EKS-DAR-00758
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00758
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK335.83.5E-100167423257
StatusUnreviewed
Ensembl ProteinENSDARP00000082742
UniProt AccessionF1Q5J2;
Protein Name
Protein Synonyms/Alias
Gene Namemap3k10
Gene Synonyms/Alias map3k10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000055672ENSDARP00000121631ENSDART00000136432
ENSDARG00000055672ENSDARP00000082742ENSDART00000088309
OrganismDanio rerio
Functional Description
Protein Length1062
Protein Sequence
(FASTA)
MDPHTRLSGV GAGGGGSAAP LPCISSGGSC GHLVPPDTQA NTNSTPFLIS INSSRNSSTI 60
PSSVGSPDSH LPHHHESSNT YWTAVFDYEA TADEELTLRR GDLLEVLSKD SKVSGDEGWW 120
TGKIQDKVGI FPCNYVTQRD SSYPALPPEA LVGGDSPLEI DFLELRLEEV IGAGGFGKVY 180
KGVWRAEEVA VKAARQDPDE DISATAENVR QEARLFWMLR HRNIIALRGV CLREPNLCLV 240
MEYARGGALN RALAGKKVPP RVLVNWAVQI ATGMDYLHNQ TFVPIIHRDL KSSNILILEP 300
VERDDLSGKT LKITDFGLAR EWHRTTKMSA AGTYAWMAPE VIKLSLFSKS SDVWSFGVLL 360
WELLTGEVPY REIDALAVAY GVAMNKLTLP IPSTCPEAFA QLLGECWCPN PRGRPAFGSI 420
LKRLEDIEQS AMFQMPLESF HSLQEDWRLE IQQMFDELRA KEKELRSWEE ALARAAEEQR 480
EQEEHLRRRE QELAEREIDI VERELNIIIH QMYQEKPQVK KRKGNFKKSR LLKLGRDSNC 540
ISLPSGFEHK ITVQASPSVD KRKCQSSEST TPPASPGVIP RLRAFRLTPS DGRKTWGRTA 600
VCKKEEPGTK KKGRTWGPSS THQRERVGGE DRLKSLGEGK VWSSSAPNLG KSPKHAPMTA 660
GFSSLNEMEE HCEFDDSSPG RLAPDLGSNG ALEDVGSGSA GLGSGIGSQD SVCRCSQRKK 720
SDLLLLGCAS LLAVVGLGSD ILQLGRQQMN QDEQDVREEQ RKKKEGLFQR TGRFRRSTSP 780
PSRTLSLSLS HNRHHDSILP SMDPSPSVTL LSLSSLSDCN STKSLLPSDP DDFAPTPSNA 840
PPVVSPAPAL NPLLDLRAES FKREPNQSLT PTHVSATMAL NRGHRRTPSD GAIRPRAQTV 900
VGHRRTPSDG SMPFPPAHAP TITPYTGSRE TLDIPRLPDP SMMFPSALRR KPAPPIPTPE 960
PDSYTGTLER PKTLEFAPRP RPTPARARPD PWKLSSLSQT LSSSPGSSCD SPLGSGDSGV 1020
SAGTGGVHQS LLDMDMEGQS QDSTVPLCGQ RAKATLCAQH SS 1062
Nucleotide Sequence
(FASTA)
ATGGATCCAC ATACGAGGCT GAGTGGAGTA GGAGCTGGAG GTGGTGGCAG TGCTGCCCCA 60
CTACCTTGCA TCAGCAGTGG GGGGTCCTGT GGACACCTGG TTCCCCCTGA TACTCAAGCA 120
AATACAAATT CAACACCTTT CCTGATAAGC ATCAACAGCA GCCGGAACTC CTCTACTATT 180
CCCTCCTCAG TGGGCTCCCC AGATTCCCAC CTACCCCATC ATCATGAAAG CAGCAACACA 240
TACTGGACCG CTGTCTTCGA TTATGAGGCT ACAGCAGACG AGGAGCTGAC CTTGCGGCGT 300
GGCGACCTAC TGGAGGTGCT GTCCAAAGAC TCCAAAGTGT CTGGAGATGA GGGATGGTGG 360
ACTGGAAAGA TCCAAGACAA GGTGGGCATA TTCCCTTGTA ATTATGTAAC CCAACGGGAT 420
TCCAGCTATC CAGCGTTACC ACCGGAAGCT CTGGTTGGTG GAGATTCACC ACTGGAAATT 480
GATTTCTTAG AGCTGCGATT GGAGGAAGTG ATTGGTGCTG GCGGCTTTGG AAAGGTGTAT 540
AAGGGTGTAT GGCGAGCTGA GGAAGTGGCT GTCAAAGCAG CTCGTCAGGA CCCAGATGAG 600
