EKS-DAR-00792

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00792

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	443.2	1.5E-132	587	886	300

Status

Unreviewed

Ensembl Protein

ENSDARP00000028652

UniProt Accession

F1RC45;

Protein Name

Protein Synonyms/Alias

Gene Name

pdgfrb

Gene Synonyms/Alias

pdgfrb;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000057345	ENSDARP00000028652	ENSDART00000028255

Organism

Danio rerio

Functional Description

Protein Length

887

Protein Sequence
(FASTA)

MCPALEESMK SSTISRIHFL FTAITTGLVL LCLGTSGLEL SPSAPQIILS INSSSSITCS 60

GWSNVTWRFR RDENIPDFRT EELSASSSVL HLEQVTWRHT GVYVCTEKKT NESREVAVFV 120

PDPDVWFLEN EHVMVTKTRE EGTIPCLVTN PSINVTLYER DTEMAVEGSY NPSVGYSAAL 180

DDRTYICKGE LNGEEKESDL FYVFSILAPE ALDPYINASK TVLKQGETLN VNCTVHGVEL 240

VFFSWDFPNK DMGGIEPLTD VLSSMSMRSC LNITDVSLDR SGQYVCHVHE GVQDQRASAS 300

INITVLEKGF VSLTPPLDRN ISAQLGENVE LKVEIEAYPK PTVQWRKDGA VIRGHSMREE 360

HETRFVSTLT LVRTRLQQMG LYKVTVQNED ALKEMIFDLE VKVPPQITEL SDHHLPEKKH 420

AVTCVAEGVP KPSIQWFSCD SMTRCSNRSA VWSPLVEDPE SVTIQTNVTY NSTRKIHQVL 480

SQVTLVRPQL LTIRCEASNE RGARARDIRL VNSTLFSQVA VLAAVLALVV IVIISIIILI 540

AVWRKKPRYE IRWKVIESVS LDGHEYIYVD PIHLPYDLAW EMPRDSLVLG RTLGSGAFGR 600

VVEATAYGLG ISQSATKVAV KMLKSTARRS ETQALMSELK IMSHLGPHIN IVNLLGACTK 660

QGPLYLVTEY CRYGDLVDYL HRNKHSFLQN FADKNHIANG TQICNDSDSG KEYVSFGSEC 720

DGGYMDMTKD EQTEYVPMQE LADTIKYADI QPSPYESPYQ QDIYQEQGHR VDHSLVISDS 780

PVLSYTDLVG FSYQVAQGME FLASKNCVHR DLAARNVLIC EGKLAKICDF GLARDIMHDN 840

NYISKGSTFL PLKWMAPESI FHNLYTTLSD VWSYGILLWE IFTLGQS 887

Nucleotide Sequence
(FASTA)

