EKS-DAR-00789

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00789

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	496.2	1.2E-148	583	893	311

Status

Unreviewed

Ensembl Protein

ENSDARP00000105658

UniProt Accession

B8A5K6;

Protein Name

Protein Synonyms/Alias

Gene Name

kitb

Gene Synonyms/Alias

kitb;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000056133	ENSDARP00000044029	ENSDART00000044030
ENSDARG00000056133	ENSDARP00000105658	ENSDART00000123777

Organism

Danio rerio

Functional Description

Protein Length

936

Protein Sequence
(FASTA)

MGHSWFLRTV LLLFALPEGW SKPVITPDAP HLVILKGKQL YLRCHDDADV NAGRVRWLRD 60

KGRRIEGELK DDEASVILLN ITETQHMGNY TCENTETEEK SSIYIYVKDL GSAFVRRMVN 120

DLQVRKGEEI TLPCLVTDPA VSHLSLQTCN GSALPAALTF ITHPQGGITI RNVSKAFEGC 180

YFCAGQLDQK PVKSREYNLV VRLAPESVPA ISLSRNENVI LIQDQEFKLS CSAVNINHDF 240

HLRWTIPSEA TALESHKSNI QPGSREYQRS ITLWIQSVKI NDTGSYRCNA RNEKGVSMAA 300

VNLEVYERGF INLTEGENRV VEVREGESLT LSVEITSYPK PNDVLWTYNN QELQNTSEHV 360

ITLHNQQYRY ISELRLVRVH GSEGGIYTFS ANHKYESVNQ SFTVHVICKP VIVSQEGPVD 420

GQVRCVASGY PVPKISWYYC EPPHTRCSHL LNATQADEEF AVITVSGSEF GRSEVESRLN 480

ISKGKFHTLE CVASAQGEQA YTLFSISERT VPHKLFTPLL SGVVSTSVLL SFILVVLLYK 540

YMQKPKYEIH WKVIDSFDGN NYTYIDPTQL PYDPKWEFPR ERLRFGKILG SGAFGKVVAA 600

TAYGLCSADT VTTVAVKMLK PSAHSTEKEA LMSELKVLSY IGNHINIVNL LGACTVGGPT 660

LVITEYCCYG DLLNFLRRKR DAFFSSKTGD GYYKNLLSQT QPSIEGTDNG YMPMRSYQKR 720

SNQTEWCDDK DDLSLDTEDL LSFSYQVAKG MDFLTSKNCI HRDLAARNVL LTQGRVAKIC 780

DFGLARDITR DSNYVLRGNA RLPVKWMSPE SLFACVYTFE SDVWSYGILL WEIFSLGNTP 840

YPGIPVGSTF YKMIQDGYRM SEPEFAPSEI YEVMRWCWSA DPLKRPPFKK LVERTELLLS 900

ETTKHVCFDS SQQQQSNACP DATPPVKCAT VSCRIT 936

Nucleotide Sequence
(FASTA)