GACATCAGTG CCACGGCAGA GAATGTGAGG CAGGAGGCCA GACTCTTCTG GATGCTGCGT 660
CACCGCAACA TCATCGCTCT ACGAGGTGTT TGTCTGCGGG AGCCAAATCT TTGCCTTGTT 720
ATGGAATATG CCCGTGGTGG GGCGCTTAAC CGGGCACTTG CTGGCAAGAA GGTGCCTCCT 780
CGGGTACTGG TGAATTGGGC TGTGCAGATT GCAACTGGAA TGGACTACTT GCACAACCAG 840
ACCTTTGTGC CAATCATCCA TCGAGACCTC AAATCCAGCA ACATTCTGAT TCTGGAGCCT 900
GTGGAGAGAG ATGACCTGAG TGGAAAGACA CTGAAGATCA CAGACTTTGG TCTTGCTCGA 960
GAATGGCATC GCACCACCAA GATGAGCGCA GCGGGCACGT ATGCCTGGAT GGCTCCAGAG 1020
GTCATCAAGC TCTCCCTGTT CTCCAAAAGC AGCGATGTGT GGAGTTTTGG AGTGTTATTG 1080
TGGGAGCTGC TGACTGGTGA AGTGCCATAC CGTGAGATCG ACGCTTTGGC TGTGGCCTAT 1140
GGAGTTGCCA TGAACAAGTT GACTCTTCCC ATCCCCTCCA CCTGCCCTGA AGCCTTTGCC 1200
CAGCTGCTGG GAGAGTGTTG GTGTCCTAAC CCACGTGGAC GACCTGCTTT TGGGAGTATC 1260
CTGAAGAGGC TGGAGGACAT CGAGCAGTCG GCCATGTTCC AGATGCCCCT GGAGTCTTTC 1320
CATTCCCTGC AGGAGGACTG GAGGCTGGAG ATTCAGCAAA TGTTTGATGA ACTACGAGCA 1380
AAGGAGAAGG AGTTGCGATC CTGGGAGGAA GCTCTGGCCC GGGCAGCGGA GGAGCAGAGG 1440
GAGCAGGAGG AGCATCTGAG GAGACGCGAG CAGGAGTTAG CAGAGCGAGA GATCGACATA 1500
GTGGAGAGAG AGCTCAACAT CATCATCCAT CAGATGTACC AAGAGAAACC GCAGGTCAAA 1560
AAGCGCAAAG GCAACTTCAA AAAGAGCCGT CTGCTCAAGC TCGGCAGAGA CAGCAACTGC 1620
ATCAGTCTGC CATCTGGTTT TGAGCATAAG ATCACAGTGC AAGCTTCGCC CAGTGTGGAC 1680
AAGAGGAAAT GTCAGAGTAG TGAAAGCACC ACTCCTCCAG CCAGCCCAGG GGTCATTCCT 1740
CGCCTCAGAG CCTTTCGCTT GACACCCAGT GATGGGAGGA AGACGTGGGG CCGGACGGCA 1800
GTGTGTAAGA AAGAGGAGCC GGGGACCAAA AAGAAGGGCC GAACATGGGG TCCGAGCTCC 1860
ACACATCAGC GTGAGAGAGT CGGTGGAGAG GACAGGCTAA AGTCTCTTGG GGAGGGCAAA 1920
GTGTGGTCCT CCAGTGCTCC AAATCTGGGG AAGTCCCCAA AACATGCTCC TATGACAGCT 1980
GGATTCTCAA GCCTAAATGA AATGGAGGAG CACTGTGAGT TTGATGACAG TTCTCCAGGG 2040
CGCCTGGCTC CTGATCTGGG CAGTAACGGT GCGCTGGAAG ACGTGGGCTC GGGATCAGCA 2100
GGTTTAGGGT CAGGAATAGG CTCTCAGGAT TCAGTTTGCC GCTGCAGCCA GAGGAAGAAG 2160
AGTGACCTGC TGTTGCTGGG CTGTGCCTCT CTACTGGCCG TTGTGGGACT CGGTTCTGAC 2220
ATCCTCCAGT TGGGACGACA ACAGATGAAT CAAGATGAGC AGGACGTGCG AGAGGAGCAG 2280
CGCAAGAAAA AAGAGGGCCT GTTCCAGCGC ACGGGTCGAT TCAGACGCAG CACTTCTCCA 2340
CCCAGCCGCA CACTCTCCCT TTCCCTGTCC CACAACCGCC ATCACGACTC CATCTTGCCC 2400
AGCATGGACC CGTCTCCATC AGTCACCCTC CTGTCCCTGT CCTCCCTCTC TGACTGTAAC 2460
TCCACCAAAT CCCTGTTGCC TTCTGATCCT GATGACTTTG CCCCGACCCC TAGTAATGCC 2520
CCTCCGGTGG TGTCACCCGC ACCGGCATTA AACCCTCTGC TGGACCTGAG AGCGGAGAGC 2580
TTTAAAAGAG AGCCCAATCA GTCCCTCACT CCCACCCATG TCTCTGCAAC CATGGCATTA 2640
AACCGCGGGC ACCGGCGGAC GCCCTCTGAT GGAGCCATTC GTCCTCGAGC GCAGACGGTT 2700
GTGGGGCATC GCCGGACCCC TTCTGATGGG AGTATGCCCT TCCCGCCTGC TCATGCCCCT 2760
