EKS-DAR-00790
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00790
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR485.42.3E-145560902343
StatusUnreviewed
Ensembl ProteinENSDARP00000075800
UniProt AccessionE7F1P1;
Protein Name
Protein Synonyms/Alias
Gene Nameflt3
Gene Synonyms/Alias flt3; CH211-140B10.8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000058503ENSDARP00000075800ENSDART00000081357
OrganismDanio rerio
Functional Description
Protein Length956
Protein Sequence
(FASTA)
MHLGIKLLLV LLVLHWSSLK DGLTEAHPRC DTDGSTVRCT LEETDLMSSD PIKLDVTEGQ 60
VVEIYSACEQ NSSNERKCLC YQRTNSSIHL LQCIEKLGNE KYSVICGNKT VTAVRATQRR 120
PSVPVLKAIL KAGSTNLAQL VCTSEGYPKP TLRWYGNSDD AEEGMTSSAC KTESTLISYY 180
SYLSKNPNQK CCASNALGEE CTEVYHYDLN EEDKQKSQNI IYLKSGQSLL LRAAKKDLRN 240
PGIKWHFNNT VIKGITSLQY YDWTEHLFIE SVNMAHSGLY LCTSDTKTPR NCSTHVKVFE 300
HDQIDILHLN ENNSILAKNK TDFCFQSQVF SYPKARCYWI TPNQTQIQCD ETSQSNFTST 360
FKLCNTEPGQ YQMKLETQEY SVMRNVSLCI SDIPKITIRK NSSFTTCETE SPLPVTVSWK 420
TCPSHAKCDP EDWKEIAADQ PEFTDSDQFC QKKIGFSRRH LKSEDHLIKC CITNVAGTGC 480
SEKILLQTKS HTYYVICFLL IVILFMIIIA LIIFIRVKKP KYQSQIQMIQ MIGPNDNDYI 540
YIDFREFKYD LKWEFPRENL ELGNELGSGA FGMVVQATAY GISKPGVSVQ VAVKMLKEKH 600
QAVEKEALMS ELKMLTHIGH HENIVNLLGA CTGSGPVYLI FQYCCNGDLL NYLKSNRECF 660
HKYLTDAFNK DRFRGLYHNF QQNRNSSEYV LSDNSQCLNV TPASKEQEKE NDALLSSSIS 720
SGSPAEEMLE CEDEHQEEEL HSLTYDDLLS FSFQVAKGMQ FLSAKNCIHR DLAARNVLVT 780
HGRQVKIADF GLARDIEHDS NYVVRGNVRL PVKWMAPESI FKGIYTMESD IWAYGILLWE 840
IFSLGVTPYP GVTVNNTFYR MIESGYHLEQ PYYAAESVYK VMCRCWALNP VDRPCFSKIV 900
AFMEKELAAL EERLYYNVGG YSHDEITYQN APVMPEDTPI VTDTHGSGAV RTEPPV 956
Nucleotide Sequence
(FASTA)
ATGCATCTTG GAATCAAGCT CTTGCTGGTG CTGCTCGTGC TGCACTGGAG CTCGTTGAAG 60
GACGGTTTAA CTGAAGCTCA TCCGCGATGC GACACTGATG GATCGACTGT AAGATGCACG 120
CTGGAAGAGA CTGACTTAAT GAGTTCTGAC CCAATCAAAC TGGATGTCAC TGAAGGACAA 180
GTGGTGGAAA TTTACAGTGC ATGTGAACAA AATAGCTCCA ATGAGCGTAA ATGTCTCTGC 240
TATCAAAGGA CAAATTCTTC TATCCATCTG TTACAATGCA TTGAAAAATT GGGAAATGAA 300
AAATATTCTG TGATCTGTGG CAATAAAACT GTTACGGCTG TTCGGGCAAC ACAAAGAAGG 360
CCATCGGTTC CAGTTCTCAA AGCTATTTTA AAGGCAGGGT CTACAAATCT AGCTCAGTTA 420
GTGTGCACTT CTGAGGGGTA CCCAAAACCA ACTCTCAGGT GGTATGGGAA CAGTGATGAT 480
GCAGAGGAGG GCATGACAAG TAGTGCGTGT AAGACAGAGA GCACTTTGAT AAGTTATTAT 540
AGTTATCTTT CTAAAAATCC AAATCAGAAA TGCTGTGCCA GTAATGCTCT GGGAGAAGAA 600
TGCACTGAGG TCTATCATTA TGATCTGAAT GAGGAGGATA AGCAAAAGTC TCAAAATATA 660
