EKS-DAR-00749
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00749
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src431.32.2E-129234484251
StatusUnreviewed
Ensembl ProteinENSDARP00000075977
UniProt AccessionE7F0I7; F1QAU3;
Protein Name
Protein Synonyms/Alias
Gene Namehck
Gene Synonyms/Alias hck;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000058647ENSDARP00000075977ENSDART00000081536
ENSDARG00000058647ENSDARP00000115909ENSDART00000135787
OrganismDanio rerio
Functional Description
Protein Length499
Protein Sequence
(FASTA)
MGCVGTKPEQ DPIGKSVNSD DNRNVAHYTK DPTTGAKANR TTSNAQTPGT DTSENIAIAL 60
YDYEAMHEGD LGFKKGDRLR ILQESGEWWK AVIISTGQEG FIPSNYVAKD TLETEEWFFK 120
GVSRKDAERQ LLASGNKTGS FMIRDSETTK GSYSLSVRDS DHQADTVKHY KIRTLDNGGF 180
YISPRITFNT LQDLVSHYKK QSDGLCQSLT SPCLSPKPQK PWEKDAWEIP RESLKLDKRL 240
GAGQFGEVWM AMYNKHTKVA VKTMKPGSMS VEAFLMEANL MKSLQHDKLV RLNAVVTKEE 300
PIYIITEFME KGSLLDFIKS DEGNRVQLPK LIDFSAQIAE GMAYIEQRNY IHRDLRAANI 360
LVNKSLVCKI ADFGLARIIE DNEYTAREGA KFPIKWTAPE AINYGSFTIK SDVWSFGILL 420
TEIISYGRTP YPGMTNPEVI RALERGYRMQ RLDSCPQELY DIMLECWKNK PEDRPTFEYL 480
QSVLEDFYTA TESQYQQQP 499
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGGGGACCAA ACCGGAGCAA GATCCTATTG GTAAATCAGT GAACAGCGAT 60
GACAACCGCA ACGTGGCACA TTACACCAAA GACCCCACAA CAGGGGCCAA AGCTAACAGA 120
ACCACCTCCA ATGCACAGAC TCCTGGGACA GATACTTCAG AAAACATTGC CATCGCTCTG 180
TATGACTATG AAGCCATGCA TGAAGGTGAC CTGGGCTTCA AGAAAGGAGA TCGGCTCAGA 240
ATCCTGCAGG AGTCCGGTGA GTGGTGGAAA GCAGTAATCA TCAGCACTGG TCAAGAGGGC 300
TTCATTCCCA GTAACTATGT TGCCAAAGAT ACTCTGGAAA CTGAAGAGTG GTTTTTTAAA 360
GGTGTCAGCA GGAAGGATGC AGAGAGACAG CTGTTGGCCT CTGGAAACAA AACAGGCTCC 420
TTCATGATCA GAGACAGTGA GACTACCAAG GGAAGCTACT CTTTGTCTGT GAGAGACAGC 480
GACCATCAGG CTGACACTGT CAAGCATTAT AAGATCCGCA CACTGGATAA CGGCGGTTTC 540
TATATTTCCC CGCGAATCAC ATTCAACACC CTGCAGGACC TGGTCAGCCA CTACAAAAAG 600
CAGAGCGATG GGCTGTGCCA GTCTCTCACC TCTCCCTGTC TGAGTCCCAA ACCTCAGAAG 660
CCTTGGGAGA AAGACGCATG GGAGATTCCA CGCGAGTCCC TCAAACTGGA CAAACGTCTG 720
GGAGCAGGAC AGTTTGGGGA GGTCTGGATG GCAATGTACA ACAAGCACAC CAAAGTGGCG 780
GTGAAGACTA TGAAGCCTGG CAGTATGTCT GTGGAAGCTT TCCTTATGGA GGCCAACTTA 840
ATGAAAAGCC TACAGCACGA CAAACTGGTC CGTCTCAACG CTGTGGTCAC CAAAGAAGAG 900
CCCATTTACA TCATTACAGA GTTCATGGAG AAAGGCAGTT TACTGGACTT CATTAAAAGC 960
GACGAAGGGA ACCGAGTCCA GCTGCCCAAA CTGATCGACT TCTCAGCACA GATTGCAGAA 1020
GGTATGGCTT ACATTGAGCA GAGGAACTAC ATTCACAGAG ATCTCCGTGC TGCCAACATC 1080
CTGGTCAACA AAAGTTTAGT GTGTAAGATT GCTGATTTTG GACTGGCACG TATCATAGAG 1140
GACAACGAAT ACACTGCTAG AGAAGGTGCA AAGTTCCCTA TTAAGTGGAC AGCTCCAGAG 1200
GCTATAAACT ATGGCTCCTT CACCATCAAA TCCGATGTGT GGTCTTTCGG CATCCTGCTG 1260
ACTGAAATCA TTAGCTATGG CCGCACGCCA TACCCAGGGA TGACCAACCC CGAGGTAATC 1320
CGTGCTCTTG AGAGAGGTTA CCGCATGCAG CGTCTGGACT CCTGTCCTCA AGAGCTCTAC 1380
GACATCATGC TAGAGTGCTG GAAGAACAAG CCTGAGGACA GACCCACCTT TGAGTACCTG 1440
CAGAGCGTGC TGGAGGACTT TTACACTGCC ACCGAGAGCC AGTATCAGCA ACAACCTTGA 1500
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl k+lG+GqfGevw++++++++kvavkt+k+g++s eafl ea+++k+l+h+klv+l 
Q: 234   LKLDKRLGAGQFGEVWMAMYNKHTKVAVKTMKPGSMSVEAFLMEANLMKSLQHDKLVRLN  293
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+m+kGslldf+k++eg++++lpkl+d++aq+aeGmay+e++n+ihr
Q: 294   AVVTKEEPIYIITEFMEKGSLLDFIKSDEGNRVQLPKLIDFSAQIAEGMAYIEQRNYIHR  353
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv++slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 354   DLRAANILVNKSLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  413
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGilltei+++G++PypGmtn ev++++ergyr+ r ++cp+ely+++lecwk++pe+
Q: 414   WSFGILLTEIISYGRTPYPGMTNPEVIRALERGYRMQRLDSCPQELYDIMLECWKNKPED  473
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq+vl
Q: 474   RPTFEYLQSVL  484
         ********986
Domain Sequence
(FASTA)
LKLDKRLGAG QFGEVWMAMY NKHTKVAVKT MKPGSMSVEA FLMEANLMKS LQHDKLVRLN 60
AVVTKEEPIY IITEFMEKGS LLDFIKSDEG NRVQLPKLID FSAQIAEGMA YIEQRNYIHR 120
DLRAANILVN KSLVCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180
WSFGILLTEI ISYGRTPYPG MTNPEVIRAL ERGYRMQRLD SCPQELYDIM LECWKNKPED 240
RPTFEYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013