EKS-DAR-00773

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00773

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	345.3	5.6E-103	1223	1481	259

Status

Unreviewed

Ensembl Protein

ENSDARP00000069816

UniProt Accession

F1Q852;

Protein Name

Protein Synonyms/Alias

Gene Name

map3k4

Gene Synonyms/Alias

map3k4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000053303	ENSDARP00000069816	ENSDART00000075333

Organism

Danio rerio

Functional Description

Protein Length

1488

Protein Sequence
(FASTA)

ETLYCTSPPQ TPRQIKRLSI KHQRSNPGSK GKGSEKLRDP LSQREREGAR SAEPPEEHSY 60

KQEKKQRFNQ RSSERDVKKK FEGAFMLDPV SKSSTIGSRN MDPRKPYLSL GMIPVRTHRQ 120

TSRTDCPADR LKFFETLRLL LKLTSMSSKK KEKEQRGLEN TAYMEQNNEV IWLELQAWHA 180

RRSVNDQDLY LFTARQHIPD IISEVLHFKV DYSSLCGLES GASVEEIDAA APFSSGLECR 240

NHLQRQRVAF DQVKRVMSLL ESVEALYPSL QTLQKDYEKY AARDFQGRVQ ALCLWLNITQ 300

DLNQKLRVMG TVLGLRDLSR IGWPIFEIPS PRCSRGNEDD EVDEDESEST TTFTAENDGE 360

ERTLSEATSD GEQSACSPPN FSRLMSEEEF LPRDNETCYC PTAIYRPFVD KALKQMGLRK 420

LILRLHKLMD RSLQRARTAL LSHMPAQELP AVPGYSLQHS DYLPELSRHF SGPVEEEAES 480

GRVSWQELMD MDLPSFRPAF LVLCRVLLNV IHECLKLRLE QRPAGEPSLL SIKQLVRECK 540

EVLKGGLLMK QYYQFMLRGV VTDHQGLQTN ANIDEFEEDL HKMLEVYFDY MRSWIQMLQQ 600

LPQASHSLKN LLEEEWNFTK VITPYIRGGE AQSGKLFCDI AGMLLKSTGE FLDAGLQKSG 660

NEFWECAEES TASDEIRRSV IETSRSLKEL FHEARERASK ALGFAKMLRK DLEIAAEEFS 720

LTSGVSSLLQ ALKNKNYVKV QIPGLEELQV FVPCDLTEQR LVILQLLNAA AGKDCSKDPD 780

EIPENEGYLL MSKHGVGDSN ADGAWAEWDG TVLKLVPQME TVDTLRAMKV DNLLLVVMQS 840

AHLVTQRKAF QQSMEELLSL SREQTSSQPL IVCALEQLKN EALQLCIKIN DAIDRVEYMF 900

MSEFEAEVEE AEKATLQQYY REAMIQGYNF AFEYHKEVVR LMSGEFRRRI GERYIAFARK 960

WMNFVLTKCE SGRGTRPRWA TQGFDFLQAI EAAFISALPE DDFVSLQALM NECIGHVIGK 1020

PHSPVSSMYF AGPRNSPRPV KVPRCHSDPP NPYLFIPSTQ AEGFSSRSLP CDLRTQLCVP 1080

GPRPTGEHGH ANKPSNDISD LLIEDPVSTG HENDRLSSVA AELQFKSLSR HSSPTEDREE 1140

PSYPKADPSS SARRSWELRN FISQSKDTAR QSPLEAVRRS IQTFDEKHYA LMRQRNIIGQ 1200

VCNTPKSYDN VMHVGLRKVT FKWQRGNKIG EGQYGKVYTC INVDTGELMA MKEIRFQPND 1260

HKTIKETADE LKIFEGIKHP NLVRYFGVEL HREEMYIFME YCDEGTLEEV SRLGLQEHVI 1320

RLYSKQITTA INVLHEHGIV HRDIKGANIF LTSSGLIKLG DFGCSVKLKN NAQTMPGEVN 1380

STLGTAAYMA PEVITRAKGE GHGRAADIWS LGCVLIEMVT GKRPWHEYEH NFQIMYRVGM 1440

GHKPPIPEKL STEGKDFLAH CLESEPKRRW TASALLDHPF VKVCTDEE 1488

Nucleotide Sequence
(FASTA)

