EKS-DAR-00456

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00456

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	476.6	3.4E-143	459	717	259

Status

Unreviewed

Ensembl Protein

ENSDARP00000071397

UniProt Accession

A2AVJ3;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

prkg2

Gene Synonyms/Alias

prkg2; DKEY-18E17.2-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000054741	ENSDARP00000071397	ENSDART00000076929

Organism

Danio rerio

Functional Description

Protein Length

768

Protein Sequence
(FASTA)

MGNGSMKLNP LKQVSGSAKS KNNGESSLVP QVLRVRVEEL ETHLKKKDED LNAKELQIKH 60

LEEQLAQQKQ TLSEISDTLR SKCLQLNKLQ DALKSQGELG LLPSPLKEKV SQGLTGLLRE 120

TLNRRKGAKA GVSAEPSSRT YDSSGIPKFY FESARVWKEQ SVKKLLTDAL NKNQYLRRLE 180

VQQVKDMVEC MYERTYQQGE YVIKQGEPGN HLFVLADGKL DVYQHNKLLT SIAVWTTFGE 240

LAILYNCTRT ASVKAASNVK TWALDREVFH NIMRMTAEAR HEQYRNFLRS VSLLASLPGD 300

KLTKIVDCLE EYYNKGDYII REGEEGNTFY IIANGKIKVT QSTQDHEEPQ IINTLGKGDY 360

FGEKALISDD VRSANIIAEE DGVECLVIDR ETFSQTVGTF DELKKYLQSY VDSLARDDKK 420

RNAKRSGSCT PPNTPVSHDM IELKERESSF ASTIPFTCLE AIATLGVGGF GRVELVKLKN 480

ENVTFALKCI KKRHIVDNRQ EEHIYSERRI LLETNCPFIV KMYRTYKDNK YVYMLLEACL 540

GGEIWSLLRD RGSFEEYTAK FCVGCVTEAF DYLHNNGIIY RDLKPENLML DTDGYVKLVD 600

FGFAKKLKCG QRTWTFCGTP EYVAPEIILN KGHGLSVDFW SLGILIFELL TGSPPFTGSD 660

QMIIYTFILK GIEKMDFPKK ITKRPGDLIR KLCRQNPSER LGNLKNGITD IKKHRWFTGF 720

SWSGLKARNL ISPLKREVKG PTDHSYFDSY PPEEEIPPDE MSGWDTDF 768

Nucleotide Sequence
(FASTA)

