EKS-DAR-00596
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00596
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK412.31.6E-12339291253
StatusUnreviewed
Ensembl ProteinENSDARP00000075786
UniProt AccessionQ6DRK7;
Protein Name
Protein Synonyms/Alias Polo-like kinase;
Gene Nameplk1
Gene Synonyms/Alias plk1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000058471ENSDARP00000075786ENSDART00000081343
OrganismDanio rerio
Functional Description
Protein Length595
Protein Sequence
(FASTA)
MSAAIAKPSA KPSAHVDPKS APLKEIPDVL VDPRTMKRYM RGRFLGKGGF AKCYEITDMD 60
TKEVFAGKVV PKSMLLKPHQ KEKMSTEIAI HKSLDNPHVV GFHGFFEDDD FVYVVLEICR 120
RRSLLELHKR RKAVTEPEAR YFMRQTIQGV QYLHNNRVIH RDLKLGNLFL NDDMDVKIGD 180
FGLATKIEFD GERKKTLCGT PNYIAPEVLC KKGHSFEVDI WSLGCILYTL LVGKPPFETS 240
CLKETYIRIK KNEYSVPRHI NPVASALIRR MLHADPTLRP SVAELLTDEF FTSGYAPMRL 300
PTSCLTVPPR FSIAPSSLDP ALLRKPLSSL NKGTDSPIEK MGKMDQPQRE DLQQRDGPEQ 360
PDTHLTDMLQ QLAVVNAAKP SDRDFIRQEE AEDPACIPVF WISKWVDYSD KYGLGYQLSD 420
NSVGVLFNDS TRLIMCADGD SLQYIDRNSL ESYLSVRSYP SALSKKITLL KYFRNYMSEH 480
LLKAGANITP REGDELTRLP YLRHWFRTKS AIVLHLSNGT VQINFFQDHT KLILCPLMGA 540
VTYINEKREF YTYKMTLIEE FGCCKELASR LRYARNMVEK LMACKSSTTA ATSAR 595
Nucleotide Sequence
(FASTA)
ATGAGTGCTG CAATTGCAAA GCCATCGGCG AAGCCATCGG CTCACGTCGA TCCCAAATCT 60
GCTCCTCTGA AAGAGATTCC CGACGTTCTG GTGGATCCGA GAACCATGAA GAGATACATG 120
AGAGGTCGCT TTTTGGGAAA AGGAGGATTC GCCAAATGCT ACGAAATCAC AGATATGGAC 180
ACAAAAGAGG TCTTCGCTGG GAAAGTTGTG CCGAAGTCGA TGCTGCTGAA GCCGCACCAG 240
AAGGAGAAAA TGAGCACAGA AATCGCCATT CACAAAAGTC TCGATAATCC GCATGTTGTG 300
GGCTTTCACG GGTTCTTTGA GGATGATGAC TTCGTGTATG TGGTGCTGGA AATCTGTCGC 360
AGAAGGTCTC TCCTTGAATT GCACAAAAGG AGGAAGGCAG TGACTGAGCC TGAGGCCCGA 420
TACTTCATGC GCCAGACTAT TCAGGGTGTT CAGTACTTGC ACAACAACAG AGTCATTCAC 480
CGTGATCTCA AACTTGGGAA TCTGTTCCTC AATGATGACA TGGATGTGAA GATCGGTGAC 540
TTTGGTTTAG CCACTAAGAT TGAGTTTGAT GGGGAGCGAA AGAAGACCCT TTGTGGCACT 600
CCAAACTACA TTGCTCCTGA GGTGCTCTGC AAGAAAGGCC ACAGCTTTGA AGTTGACATT 660
TGGTCACTAG GATGCATTCT ATACACACTG CTGGTTGGAA AGCCTCCATT TGAGACATCC 720
TGTCTGAAAG AGACCTACAT TAGGATTAAG AAGAATGAGT ACTCAGTTCC TAGACACATT 780
AATCCAGTTG CATCTGCTTT GATTCGTCGG ATGCTGCACG CTGACCCTAC ACTCAGACCT 840
TCTGTAGCTG AACTGCTGAC TGATGAGTTT TTCACCTCTG GTTATGCACC CATGCGGCTG 900
CCCACTTCCT GTCTCACTGT TCCTCCCAGG TTCTCCATCG CCCCCTCCAG CCTGGATCCT 960
GCCCTCCTCC GCAAACCTCT CTCATCACTT AATAAAGGCA CAGATAGTCC AATTGAGAAA 1020
ATGGGGAAAA TGGATCAGCC ACAAAGAGAA GATCTGCAAC AAAGAGATGG ACCAGAGCAG 1080
CCTGACACTC ACCTAACTGA CATGCTGCAG CAGCTGGCTG TCGTCAATGC AGCCAAGCCG 1140
TCTGATAGAG ACTTTATTAG ACAAGAGGAA GCTGAAGACC CTGCTTGTAT TCCTGTCTTC 1200
TGGATTAGTA AATGGGTTGA CTACTCTGAC AAATATGGCC TTGGTTACCA GTTGTCTGAT 1260