GAGACTCTCT ACTGCACCTC CCCTCCCCAA ACTCCTCGCC AGATAAAACG TTTGTCCATC 60

AAACACCAGA GAAGCAACCC GGGGTCAAAG GGCAAAGGAT CAGAGAAGTT ACGAGACCCC 120

TTGTCTCAGC GTGAGCGTGA GGGAGCCAGA TCAGCCGAAC CTCCTGAAGA GCACAGCTAC 180

AAGCAGGAAA AGAAGCAGCG CTTCAACCAG CGATCCAGCG AGCGGGACGT CAAGAAGAAG 240

TTTGAAGGCG CCTTTATGCT GGATCCTGTT TCCAAGTCCA GTACCATCGG CTCCAGAAAC 300

ATGGATCCCC GCAAGCCCTA CCTGAGTCTG GGCATGATCC CCGTTCGCAC CCATCGGCAA 360

ACTTCGCGCA CAGACTGTCC TGCAGACCGC CTTAAGTTCT TCGAGACCCT GCGGTTGCTG 420

CTTAAACTCA CCTCCATGTC ATCCAAGAAG AAGGAGAAGG AGCAGCGAGG TCTGGAGAAC 480

ACCGCTTATA TGGAGCAGAA CAACGAGGTC ATCTGGCTGG AGCTGCAGGC CTGGCACGCT 540

CGCCGTAGTG TTAATGACCA GGACCTGTAC CTGTTCACCG CTCGACAACA CATACCTGAC 600

ATCATCAGCG AGGTTTTGCA CTTCAAAGTG GACTACAGTA GCCTGTGTGG ACTCGAGAGT 660

GGCGCCTCTG TTGAGGAAAT TGATGCCGCT GCTCCTTTTT CTTCAGGGCT GGAGTGCCGC 720

AACCACCTGC AAAGGCAGCG AGTAGCTTTC GATCAGGTAA AACGGGTCAT GTCGCTGTTA 780

GAGTCGGTGG AGGCTTTGTA CCCTTCTCTG CAAACCTTGC AGAAGGACTA TGAGAAGTAT 840

GCAGCTCGGG ACTTCCAGGG CAGGGTGCAG GCGCTCTGCT TATGGCTCAA CATCACTCAG 900

GACCTGAACC AGAAACTGCG CGTGATGGGC ACCGTGCTGG GCCTCAGGGA CCTTTCCCGC 960

ATCGGCTGGC CCATCTTTGA GATTCCATCA CCTCGCTGCT CTCGAGGCAA TGAGGATGAT 1020

GAGGTGGATG AGGATGAATC AGAGTCCACC ACTACCTTTA CTGCCGAAAA CGATGGGGAA 1080

GAAAGGACTT TAAGTGAGGC AACCAGTGAC GGTGAGCAGT CGGCCTGCTC CCCGCCAAAT 1140

TTTTCACGCC TTATGTCAGA GGAGGAGTTC CTCCCTCGGG ACAACGAGAC CTGCTACTGT 1200

CCTACTGCCA TATACAGGCC GTTTGTGGAT AAGGCACTTA AACAGATGGG ACTGCGTAAA 1260

TTGATCCTCA GACTGCACAA GCTGATGGAC CGCTCTCTGC AGAGGGCCAG AACTGCTCTG 1320

TTGAGTCACA TGCCAGCTCA AGAGTTGCCA GCGGTCCCGG GTTATTCTTT GCAGCACTCT 1380

GACTACCTTC CAGAGCTTTC TCGTCACTTT TCCGGTCCAG TAGAAGAGGA GGCAGAGTCG 1440

GGACGGGTAT CATGGCAGGA GCTGATGGAC ATGGACCTGC CCTCATTCCG ACCAGCTTTC 1500

CTGGTGCTTT GCCGTGTGCT GCTAAACGTT ATTCACGAGT GCCTCAAACT GCGCCTTGAG 1560

CAAAGGCCTG CAGGAGAACC ATCCCTGCTC AGCATCAAAC AGTTGGTGCG CGAGTGTAAA 1620

GAGGTTCTTA AAGGAGGGCT CCTAATGAAA CAGTACTACC AGTTCATGCT GCGTGGCGTC 1680

GTCACTGACC ATCAGGGGCT GCAGACCAAT GCCAACATTG ACGAGTTTGA GGAGGATCTC 1740

CATAAAATGC TGGAGGTGTA CTTTGACTAC ATGCGCAGCT GGATCCAGAT GTTACAGCAG 1800

