EKS-DAR-00446

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00446

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	603.9	7.6E-182	450	728	279

Status

Unreviewed

Ensembl Protein

ENSDARP00000006738

UniProt Accession

F1QH83;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase tousled-like 1-B;

Gene Name

tlk1b

Gene Synonyms/Alias

tlk1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000059190	ENSDARP00000006738	ENSDART00000009936
ENSDARG00000059190	ENSDARP00000076656	ENSDART00000082219

Organism

Danio rerio

Functional Description

Protein Length

756

Protein Sequence
(FASTA)

MSVQSNSNSS GSLDGAPSCS QFSTGSPTPG SVSPLDIFAP RRHKEGMDEL HSLDPRRQEL 60

LEARFIGAVS GNTGGSTGSA SGGPKGLNNN ECSSHSFGSL GSSSDKESET PEKKHSESSR 120

GRKRKVDNQS ESSQGKSSGR GPKISDYFDF QGGNGSSPVR GLPPVLRSPQ NSHSVPGAIV 180

RQNSSSPTSL CFMDHTMNLK QLSSRSVQTD LTLLKLAALE SNKNLDLEKK EGRIDDLLRA 240

NCDLRRQIDE QQKLLERFKE RLNKCTTMSK KLLIEKSTQE KQSCREKSMQ DRLRLGHFTT 300

VRHGASYSEQ WTDGYAFQNL VKQQEWINQQ REEIERQRKL LAKRKPPSTP SSQSPTPNES 360

KQRKTKAVNG ADNDPFLKPS LPTLLTVAEY HEQEEIFKLR LGHLKKEEAE IQAELERLER 420

VRNLHIRELK RINNEDSSQF KDHPTLNERY LLLHLLGRGG FSEVYKAFDL FEQRYAAVKI 480

HQLNKNWREE KKENYHKHAC REYRIHKQLD HPRIVKLYDY FSLDTDTFCT VLEFCEGNDL 540

DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD LKPGNILLVD GTACGEIKIT 600

DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK EPPKISNKVD VWSVGVIFFQ 660

CLYGRKPFGH NQSQQDILQE NTILKATEVQ FPAKPVASNE AKAFIRRCLA YRKEDRFDVH 720

QLGSDSYLLP HMRRSNSSGN LQATPASPAP SGIISY 756

Nucleotide Sequence
(FASTA)

