EKS-DAR-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	402.6	1.7E-120	4	286	283

Status

Unreviewed

Ensembl Protein

ENSDARP00000073666

UniProt Accession

Q9DE44;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent protein kinase 5;

Gene Name

cdk5

Gene Synonyms/Alias

cdk5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000056683	ENSDARP00000108255	ENSDART00000128679
ENSDARG00000056683	ENSDARP00000073666	ENSDART00000079210

Organism

Danio rerio

Functional Description

Protein Length

292

Protein Sequence
(FASTA)

MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 60

KNIVRLHDVL HSDKKLTLVF EYCDQDLKKY FDSCNGDLDP EIVKSFMYQL LKGLAFCHSR 120

NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 180

TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWQTM NKLPDYKPYP 240

MYPATTSLVN VVPKLSSTGR DLLQNLLKCN PVQRISAEEA LQHPYFADFC PP 292

Nucleotide Sequence
(FASTA)

ATGCAAAAGT ATGAGAAGCT GGAGAAGATA GGAGAGGGTA CATATGGTAC CGTTTTCAAG 60

GCTAAAAACA GAGAAACGCA CGAAATTGTG GCCCTCAAAC GAGTCCGACT GGATGATGAT 120

GATGAGGGCG TACCAAGTTC AGCTTTACGA GAAATTTGCC TCCTGAAAGA ACTGAAGCAT 180

AAAAACATTG TAAGGTTACA TGACGTCCTT CACAGTGATA AGAAACTCAC ATTAGTGTTT 240

GAATACTGTG ATCAGGATTT GAAGAAATAC TTTGACAGCT GTAATGGTGA CTTGGATCCA 300

GAGATTGTCA AGTCTTTTAT GTACCAGTTG TTGAAGGGTC TCGCCTTCTG CCACAGCAGA 360

AATGTTCTCC ACCGTGACCT TAAACCACAA AACCTGCTCA TCAACAGAAA CGGGGAACTG 420

AAGTTGGCTG ATTTCGGCTT GGCCAGAGCG TTTGGGATCC CTGTACGCTG TTATTCTGCT 480

GAGGTGGTGA CGTTGTGGTA CAGGCCTCCG GATGTACTGT TTGGTGCTAA ACTCTACTCT 540

ACCTCTATCG ACATGTGGTC TGCAGGCTGT ATATTTGCAG AACTGGCAAA TGCAGGACGG 600

CCTTTATTTC CTGGTAACGA TGTGGACGAT CAGCTAAAGA GGATCTTTCG ATTGCTGGGA 660

ACGCCAACAG AAGAACAGTG GCAGACTATG AATAAACTTC CAGATTATAA GCCGTACCCG 720

ATGTATCCAG CTACTACATC ACTTGTGAAC GTCGTGCCGA AACTCAGCAG CACCGGCAGA 780

GATTTACTAC AGAATCTTCT GAAATGTAAT CCAGTACAGC GAATCTCAGC AGAAGAAGCT 840

CTACAGCACC CTTACTTTGC TGATTTCTGC CCACCATAA 879

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklekigeGtyg+v+kak++et+e+vAlK++rl++++egvp++alrEi llkelkhkni

Q: 4     YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI  63

         99**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L++v++ ++kkl+Lvfe+++qdLkk++++++  +l++e vks+++qll+gla++Hs++

Q: 64    VRLHDVLH-SDKKLTLVFEYCDQDLKKYFDSCNG-DLDPEIVKSFMYQLLKGLAFCHSRN  121

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlaraf+ p++ y+ evvTlwYr+P++L+gak Yst

Q: 122   VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST  181

         ************************************************************

S: 181   avDiWsvgcilaellt.rkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         ++D+Ws+gci+ael++  +plf+g++  dql+rif+llgtp+e++w++++klp+yk  +p

Q: 182   SIDMWSAGCIFAELANaGRPLFPGNDVDDQLKRIFRLLGTPTEEQWQTMNKLPDYK-PYP  240

         **************97369*************************************.555

S: 240   kkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          ++++ +l ++v+kl+++++dll++ll+++p +Risa+ealqh+yf

Q: 241   MYPATtSLVNVVPKLSSTGRDLLQNLLKCNPVQRISAEEALQHPYF  286

         5555559**************************************9

Domain Sequence
(FASTA)

YEKLEKIGEG TYGTVFKAKN RETHEIVALK RVRLDDDDEG VPSSALREIC LLKELKHKNI 60

VRLHDVLHSD KKLTLVFEYC DQDLKKYFDS CNGDLDPEIV KSFMYQLLKG LAFCHSRNVL 120

HRDLKPQNLL INRNGELKLA DFGLARAFGI PVRCYSAEVV TLWYRPPDVL FGAKLYSTSI 180

DMWSAGCIFA ELANAGRPLF PGNDVDDQLK RIFRLLGTPT EEQWQTMNKL PDYKPYPMYP 240

ATTSLVNVVP KLSSTGRDLL QNLLKCNPVQ RISAEEALQH PYF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0035173	; F:histone kinase activity
GO:0021954	; P:central nervous system neuron development
GO:0060059	; P:embryonic retina morphogenesis in camera-type eye
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0021634	; P:optic nerve formation
GO:0048935	; P:peripheral nervous system neuron development
GO:0010842	; P:retina layer formation

KEGG

dre:65234

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013