EKS-DAR-00081

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00081

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	354.2	1.0E-105	12	295	284

Status

Unreviewed

Ensembl Protein

ENSDARP00000051002

UniProt Accession

Q2V6H0;

Protein Name

Protein Synonyms/Alias

Cdk7; Novel protein (Zgc:85821);

Gene Name

cdk7

Gene Synonyms/Alias

cdk7; CH211-198E13.4; CH211-198E13.4-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000051916	ENSDARP00000051002	ENSDART00000051003
ENSDARG00000051916	ENSDARP00000068117	ENSDART00000073627

Organism

Danio rerio

Functional Description

Protein Length

345

Protein Sequence
(FASTA)

MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKTTNTIVAI KKIKVGHRTE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDYMETDLEV IIKDTSLVLT PANIKAYILM 120

TLQGLEYMHN HWILHRDLKP NNLLLDENGV LKLADFGLAK AFGSPNRVYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLAGDSDLD QLTKIFEALG TPTDEIWPGM 240

SSLPDYVSFK PFPGTPLEHI FSAAGDDLLE LLRGLFTYNP CSRTTAMQAL KMKYFSNRPG 300

PTPGPQLPRP NSSTEALKEK ENLLIGIKRK RDSIEQGTLK KKLVF 345

Nucleotide Sequence
(FASTA)

ATGGCATTAG ATGTAAAGTC AAGGGCAAAG CGTTATGAAA AGCTGGACTT TTTGGGTGAA 60

GGACAGTTTG CTACTGTTTA CAAGGCAAGA GACAAAACCA CGAACACCAT TGTCGCTATC 120

AAAAAGATAA AAGTGGGACA CAGAACAGAG GCTAAAGATG GCATCAACAG AACAGCTCTT 180

CGAGAGATTA AGTTGTTGCA AGAGCTCAGT CATCCAAACA TTATTGGTCT CCTGGATGCT 240

TTTGGACACA AATCTAATAT TAGTCTGGTC TTTGATTACA TGGAGACAGA TCTCGAGGTA 300

ATCATAAAGG ACACCAGTCT CGTACTGACA CCAGCCAATA TAAAGGCATA CATCCTCATG 360

ACACTACAGG GTCTGGAATA CATGCACAAT CACTGGATCC TGCACAGGGA TCTGAAACCC 420

AATAATTTAC TGCTGGATGA GAATGGAGTC TTGAAGCTTG CTGATTTTGG CTTGGCCAAA 480

GCGTTTGGAA GCCCAAACAG AGTGTATACA CATCAAGTTG TCACAAGATG GTATCGGGCT 540

CCAGAGCTGC TCTTTGGTGC CAGGATGTAT GGTGTAGGTG TGGACATGTG GGCAGTTGGC 600

TGCATTCTTG CTGAGCTTTT ACTCCGGGTG CCATTTTTAG CTGGAGATTC AGACTTGGAT 660

CAGCTGACGA AGATATTTGA AGCTTTGGGA ACACCAACAG ATGAGATCTG GCCTGGGATG 720

TCGAGTCTCC CAGACTATGT GTCATTTAAG CCATTTCCTG GCACTCCACT GGAGCACATC 780

TTCAGTGCTG CCGGCGATGA CCTGCTGGAG CTTCTGAGGG GGTTATTCAC CTATAACCCC 840

TGCTCACGCA CCACAGCTAT GCAGGCTTTG AAAATGAAGT ATTTCAGCAA TAGACCAGGA 900

CCAACCCCAG GCCCTCAACT ACCCAGACCA AACTCCTCAA CAGAAGCCCT GAAAGAGAAA 960

GAAAACCTGC TGATAGGAAT CAAGAGGAAA CGTGACAGTA TTGAACAGGG TACCCTTAAA 1020

AAGAAGCTGG TGTTTTAA 1038

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki++ +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKTTNTIVAIKKIKVGHRTEakdGINRTALREIKLLQELSH  71

         99********************************98765555******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+++e+dL+ ++k+++   l+++++k ++l+ l+gl+y+H

Q: 72    PNIIGLLDAFG-HKSNISLVFDYMETDLEVIIKDTSL-VLTPANIKAYILMTLQGLEYMH  129

         ***********.99***********************.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla+af+sp++ yt++vvT+wYraPelL+ga+

Q: 130   NHWILHRDLKPNNLLLDENGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p++ g+s+ dql++if+ lgtp++++wp++s+lp+y  s

Q: 190   YGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPTDEIWPGMSSLPDYV-S  248

         *********************************************************8.*

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ + + l++ ++++ ++ l+ll+ l++++p +R++a +al+ kyf

Q: 249   FKPFPGTPLEHIFSAAGDDLLELLRGLFTYNPCSRTTAMQALKMKYF  295

         **************999*****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KTTNTIVAIK KIKVGHRTEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DYMETDLEVI IKDTSLVLTP ANIKAYILMT LQGLEYMHNH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKA FGSPNRVYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLAGDSDLDQ LTKIFEALGT PTDEIWPGMS SLPDYVSFKP 240

FPGTPLEHIF SAAGDDLLEL LRGLFTYNPC SRTTAMQALK MKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:405897

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013