EKS-DAR-00629

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00629

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	362.6	3.0E-108	234	530	297

Status

Unreviewed

Ensembl Protein

ENSDARP00000071913

UniProt Accession

F1QAH4;

Protein Name

Protein Synonyms/Alias

Gene Name

si:dkey-101k6.5

Gene Synonyms/Alias

si:dkey-101k6.5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000055136	ENSDARP00000071913	ENSDART00000077446
ENSDARG00000055136	ENSDARP00000120717	ENSDART00000131738

Organism

Danio rerio

Functional Description

Protein Length

590

Protein Sequence
(FASTA)

MGLWTRTSAL LCCFCLLQVQ SLSPIKTNLC KWCDHSSPVC EDNVCMSNCS LTSYCFLAEE 60

VCVAIWKKDN VSVSVRTLCY DPQHMLENIM LANYSSKECL MSPHPSEDGL LFICSCVGDQ 120

ECNDRLIFDK GPNGFSKLKS KDVIPVVVIS LVPPLLVAVI ATMAFYLYRT RQPGKKPKEW 180

GPRRTHYQSL DPAEGQANGI DFSAKRPSLS DDINSEMSST CANNLNHNTE QLPIQLEALV 240

GKGRFAEVWR ARLSHNESGQ YETVAVKIFP AVEYSSWCNE RAIFSDANLK HENVVQFLTA 300

EERGGTSATS QRQYWLIMAY YNMGNLQDFL VGNILTWAEL CSLAGSVARG LAHLHSDTTP 360

CGIQKVPIAH RDLKSSNIVL KNQSECVLCD FGLALRLDLS LTVDDFANSG QVGTARYMAP 420

EVLESRVNLE DLESFKQIDI YSMALVMWEM VSRCDVIGEV KSYEPPFGSK VCEQPCVDSM 480

RDLVLRDRGR PDIPDSWTTH SGMQLLCATI TECWDHDPEA RLTAHCVVER FNTLAQEELE 540

NSICTHTPST PPTEDQTPTL PSHPPCTDHS ADICPHVTAD IVSSRQHSQV 590

Nucleotide Sequence
(FASTA)

