EKS-DAR-00754

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00754

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	346.7	1.5E-103	249	498	250

Status

Unreviewed

Ensembl Protein

ENSDARP00000078382

UniProt Accession

Q08BY6;

Protein Name

Protein Synonyms/Alias

Zgc:153964;

Gene Name

ptk6b

Gene Synonyms/Alias

ptk6b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000059956	ENSDARP00000078382	ENSDART00000083947

Organism

Danio rerio

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MGECCRKTCP CLKTIWDKIY GPPQAEGENS VKVDGDFTNK GFDKNETERR YSKPKIKPPL 60

PPSANNNAAI YMALWDFKAR NDQELSFKAG DKFEITDRSG DWWTANKKDI FGRVTTGFVP 120

YNYLARDSVE SQPWFFGKMN RVGAVSHLMS DENNYGSFLV RVSESDDMGY VLSVRTKENA 180

KHFKIFQTGD QFYVDALFKF SSIVEVIEHY QSHPLSIGDL LSEPCIRIKP ENVPPPSTDE 240

WELPKEEFQL ENQLGSGHFA DVYSGKWKNH SKVAIKILKN NDALVLREFQ LEVQIMKRLR 300

HKHLISLFAV CTSSSPFYII TELIEKGDLL HFLRNPEGRS LQMESLIDMA AQVADGMAYL 360

EANNSIHRDL AARNVLVGDG YVCKIADFGL ARIIKEPVYL SDDKKIPYKW TAPEAIGHGT 420

YSSKSDVWSF GILLYEIVTH GGIPYPGVNT GEVYDLITKE NYRMPSPPKC PQAIYNIMRA 480

CWRIESVDRP NFKVLKDELD NYQGQYSSVG N 511

Nucleotide Sequence
(FASTA)

ATGGGGGAAT GTTGTAGGAA AACTTGCCCA TGTCTCAAGA CAATATGGGA CAAAATATAC 60

GGACCACCAC AAGCGGAGGG GGAAAATAGC GTGAAAGTTG ACGGTGACTT TACGAACAAG 120

GGCTTCGACA AGAATGAGAC TGAACGCCGT TATTCGAAGC CGAAGATCAA GCCGCCTTTA 180

CCACCGAGTG CAAACAACAA TGCTGCTATT TACATGGCAC TGTGGGACTT CAAGGCGCGC 240

AACGACCAGG AGTTGTCCTT TAAAGCTGGA GATAAGTTCG AGATTACCGA CCGTTCCGGT 300

GACTGGTGGA CTGCCAATAA AAAGGACATA TTCGGCCGTG TGACCACCGG TTTTGTTCCT 360

TACAATTATC TGGCTCGAGA TTCCGTAGAG TCTCAACCGT GGTTTTTTGG AAAGATGAAT 420

CGTGTTGGAG CAGTGAGCCA CCTCATGTCT GATGAAAATA ATTATGGATC TTTTCTTGTG 480

CGGGTCAGTG AGAGTGACGA CATGGGCTAC GTACTGTCAG TGAGGACAAA GGAAAATGCA 540

AAGCACTTCA AGATCTTTCA GACTGGTGAT CAGTTCTACG TGGATGCGTT GTTTAAGTTC 600

AGCAGTATAG TAGAAGTGAT TGAACATTAT CAAAGTCACC CACTCTCCAT TGGGGACCTA 660

CTGAGTGAGC CTTGCATTCG GATAAAGCCG GAGAATGTGC CACCTCCCTC AACGGATGAA 720

TGGGAGCTGC CTAAAGAGGA ATTTCAGCTG GAGAATCAGC TTGGCAGTGG TCACTTTGCT 780

GATGTGTACA GTGGCAAATG GAAAAATCAC TCTAAAGTGG CCATAAAAAT CCTCAAGAAC 840

AACGATGCTC TTGTGCTGAG GGAGTTTCAG TTGGAGGTGC AGATCATGAA GCGTTTACGT 900

CACAAGCACC TGATTTCTCT CTTTGCTGTG TGCACTTCCT CCTCACCGTT TTACATCATC 960

ACCGAACTAA TAGAAAAGGG CGACTTGCTT CATTTCCTCA GAAATCCAGA GGGAAGATCA 1020

TTGCAGATGG AGTCTCTGAT TGACATGGCA GCTCAAGTGG CAGATGGGAT GGCATATTTA 1080

GAGGCAAATA ACAGTATTCA TAGGGACCTC GCTGCCAGAA ATGTGCTTGT AGGAGATGGA 1140

TATGTCTGCA AAATTGCTGA TTTTGGCCTA GCTCGAATCA TTAAGGAGCC AGTTTATTTA 1200

AGCGATGACA AGAAAATACC ATATAAATGG ACAGCACCTG AGGCCATTGG TCATGGCACT 1260

TACTCCAGTA AATCTGATGT CTGGTCCTTT GGGATTCTCC TTTATGAGAT TGTTACTCAT 1320

GGAGGAATAC CTTATCCAGG TGTCAACACT GGTGAGGTGT ATGATCTCAT AACGAAGGAA 1380

AACTACAGAA TGCCTTCACC ACCCAAGTGT CCACAAGCCA TTTACAACAT CATGCGAGCT 1440

TGCTGGAGAA TAGAGTCAGT GGACAGACCC AACTTTAAGG TTTTGAAGGA TGAGCTGGAC 1500

AACTATCAAG GCCAATATAG CAGTGTGGGA AATTAA 1536

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60

         +l+++lG+G+f +v+ gkwk++ kva+k lk+++ l  ++f+ e+qi+k+lrh++l++l+

Q: 249   QLENQLGSGHFADVYSGKWKNHSKVAIKILKNNDaLVLREFQLEVQIMKRLRHKHLISLF  308

         7999***************************987699***********************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av+++  P+yi+tel++kG ll+fl++ eg++l++++l+d+aaqva+Gmayle++n ihr

Q: 309   AVCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQMESLIDMAAQVADGMAYLEANNSIHR  368

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dlaarnvlvg+  v+k+adfGlar+i++  y +  ++k+P+kWtaPeai  g+++ ksdv

Q: 369   DLAARNVLVGDGYVCKIADFGLARIIKEPVYLSD-DKKIPYKWTAPEAIGHGTYSSKSDV  427

         *******************************986.59***********************

S: 181   WsfGillteivtkGkvPypGmtneevleqve.rgyrlprpeecpeelyelllecwkkdpe  239

         WsfGill+eivt+G +PypG+++ ev + ++ ++yr+p p +cp+ +y+++  cw+ ++

Q: 428   WSFGILLYEIVTHGGIPYPGVNTGEVYDLITkENYRMPSPPKCPQAIYNIMRACWRIESV  487

         ****************************986268**************************

S: 240   erPtfetlqev  250

         +rP f++l+

Q: 488   DRPNFKVLKDE  498

         ******99865

Domain Sequence
(FASTA)

QLENQLGSGH FADVYSGKWK NHSKVAIKIL KNNDALVLRE FQLEVQIMKR LRHKHLISLF 60

AVCTSSSPFY IITELIEKGD LLHFLRNPEG RSLQMESLID MAAQVADGMA YLEANNSIHR 120

DLAARNVLVG DGYVCKIADF GLARIIKEPV YLSDDKKIPY KWTAPEAIGH GTYSSKSDVW 180

SFGILLYEIV THGGIPYPGV NTGEVYDLIT KENYRMPSPP KCPQAIYNIM RACWRIESVD 240

RPNFKVLKDE 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

dre:767734

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013