ATGAGTGTCC AAAGTAACAG CAACAGCAGT GGAAGTTTGG ACGGAGCGCC ATCTTGCTCT 60

CAGTTCTCGA CTGGATCTCC GACCCCGGGC TCAGTTTCTC CGCTCGATAT ATTCGCTCCG 120

CGGAGGCATA AAGAAGGTAT GGATGAGCTG CATTCTCTGG ATCCACGCCG GCAGGAGCTT 180

TTGGAGGCAC GTTTCATTGG GGCTGTGAGT GGCAACACGG GAGGAAGCAC AGGGAGCGCG 240

AGCGGTGGAC CTAAGGGTTT GAACAATAAC GAGTGCTCCA GTCACAGTTT TGGCAGCCTG 300

GGGTCATCGA GTGACAAGGA GTCCGAGACT CCAGAGAAGA AGCACTCCGA GTCATCCAGA 360

GGAAGAAAGA GGAAGGTTGA TAACCAATCT GAGAGCAGCC AAGGAAAGTC TTCCGGCCGA 420

GGGCCTAAGA TCAGCGATTA TTTTGATTTC CAGGGAGGAA ACGGATCGAG TCCAGTCCGG 480

GGTCTTCCTC CGGTCCTGCG CTCGCCACAG AACTCTCACT CTGTGCCTGG AGCCATCGTC 540

AGACAGAACA GCTCATCACC CACCAGCCTG TGTTTCATGG ATCACACGAT GAATCTGAAA 600

CAGCTGAGCA GCAGAAGTGT CCAGACGGAT TTGACACTGT TGAAACTGGC TGCACTTGAG 660

AGCAATAAGA ATCTTGACCT TGAGAAGAAG GAGGGCAGAA TAGATGATCT ACTCAGGGCG 720

AACTGTGACC TCCGCAGACA GATAGATGAG CAGCAGAAAC TGCTGGAACG TTTCAAGGAG 780

CGTCTGAACA AATGCACTAC GATGAGTAAA AAACTCCTGA TTGAGAAGAG CACTCAAGAG 840

AAACAGTCCT GCCGGGAAAA GAGCATGCAG GACCGGCTGC GTCTAGGACA CTTCACCACA 900

GTCCGACATG GGGCATCCTA CTCGGAACAG TGGACTGATG GTTATGCCTT CCAGAACCTC 960

GTCAAGCAGC AGGAGTGGAT AAACCAGCAG CGGGAAGAGA TTGAGAGGCA GCGAAAACTT 1020

CTAGCCAAGC GCAAACCTCC CAGCACACCC TCCTCCCAGA GCCCGACCCC CAATGAGTCC 1080

AAACAGAGAA AGACCAAAGC GGTGAACGGA GCTGACAACG ACCCCTTCCT CAAACCCAGC 1140

CTGCCGACAC TGTTGACTGT GGCGGAGTAT CATGAGCAGG AGGAAATCTT CAAATTGAGA 1200

CTGGGTCATC TCAAAAAGGA GGAGGCAGAG ATCCAGGCGG AGCTGGAACG GTTGGAGCGT 1260

GTGAGGAATC TGCACATTCG AGAGCTTAAG AGAATCAACA ATGAGGACAG TTCTCAGTTT 1320

AAAGACCATC CAACTCTTAA TGAACGATAT CTTCTGTTAC ACTTGCTGGG AAGAGGAGGT 1380

TTCAGTGAAG TTTATAAGGC ATTTGACCTG TTTGAGCAGC GATACGCAGC GGTGAAGATC 1440

CACCAGCTCA ACAAGAACTG GAGAGAAGAG AAGAAAGAGA ATTACCATAA ACATGCCTGT 1500

AGAGAATACA GAATCCACAA GCAACTGGAC CATCCTAGAA TAGTCAAACT CTATGATTAC 1560

TTCTCGCTGG ACACCGACAC ATTCTGCACT GTTCTGGAGT TCTGTGAGGG GAATGATCTG 1620

GATTTCTATC TGAAGCAACA CAAGCTGATG TCCGAGAAAG AAGCTCGATC TATCGTCATG 1680

CAGATCGTCA ACGCGCTCCG ATACCTCAAC GAGATCAAAC CTCCCATCAT CCACTACGAC 1740

TTGAAGCCAG GAAATATCCT GTTGGTGGAT GGAACGGCTT GTGGGGAGAT AAAGATTACA 1800

GACTTCGGCT TGTCTAAAAT CATGGACGAC GACAGCTATG GAGTGGACGG GATGGACCTG 1860

ACATCACAGG GAGCCGGAAC CTACTGGTAT TTGCCACCCG AGTGTTTTGT CGTTGGTAAA 1920

GAGCCTCCAA AGATCTCGAA TAAAGTGGAC GTGTGGTCTG TTGGCGTCAT CTTCTTCCAG 1980

TGCCTGTATG GACGAAAGCC GTTTGGCCAT AATCAATCCC AGCAAGACAT CCTTCAAGAG 2040

AACACCATCC TCAAAGCCAC TGAGGTGCAG TTTCCGGCCA AACCTGTGGC TAGCAATGAG 2100

GCTAAGGCGT TTATCCGCCG CTGTCTGGCC TACAGGAAGG AGGATCGCTT TGATGTGCAC 2160

CAGCTGGGAA GTGACTCGTA TCTTCTTCCC CACATGAGAC GATCTAATTC GTCGGGGAAC 2220

CTACAGGCCA CGCCTGCCAG CCCCGCCCCT TCAGGAATCA TCTCCTACTG A 2271

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl eqry+avkihqlnk+w++ekkeny+kha+reyrihk+l

Q: 450   YLLLHLLGRGGFSEVYKAFDLFEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKQL  509

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvle++egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 510   DHPRIVKLYDYFSLDTDTFCTVLEFCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  569

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 570   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  628

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 629   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  688

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpv s+eakafirrclayrkedr+dv+ql +d yl

Q: 689   VQFPAKPVASNEAKAFIRRCLAYRKEDRFDVHQLGSDSYL  728

         *************************************997

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LFEQRYAAVK IHQLNKNWRE EKKENYHKHA CREYRIHKQL 60

DHPRIVKLYD YFSLDTDTFC TVLEFCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPAKPVASN EAKAFIRRCL AYRKEDRFDV HQLGSDSYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013