EKS-DAR-00432

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00432

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	552.2	3.5E-166	411	687	277

Status

Unreviewed

Ensembl Protein

ENSDARP00000089041

UniProt Accession

F1RBS5;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

fgfr2

Gene Synonyms/Alias

fgfr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000058115	ENSDARP00000124472	ENSDART00000150061
ENSDARG00000058115	ENSDARP00000075358	ENSDART00000080914
ENSDARG00000058115	ENSDARP00000089041	ENSDART00000098269
ENSDARG00000058115	ENSDARP00000123845	ENSDART00000149602
ENSDARG00000058115	ENSDARP00000124761	ENSDART00000149125
ENSDARG00000058115	ENSDARP00000075360	ENSDART00000080916
ENSDARG00000058115	ENSDARP00000006382	ENSDART00000007408

Organism

Danio rerio

Functional Description

Protein Length

751

Protein Sequence
(FASTA)

MGSVSRGRPR RRGGCGDTPT TDGMFARGWL LGALLLMTLA TVSVARPSLK IDLVNTSAPE 60

DAISSGDDED DTERSDDVGA DGEQMRLPYW TFPEKMEKKL HAVPAANTVK FRCAAAGNPK 120

PKMRWLKNAK PFRQEDRMGG YKVRLQHWTL IMESVVPSDK GNYTCLVENQ YGSINHTYTL 180

DVVERSPHRP ILQAGLPANV TVQVGQDAKF VCKVYSDAQP HIQWLQHYTK NGSRYGPDGL 240

PYVRVLKTAG VNTTDKEIEV LYLPNVTFED AGEYTCLAGN SIGISYHTAW LTVHPAETNP 300

IETDYPPDYV EIAIYCIGVF LIACMVVIVV VCRMRTSAKK PDFSSQPAVH KLTKQIPLRR 360

QVTVSSDSSS SMSSSTPLVR ITTRRSSAHD DPIPEYDLPE DPRWEFSRDK LTLGKPLGEG 420

CFGQVVMAEA LGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM IGRHKNIINL 480

LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEPLTF KDLVSCTYQV 540

ARGMEYLASQ KCIHRDLAAR NVLVTESNVM KIADFGLARD VHNIDYYKKT TNGRLPVKWM 600

APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTN 660

ELYMMMKDCW HAISSHRPTF KQLVEDLDRI LTLATNEEYL DLCAPVEQYS PSFPDTRSSC 720

SSGDDSVFSH DPLADEPCLP KYQHINGGIK T 751

Nucleotide Sequence
(FASTA)

