EKS-DAR-00638

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00638

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	455.7	1.3E-136	548	833	286

Status

Unreviewed

Ensembl Protein

ENSDARP00000076054

UniProt Accession

F6NI62;

Protein Name

Protein Synonyms/Alias

Gene Name

ddr2b

Gene Synonyms/Alias

ddr2b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000058695	ENSDARP00000076054	ENSDART00000081613
ENSDARG00000058695	ENSDARP00000123523	ENSDART00000147146

Organism

Danio rerio

Functional Description

Protein Length

838

Protein Sequence
(FASTA)

MFQMSQYFVV FLLFGAVNSQ VNPAVCRYPL GMNGGQIQDE DISASSQWSE STAARYGRLD 60

FDDGDGAWCP DVMAEAHSLK EFLQIDLRTL HFVTLVGTQG RHADGVGNEF AQRYRIKYSR 120

DGTRWVSWRD RQGRQIIEGN SNAYDIVLKD LEPPIIARFV RFMPVTDPSM IVCMRVELYG 180

CEWLDGLVSY SAPAGQQMTF RGQQIYLNDT VYDGAVSSSM AEGLGQLTDG SWGLDDFTKS 240

QVYGVWPGYD YVGWTNASLP GGSVEMTFEF DRVRNFTSMK VHCNNMYAWG VKMFRQAVCS 300

FRSDADWEPN PVFFKPKADS ISPSARFITV ALGNRMASAI RCRFAFSDIW MMFSEIAFQS 360

DTAVYNTSLV PRKRNQAPVD DPTHKIDDSS TRILIGCLVA IIAILLAIII IILWRQVWQK 420

MIEKASRRML DDELAVRLSV QREAFVHRSS SLSSDVESTS TYERIFPLGS DYQEPSQLLR 480

KLPEFQAMEN LAMIDGASEP SPAQGTDEAP HYAEADIPGA HSYRVTVVNM PLSPGRDGAL 540

EEFPRDRLTF KEKLGEGQFG EVHLCEAEGM QEFMKDHCDD ICVDPMLVAV KTLREDADKN 600

ARNDFMKEIR IISRLRDPNI IRLLAVCVES DPLCMITEYM ENGDLNQFLS RHQLQEDGVQ 660

ADSTSISYGT LINMASQISS GMKYLSSLNF VHRDLATRNC LVGMNNIIKI ADFGMSRNLY 720

RGDYYRIQGR AVLPIRWMSW ESILLGKFTM ASDVWAFGVT LWEILTLCKE QPYAQFTDEQ 780

VIENTGEFFR DQNKQVYLLR PACCPESLYS LMLNCWRRNA KERPTFLEIH STLTEQHD 838

Nucleotide Sequence
(FASTA)

