EKS-DAR-00627
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00627
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR365.73.4E-109342631290
StatusUnreviewed
Ensembl ProteinENSDARP00000076901
UniProt AccessionE7F998;
Protein Name
Protein Synonyms/Alias
Gene NameLOC100334928
Gene Synonyms/Alias LOC100334928;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000059363ENSDARP00000076901ENSDART00000082466
OrganismDanio rerio
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MERLGPPGLG SGSVLLVFLM SALLRTADLR ICSSCKPHPV NCVSNQCFSN CSVSTECVNE 60
QDVCAAVWWR DAGLVMVETL CHDPLKPMLG VMVEDILISE CVLQEQNIHG RHLRVCSCTG 120
DQCNQNLLLR KLTEEEKLSK TNSSSGFRLK QNCKFCDVES SVCNASGVCE SACGINSICE 180
TPDEVCASAW RSNGGNSSIE TVCHNPALLF HGHNLTDSQS RVCQMRRVEE DLYICSCNDE 240
ECNDRLFFNH DLKQYPGVQF NPPSESSWFS LAPVLISVFV LIPIVLLSVF YCYHISQHKL 300
KLPNKKSLDS ERCNIFMNPE EHSDSSSINA NSLNHNTELL PIQLDRVVGK GRFADVYKAK 360
LKQSADSFQT VAVKIFPYEE FSSWKSEWQI FSDVELRHEN VLQFLTAEER TAERQYWLIT 420
AYHERGNLQE LLALQVIGWE EMCRLGVSLA RGVAHLHSDR TPCGRAKVSI AHRDLKSSNV 480
LVKSDWSCCV CDFGLSLRLD SCLSPEELAN SGQVGTARYM APEVLESRMD LENTESFKQA 540
DVYSMALVLW EIMSRCSATG DVRDYEPPFG KLKGHPCVES MKDDVIRDRL RPEIPTSWSK 600
HAGVHHLSST IEECWDHDPE ARLTAQCVVE RFDDIINSDV ILPISPDTKS AGDSGIQEM 659
Nucleotide Sequence
(FASTA)
ATGGAGCGGC TCGGTCCGCC GGGCTTGGGC TCCGGTTCGG TTCTGCTCGT GTTTCTCATG 60
TCTGCTCTTC TCCGCACTGC TGATCTCCGC ATCTGCAGCT CCTGTAAGCC TCATCCAGTC 120
AACTGTGTGT CAAATCAGTG CTTCTCCAAC TGCAGTGTGT CTACAGAGTG TGTGAATGAG 180
CAGGACGTCT GTGCCGCCGT CTGGTGGAGA GATGCTGGAC TGGTGATGGT GGAGACTCTC 240
TGTCATGACC CACTAAAGCC GATGCTCGGT GTGATGGTGG AGGATATTCT CATCTCGGAG 300
TGTGTGTTGC AGGAACAAAA CATTCACGGA AGACACCTGC GTGTGTGTAG CTGCACAGGA 360
GACCAGTGCA ACCAGAACTT GCTGCTGCGC AAACTCACTG AGGAGGAGAA ATTGTCGAAG 420
ACAAACTCCA GCAGCGGCTT CAGACTCAAA CAGAACTGTA AGTTTTGTGA TGTTGAGTCT 480
TCGGTGTGTA ACGCCAGCGG TGTGTGTGAG TCCGCCTGCG GCATAAACTC CATCTGTGAG 540
ACACCGGACG AGGTCTGCGC CAGCGCCTGG AGGAGTAACG GGGGAAACTC CAGCATAGAG 600
ACGGTGTGTC ACAATCCAGC GCTGTTGTTT CACGGCCACA ATCTGACGGA CTCTCAGAGC 660
CGCGTGTGTC AGATGAGGAG GGTGGAGGAG GACTTGTACA TCTGCTCCTG TAACGATGAG 720
GAGTGCAATG ATCGCCTCTT CTTTAACCAC GATTTGAAAC AATATCCAGG GGTTCAGTTC 780
AATCCCCCCT CTGAGTCATC ATGGTTCAGT CTGGCTCCAG TGCTGATCTC CGTCTTTGTC 840
CTCATCCCAA TCGTCCTGCT CTCCGTCTTC TACTGTTACC ACATCAGTCA GCACAAACTG 900
AAGCTCCCCA ATAAGAAGAG TCTGGACAGC GAGAGATGCA ACATTTTCAT GAATCCAGAA 960
GAGCATTCGG ACAGCAGCTC CATCAACGCC AACAGCCTGA ACCACAACAC TGAGCTGCTG 1020
CCCATCCAGC TGGACAGAGT TGTGGGAAAA GGACGATTCG CAGACGTTTA TAAAGCCAAG 1080
CTGAAGCAGA GCGCAGACTC CTTCCAGACG GTGGCGGTAA AGATCTTCCC GTATGAGGAG 1140
TTTTCCTCGT GGAAGAGTGA ATGGCAGATT TTCTCTGACG TCGAACTTCG GCATGAAAAC 1200
GTCCTGCAGT TTCTGACAGC AGAAGAGCGG ACGGCAGAGC GACAGTATTG GCTGATCACG 1260
