EKS-DAR-00835

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00835

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	494.2	1.8E-148	77	343	267

Status

Unreviewed

Ensembl Protein

ENSDARP00000076092

UniProt Accession

E7FD31;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA (1 of 2)

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000058760	ENSDARP00000076092	ENSDART00000081651

Organism

Danio rerio

Functional Description

Protein Length

1757

Protein Sequence
(FASTA)

MSGEVRLKKL EKLILDGPVQ ANGQCFSVES LLDVLICIYD ECTNSPLRRE KNVAEFLEWA 60

KPFTSKVKQM RLHKEDFEIL KVIGRGAFGE VAVVKVKSSD KVFAMKILNK WEMLKRAETA 120

CFREERDVLV NGDSQWITTL HYAFQDDNFL YLVMDYYVGG DLLTLLSKFE DRLPEDMARF 180

YLAEMVLAID SVHQLHYVHR DIKPDNILID VNGHIRLADF GSCLKLTEDG TVQSSVAVGT 240

PDYISPEILQ AMEDGKGKYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 300

FQFPAQMTDV SENAKDLIRR LICCREHRLG QNGIEDFKQH PFFSGIDWQN IRNCDAPYIP 360

EVSSPSDTSN FDVDDDCLKN TETMPPPSHT AFSGHHLPFV GFTYTSNCTL SDRGCLRESA 420

APAQMDVCVQ RGLEDSLATE AYERRIRRLE QEKLELGRKL QESTKAVQAL QYSSSDGPVS 480

SNREFEIRGL KEEIEMLKKQ IADTGQVEQQ LEQAISARSD MEDSSKQIRS LEKQLKSTKQ 540

ERDDLQKRLQ ESSDKQKVQG KELKEADSQR KMAMQEFAEV SEKVTELRSL KQRLTRQLRD 600

KEEELDSLNQ KVEALRLDVR KAERAKKEME VQAEEWSAEA QKEKKLRERS EQFSRQLEEE 660

LDSIKQKHVG RSPSTGSSEQ NQELSKLRAD LEKKTVHFKE ELSRIEQQHA NELKSLKKEL 720

KESEGQQLSL KKEIMMLKDK LDKSRRESHS ERDELEFERV LLSEENKKLS SELDKLSCSN 780

KQLEEKIRVL ADEKESVAHW EAQITEIIQW VSDEKDARGY LQALATKMTE ELEGLKNASL 840

GARATDMPWK VRRLAKLDMS ARLELQSALD AEIKAKQTIQ DELNKVKASH MATECKLEES 900

EKQNQDLQAE IQRLKQETDN LRMSKGVKHQ DSQNSFLAFL NAPTSALDQF DRSTASGPAG 960

KGRRIDSIDN FSLSNTPSRE EDGRSQATSH SRSPSTTSDV ESHEQVDQPQ RGAQTPVRSG 1020

YSSSAHTIPK PKAHQFVVKT FNTPTKCNQC TSLMVGIIRQ GCTCEVCNFS CHVTCADKAP 1080

AVCPIPPDQT KGPLGIDPQK GIGTAYEGHV KVPKPLGVKK GWQRAIAVVC DFKLFLYDLP 1140

EGKAAQPGVV VNQVIDMRDE EFSVSPVLAS DVIHANRKDI PCIFRVTASQ LCASSNKKCS 1200

ILILADSDQE RTKWVGLLKE LHRLLKKSKL KERFVYVPKE AYDCALPLIK TTQSAAIIDH 1260

ERIALGNEEG LYVIHVTKDE IIKVGDNKKV HQIELIPSEQ LIAVISGRNG HVRLYPMTAL 1320

DDRDVESYKI AETKGCQTLL SGTIRHGSLT CLFVAMKKPD KVIVYELNKS KARHRKLREI 1380

LVPGSVQWMG LQGEKLCVGF QSGFLRYSLQ GDGGTSSLLH PDDHTLGFIE QLGLDSLCAV 1440

EISSKELLLC FSSIGIYVDY QGRRSRQQEL MWPATPTACR YNAPYLSVYS ENAVDVFDVN 1500

TMEWIQTIPL KKVHPLNSDG SLNLLGLETV RLIYFKNKTA EGDELVVPET SDNSRKQMVR 1560

STASKRRFSF RIPEEERVLQ RREMLRDPEI RNKLISNPTN FNHVVHMGPG DGIQILKELP 1620

MNMRSQESRG VLGASVSIPS ISRTRPEPGR SMSASSGLGT RSSSQNGSAL RRDFSVGNYG 1680

STKRQMTSPS DGSLSSGGGM DCGGDAPLSQ FDREDSESPR HSTASNSSNL SSPPSPSSPH 1740

KSKTQSLERG EHLGWGT 1757

Nucleotide Sequence
(FASTA)