CTTCCTCAAG CATCCCACAG CCTGAAGAAC CTGCTGGAGG AGGAATGGAA CTTTACCAAA 1860

GTCATCACTC CATACATCCG AGGCGGAGAA GCCCAGTCTG GGAAGCTCTT CTGTGACATT 1920

GCTGGCATGC TGCTAAAGTC CACTGGAGAG TTTCTGGATG CTGGCCTTCA GAAGAGTGGC 1980

AATGAGTTCT GGGAGTGTGC AGAAGAGAGC ACCGCTTCAG ATGAGATCAG GCGTTCAGTG 2040

ATTGAGACGA GTCGTTCGCT CAAAGAGCTC TTTCATGAAG CTAGAGAAAG AGCATCTAAA 2100

GCGCTGGGCT TTGCCAAGAT GCTGCGTAAG GATCTGGAGA TTGCTGCTGA AGAATTCAGC 2160

TTGACCAGTG GAGTTTCTTC TCTCCTCCAA GCACTGAAGA ACAAGAATTA CGTCAAAGTC 2220

CAGATCCCAG GACTGGAGGA GCTGCAGGTG TTTGTCCCGT GTGATCTGAC GGAGCAGCGG 2280

CTGGTCATCT TGCAGCTGTT GAATGCAGCA GCTGGAAAGG ACTGCTCTAA AGACCCAGAT 2340

GAGATCCCAG AAAACGAGGG CTATCTGCTG ATGAGCAAAC ACGGGGTTGG GGACTCGAAC 2400

GCTGATGGAG CTTGGGCTGA ATGGGACGGC ACAGTGCTCA AACTGGTGCC GCAGATGGAG 2460

ACGGTGGACA CATTAAGGGC CATGAAGGTG GACAATCTGT TGCTGGTGGT GATGCAGTCG 2520

GCTCATTTGG TAACCCAACG CAAAGCTTTC CAGCAATCTA TGGAGGAACT TCTCTCCCTC 2580

AGCCGAGAGC AGACATCTAG CCAGCCGCTC ATTGTCTGCG CTCTGGAGCA ACTCAAGAAT 2640

GAAGCTCTCC AACTGTGCAT CAAGATCAAC GATGCGATTG ATCGTGTGGA GTACATGTTC 2700

ATGTCCGAGT TTGAGGCTGA GGTGGAGGAG GCGGAGAAGG CCACGCTGCA GCAGTATTAC 2760

AGAGAGGCCA TGATCCAGGG ATACAACTTT GCTTTCGAGT ACCATAAAGA GGTTGTGCGG 2820

TTGATGTCCG GGGAGTTCAG ACGAAGGATA GGAGAGCGTT ACATCGCTTT TGCCCGCAAG 2880

TGGATGAACT TTGTCCTCAC AAAGTGTGAA AGCGGAAGAG GCACTCGTCC AAGGTGGGCG 2940

ACGCAGGGCT TTGATTTTCT TCAAGCGATC GAGGCTGCGT TTATATCAGC CCTGCCAGAA 3000

GATGATTTTG TGAGTCTTCA AGCTCTCATG AATGAGTGTA TTGGGCATGT TATTGGCAAA 3060

CCACACAGTC CAGTCAGCAG TATGTACTTT GCAGGCCCAC GAAACAGCCC TCGACCTGTG 3120

AAAGTCCCCC GCTGTCACAG CGATCCTCCA AACCCGTACC TCTTCATCCC TTCCACCCAA 3180

GCAGAGGGTT TCAGCTCTCG GAGTCTGCCC TGTGATCTGC GTACCCAGTT GTGTGTCCCA 3240

GGTCCCCGTC CCACAGGGGA ACACGGCCAC GCCAACAAAC CCTCGAATGA CATCAGTGAT 3300

TTGCTCATCG AGGATCCAGT CTCCACTGGA CATGAGAATG ACCGTCTGTC GTCTGTGGCT 3360

GCGGAGCTGC AGTTTAAATC CCTCAGTCGA CACTCCAGCC CAACGGAGGA CAGGGAAGAG 3420

CCGTCGTATC CCAAAGCAGA CCCCAGCAGT TCAGCCCGTC GCAGCTGGGA GCTTCGCAAC 3480

TTCATCAGCC AGTCTAAAGA CACAGCGCGT CAGAGCCCCC TGGAGGCAGT GCGGCGCTCC 3540