ATGGGATCCG TGTCCAGGGG GAGGCCGAGG AGGAGGGGGG GATGTGGAGA CACGCCCACC 60

ACTGATGGGA TGTTCGCCCG AGGGTGGCTT CTGGGTGCTC TCCTGCTAAT GACCCTGGCA 120

ACGGTATCTG TGGCACGGCC GTCATTGAAG ATTGACTTGG TGAATACATC TGCACCTGAA 180

GATGCCATCT CATCCGGTGA CGATGAGGAC GACACAGAGC GGTCAGACGA TGTTGGGGCA 240

GACGGTGAAC AAATGCGGCT GCCATATTGG ACCTTTCCAG AGAAGATGGA GAAGAAGCTG 300

CATGCCGTCC CGGCGGCCAA CACGGTGAAG TTTCGCTGCG CGGCAGCCGG AAATCCTAAA 360

CCCAAAATGC GCTGGCTGAA AAACGCAAAA CCCTTCAGAC AGGAGGATCG CATGGGCGGC 420

TACAAGGTTC GACTCCAGCA CTGGACCCTG ATCATGGAGA GCGTGGTTCC CTCTGATAAA 480

GGAAACTACA CCTGTCTGGT GGAGAACCAG TATGGCTCCA TCAATCACAC ATACACGCTG 540

GATGTCGTTG AACGCTCTCC TCACCGGCCC ATTCTCCAGG CAGGCCTGCC AGCAAACGTC 600

ACTGTGCAAG TTGGACAAGA TGCGAAGTTC GTCTGTAAAG TTTACAGTGA TGCTCAGCCT 660

CATATCCAGT GGTTGCAGCA CTATACGAAG AACGGCAGCC GCTATGGTCC TGATGGACTT 720

CCTTATGTCC GCGTATTGAA GACGGCAGGT GTGAACACTA CGGATAAAGA GATCGAGGTG 780

CTCTACCTGC CTAATGTAAC TTTCGAGGAT GCGGGCGAGT ATACGTGTTT GGCGGGTAAC 840

TCTATTGGGA TCTCCTATCA CACTGCTTGG TTGACGGTGC ATCCAGCTGA GACGAATCCC 900

ATCGAGACGG ATTATCCTCC AGATTATGTG GAGATCGCCA TCTACTGTAT AGGTGTGTTT 960

CTGATCGCCT GTATGGTGGT GATCGTGGTG GTTTGCCGGA TGAGGACGTC GGCTAAGAAG 1020

CCTGATTTCA GCAGTCAGCC AGCAGTGCAC AAGCTCACCA AACAGATCCC CCTGCGCCGC 1080

CAGGTAACAG TGTCGTCAGA CTCCAGCTCC TCCATGAGCT CTAGCACGCC ATTGGTCAGA 1140

ATCACCACTC GCCGGAGCTC CGCCCACGAT GATCCCATTC CAGAATACGA CCTCCCTGAG 1200

GACCCACGCT GGGAGTTTTC TAGAGACAAG TTAACTCTGG GTAAGCCTCT CGGCGAGGGC 1260

TGCTTTGGTC AGGTTGTGAT GGCTGAAGCT CTTGGCATTG ACAAGGACAA ACCGAAAGAG 1320

GCTGTGACTG TGGCTGTCAA GATGCTAAAA GATGATGCGA CCGAGAAGGA TCTTTCTGAC 1380

CTGGTGTCAG AGATGGAGAT GATGAAGATG ATTGGCCGGC ACAAGAACAT CATCAATCTG 1440

TTGGGAGCGT GCACACAGGA TGGTCCATTA TATGTCATTG TTGAGTATGC ATCTAAAGGG 1500

AACCTCCGGG AGTATCTGAG GGCCCGGCGG CCCCCAGGAA TGGAGTATTC CTATGATATA 1560

GCCCGCGTAT CAGATGAGCC TCTCACTTTC AAAGATCTGG TCTCCTGCAC TTATCAAGTT 1620

GCCCGTGGCA TGGAGTATTT AGCCTCTCAG AAGTGTATAC ACCGAGATTT GGCCGCGAGG 1680

AATGTGTTGG TCACGGAGAG CAACGTTATG AAGATCGCAG ACTTCGGTCT GGCCAGAGAC 1740

GTCCACAACA TAGATTACTA TAAAAAGACC ACAAATGGTC GTCTGCCTGT GAAATGGATG 1800

GCTCCAGAAG CACTGTTCGA CCGAGTTTAT ACACACCAGA GTGACGTCTG GTCGTTTGGG 1860

GTTTTAATGT GGGAGATCTT CACTCTCGGC GGTTCTCCGT ATCCTGGAAT ACCTGTCGAG 1920

GAGCTCTTTA AACTATTAAA AGAGGGTCAT CGCATGGACA AACCTGCTAA CTGCACCAAT 1980

GAGTTGTACA TGATGATGAA GGACTGCTGG CATGCCATCT CCTCCCACAG ACCCACATTC 2040

AAGCAGTTGG TGGAGGATCT GGACCGCATT CTCACTCTGG CAACCAACGA GGAATATCTG 2100

GACCTGTGTG CCCCGGTGGA GCAATACTCT CCCAGCTTCC CCGACACACG CAGCTCCTGC 2160

TCCTCCGGAG ACGACTCCGT ATTTTCCCAT GATCCCTTAG CGGACGAGCC CTGCCTTCCC 2220

AAATACCAGC ACATCAACGG CGGCATAAAA ACATGA 2256

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 411   LTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  470

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG+hkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d +++s+e lt+

Q: 471   IGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTF  530

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yqvarGmeylas+kcihrdlaarnvlvte nv+kiadfGlardvh+idyykkt

Q: 531   KDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKT  590

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 591   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  650

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++m++cwha +s+rptfkqlvedl

Q: 651   RMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDL  687

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA LGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGRHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEPLTF 120

KDLVSCTYQV ARGMEYLASQ KCIHRDLAAR NVLVTESNVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMKDCW HAISSHRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0017134	; F:fibroblast growth factor binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0003146	; P:heart jogging
GO:0001947	; P:heart looping
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013