ATGTCTGGGG AAGTGCGTTT GAAAAAGCTG GAAAAACTGA TCCTGGATGG TCCTGTCCAG 60

GCTAATGGAC AGTGTTTTAG TGTGGAAAGT CTTCTGGATG TTCTCATCTG CATTTATGAT 120

GAGTGCACCA ACTCCCCACT GAGAAGAGAG AAAAATGTTG CTGAGTTTTT GGAATGGGCC 180

AAACCGTTCA CCTCTAAAGT GAAACAGATG CGATTGCACA AGGAGGACTT CGAGATACTG 240

AAGGTCATTG GTCGAGGAGC TTTCGGCGAG GTAGCAGTTG TAAAGGTGAA AAGTTCAGAC 300

AAGGTGTTTG CCATGAAGAT CCTCAACAAG TGGGAGATGC TGAAACGAGC AGAGACAGCA 360

TGTTTTCGGG AGGAACGGGA TGTGCTGGTG AACGGGGACA GTCAGTGGAT CACCACACTA 420

CACTACGCTT TTCAGGATGA CAACTTCCTG TACCTGGTGA TGGATTACTA TGTGGGCGGT 480

GACCTCTTGA CTCTCCTCAG CAAGTTTGAG GATCGTTTAC CAGAGGACAT GGCCCGCTTC 540

TACCTGGCGG AGATGGTTCT GGCCATCGAT TCTGTGCATC AGCTCCATTA CGTCCACAGA 600

GACATTAAGC CAGATAACAT CCTCATAGAT GTGAACGGAC ATATTCGACT CGCAGATTTC 660

GGCTCCTGTC TGAAACTCAC GGAGGATGGA ACGGTGCAGT CGTCTGTTGC TGTGGGCACG 720

CCAGACTACA TCTCTCCTGA GATCCTGCAG GCCATGGAGG ATGGGAAAGG GAAATATGGC 780

CCTGAATGTG ACTGGTGGTC ACTGGGTGTT TGCATGTATG AAATGCTCTA TGGGGAAACT 840

CCTTTCTATG CTGAGTCCCT GGTGGAAACC TATGGCAAGA TTATGAACCA CAAGGAACGG 900

TTCCAGTTTC CTGCTCAAAT GACGGACGTG TCTGAAAATG CCAAAGATCT GATCCGCAGA 960

CTCATCTGCT GCAGAGAGCA CAGGCTAGGG CAGAACGGCA TCGAGGACTT CAAACAACAC 1020

CCCTTCTTCT CTGGCATTGA CTGGCAGAAC ATCCGCAACT GTGACGCCCC CTACATCCCT 1080

GAAGTCAGCA GCCCGTCTGA CACATCAAAC TTTGACGTGG ACGACGACTG CCTCAAGAAC 1140

ACGGAGACGA TGCCACCTCC TTCCCACACC GCTTTTTCAG GACACCATCT CCCATTTGTT 1200

GGATTCACCT ACACCAGCAA CTGTACACTC TCTGATCGGG GTTGCCTGCG TGAGTCTGCG 1260

GCTCCAGCAC AGATGGATGT TTGTGTTCAG CGCGGCCTGG AGGACAGTCT GGCCACTGAG 1320

GCGTACGAGA GGAGGATTCG CCGTCTGGAG CAGGAGAAAC TGGAGCTCGG TCGCAAGCTA 1380

CAAGAGTCCA CAAAAGCGGT ACAGGCTCTG CAGTATTCCA GCTCGGATGG GCCTGTTTCC 1440

TCCAACAGAG AGTTTGAGAT CCGCGGACTG AAGGAGGAGA TAGAAATGCT AAAAAAACAG 1500

ATTGCAGATA CAGGACAGGT GGAGCAGCAG CTGGAACAAG CCATTTCTGC ACGCAGTGAT 1560

ATGGAGGACT CCTCCAAACA GATCCGGTCT CTGGAAAAAC AGCTCAAGAG CACAAAGCAG 1620

GAGAGAGATG ACCTGCAGAA GCGTCTGCAG GAGTCCTCAG ACAAGCAGAA AGTTCAGGGG 1680

AAGGAGCTGA AGGAGGCCGA CAGTCAGAGG AAAATGGCCA TGCAGGAGTT TGCGGAGGTG 1740

AGCGAGAAAG TGACGGAGCT GAGGTCACTC AAACAGCGTC TGACCCGACA GCTACGGGAC 1800

AAAGAGGAGG AGCTGGATTC ACTCAATCAG AAGGTGGAGG CGCTTCGGCT GGATGTGCGC 1860

AAAGCAGAGA GAGCCAAGAA AGAGATGGAG GTCCAGGCTG AAGAGTGGTC TGCTGAGGCT 1920

CAGAAAGAGA AGAAGTTGAG GGAGCGCAGC GAGCAGTTCA GCAGACAGCT GGAAGAAGAG 1980

CTGGACAGCA TCAAGCAGAA GCATGTGGGC CGCTCTCCAA GCACGGGGTC GTCTGAGCAG 2040

AACCAAGAGC TTAGTAAACT ACGAGCAGAC CTGGAAAAGA AGACGGTGCA CTTCAAAGAA 2100