ACTATTACAC CATATACAGG TTCTCGAGAA ACTCTTGACA TTCCACGTCT GCCTGACCCG 2820
TCTATGATGT TCCCCTCAGC ACTTCGGCGC AAACCTGCAC CTCCCATCCC CACACCTGAG 2880
CCAGATAGCT ATACGGGCAC TCTAGAGCGT CCCAAAACCC TGGAGTTTGC TCCTCGTCCC 2940
CGTCCCACCC CAGCCCGTGC CCGTCCAGAC CCCTGGAAAC TGTCTTCTCT GTCCCAGACA 3000
CTCAGCTCTT CTCCGGGCAG CAGCTGCGAC AGTCCGCTGG GTTCGGGTGA CAGCGGTGTC 3060
AGTGCCGGCA CCGGCGGTGT CCATCAGAGC CTCCTGGACA TGGACATGGA GGGCCAGAGC 3120
CAGGACAGCA CGGTCCCCCT GTGCGGACAA CGCGCAAAGG CCACTCTCTG CGCTCAGCAT 3180
TCCTCATAG 3189
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         lee+ig+g fgkvyk+ wr++evavK++r++  e  ++++e++++ea+l+++l+h+nii+
Q: 167   LEEVIGAGGFGKVYKGVWRAEEVAVKAARQDPDEdiSATAENVRQEARLFWMLRHRNIIA  226
         789****************************99989999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l+Gvcl+epnl+lvmey++gg+L+++l++   ++++++vlv+wa+qiA Gm+YLh+++ +
Q: 227   LRGVCLREPNLCLVMEYARGGALNRALAG---KKVPPRVLVNWAVQIATGMDYLHNQTFV  283
         *****************************...99**************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         +iihrdLks+n+L+       + + ktlki+dFG are++++tkmsaagt+awmaPEv+k
Q: 284   PIIHRDLKSSNILIlepverdDLSGKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIK  343
         *******************99999************************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
          + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe +++L+
Q: 344   LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEAFAQLL  403
         ************************************************************
S: 234   kecwnedpekRpsfseivks  253
          ecw  +p+ Rp f +i+k 
Q: 404   GECWCPNPRGRPAFGSILKR  423
         ****************9986
Domain Sequence
(FASTA)
LEEVIGAGGF GKVYKGVWRA EEVAVKAARQ DPDEDISATA ENVRQEARLF WMLRHRNIIA 60
LRGVCLREPN LCLVMEYARG GALNRALAGK KVPPRVLVNW AVQIATGMDY LHNQTFVPII 120
HRDLKSSNIL ILEPVERDDL SGKTLKITDF GLAREWHRTT KMSAAGTYAW MAPEVIKLSL 180
FSKSSDVWSF GVLLWELLTG EVPYREIDAL AVAYGVAMNK LTLPIPSTCP EAFAQLLGEC 240
WCPNPRGRPA FGSILKR 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00377
EKS-CAJ-00382
EKS-CAP-00411
EKS-DRM-00176
EKS-EQC-00373
EKS-FEC-00366
EKS-GAA-00461
EKS-GOG-00369
EKS-ICT-00357
EKS-LAC-00393
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-OCP-00076
EKS-ORN-00485
EKS-ORC-00355
EKS-ORL-00447
EKS-OTG-00380
EKS-PAT-00359
EKS-RAN-00393
EKS-SUS-00331
EKS-TAR-00480
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
EKS-XIM-00474
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
dre:560932;
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013