ATGTGTCCTG CTCTAGAAGA AAGCATGAAG AGTTCGACCA TCAGCCGCAT CCACTTCCTA 60

TTCACTGCTA TCACAACAGG ACTGGTTCTG CTCTGTCTGG GCACTTCAGG TCTGGAGCTC 120

AGTCCCAGCG CTCCACAGAT CATCCTGTCC ATCAACTCGT CCTCCAGCAT CACCTGCTCC 180

GGCTGGAGTA ACGTCACCTG GCGCTTCAGG CGGGACGAGA ACATCCCAGA CTTTCGCACA 240

GAGGAGCTCA GCGCCTCCTC CAGCGTCCTG CATCTGGAGC AGGTGACCTG GAGACACACC 300

GGGGTTTATG TGTGCACCGA GAAGAAGACC AATGAATCCA GAGAGGTGGC CGTCTTTGTG 360

CCTGATCCTG ACGTGTGGTT CCTGGAGAAT GAACACGTGA TGGTGACTAA GACGCGAGAG 420

GAAGGCACGA TCCCATGTCT GGTGACGAAC CCATCAATAA ACGTCACGCT GTACGAGAGG 480

GACACCGAGA TGGCAGTGGA GGGCTCTTAT AACCCCAGCG TGGGCTACAG CGCCGCCCTG 540

GATGACAGAA CCTACATATG CAAAGGAGAG CTGAATGGAG AGGAAAAAGA GTCAGATCTC 600

TTCTACGTTT TCAGTATACT GGCTCCCGAG GCTCTGGATC CCTACATCAA CGCCTCCAAA 660

ACGGTCCTAA AGCAGGGCGA GACGCTCAAC GTCAACTGCA CCGTTCACGG CGTGGAGCTG 720

GTCTTCTTCT CCTGGGATTT TCCCAACAAA GACATGGGAG GCATCGAGCC CCTGACGGAC 780

GTCCTGTCCT CCATGAGCAT GAGGTCATGT CTGAACATCA CAGACGTCTC TCTGGACAGA 840

TCTGGACAGT ACGTTTGTCA TGTTCATGAG GGAGTGCAGG ACCAGAGAGC TTCAGCCAGC 900

ATCAACATCA CTGTACTGGA GAAGGGTTTT GTGTCTCTGA CTCCTCCTCT GGACAGAAAC 960

ATCTCTGCGC AGCTCGGAGA AAACGTGGAG CTGAAGGTGG AGATCGAGGC GTATCCCAAA 1020

CCTACAGTCC AGTGGAGGAA AGACGGTGCT GTTATCAGAG GACACAGCAT GAGGGAGGAG 1080

CACGAAACGA GGTTTGTCAG CACATTGACC CTGGTCAGAA CTCGACTGCA GCAGATGGGT 1140

CTCTACAAAG TCACCGTCCA AAATGAAGAC GCCCTCAAAG AGATGATCTT TGACCTAGAG 1200

GTGAAAGTTC CTCCTCAGAT AACGGAGCTG TCAGATCATC ACCTGCCGGA GAAGAAGCAC 1260

GCAGTGACCT GTGTGGCAGA AGGAGTGCCC AAACCCAGCA TTCAGTGGTT CAGCTGCGAC 1320

AGCATGACCA GGTGCAGTAA CAGAAGTGCT GTATGGAGCC CTCTAGTGGA GGATCCAGAG 1380

AGCGTCACCA TCCAGACTAA TGTCACCTAC AACAGCACAC GCAAGATCCA CCAGGTGCTT 1440

AGTCAGGTGA CGCTGGTCCG GCCGCAGTTG CTCACCATCC GCTGTGAGGC CAGCAATGAG 1500

AGAGGAGCCC GAGCCCGGGA CATCAGACTG GTCAACAGCA CGCTGTTCTC TCAGGTAGCT 1560

GTTCTGGCCG CTGTCTTAGC GCTGGTGGTC ATCGTCATCA TCTCCATCAT CATCCTCATT 1620

GCTGTGTGGA GGAAGAAGCC GCGGTATGAA ATCAGGTGGA AGGTGATTGA ATCAGTCAGT 1680

TTGGATGGAC ACGAGTACAT CTACGTTGAC CCCATTCATC TGCCCTATGA CCTGGCCTGG 1740

GAGATGCCAC GCGACAGTTT GGTGCTGGGT CGTACATTAG GTTCTGGGGC ATTCGGTCGT 1800

GTTGTCGAGG CAACAGCGTA TGGTCTTGGC ATTTCCCAGT CGGCCACTAA AGTGGCAGTG 1860

AAAATGCTCA AATCAACGGC TCGCAGAAGT GAGACACAAG CGCTGATGTC TGAACTCAAG 1920

ATCATGAGTC ATCTGGGTCC TCACATCAAC ATCGTCAACC TGCTGGGCGC CTGCACAAAA 1980

CAAGGTCCGT TATATTTGGT GACAGAATAC TGCCGATATG GAGATCTGGT GGACTACCTG 2040

CACAGAAACA AACACAGCTT CCTCCAGAAC TTCGCCGATA AAAACCACAT CGCCAATGGC 2100

ACTCAGATCT GCAACGACAG TGACAGTGGG AAAGAGTATG TGTCGTTCGG CAGCGAGTGT 2160

GATGGAGGTT ACATGGACAT GACCAAAGAC GAGCAGACTG AATACGTCCC GATGCAGGAG 2220

CTCGCGGACA CTATCAAGTA CGCAGACATC CAGCCGTCAC CCTACGAGTC TCCGTACCAG 2280

CAGGACATCT ACCAGGAGCA AGGTCACAGG GTGGATCATT CTCTGGTCAT CAGTGATTCT 2340

CCGGTTCTCA GCTATACTGA TCTGGTTGGT TTTAGTTACC AGGTGGCCCA AGGCATGGAG 2400

TTCCTGGCCT CAAAGAACTG TGTCCATCGA GATCTGGCCG CAAGAAATGT CCTGATCTGT 2460

GAAGGCAAAC TGGCCAAGAT CTGCGACTTT GGCCTGGCCA GAGACATCAT GCACGACAAC 2520

AACTACATCT CCAAAGGCAG CACCTTTCTT CCTCTGAAGT GGATGGCGCC CGAGAGCATC 2580

TTTCATAACC TGTACACGAC TCTGAGTGAC GTCTGGTCTT ACGGCATCTT ACTGTGGGAG 2640

ATCTTCACCC TCGGTCAGTC C 2661

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveatayGl+ s+++ kvavkmlkstar se +almselki+shlG

Q: 587   LVLGRTLGSGAFGRVVEATAYGLGISQSATKVAVKMLKSTARRSETQALMSELKIMSHLG  646

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h nivnllGactk Gp+y++teyc+yGdl++yl+r+++sfl+++++k++  +     +

Q: 647   PHINIVNLLGACTKQGPLYLVTEYCRYGDLVDYLHRNKHSFLQNFADKNHIANGTQICN-  705

         ******************************************99999955555444444.

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

            + s + ++s+ se ++ y+d+ kd                ++d+++s +++++++++

Q: 706   --DSDSGKEYVSFGSECDGGYMDMTKDeqteyvpmqeladtikYADIQPSPYESPYQQDI  763

         ..567889999*************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          + + ++v  +l   ds vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 764   YQEQGHRVDHSLVISDSPVLSYTDLVGFSYQVAQGMEFLASKNCVHRDLAARNVLICEGK  823

         9999999999999999********************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         ++kicdfGlardim+d ny++kG+++lp+kwmapesif++lyt+ sdvwsyGillweif+

Q: 824   LAKICDFGLARDIMHDNNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFT  883

         ************************************************************

S: 285   lGs  287

lG+

Q: 884   LGQ  886

**7

Domain Sequence
(FASTA)

LVLGRTLGSG AFGRVVEATA YGLGISQSAT KVAVKMLKST ARRSETQALM SELKIMSHLG 60

PHINIVNLLG ACTKQGPLYL VTEYCRYGDL VDYLHRNKHS FLQNFADKNH IANGTQICND 120

SDSGKEYVSF GSECDGGYMD MTKDEQTEYV PMQELADTIK YADIQPSPYE SPYQQDIYQE 180

QGHRVDHSLV ISDSPVLSYT DLVGFSYQVA QGMEFLASKN CVHRDLAARN VLICEGKLAK 240

ICDFGLARDI MHDNNYISKG STFLPLKWMA PESIFHNLYT TLSDVWSYGI LLWEIFTLGQ 300

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084	; P:vascular endothelial growth factor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409

; IG; 3.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR00109	; TYRKINASE.
PR01832	; VEGFRECEPTOR.

Created Date

20-Feb-2013