ATTTATCTTA AATCTGGTCA ATCTTTGCTG CTCAGAGCTG CCAAAAAAGA TTTGAGAAAC 720
CCAGGAATAA AATGGCACTT TAATAACACA GTGATCAAGG GAATCACCTC ATTACAATAT 780
TATGACTGGA CAGAGCACCT CTTTATCGAA TCAGTTAATA TGGCACACAG TGGGCTTTAC 840
CTCTGCACAT CAGATACTAA AACCCCCCGA AATTGCAGCA CCCATGTCAA GGTCTTTGAA 900
CATGATCAAA TTGACATATT GCATCTGAAC GAGAACAACA GCATACTAGC AAAAAATAAG 960
ACAGACTTTT GCTTCCAGTC TCAGGTTTTC TCCTACCCAA AAGCCCGGTG TTATTGGATC 1020
ACACCAAATC AAACACAAAT ACAGTGTGAC GAAACTTCCC AATCAAATTT TACCAGTACG 1080
TTTAAGCTGT GTAACACTGA ACCAGGTCAG TATCAAATGA AACTCGAGAC TCAGGAATAC 1140
AGTGTCATGA GGAATGTATC TCTGTGTATC TCAGATATTC CTAAAATTAC AATACGCAAA 1200
AATTCAAGCT TCACTACTTG TGAGACTGAA AGCCCTTTAC CTGTGACTGT ATCCTGGAAG 1260
ACCTGCCCAT CCCATGCTAA ATGTGATCCT GAAGACTGGA AAGAGATAGC TGCTGACCAG 1320
CCAGAGTTTA CAGATTCAGA TCAGTTCTGT CAGAAGAAAA TTGGCTTTTC CAGACGGCAC 1380
CTGAAAAGCG AGGACCATCT TATCAAATGC TGCATCACTA ATGTTGCAGG GACTGGCTGC 1440
AGTGAAAAAA TACTACTGCA AACCAAGTCT CACACTTATT ATGTGATCTG TTTCCTGCTC 1500
ATCGTTATAC TCTTCATGAT TATCATTGCA TTAATCATCT TCATCAGAGT TAAGAAACCT 1560
AAGTACCAGA GTCAGATCCA GATGATTCAG ATGATCGGAC CCAACGACAA TGATTACATT 1620
TATATTGACT TCAGAGAGTT CAAATATGAC TTGAAATGGG AATTTCCTCG CGAAAATCTC 1680
GAACTTGGGA ATGAACTTGG ATCTGGTGCT TTTGGGATGG TTGTTCAGGC TACAGCATAT 1740
GGGATCAGCA AGCCGGGTGT TTCTGTTCAG GTAGCGGTAA AAATGTTAAA GGAGAAGCAC 1800
CAGGCAGTGG AGAAGGAAGC TCTGATGTCT GAACTGAAAA TGCTGACTCA TATTGGACAC 1860
CATGAGAACA TTGTCAACCT GCTTGGTGCT TGCACGGGAT CAGGTCCTGT TTACCTGATC 1920
TTCCAGTACT GCTGTAACGG AGATCTCCTG AATTACCTGA AGAGCAACAG AGAATGCTTT 1980
CACAAATATC TGACGGACGC TTTCAACAAG GACAGATTCA GGGGCCTCTA CCACAACTTC 2040
CAGCAGAACA GAAACTCCAG TGAGTATGTT CTGTCTGATA ACAGCCAATG CCTAAATGTG 2100
ACTCCTGCTA GCAAAGAACA GGAGAAAGAA AACGATGCGC TTCTGAGTAG CAGCATCAGC 2160
TCAGGGTCTC CTGCTGAGGA AATGCTTGAG TGTGAAGACG AGCATCAAGA AGAGGAACTT 2220
CACAGTCTCA CCTATGATGA CCTTCTGAGT TTCTCTTTTC AAGTTGCAAA GGGCATGCAG 2280
TTCCTGTCTG CTAAAAATTG CATCCACAGG GACTTGGCAG CCAGAAATGT TTTGGTGACA 2340
CACGGCAGAC AGGTGAAAAT CGCTGACTTT GGTCTTGCCA GAGACATTGA GCATGACTCC 2400
AACTACGTTG TAAGAGGAAA TGTGCGTTTG CCGGTGAAAT GGATGGCACC TGAGAGTATT 2460
TTTAAAGGCA TCTACACAAT GGAGAGTGAC ATCTGGGCCT ATGGCATTCT GCTCTGGGAG 2520
ATCTTTTCTC TAGGAGTCAC CCCATATCCT GGTGTGACTG TGAACAACAC TTTCTACAGA 2580
ATGATTGAAA GTGGATATCA CTTGGAGCAG CCCTATTATG CAGCAGAATC TGTGTACAAG 2640
GTTATGTGTC GCTGCTGGGC GTTGAATCCT GTAGATCGGC CTTGTTTCTC CAAAATTGTG 2700
GCTTTCATGG AAAAAGAGCT GGCAGCTTTA GAAGAGAGGC TGTATTACAA TGTCGGAGGA 2760