ATGGGTCTGT GGACTCGAAC ATCTGCTCTT CTGTGCTGCT TCTGTCTTCT GCAGGTGCAG 60

AGTTTAAGCC CCATAAAGAC CAACCTGTGT AAGTGGTGTG ATCACTCCAG TCCTGTGTGT 120

GAAGACAACG TCTGCATGAG CAACTGCAGT CTGACCTCTT ACTGCTTTCT GGCTGAAGAA 180

GTGTGTGTAG CCATATGGAA GAAGGACAAT GTGAGCGTGA GTGTGCGGAC GCTGTGTTAT 240

GACCCCCAGC ATATGCTGGA GAACATAATG CTGGCGAATT ACTCGTCCAA GGAGTGTCTG 300

ATGAGCCCTC ATCCATCTGA AGATGGCCTG CTCTTCATCT GCAGTTGTGT TGGAGATCAG 360

GAGTGTAACG ACAGGCTCAT CTTTGATAAA GGACCCAATG GATTCTCAAA GCTGAAGTCT 420

AAAGACGTGA TTCCAGTCGT GGTCATAAGC CTGGTTCCTC CCCTCTTAGT AGCGGTCATT 480

GCGACCATGG CTTTTTACCT GTATCGCACA CGTCAGCCAG GCAAAAAGCC CAAGGAATGG 540

GGACCACGAC GGACCCACTA CCAGTCTCTT GATCCTGCCG AGGGCCAAGC TAATGGCATC 600

GACTTTAGTG CCAAGCGGCC ATCCCTCAGC GATGACATCA ATTCAGAAAT GTCATCGACT 660

TGTGCCAATA ATCTAAACCA CAACACGGAG CAGCTGCCCA TCCAGCTGGA GGCGCTGGTG 720

GGTAAAGGGC GCTTCGCGGA GGTATGGCGG GCACGACTTA GTCATAATGA AAGCGGGCAG 780

TATGAAACGG TGGCTGTGAA GATTTTTCCA GCAGTGGAGT ATTCATCGTG GTGTAACGAA 840

AGAGCCATAT TCTCTGATGC CAACTTGAAA CATGAGAACG TGGTGCAGTT TCTGACGGCT 900

GAGGAGCGGG GCGGTACGTC TGCCACCTCC CAGAGGCAAT ACTGGCTCAT CATGGCTTAT 960

TATAACATGG GCAACCTTCA AGACTTTCTG GTTGGGAATA TTCTGACATG GGCAGAGTTG 1020

TGTTCACTAG CAGGCTCTGT GGCAAGAGGA CTGGCGCACC TGCACAGTGA CACGACGCCA 1080

TGTGGCATAC AAAAAGTGCC CATCGCCCAT CGAGATCTGA AGAGCAGCAA CATTGTGTTG 1140

AAGAACCAAA GCGAATGCGT GCTCTGTGAT TTCGGCCTGG CTCTGCGACT TGACCTGTCT 1200

CTCACTGTAG ATGATTTCGC CAACAGTGGA CAGGTGGGAA CTGCCCGCTA TATGGCCCCA 1260

GAAGTTCTGG AGTCCAGGGT GAATCTCGAG GACCTGGAGT CCTTTAAACA GATTGATATC 1320

TACTCCATGG CTCTAGTGAT GTGGGAAATG GTCTCTAGGT GTGACGTCAT AGGAGAGGTA 1380

AAGAGTTACG AACCTCCATT TGGCTCCAAA GTGTGTGAGC AGCCGTGTGT GGACAGCATG 1440

AGAGACCTGG TGTTGAGAGA CCGAGGAAGA CCAGATATTC CAGACAGCTG GACCACACAT 1500

TCAGGCATGC AGTTGTTGTG CGCGACTATA ACGGAGTGCT GGGATCACGA CCCGGAGGCT 1560

CGACTGACGG CTCACTGCGT GGTGGAGCGC TTTAACACTC TGGCTCAGGA AGAGCTGGAG 1620

AACTCCATCT GCACCCACAC ACCCTCAACA CCACCTACAG AAGACCAAAC CCCGACCCTG 1680

CCCTCTCACC CACCCTGCAC AGACCACAGC GCTGACATCT GTCCGCACGT CACAGCTGAC 1740

ATCGTTTCCT CCAGGCAACA TAGTCAAGTT TAA 1773

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l  l+gkGr++eVw+a+l++      e+vAvKif++ + +sw +E++i++  +l+hen

Q: 234   IQLEALVGKGRFAEVWRARLSHnesgqyETVAVKIFPAVEYSSWCNERAIFSDANLKHEN  293

         688999**************988999999*******************************

S: 55    ilqfiaadk...keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlah  111

         ++qf++a++   +++ s+ +++l+++y+++g+L+d+L  ++l++ el+ la s+a+Glah

Q: 294   VVQFLTAEErggTSATSQRQYWLIMAYYNMGNLQDFLVGNILTWAELCSLAGSVARGLAH  353

         ********964345567789****************************************

S: 112   LHeeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqv  171

         LH++ ++ +g +K  iaHRDlks Ni++k++  c+++D+GLal+l+ + ++ d a++ qv

Q: 354   LHSD-TTPCGIQKVPIAHRDLKSSNIVLKNQSECVLCDFGLALRLDLSLTVDDFANSGQV  412

         ****.67889**************************************************

S: 172   GtkRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevv  231

         Gt RYmaPEvle+++nl+d+e+fk++D+Ys++Lv+WE++sRc+   +ev+ y++pf ++v

Q: 413   GTARYMAPEVLESRVNLEDLESFKQIDIYSMALVMWEMVSRCDV-IGEVKSYEPPFGSKV  471

         *******************************************9.999************

S: 232   gsdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

          ++P++++m+++v++++ rP ip++w++++ ++ l+ +++ecWd+dpeaRlta++v +r

Q: 472   CEQPCVDSMRDLVLRDRGRPDIPDSWTTHSGMQLLCATITECWDHDPEARLTAHCVVER  530

         ********************************************************887

Domain Sequence
(FASTA)

IQLEALVGKG RFAEVWRARL SHNESGQYET VAVKIFPAVE YSSWCNERAI FSDANLKHEN 60

VVQFLTAEER GGTSATSQRQ YWLIMAYYNM GNLQDFLVGN ILTWAELCSL AGSVARGLAH 120

LHSDTTPCGI QKVPIAHRDL KSSNIVLKNQ SECVLCDFGL ALRLDLSLTV DDFANSGQVG 180

TARYMAPEVL ESRVNLEDLE SFKQIDIYSM ALVMWEMVSR CDVIGEVKSY EPPFGSKVCE 240

QPCVDSMRDL VLRDRGRPDI PDSWTTHSGM QLLCATITEC WDHDPEARLT AHCVVER 297

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013