CCGCAGCAAA ATATGGCAGA CTGGACTGTG AGGAGGGCGA TGGAGCTTGG 240
TGTCCTGAGA TCCCAGCAGA ACCAGAGAAC ATGAAGGAGT TCCTTCAGAT CGACCTGCGC 300
TCTCTGCATT TCATCACTCT GGTGGGCACT CAGGGGCGAC ACGCAGGCGG CATCGGCAAT 360
GAATTCGCCC AGACGTACAA GATTAAATAC AGCCGTGACG GAAGTCGCTG GATCTCCTGG 420
AGGAACCGAC AGGGCAAAGA GGTGATTGAG GGAAACAGAA ATGCCTATGA CATCGTGTTG 480
AAGGACCTGG AGCCGCCCAT CATTGCCCGT TTCGTCCGAT TCATGCCCGT CATTGATCAC 540
TCTATGAATG TGTGTATGCG TGTGGAACTG TACGGCTGTG AGTGGCTGGA TGGACTGGTT 600
TCATATAATT CCCCACTCGG CCAGCAGATG AGTCTGAATG GACAACATAT TTATCTTAAT 660
GACTCTGTGT ATGATGGAGC CATGAGTTAC AGTATGACAG AAGGACTTGG ACAACTGACG 720
GATGGCATGT GCGGCCTGGA TGACTTCACT CTCAGTCACG TCTACAACGT TTGGCCTGGT 780
TATGACTACG TCGGCTGGAC CAATGAGAGC TTTCCCAACG GTTATGTTGA GATCATGTTT 840
GAGTTTGACC GCACCCGCAA CTTCACCACC ATGAAGGTGC ACTGCAACAA CATGTTCTCC 900
CGAAGAGTGA AGACCTTTCA GAAGGTGGTG TGTTATTTCC GCTCAGAGCT GGATTGGGAG 960
GCGACGCCTG TATCATTCAG CCCGGTGATG GATGATGTGA ACCCCAGTGC TCGATTCGTC 1020
ACCGTCTCGC TCTATAACCA CATGGCCAGT GCTATTAAGT GCCAGTACTA CTTTTCTGAC 1080
ATCTGGATGA TGTTCAGTGA AATCACCTTT CAGTCAGATA CAGCCATGTA CAACACAACT 1140
CTGACTCCCC CCAGGACCGA CCCTCCTCTC ACCAACCAGC CAGGGGATGA CCCTACACAC 1200
AAAGTAGATG ACAGCAATAC CCGGATCCTA ATTGGCTGCC TTGTTGCAAT CATTTTTATT 1260
TTAGTGGCAA TTATTGTTAT TATACTATGG CGACAAGTCT GGCAAAAGAT GCTCGAGAAG 1320
GTGTCTCGGA GGATGCTGGA CGATGAACTA ACTGCTAGTC TGTCAATACA GAGTGAGACC 1380
TTCACCTATA ACAACAACAA CAGCCCGTCC TCAGTGCCCA GTGAGCAGGA GTCCAGCTCC 1440
ACCTACGAGC GTATATTCCC TCTGGGCCCC GACTACCAAG AGCCCTCACG GCTGGTTCGT 1500
AAACTGCCTG AGTTTTCCCA AACATCCGAG GATACCGCAT CAACAATTAC AGCTTCCAAG 1560
ACCCCTTCAG TCAATGTCCA AGAGGGCGTC CCACATTACG CAGAGGCAGA CATTGTTAAC 1620
CTGCAGGGCG TCACAGGGGG AAACACATAC GCTGTACCTG CTCTTACTAT GGACCTACTG 1680
TCAGGGAAAG ACGTCGCTGT GGAGGAGTTT TCTCGCAAAC TGCTTACCTT TAAAGAAAAG 1740
TTGGGAGAAG GGCAGTTCGG AGAGGTGCAT TTATGTGAAG CAGAAGGCAT GCAAGACTTC 1800
ATGGATAAGG ACTTCTCCTT CGATGTCACT GAAAACCAAA CAGTGCTTGT AGCTGTTAAA 1860
ATGCTTCGAG CAGATGCAAA TAAAAATGCC AGGAATGATT TCTTAAAGGA GATAAAAATC 1920
ATGTCCCGTT TGAAAGACCC AAACATCATC AGGCTGCTGG CGGTGTGCAT GAGCTCTGAT 1980
CCTCTGTGTA TGATCACCGA GTACATGGAG AACGGAGATC TTAATCAGTT CCTGTCCCGC 2040
CATGAGCCCG AGGGCATGAT CGCTCTACTC AGCAATGCCC CAACAGTCAG CTACAGCAAC 2100
CTGCACCACA TGGCCAGCCA GATCGCCTCA GGCATGAAGT ACCTGTCTTC ACTCAACTTC 2160
GTACATCGAG ACTTGGCCAC CCGTAACTGC CTAGTGGGAA AGAACTTTAC CATCAAGATT 2220
GCAGACTTTG GGATGAGCAG AAACCTGTAT AGCGGAGACT ATTATCGTAT CCAAGGCAGA 2280
GCGGTGCTGC CCATCCGCTG GATGTCCTGG GAAAGCATTC TTTTGGGGAA ATTCACCACA 2340
TCCAGTGACG TGTGGGCTTT TGGTGTGACG CTTTGGGAGA TGCTTACCTT CTGCAAAGAG 2400
CAGCCTTATT CACAGCTCTC AGACGAGCAG GTCATTGAAA ACACAGGGGA GTTCTTTCGG 2460
GATCAGAGGA GACAGATATA CCTGCCGCAG CCACCGATGT GTCCTGACCC CGTCTACAAG 2520
CTCATGTTGA GCTGCTGGCA CAGGAACACC AAAGAGCGTC CATCCTTCCA GGAGATTCAT 2580
CACACGCTAC TGGAGTGCAA GCCCTAG 2607