TACAGTCACG ATGAAATAAC ATACCAGAAT GCACCAGTGA TGCCTGAAGA TACACCGATA 2820
GTCACGGATA CACATGGTTC TGGAGCAGTA AGAACAGAAC CTCCTGTTTG A 2871
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         lelG+ lGsGafG vv+atayG+sk +++++vavkmlk++ ++ ekealmselk+l+h+G
Q: 560   LELGNELGSGAFGMVVQATAYGISKPGVSVQVAVKMLKEKHQAVEKEALMSELKMLTHIG  619
         789*********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gp+y+i++ycc Gdllnyl+++re f+k  ++ ++++++   +++
Q: 620   HHENIVNLLGACTGSGPVYLIFQYCCNGDLLNYLKSNRECFHKYLTDAFNKDRFRGLYHN  679
         *************************************************99999999998
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkks....alerevkaal  176
         ++++   r++s++  +++++ +++ +++++ ++ + d+l s++++s     +  e++++ 
Q: 680   FQQN---RNSSEYVLSDNSQCLNVTPASKEQEKEN-DALLSSSISSgspaEEMLECEDEH  735
         8333...3333444445556688888665544444.444333333311103334667788
S: 177   eeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlard  236
         +ee+ ++l+++dllsfs+qvakGm+fl++knc+hrdlaarnvl+t+G+ vki+dfGlard
Q: 736   QEEELHSLTYDDLLSFSFQVAKGMQFLSAKNCIHRDLAARNVLVTHGRQVKIADFGLARD  795
         899999******************************************************
S: 237   imkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvd  296
         i +dsnyvv+Gn rlpvkwmapesif+++yt++sd+w+yGillweifslG+tpypg+ v+
Q: 796   IEHDSNYVVRGNVRLPVKWMAPESIFKGIYTMESDIWAYGILLWEIFSLGVTPYPGVTVN  855
         ************************************************************
S: 297   skfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         ++fy++i++Gy+++qp ya+e +y++m +cw+ +p  rp f+++v +
Q: 856   NTFYRMIESGYHLEQPYYAAESVYKVMCRCWALNPVDRPCFSKIVAF  902
         ********************************************987
Domain Sequence
(FASTA)
LELGNELGSG AFGMVVQATA YGISKPGVSV QVAVKMLKEK HQAVEKEALM SELKMLTHIG 60
HHENIVNLLG ACTGSGPVYL IFQYCCNGDL LNYLKSNREC FHKYLTDAFN KDRFRGLYHN 120
FQQNRNSSEY VLSDNSQCLN VTPASKEQEK ENDALLSSSI SSGSPAEEML ECEDEHQEEE 180
LHSLTYDDLL SFSFQVAKGM QFLSAKNCIH RDLAARNVLV THGRQVKIAD FGLARDIEHD 240
SNYVVRGNVR LPVKWMAPES IFKGIYTMES DIWAYGILLW EIFSLGVTPY PGVTVNNTFY 300
RMIESGYHLE QPYYAAESVY KVMCRCWALN PVDRPCFSKI VAF 343
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TAR-00506
EKS-TEN-00504
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013162; CD80_C2-set.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF08205; C2-set_2; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013