GAGCTTTCCC GCATAGAACA GCAACATGCC AATGAACTGA AGAGCCTGAA GAAGGAACTG 2160

AAAGAGTCAG AGGGACAGCA GCTCAGCTTG AAGAAAGAGA TCATGATGCT TAAAGACAAG 2220

CTGGACAAGT CCCGCAGAGA GAGTCATAGC GAACGAGACG AGCTTGAGTT TGAGCGAGTG 2280

CTGCTGTCTG AAGAAAACAA GAAACTGTCC AGTGAACTCG ACAAGTTGAG CTGCAGTAAC 2340

AAACAGCTGG AGGAGAAGAT TAGAGTACTG GCTGATGAGA AAGAGAGCGT GGCTCACTGG 2400

GAGGCCCAAA TCACAGAAAT CATTCAGTGG GTCAGTGATG AGAAAGATGC TCGAGGATAT 2460

CTGCAGGCTT TGGCCACTAA GATGACAGAG GAACTGGAAG GCCTGAAGAA TGCCAGTTTG 2520

GGTGCACGTG CCACTGACAT GCCATGGAAG GTGAGACGTC TGGCCAAACT GGATATGTCT 2580

GCCCGTCTGG AACTGCAGTC TGCACTGGAT GCTGAGATTA AAGCCAAACA AACCATCCAG 2640

GATGAGCTCA ACAAAGTCAA GGCATCCCAT ATGGCTACTG AGTGCAAACT GGAGGAGTCG 2700

GAAAAGCAAA ACCAGGACCT GCAGGCAGAG ATCCAGAGGC TGAAACAAGA AACGGACAAT 2760

CTGCGCATGT CTAAAGGTGT CAAGCACCAA GACTCCCAGA ATTCCTTCCT GGCATTCCTC 2820

AATGCTCCAA CCTCAGCTCT GGATCAGTTT GATCGCTCCA CTGCCAGTGG GCCGGCTGGT 2880

AAAGGCAGAC GTATTGATTC CATTGATAAC TTCAGCCTCT CCAACACACC GTCACGGGAG 2940

GAAGATGGAA GATCCCAGGC GACGTCCCAC TCTCGCTCGC CCTCTACCAC TAGCGACGTG 3000

GAGTCTCATG AGCAGGTAGA TCAGCCACAG CGAGGTGCAC AAACTCCTGT ACGATCAGGA 3060

TACAGCAGCT CCGCTCACAC CATACCTAAA CCAAAAGCCC ATCAGTTTGT GGTGAAAACC 3120

TTCAACACAC CTACTAAATG TAACCAGTGT ACGTCTCTGA TGGTGGGGAT CATCCGTCAG 3180

GGCTGCACGT GTGAAGTCTG TAACTTCTCC TGTCATGTGA CGTGTGCGGA TAAAGCTCCC 3240

GCTGTGTGCC CGATCCCACC AGATCAAACC AAAGGACCGC TCGGCATCGA CCCTCAGAAG 3300

GGCATCGGCA CAGCATATGA GGGCCACGTA AAGGTGCCCA AACCTTTAGG CGTGAAAAAG 3360

GGATGGCAGA GGGCCATTGC TGTGGTCTGT GACTTCAAAC TCTTTTTATA TGATCTCCCG 3420

GAAGGCAAAG CTGCTCAGCC TGGTGTCGTG GTGAACCAGG TCATTGACAT GAGGGATGAG 3480

GAATTTTCTG TTAGCCCTGT TTTGGCGTCA GATGTCATTC ATGCAAACAG GAAGGATATT 3540

CCCTGTATCT TCAGAGTGAC AGCATCACAG CTCTGCGCCT CCAGCAATAA AAAATGCTCC 3600

ATTTTGATCC TGGCCGACAG CGATCAGGAA AGAACAAAGT GGGTCGGCCT TTTGAAGGAG 3660

CTGCACCGGC TCTTGAAGAA AAGCAAACTG AAAGAACGCT TTGTTTACGT CCCTAAAGAA 3720

GCATATGACT GCGCACTGCC TCTCATCAAA ACCACACAGT CTGCTGCTAT TATAGATCAT 3780

GAGAGGATTG CTCTGGGAAA CGAGGAGGGG TTATACGTTA TTCATGTTAC CAAAGATGAA 3840

ATTATCAAAG TAGGGGACAA CAAAAAGGTT CATCAAATCG AACTGATCCC ATCAGAGCAG 3900

TTGATTGCTG TGATATCCGG CCGAAATGGC CACGTGCGCT TATACCCAAT GACGGCACTG 3960

GATGATCGCG ATGTCGAATC CTACAAGATA GCCGAAACCA AAGGCTGCCA AACTCTCCTT 4020

TCTGGCACAA TTAGACACGG ATCTCTCACC TGTCTCTTTG TGGCCATGAA GAAACCCGAC 4080

AAGGTGATCG TCTACGAGCT CAACAAAAGC AAAGCGCGTC ATCGGAAGCT GCGGGAAATC 4140

CTGGTCCCGG GAAGCGTGCA GTGGATGGGG CTCCAGGGCG AGAAGCTTTG CGTTGGTTTT 4200