ATGGGACACT CGTGGTTTCT ACGTACAGTT CTACTTTTAT TCGCCCTACC TGAAGGATGG 60

TCTAAACCGG TTATCACTCC TGATGCCCCC CATCTGGTGA TTCTTAAAGG TAAACAACTG 120

TATCTCCGCT GTCACGATGA TGCAGATGTG AACGCAGGCA GGGTGCGATG GCTCCGGGAT 180

AAAGGTCGGA GAATTGAAGG AGAGCTAAAG GATGATGAAG CCAGTGTCAT TCTCCTCAAC 240

ATCACAGAAA CGCAGCATAT GGGCAATTAC ACCTGTGAGA ACACAGAAAC TGAAGAGAAG 300

AGCTCTATTT ACATTTATGT GAAAGATCTG GGCAGTGCAT TTGTTCGGCG CATGGTGAAC 360

GACCTTCAAG TGAGAAAAGG AGAGGAAATC ACTCTTCCTT GTTTAGTAAC AGACCCAGCT 420

GTCAGTCACT TGTCTCTGCA GACCTGTAAT GGCTCTGCCC TACCAGCTGC TCTCACCTTC 480

ATCACGCACC CTCAGGGAGG AATCACCATC AGAAATGTGT CCAAAGCCTT TGAGGGCTGC 540

TACTTCTGCG CCGGACAACT GGATCAAAAA CCTGTCAAAT CCAGAGAGTA TAACTTGGTT 600

GTGCGGCTAG CACCAGAGTC CGTGCCAGCA ATCAGCCTCT CCAGAAATGA AAATGTGATC 660

CTGATCCAAG ACCAGGAGTT TAAGCTCAGC TGCAGCGCCG TCAACATCAA CCACGATTTC 720

CACCTGAGAT GGACAATCCC TTCTGAAGCG ACAGCACTGG AAAGCCATAA ATCAAACATT 780

CAGCCTGGAT CTAGAGAATA TCAGCGATCA ATAACATTGT GGATCCAATC TGTGAAGATA 840

AACGACACGG GATCCTATCG CTGTAATGCC AGGAATGAGA AGGGGGTCTC CATGGCTGCT 900

GTCAATCTGG AGGTTTACGA GCGTGGTTTC ATTAACCTCA CAGAAGGAGA GAACAGGGTG 960

GTGGAGGTGC GAGAGGGAGA AAGTCTGACC CTCAGTGTAG AAATAACTTC ATACCCCAAA 1020

CCCAACGACG TCTTGTGGAC TTATAACAAC CAGGAGCTCC AGAACACATC TGAGCATGTC 1080

ATTACACTGC ACAACCAACA ATACAGGTAC ATCAGTGAAC TGAGGCTGGT TCGAGTTCAT 1140

GGATCAGAAG GCGGGATCTA CACTTTCTCA GCCAATCACA AATACGAGTC GGTCAATCAG 1200

TCATTCACCG TTCATGTTAT TTGTAAACCA GTGATTGTTT CCCAGGAAGG GCCTGTTGAT 1260

GGACAGGTGC GGTGCGTTGC TTCAGGATAT CCTGTCCCCA AAATATCTTG GTATTACTGC 1320

GAGCCACCAC ATACTCGATG CTCCCACCTG TTGAATGCGA CACAAGCAGA TGAGGAGTTT 1380

GCTGTAATTA CAGTGTCGGG GTCAGAGTTC GGACGAAGTG AGGTGGAGAG TCGACTTAAT 1440

ATCAGCAAAG GGAAATTTCA CACTCTTGAG TGTGTGGCAA GCGCTCAAGG AGAACAGGCC 1500

TACACCCTTT TTTCAATTAG TGAGAGAACC GTGCCTCATA AACTCTTCAC ACCGCTGCTA 1560

TCTGGGGTTG TGTCCACTTC TGTTTTGCTT AGCTTCATTC TGGTGGTTCT GCTTTACAAA 1620

TACATGCAGA AGCCTAAATA TGAAATCCAC TGGAAGGTGA TTGACAGTTT TGATGGCAAC 1680

AATTATACCT ACATAGACCC AACGCAGCTC CCTTATGACC CAAAATGGGA GTTTCCACGG 1740

GAAAGACTGC GCTTTGGTAA AATCCTTGGC TCTGGAGCGT TTGGTAAAGT GGTGGCAGCT 1800

ACTGCATATG GACTTTGCTC AGCCGACACA GTGACCACTG TTGCTGTAAA AATGCTAAAA 1860

CCGAGTGCGC ACTCCACTGA GAAAGAGGCT CTAATGTCGG AGTTAAAAGT CCTGAGTTAC 1920

ATCGGTAACC ATATAAACAT CGTCAACTTG CTTGGCGCCT GTACAGTAGG AGGTCCCACT 1980

CTAGTGATCA CAGAATACTG TTGCTATGGC GACCTGCTAA ACTTCCTAAG AAGAAAACGG 2040

GATGCTTTCT TCAGTTCCAA AACAGGCGAT GGATATTACA AAAATCTGCT CAGCCAAACA 2100

CAACCCTCAA TAGAGGGCAC CGATAATGGT TACATGCCCA TGAGGTCATA TCAGAAGAGA 2160

TCAAATCAGA CAGAATGGTG TGATGACAAA GATGATCTAT CTTTGGATAC CGAAGATCTG 2220

CTCAGCTTCT CGTATCAAGT GGCTAAAGGC ATGGACTTCC TCACATCCAA AAATTGCATT 2280