Domain Profile
S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55
         L++keklGeG+fgev+lCe eg++d+++kd     ++++++lvavk+lr+danknar+df
Q: 575   LTFKEKLGEGQFGEVHLCEAEGMQDFMDKDfsfdvTENQTVLVAVKMLRADANKNARNDF  634
         789******************************999************************
S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaed..selakek  113
         lkeiki+srlkdPni+rll+vc+  +plc+i+ey+enGdlnqfls+he+e   + l++++
Q: 635   LKEIKIMSRLKDPNIIRLLAVCMSSDPLCMITEYMENGDLNQFLSRHEPEGmiALLSNAP  694
         ************************************************98622567899*
S: 114   tlsyellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdy  173
         t+sy++l ++a+qiasg+kyL+slnfvhrdlatrnclvg++ft+kiadfg+sr+ly+gdy
Q: 695   TVSYSNLHHMASQIASGMKYLSSLNFVHRDLATRNCLVGKNFTIKIADFGMSRNLYSGDY  754
         ************************************************************
S: 174   yrvqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvien  233
         yr+qGravlPiRwm+wesillgkftt sDvWafgvtlwe+lt+c+eqPy++l+deqvien
Q: 755   YRIQGRAVLPIRWMSWESILLGKFTTSSDVWAFGVTLWEMLTFCKEQPYSQLSDEQVIEN  814
         ************************************************************
S: 234   agelfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282
         +ge+frdq r+++l++P++cp+ +y+l+l+Cw+r+++eRPsf+e+h+ l
Q: 815   TGEFFRDQRRQIYLPQPPMCPDPVYKLMLSCWHRNTKERPSFQEIHHTL  863
         **********************************************876
Domain Sequence
(FASTA)
LTFKEKLGEG QFGEVHLCEA EGMQDFMDKD FSFDVTENQT VLVAVKMLRA DANKNARNDF 60
LKEIKIMSRL KDPNIIRLLA VCMSSDPLCM ITEYMENGDL NQFLSRHEPE GMIALLSNAP 120
TVSYSNLHHM ASQIASGMKY LSSLNFVHRD LATRNCLVGK NFTIKIADFG MSRNLYSGDY 180
YRIQGRAVLP IRWMSWESIL LGKFTTSSDV WAFGVTLWEM LTFCKEQPYS QLSDEQVIEN 240
TGEFFRDQRR QIYLPQPPMC PDPVYKLMLS CWHRNTKERP SFQEIHHTL 289
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00271
EKS-ANC-00279
EKS-BOT-00289
EKS-CAJ-00295
EKS-CAF-00295
EKS-CAP-00324
EKS-DRM-00147
EKS-ECT-00035
EKS-EQC-00280
EKS-FEC-00275
EKS-GAM-00184
EKS-GAG-00242
EKS-GAA-00357
EKS-GOG-00288
EKS-HOS-00295
EKS-ICT-00274
EKS-LAC-00303
EKS-LOA-00299
EKS-MAM-00292
EKS-MEG-00231
EKS-MOD-00284
EKS-MUM-00320
EKS-MUP-00285
EKS-MYL-00292
EKS-NOL-00266
EKS-ORN-00376
EKS-ORC-00271
EKS-ORL-00347
EKS-OTG-00295
EKS-PAT-00274
EKS-PES-00257
EKS-PEM-00160
EKS-POA-00281
EKS-RAN-00306
EKS-SAH-00271
EKS-SUS-00254
EKS-TEN-00374
EKS-TUB-00030
EKS-XET-00361
EKS-XIM-00368
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155; P:cell adhesion
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000421; Coagulation_fac_5/8-C_type_dom.
IPR008979; Galactose-bd-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00754; F5_F8_type_C; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00231; FA58C; 1.
SM00219; TyrKc; 1.
Prosites
PS01285; FA58C_1; 1.
PS01286; FA58C_2; 1.
PS50022; FA58C_3; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013