ATACAAACCT TCGATGAGAA ACACTATGCG CTTATGAGAC AGAGAAACAT CATTGGACAG 3600

GTTTGCAACA CGCCGAAGTC CTACGATAAC GTGATGCATG TGGGCCTGCG CAAAGTCACC 3660

TTTAAATGGC AGAGAGGAAA CAAGATCGGT GAAGGGCAGT ATGGGAAGGT TTACACATGC 3720

ATCAATGTGG ACACTGGTGA ACTAATGGCC ATGAAGGAGA TTCGCTTTCA GCCTAATGAC 3780

CACAAAACCA TCAAGGAAAC GGCCGATGAG CTGAAGATCT TCGAAGGAAT CAAACATCCC 3840

AACCTCGTCC GCTACTTCGG TGTTGAGTTG CACAGGGAGG AGATGTACAT CTTCATGGAG 3900

TACTGTGATG AAGGCACGCT GGAGGAAGTG TCCCGTCTGG GCCTCCAGGA ACACGTCATT 3960

CGCCTCTACA GCAAACAGAT CACCACGGCC ATCAATGTCC TGCATGAACA CGGCATCGTC 4020

CACCGAGACA TTAAAGGAGC GAATATCTTC CTCACGTCTT CGGGTCTGAT AAAGCTGGGG 4080

GATTTTGGCT GCTCAGTGAA GCTGAAAAAC AACGCTCAGA CGATGCCTGG AGAGGTGAAC 4140

AGCACTCTGG GAACAGCAGC ATACATGGCT CCTGAGGTGA TCACCAGAGC GAAGGGTGAA 4200

GGTCACGGTC GAGCTGCTGA TATCTGGAGT CTCGGTTGTG TTCTCATAGA AATGGTCACT 4260

GGAAAGAGAC CTTGGCACGA GTACGAGCAT AACTTCCAGA TCATGTATAG AGTGGGAATG 4320

GGCCACAAAC CGCCCATTCC TGAAAAGCTG AGCACAGAGG GGAAGGATTT TCTGGCTCAC 4380

TGTCTGGAGA GCGAACCCAA GCGGCGCTGG ACCGCCAGTG CCCTGCTGGA CCACCCTTTT 4440

GTCAAGGTCT GCACAGATGA AGAGTGA 4467

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1223  WQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1279

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi +++++LHe+

Q: 1280  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITTAINVLHEH  1337

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1338  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1397

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcv+iem+tgkrP++e++++++im++vg+ + kP+ipekls+egkd

Q: 1398  KGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGH-KPPIPEKLSTEGKD  1456

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +cle++pk+r++a+ LL+h+f+

Q: 1457  FLAHCLESEPKRRWTASALLDHPFV  1481

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIN VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITTAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVLIEMVTGK RPWHEYEHNF QIMYRVGMGH KPPIPEKLST EGKDFLAHCL 240

ESEPKRRWTA SALLDHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013