AACAGTGTAG GTGTTCTGTT CAATGATTCC ACACGGTTGA TCATGTGTGC TGACGGTGAT 1320
AGCCTGCAGT ACATCGATCG CAACTCTCTA GAATCCTACC TCAGTGTTCG CTCGTATCCC 1380
TCTGCACTCT CCAAAAAGAT TACACTCCTT AAGTACTTCA GGAATTACAT GAGTGAGCAC 1440
TTGCTGAAGG CTGGAGCGAA TATAACTCCT CGGGAAGGGG ATGAACTGAC CCGATTGCCT 1500
TACCTTCGCC ACTGGTTCCG CACAAAGAGT GCTATTGTGC TACACCTGAG TAATGGGACT 1560
GTGCAAATCA ATTTTTTCCA GGATCACACT AAGCTTATTT TGTGTCCACT AATGGGAGCA 1620
GTGACGTACA TCAATGAGAA GCGAGAGTTT TACACCTACA AGATGACCTT AATCGAGGAG 1680
TTCGGCTGCT GTAAAGAGTT GGCTAGCCGT TTGCGCTATG CTCGCAACAT GGTGGAGAAG 1740
CTCATGGCCT GCAAAAGCAG CACAACAGCT GCTACTTCAG CACGCTAA 1788
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y rg++lGkGgfakcye++d++tkevfa kvvpks+l k++q+ek+++ei+ih+sl+ ++
Q: 39    YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPH  98
         89**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         +v ++ ffed+++vy+vle+c+rrsl el+krrka+tepe+ry++rq ++g++ylh++r+
Q: 99    VVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRV  158
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         +hrdlklgnlfln++++vkigdfGlat++e ++erkktlcGtPnyiaPevl kkghs+ev
Q: 159   IHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEV  218
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diWslGcilytllvGkPPfet++lkety +ikk+eys+P+++++ a+ li+++l+++P+ 
Q: 219   DIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTL  278
         ************************************************************
S: 241   rpsleevlkdefl  253
         rps+ e+l+def+
Q: 279   RPSVAELLTDEFF  291
         ************8
Domain Sequence
(FASTA)
YMRGRFLGKG GFAKCYEITD MDTKEVFAGK VVPKSMLLKP HQKEKMSTEI AIHKSLDNPH 60
VVGFHGFFED DDFVYVVLEI CRRRSLLELH KRRKAVTEPE ARYFMRQTIQ GVQYLHNNRV 120
IHRDLKLGNL FLNDDMDVKI GDFGLATKIE FDGERKKTLC GTPNYIAPEV LCKKGHSFEV 180
DIWSLGCILY TLLVGKPPFE TSCLKETYIR IKKNEYSVPR HINPVASALI RRMLHADPTL 240
RPSVAELLTD EFF 253
Keyword3D-structure; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00244
EKS-ANC-00253
EKS-BOT-00261
EKS-CAE-00235
EKS-CAJ-00267
EKS-CAF-00268
EKS-CAP-00296
EKS-CII-00158
EKS-CIS-00035
EKS-DRM-00134
EKS-ECT-00012
EKS-EQC-00256
EKS-FEC-00247
EKS-GAM-00161
EKS-GAG-00220
EKS-GAA-00322
EKS-GOG-00259
EKS-HOS-00268
EKS-ICT-00246
EKS-LAC-00273
EKS-LOA-00271
EKS-MAM-00263
EKS-MEG-00209
EKS-MIM-00017
EKS-MOD-00258
EKS-MUM-00291
EKS-MUP-00258
EKS-MYL-00262
EKS-ORN-00340
EKS-ORA-00231
EKS-ORC-00247
EKS-ORL-00317
EKS-OTG-00267
EKS-PAT-00248
EKS-PES-00234
EKS-POA-00254
EKS-RAN-00276
EKS-SAH-00247
EKS-TAG-00279
EKS-TAR-00335
EKS-TEN-00331
EKS-TUB-00014
EKS-TUT-00029
EKS-XET-00336
EKS-XIM-00332
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000278; P:mitotic cell cycle
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013