GCCTATCACG AGCGAGGAAA CCTGCAGGAG CTGCTGGCGC TACAAGTGAT TGGCTGGGAG 1320
GAGATGTGCC GATTGGGCGT GTCTCTGGCA AGGGGCGTGG CTCACCTGCA CTCGGATAGG 1380
ACACCGTGCG GAAGAGCCAA AGTGTCGATT GCGCACCGAG ACCTGAAGAG CTCAAACGTT 1440
CTGGTGAAAA GCGACTGGAG CTGCTGCGTC TGCGATTTCG GCCTCAGCCT GAGACTCGAC 1500
AGCTGCCTGA GTCCTGAGGA GCTGGCCAAT AGCGGACAGG TGGGAACGGC GCGTTATATG 1560
GCTCCAGAAG TGCTGGAGTC GCGGATGGAT CTGGAAAACA CAGAGTCCTT CAAGCAGGCG 1620
GATGTTTACT CCATGGCCCT GGTGCTGTGG GAGATCATGT CCAGATGCAG CGCTACTGGA 1680
GATGTGCGGG ATTATGAGCC TCCGTTCGGG AAGCTGAAGG GTCACCCGTG TGTGGAGAGC 1740
ATGAAAGATG ATGTCATCAG AGATCGATTG AGACCTGAGA TCCCGACCAG CTGGAGCAAA 1800
CACGCGGGTG TTCATCATTT GAGCTCCACC ATTGAGGAGT GCTGGGATCA CGACCCCGAG 1860
GCGCGTCTGA CGGCGCAGTG TGTGGTGGAG CGCTTCGATG ACATCATCAA TAGTGACGTT 1920
ATCCTCCCCA TCAGCCCCGA CACCAAGAGC GCAGGGGATT CTGGGATACA AGAGATGTAG 1980
Domain Profile
S: 1     lklleligkGrygeVwkaklrg.....eevAvKifstedeaswkrEkeiyqtvllrheni  55
         ++l +++gkGr+++V+kakl++     ++vAvKif++e+ +swk+E +i++ v lrhen+
Q: 342   IQLDRVVGKGRFADVYKAKLKQsadsfQTVAVKIFPYEEFSSWKSEWQIFSDVELRHENV  401
         78999*****************999999********************************
S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115
         lqf++a+++++  + +++l+t+yhe+g+L++ L  +++ +ee++rl  sla+G+ahLH++
Q: 402   LQFLTAEERTA--ERQYWLITAYHERGNLQELLALQVIGWEEMCRLGVSLARGVAHLHSD  459
         *******9884..58*********************************************
S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175
          ++ +g+ K +iaHRDlks N+lvk+d +cc++D+GL+l+l++  + ++la++ qvGt R
Q: 460   -RTPCGRAKVSIAHRDLKSSNVLVKSDWSCCVCDFGLSLRLDSCLSPEELANSGQVGTAR  518
         .678899*****************************************************
S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235
         YmaPEvle++++l+++e+fk+aDvYs++LvlWE++sRc++ ++ v +y++pf  +++ +P
Q: 519   YMAPEVLESRMDLENTESFKQADVYSMALVLWEIMSRCSA-TGDVRDYEPPF-GKLKGHP  576
         ****************************************.99*********.7899***
S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290
         ++e+mk+ v++++lrP+ip++w+k++ +++ls+++eecWd+dpeaRlta++v +r
Q: 577   CVESMKDDVIRDRLRPEIPTSWSKHAGVHHLSSTIEECWDHDPEARLTAQCVVER  631
         ****************************************************887
Domain Sequence
(FASTA)
IQLDRVVGKG RFADVYKAKL KQSADSFQTV AVKIFPYEEF SSWKSEWQIF SDVELRHENV 60
LQFLTAEERT AERQYWLITA YHERGNLQEL LALQVIGWEE MCRLGVSLAR GVAHLHSDRT 120
PCGRAKVSIA HRDLKSSNVL VKSDWSCCVC DFGLSLRLDS CLSPEELANS GQVGTARYMA 180
PEVLESRMDL ENTESFKQAD VYSMALVLWE IMSRCSATGD VRDYEPPFGK LKGHPCVESM 240
KDDVIRDRLR PEIPTSWSKH AGVHHLSSTI EECWDHDPEA RLTAQCVVER 290
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017194; Transform_growth_fac-b_typ-2.
IPR015013; Transforming_GF_b_rcpt_2_ecto.
Pfam
PF08917; ecTbetaR2; 2.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013