CATAGGGATC TGGCTGCCAG GAATGTTTTA CTCACTCAGG GTCGGGTAGC GAAGATATGT 2340

GATTTCGGTT TGGCACGTGA CATCACAAGA GATTCCAACT ACGTCCTGAG AGGAAATGCA 2400

CGTCTGCCAG TGAAATGGAT GTCCCCGGAA AGCTTGTTTG CTTGTGTGTA CACTTTTGAG 2460

AGTGACGTCT GGTCCTACGG CATCTTACTA TGGGAGATCT TCTCTCTGGG TAACACACCA 2520

TATCCGGGGA TTCCAGTTGG ATCCACATTC TATAAGATGA TACAAGATGG ATACAGAATG 2580

AGTGAGCCTG AGTTCGCTCC AAGTGAAATT TACGAGGTGA TGAGATGGTG CTGGAGTGCC 2640

GACCCTCTAA AAAGACCACC TTTCAAGAAG CTGGTGGAAA GAACCGAGCT CCTGCTGTCG 2700

GAAACCACCA AACATGTATG TTTTGACTCA AGTCAGCAAC AGCAAAGCAA TGCTTGCCCT 2760

GATGCAACTC CTCCAGTTAA GTGTGCGACT GTATCTTGCA GGATTACTTG A 2811

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l++Gk+lGsGafGkvv atayGl  +d+v +vavkmlk++a+s+ekealmselk+ls++G

Q: 583   LRFGKILGSGAFGKVVAATAYGLCSADTVTTVAVKMLKPSAHSTEKEALMSELKVLSYIG  642

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h nivnllGact+gGp++viteyccyGdlln+lrrkr++f+++       k+ + ++k+

Q: 643   NHINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDAFFSS-------KTGDGYYKN  695

         *****************************************933.......356789998

S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180

         l     l +++ +   +++ y+ ++          ++k+++++          +  +++d

Q: 696   L-----LSQTQPSIEGTDNGYMPMRS---------YQKRSNQT----------EWCDDKD  731

         8.....55556666667889**9998.........23322222..........3345667

S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240

         + +l+ edllsfsyqvakGm+fl sknc+hrdlaarnvllt+G+v+kicdfGlardi++d

Q: 732   DLSLDTEDLLSFSYQVAKGMDFLTSKNCIHRDLAARNVLLTQGRVAKICDFGLARDITRD  791

         899*********************************************************

S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300

         snyv +Gnarlpvkwm+pes+f ++yt++sdvwsyGillweifslG tpypg++v s+fy

Q: 792   SNYVLRGNARLPVKWMSPESLFACVYTFESDVWSYGILLWEIFSLGNTPYPGIPVGSTFY  851

         ************************************************************

S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342

         k+i++Gyrm++p++a++eiye+m+ cw a+p krp+fk+lve

Q: 852   KMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKLVE  893

         ***************************************985

Domain Sequence
(FASTA)

LRFGKILGSG AFGKVVAATA YGLCSADTVT TVAVKMLKPS AHSTEKEALM SELKVLSYIG 60

NHINIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDA FFSSKTGDGY YKNLLSQTQP 120

SIEGTDNGYM PMRSYQKRSN QTEWCDDKDD LSLDTEDLLS FSYQVAKGMD FLTSKNCIHR 180

DLAARNVLLT QGRVAKICDF GLARDITRDS NYVLRGNARL PVKWMSPESL FACVYTFESD 240

VWSYGILLWE IFSLGNTPYP GIPVGSTFYK MIQDGYRMSE PEFAPSEIYE VMRWCWSADP 300

LKRPPFKKLV E 311

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

dre:497629

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013