CAGTCTGGGT TTTTGCGCTA CAGTCTTCAG GGCGATGGAG GCACCAGCAG CCTCCTCCAT 4260

CCTGATGATC ACACGCTGGG CTTCATTGAG CAGCTCGGGC TTGACTCTCT GTGTGCTGTG 4320

GAGATCTCCA GTAAAGAGCT GCTCTTGTGT TTTAGCAGTA TAGGCATATA TGTGGACTAT 4380

CAAGGCAGAC GGTCACGACA GCAGGAGCTG ATGTGGCCGG CGACACCAAC TGCATGTCGT 4440

TATAATGCAC CTTATCTGTC AGTGTACAGT GAGAATGCGG TAGATGTATT TGATGTCAAC 4500

ACTATGGAGT GGATTCAAAC AATTCCTTTG AAAAAGGTCC ATCCACTGAA CTCTGATGGC 4560

TCTCTAAACC TGCTGGGGCT GGAGACTGTA CGGCTCATCT ACTTCAAGAA CAAGACAGCA 4620

GAGGGAGATG AGCTGGTGGT GCCAGAGACA TCTGACAACA GTCGCAAACA GATGGTGCGC 4680

AGTACGGCGA GCAAACGCCG CTTTTCTTTC CGCATACCGG AGGAGGAGAG AGTTCTGCAG 4740

AGGAGGGAGA TGCTGAGAGA CCCAGAAATA AGGAATAAGT TGATTTCAAA CCCAACTAAC 4800

TTCAACCATG TGGTTCATAT GGGTCCGGGA GATGGGATCC AGATCCTGAA AGAACTGCCA 4860

ATGAACATGC GCTCTCAGGA GAGCCGCGGT GTTCTGGGAG CATCTGTCAG CATCCCCTCC 4920

ATCAGCAGGA CCAGGCCTGA ACCGGGCCGA TCTATGAGCG CCAGTAGCGG CCTTGGCACA 4980

CGCTCCTCCT CTCAAAACGG CAGCGCACTG AGACGGGACT TTTCTGTCGG CAACTATGGT 5040

TCCACCAAAC GGCAGATGAC ATCACCATCT GATGGCTCTC TGTCATCCGG AGGGGGCATG 5100

GACTGCGGTG GTGATGCCCC CCTCTCCCAG TTCGACAGAG AGGATTCAGA GTCTCCACGT 5160

CACTCCACAG CCTCCAACAG CTCAAACCTG AGCAGCCCCC CAAGCCCTTC ATCCCCACAC 5220

AAGAGCAAGA CCCAATCTCT GGAGCGCGGC GAGCACCTCG GCTGGGGCAC ATGA 5274

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+++kv+amkil+k+e+lkrae+a+freerdvlv++ds+w

Q: 77    FEILKVIGRGAFGEVAVVKVKSSDKVFAMKILNKWEMLKRAETACFREERDVLVNGDSQW  136

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd+++lylvm+y+vGGdlltllsk+ed+lpe++arfylae+vla+dsvh+l+

Q: 137   ITTLHYAFQDDNFLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVLAIDSVHQLH  196

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 197   YVHRDIKPDNILIDVNGHIRLADFGSCLKLTEDGTVQSSVAVGTPDYISPEILQAMEDGK  256

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp++  +vse+akd

Q: 257   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQMtDVSENAKD  316

         *************************************************998********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++ re+rlg++gied+k+hpff

Q: 317   LIRRLICCREHRLGQNGIEDFKQHPFF  343

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKV KSSDKVFAMK ILNKWEMLKR AETACFREER DVLVNGDSQW 60

ITTLHYAFQD DNFLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYLAEMV LAIDSVHQLH 120

YVHRDIKPDN ILIDVNGHIR LADFGSCLKL TEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPAQ MTDVSENAKD 240

LIRRLICCRE HRLGQNGIED FKQHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013