ATGGGAAATG GCTCGATGAA GCTGAACCCT CTAAAGCAGG TCAGTGGATC GGCCAAATCC 60

AAAAACAATG GAGAATCAAG CTTGGTCCCT CAAGTCCTCA GAGTACGTGT GGAAGAATTA 120

GAGACTCATC TGAAGAAGAA GGATGAAGAC CTGAATGCCA AAGAGCTTCA GATCAAGCAT 180

CTGGAGGAGC AGCTGGCCCA GCAGAAGCAG ACCCTCTCTG AGATCTCTGA CACGTTAAGG 240

AGCAAGTGTC TCCAGCTCAA CAAGCTTCAG GACGCTCTGA AGAGTCAAGG GGAGCTGGGC 300

CTCCTGCCCT CACCCCTCAA GGAGAAAGTC AGTCAAGGTC TCACAGGCCT GCTCAGAGAA 360

ACACTCAACA GGAGAAAAGG AGCAAAAGCT GGAGTATCAG CAGAGCCTTC ATCCAGAACG 420

TATGATTCCA GTGGGATTCC AAAGTTCTAC TTCGAGAGCG CACGAGTCTG GAAAGAGCAG 480

AGTGTAAAGA AGCTCCTGAC AGATGCTCTG AATAAGAACC AGTATCTGAG GAGACTGGAA 540

GTGCAGCAGG TCAAAGACAT GGTCGAATGT ATGTATGAAC GGACCTACCA GCAGGGAGAG 600

TATGTCATCA AACAAGGAGA GCCTGGAAAC CACTTGTTTG TGCTTGCAGA TGGCAAGCTG 660

GACGTCTATC AGCACAACAA ACTGCTCACA TCAATAGCAG TCTGGACCAC GTTTGGTGAA 720

CTGGCCATCT TGTACAATTG CACCAGGACT GCATCAGTCA AAGCGGCCAG CAATGTGAAG 780

ACATGGGCTC TGGATCGAGA AGTCTTCCAC AACATCATGC GCATGACTGC CGAGGCTCGA 840

CACGAGCAAT ACCGCAACTT CCTGAGAAGT GTTTCACTTC TTGCCAGTCT TCCTGGGGAC 900

AAGCTAACAA AGATTGTGGA CTGCTTAGAG GAGTATTATA ATAAAGGAGA TTACATCATC 960

CGGGAGGGAG AGGAAGGAAA CACCTTTTAT ATAATTGCCA ATGGAAAGAT TAAAGTCACA 1020

CAGAGCACAC AGGATCATGA AGAGCCTCAG ATCATCAACA CCTTGGGGAA GGGGGATTAT 1080

TTCGGAGAGA AGGCCCTCAT CAGTGATGAT GTGAGATCTG CAAATATAAT CGCAGAAGAG 1140

GATGGTGTGG AGTGCCTTGT GATCGATCGA GAAACTTTCA GTCAGACTGT TGGAACTTTT 1200

GACGAGCTTA AGAAGTATCT TCAGAGCTAT GTCGATAGTT TGGCACGAGA TGATAAGAAA 1260

AGAAATGCTA AGAGGTCAGG AAGCTGCACT CCACCCAACA CACCAGTGTC ACATGACATG 1320

ATCGAGCTAA AGGAGAGAGA GAGCAGCTTT GCATCCACTA TACCCTTCAC CTGCCTTGAG 1380

GCTATTGCCA CTCTGGGAGT CGGAGGCTTT GGCAGAGTTG AACTGGTGAA ACTGAAGAAT 1440

GAAAATGTGA CATTTGCTCT AAAATGCATC AAGAAACGGC ACATTGTGGA TAACAGACAA 1500

GAAGAGCACA TTTACTCTGA GAGGAGGATC TTGCTGGAGA CAAACTGTCC TTTCATTGTG 1560

AAAATGTATC GCACATACAA AGACAACAAG TATGTGTACA TGCTGCTGGA GGCCTGTCTG 1620

GGTGGAGAGA TTTGGAGTCT TCTGAGGGAC AGGGGGAGTT TTGAAGAGTA CACTGCAAAG 1680

TTCTGCGTGG GCTGTGTAAC AGAGGCTTTT GACTATCTGC ATAATAATGG CATCATATAC 1740

AGAGACCTAA AGCCTGAGAA TCTGATGCTG GACACAGATG GATACGTCAA GTTGGTGGAT 1800

TTTGGCTTTG CCAAGAAGCT GAAGTGTGGC CAGAGGACAT GGACATTCTG TGGGACTCCA 1860

GAGTATGTGG CGCCTGAGAT CATCCTCAAT AAAGGCCACG GGCTTAGTGT CGACTTCTGG 1920

TCTTTAGGAA TCCTGATATT TGAACTTCTT ACTGGAAGCC CGCCTTTTAC TGGCTCAGAT 1980

CAGATGATTA TATATACATT CATTCTGAAA GGAATTGAGA AGATGGACTT CCCGAAAAAG 2040

ATCACCAAGA GGCCAGGTGA CCTTATTCGA AAGCTGTGCA GACAAAACCC TTCAGAGCGA 2100

CTGGGCAACC TGAAGAATGG AATAACTGAT ATTAAAAAGC ACAGATGGTT TACAGGTTTT 2160

AGCTGGAGTG GTCTGAAAGC CCGAAATCTG ATATCACCAC TTAAAAGAGA GGTGAAGGGA 2220

CCCACTGACC ACAGTTACTT TGATAGTTAT CCTCCTGAAG AAGAAATCCC TCCAGATGAA 2280

ATGTCAGGCT GGGACACAGA CTTCTAA 2307

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+ iatlgvggfgrvelvk+k+ e+ +falk++kk+hivd++q+eh++se+ril e++++

Q: 459   LEAIATLGVGGFGRVELVKLKN-ENVTFALKCIKKRHIVDNRQEEHIYSERRILLETNCP  517

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivk+yrt+kd+kyvy+lleaclgge+w++lrdrgsf++ takf+v+cv+ea++ylh+++

Q: 518   FIVKMYRTYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNG  577

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld++gy+klvdfgfakklk g++twtfcgtpeyvapeiilnkgh lsv

Q: 578   IIYRDLKPENLMLDTDGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSV  637

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgil++elltg+ppf+g+d++ +y+ ilkgi+k+++p+kitk++ dli+klcr+np

Q: 638   DFWSLGILIFELLTGSPPFTGSDQMIIYTFILKGIEKMDFPKKITKRPGDLIRKLCRQNP  697

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+wf

Q: 698   SERLGNLKNGITDIKKHRWF  717

         *******************9

Domain Sequence
(FASTA)

LEAIATLGVG GFGRVELVKL KNENVTFALK CIKKRHIVDN RQEEHIYSER RILLETNCPF 60

IVKMYRTYKD NKYVYMLLEA CLGGEIWSLL RDRGSFEEYT AKFCVGCVTE AFDYLHNNGI 120

IYRDLKPENL MLDTDGYVKL VDFGFAKKLK CGQRTWTFCG TPEYVAPEII LNKGHGLSVD 180

FWSLGILIFE LLTGSPPFTG SDQMIIYTFI LKGIEKMDFP KKITKRPGDL IRKLCRQNPS 240

ERLGNLKNGI TDIKKHRWF 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

dre:100125912

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013