ATGTTCCAGA TGAGTCAATA CTTCGTTGTC TTTCTCCTGT TTGGAGCCGT GAATTCACAG 60

GTAAACCCAG CTGTATGTAG GTATCCTCTA GGAATGAATG GAGGTCAAAT TCAGGATGAA 120

GATATTTCTG CTTCCAGCCA ATGGTCAGAG TCCACCGCCG CTCGATATGG CAGATTGGAT 180

TTTGATGATG GAGATGGTGC GTGGTGTCCG GATGTCATGG CTGAAGCGCA CAGTCTGAAG 240

GAGTTTCTGC AGATTGACCT CCGCACTCTG CATTTTGTCA CTTTGGTTGG CACACAGGGA 300

CGTCATGCAG ACGGGGTGGG CAATGAATTT GCCCAGAGAT ACAGGATTAA ATACAGCCGG 360

GACGGCACTC GATGGGTCTC CTGGCGGGAC CGGCAAGGTC GACAGATCAT TGAAGGAAAC 420

AGTAACGCCT ATGACATCGT GCTTAAGGAC CTGGAGCCTC CTATTATTGC TCGTTTTGTG 480

CGCTTCATGC CTGTGACTGA CCCGTCTATG ATTGTGTGTA TGAGGGTGGA GCTCTACGGC 540

TGTGAATGGC TCGATGGCCT TGTGTCCTAC AGCGCCCCTG CTGGCCAACA GATGACTTTC 600

AGAGGCCAGC AGATCTACTT AAATGACACC GTGTATGACG GAGCCGTTAG TTCCAGCATG 660

GCAGAAGGTC TCGGGCAGCT GACTGACGGC AGCTGGGGTT TGGACGACTT CACTAAAAGT 720

CAGGTGTATG GAGTCTGGCC TGGCTATGAC TATGTGGGCT GGACGAATGC TAGTTTACCT 780

GGTGGCTCGG TGGAGATGAC CTTTGAGTTT GACCGGGTCC GAAACTTCAC CTCAATGAAG 840

GTCCACTGTA ACAACATGTA CGCATGGGGA GTGAAGATGT TCCGACAGGC CGTGTGTTCC 900

TTCCGTTCGG ATGCAGACTG GGAGCCCAAT CCTGTGTTTT TCAAGCCGAA AGCAGACAGC 960

ATCAGTCCAA GTGCTCGCTT TATCACTGTT GCTCTTGGCA ACCGCATGGC CAGCGCAATC 1020

AGGTGCCGTT TTGCGTTCAG TGACATCTGG ATGATGTTCA GCGAAATTGC TTTCCAGTCA 1080

GATACAGCAG TGTACAACAC CTCTCTTGTA CCTCGCAAAC GTAACCAAGC TCCAGTGGAT 1140

GATCCCACCC ACAAAATCGA TGACAGCAGT ACAAGGATCC TCATCGGCTG TTTGGTGGCC 1200

ATTATTGCCA TTCTGTTGGC CATCATAATC ATCATACTAT GGCGACAGGT CTGGCAGAAG 1260

ATGATTGAGA AGGCCTCTCG GCGTATGCTG GACGATGAGC TGGCCGTGCG TCTGTCTGTT 1320

CAGAGAGAGG CGTTTGTCCA CCGCAGCTCC TCTCTGTCCA GCGACGTCGA ATCCACTTCC 1380

ACATACGAGC GCATTTTCCC ATTGGGATCT GACTATCAGG AGCCTTCACA ACTTTTACGC 1440

AAGCTACCAG AATTCCAGGC TATGGAAAAC CTTGCGATGA TCGATGGTGC TTCTGAACCC 1500

TCTCCAGCTC AGGGTACAGA TGAAGCTCCA CACTACGCAG AGGCAGACAT CCCTGGAGCT 1560

CACAGCTATC GCGTCACTGT GGTCAACATG CCTTTATCTC CTGGAAGAGA CGGAGCTCTG 1620

GAGGAGTTTC CCAGGGACAG ACTGACCTTC AAAGAGAAGC TCGGAGAAGG ACAGTTTGGA 1680

GAGGTTCATC TGTGTGAAGC TGAAGGAATG CAGGAATTCA TGAAGGACCA TTGTGATGAC 1740

ATTTGCGTTG ACCCAATGCT CGTAGCGGTC AAAACCCTGA GAGAGGACGC TGACAAAAAT 1800

GCAAGGAACG ACTTCATGAA AGAGATCAGG ATCATCTCGC GATTAAGAGA CCCGAACATC 1860

ATTCGCCTGT TGGCGGTGTG TGTTGAGAGC GATCCGCTGT GCATGATCAC GGAGTACATG 1920

GAGAACGGAG ACCTCAATCA GTTCCTGTCC CGCCACCAGC TGCAGGAAGA CGGAGTTCAG 1980

GCTGACTCTA CTTCCATCAG CTACGGAACG CTGATCAACA TGGCCTCTCA GATTTCCTCT 2040

GGAATGAAGT ATCTGTCATC CCTGAATTTC GTTCACCGTG ATCTCGCCAC ACGCAACTGT 2100

TTAGTCGGCA TGAACAACAT CATCAAGATC GCAGACTTTG GCATGAGCCG AAACCTGTAC 2160

CGTGGAGATT ACTACCGCAT ACAGGGGCGT GCAGTGCTCC CCATCCGCTG GATGTCCTGG 2220

GAGAGCATCC TACTGGGTAA ATTCACCATG GCCAGTGACG TGTGGGCATT CGGCGTGACC 2280

CTGTGGGAGA TTCTAACCCT GTGCAAAGAG CAGCCGTATG CCCAGTTTAC AGACGAACAG 2340

GTGATCGAAA ACACCGGAGA GTTTTTCAGG GACCAAAATA AACAGGTGTA TCTGCTGAGG 2400

CCGGCCTGCT GCCCTGAGTC ACTGTACAGC CTCATGCTCA ACTGCTGGAG GAGAAACGCC 2460

AAAGAAAGAC CCACCTTCTT GGAGATCCAC AGCACACTGA CAGAGCAACA TGATTAA 2517

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledlkekd...skgsallvavkslredanknarkdflk  57

         L++keklGeG+fgev+lCe eg++++++        +++lvavk+lreda knar+df+k

Q: 548   LTFKEKLGEGQFGEVHLCEAEGMQEFMKDHcddICVDPMLVAVKTLREDADKNARNDFMK  607

         789**********************986533336679***********************

S: 58    eikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflsehe.aedselakektls  116

         ei+i+srl+dPni+rll+vcv+ +plc+i+ey+enGdlnqfls+h+  ed+  a+++++s

Q: 608   EIRIISRLRDPNIIRLLAVCVESDPLCMITEYMENGDLNQFLSRHQlQEDGVQADSTSIS  667

         *********************************************956778889999***

S: 117   yellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdyyrv  176

         y +l+++a+qi sg+kyL+slnfvhrdlatrnclvg +  +kiadfg+sr+ly gdyyr+

Q: 668   YGTLINMASQISSGMKYLSSLNFVHRDLATRNCLVGMNNIIKIADFGMSRNLYRGDYYRI  727

         ************************************************************

S: 177   qGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvienage  236

         qGravlPiRwm+wesillgkft asDvWafgvtlweiltlc+eqPy ++tdeqvien+ge

Q: 728   QGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPYAQFTDEQVIENTGE  787

         ************************************************************

S: 237   lfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282

         +frdq+++v+l+rPa cp++ly l+l+Cwrr+ +eRP+f e+h  l

Q: 788   FFRDQNKQVYLLRPACCPESLYSLMLNCWRRNAKERPTFLEIHSTL  833

         *******************************************875

Domain Sequence
(FASTA)

LTFKEKLGEG QFGEVHLCEA EGMQEFMKDH CDDICVDPML VAVKTLREDA DKNARNDFMK 60

EIRIISRLRD PNIIRLLAVC VESDPLCMIT EYMENGDLNQ FLSRHQLQED GVQADSTSIS 120

YGTLINMASQ ISSGMKYLSS LNFVHRDLAT RNCLVGMNNI IKIADFGMSR NLYRGDYYRI 180

QGRAVLPIRW MSWESILLGK FTMASDVWAF GVTLWEILTL CKEQPYAQFT DEQVIENTGE 240

FFRDQNKQVY LLRPACCPES LYSLMLNCWR RNAKERPTFL EIHSTL 286

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155	; P:cell adhesion
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01285	; FA58C_1; 1.
PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013