EKS-DAR-00872

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00872

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	414.0	5.7E-124	23	305	283

Status

Unreviewed

Ensembl Protein

ENSDARP00000075784

UniProt Accession

E7F292;

Protein Name

Protein Synonyms/Alias

Gene Name

mapk13

Gene Synonyms/Alias

mapk13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000058470	ENSDARP00000075784	ENSDART00000081341
ENSDARG00000058470	ENSDARP00000126173	ENSDART00000151388

Organism

Danio rerio

Functional Description

Protein Length

362

Protein Sequence
(FASTA)

MESRVEFSRE EINSTVWEVP AKYVCLKQIG TGAYGSVCSS INNKTKEKVA IKKLHRPFQS 60

EIFAKRAYRE LRLLKHMKHE NVIGLLDVFT PATRLDEFQD FYLVMPYMYT DLSKVKGLLT 120

EDRIQFLVYQ MLCGLKYIHG AGIIHRDLKP GNLAVNQDCE LKILDFGLAR HTDAEMTGYV 180

VTRWYRAPEV ILNWMHYTQT VDIWSVGCIM GEMFNGKTLF KGKDYMDQLT QIMKVAGTPG 240

PEFVEKLESP EAKSYVRSLP HYPHRDFSTL FPRASKKAVE LLEKMLVLDA DARLTASGAL 300

AHSYFDGLRD PDDWPEPTAY DDSYDNATLP LEEWKRLSFK EVRSFVPFPR RDSKRRNTLT 360

MS 362

Nucleotide Sequence
(FASTA)

ATGGAGTCTC GGGTGGAATT TAGTCGTGAG GAGATCAACA GTACGGTATG GGAAGTCCCG 60

GCAAAGTACG TTTGCTTAAA GCAGATTGGA ACGGGAGCGT ATGGCAGCGT TTGCTCGTCC 120

ATCAACAACA AAACCAAAGA GAAGGTGGCC ATCAAGAAGC TGCACCGACC ATTTCAGTCG 180

GAGATCTTTG CGAAGAGAGC ATACCGTGAA TTGAGACTGC TCAAGCATAT GAAACATGAA 240

AATGTAATAG GCTTACTAGA CGTCTTCACT CCTGCCACCA GACTGGACGA ATTCCAAGAC 300

TTCTACCTGG TGATGCCGTA CATGTACACC GATCTCTCTA AAGTCAAGGG CCTTCTTACA 360

GAAGATCGTA TCCAGTTCTT GGTCTATCAG ATGCTGTGTG GACTAAAGTA CATTCATGGC 420

GCTGGCATCA TTCACAGAGA CCTCAAACCA GGAAACTTGG CTGTGAATCA AGACTGCGAG 480

CTGAAGATCT TGGATTTTGG CCTGGCGCGT CATACAGATG CTGAGATGAC GGGTTATGTG 540

GTGACACGGT GGTATCGAGC CCCGGAGGTC ATTCTGAACT GGATGCACTA CACGCAGACA 600

GTGGATATCT GGTCTGTTGG GTGCATCATG GGTGAAATGT TCAATGGAAA AACACTCTTT 660

AAAGGAAAAG ACTACATGGA TCAGCTGACT CAGATAATGA AAGTTGCAGG AACACCAGGC 720

CCAGAATTCG TGGAGAAGCT GGAAAGCCCA GAGGCAAAGA GTTATGTCAG ATCCCTGCCC 780

CACTACCCAC ACAGAGATTT CTCCACATTG TTTCCCAGAG CTAGTAAAAA AGCGGTAGAG 840

CTGCTTGAGA AGATGCTGGT GTTAGATGCT GATGCCCGTC TCACTGCTAG TGGTGCGTTG 900

GCACACAGTT ATTTTGATGG TCTAAGAGAT CCAGATGACT GGCCGGAGCC TACTGCATAT 960

GATGACAGCT ACGACAATGC CACATTGCCC TTGGAAGAGT GGAAACGTTT ATCGTTTAAA 1020

GAAGTGAGAA GCTTTGTTCC TTTCCCAAGA AGGGACTCAA AGAGAAGAAA CACACTCACG 1080

ATGTCCTAG 1089

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y  lk++g+Gayg v+s+++++t+e+vaikkl rpfq+e+ akr++REl+llk++kheN+

Q: 23    YVCLKQIGTGAYGSVCSSINNKTKEKVAIKKLHRPFQSEIFAKRAYRELRLLKHMKHENV  82

         56789*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp++ l+e++d+Ylv+ +m tdL+kv  +  l++++i++l+yq+l+glky+H

Q: 83    IGLLDVFTPATRLDEFQDFYLVMPYMYTDLSKV--KGLLTEDRIQFLVYQMLCGLKYIHG  140

         *******************************98..5689*********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKP+Nl+vn+dcelkildFGlar++d+e    +t+yv+trwYraPe++l++++

Q: 141   AGIIHRDLKPGNLAVNQDCELKILDFGLARHTDAE----MTGYVVTRWYRAPEVILNWMH  196

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         yt++vDiWsvGCI++E+++gk+lf+gkd++dql++i++v gtp  ef++k+es ea++y+

Q: 197   YTQTVDIWSVGCIMGEMFNGKTLFKGKDYMDQLTQIMKVAGTPGPEFVEKLESPEAKSYV  256

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +slp+++++df++lfp+as++a++Llek+Lvld+d R++++ aL+h Y+

Q: 257   RSLPHYPHRDFSTLFPRASKKAVELLEKMLVLDADARLTASGALAHSYF  305

         ***********************************************96

Domain Sequence
(FASTA)

YVCLKQIGTG AYGSVCSSIN NKTKEKVAIK KLHRPFQSEI FAKRAYRELR LLKHMKHENV 60

IGLLDVFTPA TRLDEFQDFY LVMPYMYTDL SKVKGLLTED RIQFLVYQML CGLKYIHGAG 120

IIHRDLKPGN LAVNQDCELK ILDFGLARHT DAEMTGYVVT RWYRAPEVIL NWMHYTQTVD 180

IWSVGCIMGE MFNGKTLFKG KDYMDQLTQI MKVAGTPGPE FVEKLESPEA KSYVRSLPHY 240

PHRDFSTLFP RASKKAVELL EKMLVLDADA RLTASGALAH SYF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

dre:100002318

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013